Homeostasis

Neutrophils respond to cytokine withdrawal for apoptosis following infection

Published in Health and Medicine Week, August 4th, 2003

Homeostasis of immune cells following infection may occur due to cytokine withdrawal and subsequent apoptosis.

According to a study from Switzerland, "Neutrophils are constantly produced in large numbers in the bone marrow, and the same numbers of cells need to die within a defined time period in order to keep cellular homeostasis under physiologic conditions. Changing the rate of apoptosis rapidly changes cell numbers in such systems. For instance, in many bacterial and autoimmune inflammatory diseases, delayed apoptosis is one important mechanism for neutrophil accumulation.

"Excessive production of granulocyte/macrophage colony-stimulating factor...

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Source: Health and Medicine Week (2003-08-04)

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