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Health & Medicine Week

Susan Hasty, Publisher
Table of Contents . . . September 1st, 2003
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Health & Medicine Week | Other Publications

Adolescent Medicine - Relationship-based intervention improves maternal sensitivity in young mothers

Tissue Engineering - Carnegie Mellon develops new process for growing bone

Complementary and Alternative Medicine - Brain scans, blood tests show positive effects of meditation

Exercise - Women benefit from physical activity during and after menopause

Fitness - Physical activity definitions broadened to include daily activities

HIV/AIDS Epidemiology - Prevalence of HIV infection increasing in older Americans

Pain Medicine - Hypnosis doesn't improve pain relief strategies

Acute Leukemia - Targeting TNF pathway along with ATRA may represent route to treat leukemias

Adhesions - Biomaterials company receives U.S. patent on polymer technology

Algal Immune Effectors - Polysaccharide extracts from different algae produce different immune effects

Allergic Rhinitis - Mast cell product-antagonizing is short-term treatment, long-term solutions needed

Allergic Rhinitis - Rhinitis immunotherapy using specific subcutaneous allergen is better than drugs

Allergies - Latex allergy may create cross-reactive fruit allergies; kiwi is highest risk

Allergy Medicine - Protein digestibility related to allergenicity

Alzheimer Disease - As U.S. population ages, AD prevalence expected to increase substantially

Alzheimer Disease - Regulation of glucose by HIF-1 protects neurons from amyloid beta peptide

Amyotrophic Lateral Sclerosis - Catalytic antioxidant, AEOL 10150, selected for development as ALS treatment

Amyotrophic Lateral Sclerosis - Rights acquired to ALS gene therapy from Salk Institute

Anal Fissure Pain - Progress reported on Cellegesic phase III trial

Aneurysm Repair - Seniority of surgeon did not affect aneurysm surgery outcome

Animal Models - Research hampered by shortage of monkeys

Anorexia Nervosa - Genes showing differential expression in anorexia mutant mouse identified

Antiangiogenesis - Novel 1,3,4-trisubstituted pyrazole derivatives stifle tumor growth mechanisms

Antibiotic Research - Resistance may occur in bacteria if innate antibiotic proteins are used

Antibiotic Resistance - Newly discovered inhibitors of bacterial lactamases may prevent resistance

Antibiotic Resistance - World Health Organization: Farmers should cut antibiotic use

Antibiotics - N- and C-terminal modifications of negamycin affect antibacterial activity

Antiemetics - Swiss pharmaceutical group announces European drug submission for palonosetron

Antifungal Research - Gallerimycin, a moth-derived antifungal peptide, isn't active against yeast

Antimetastatic Action - TSLC1 gene in human lung cancer is probably a cell adhesion molecule

Antimicrobial Resistance - Vancomycin-resistant infections are low among liver transplant candidates

Antisense Technology - Egr-1 inhibition reverses the transformation of prostate cancer cells

Antisense Technology - New MAST technology has universal applications for tracking desired mRNA sites

Antiviral Therapy - Novel DSTP derivative inhibits growth of HIV and herpesviruses

Antiviral Therapy - Several factors contribute to treatment failure in chronic hepatitis C

Arousal - Researchers close in on scientific definition of arousal

Artificial Heart - Ventracor reports on first patient

Asthma - Airway epithelium is in constant repair; allergens create cyclic Th2 response

Asthma - Biomedical engineer receives $1.8 million grant to study lung damage

Asthma - Disodium chromoglycate doesn't help kids with asthma

Asthma - Food allergy may be a source to consider for asthma of unknown origin

Asthma - Labeling changes required for drug products that contain salmeterol

Asthma - Patent awarded for therapeutic uses of interleukin-9 receptor protein

Asthma - Revotar reports positive results with small molecule selectin antagonist

Asthma - Study links preschool snoring, asthma, and nighttime cough

Asthma - Study of glucocorticoid-receptor interactions may lead to new anti-asthma agents

Asthma Therapy - Nramp gene determines efficacy of mycobacteria-based asthma treatment

Atherosclerosis - Patient enrollment completed in phase IIb CART-2 study with AGI-1067

Atherosclerosis - Vitamins restore blood vessel performance in kids with high cholesterol

Atopic Dermatitis - FDA approves skin emulsion

Atrial Fibrillation - First patient dosed in phase III atrial arrhythmia studies

Autoimmune Disease - Array analysis of autoimmune disease leads to vaccine development

Autoimmune Disease - Autoreactive B lymphocytes may be removable by recombinant fusion proteins

Autoimmune Disease - Some MG seronegative patients may be MuSK antibody positive

Autoimmune Disease - Systemic lupus erythematosus is more prevalent than was previously thought

Autoimmune Disease - Targeted DNA vaccine may reverse disease

B Cell Function - Efficient Vav3 translocation to B cell membrane rafts requires Grb2 and BLNK

Back Injury - Can effective stress management prevent back injuries in nurses?

Bacteriology - Proteinases secreted by Bacillus intermedius during sporulation studied

Barrett Esophagus - FDA approves Photofrin for the ablation of high-grade dysplasia

Bee Venom - Breast cancer, metastasis, growth reduced with i.v. bee venom therapy in murine model

Beta-Thalassemia - Drug may eliminate transfusions in patients with blood disorder

Biliary Cirrhosis - Symptoms, cirrhosis disease progression are known; cause and cure remain elusive

Biliary Stent - Percutaneous transhepatic retrieval of a displaced biliary stent is feasible

Bioengineering - A novel skin model invites new ways to explore angiogenesis in vitro

Bioengineering - Hybrid fermentation devices increase the output of recombinant molecules

Biomarkers - New screening for CAR reveals transfection efficiency in cancer cells

Bipolar Disorder - Dopamine receptor genotype doesn't affect TSD efficacy for bipolar patients

Blood Safety - All donations now screened for West Nile in U.S.

Blood Screening - FDA license granted for new HIV test kit

Bone Marrow Imaging - Diffusion-weighted imaging can detect bone marrow alterations

Bone Marrow Transplant - Antithymocyte globulin lowers GVHD, worsens T-cell deficiency

Bone Regeneration - Collagen-hydroxyapatite/tricalcium phosphate microspheres deliver rhTGF-beta 1

Bone Tumors - Nuclear medicine bone scan can give a potentially misleading appearance

Bone Tumors - Rotationplasty may be an effective partial limb salvage procedure

Bone Tumors - Zoledronic acid will improve patients' quality of life

Borna Disease Virus - Seropositive schizophrenic patients respond to cerebrospinal fluid filtration

Brachytherapy - Company plans to increase sales of I-Plant prostate cancer seed

Brain Cancer - Welsh study set to accelerate search for new treatment

Brain Tumor - Research: GliaSite RTS is a safe and effective treatment for brain tumors

Breast Cancer - Breast cancer screening should be encouraged by general practitioners

Breast Cancer - Duke University's hyperthermia treatment acquired

Breast Cancer - First component of rolling NDA submitted for RSR13

Breast Cancer - Program for low-income women suggests vital importance of access to screening

Breast Cancer - Syngeneic stem cell grafts offer little improvement over autografts for breast cancer patients

Breast Cancer - Systemic redundancies may mask the effects of PAI-1 on cancer inactivation

Breast Cancer - Trial tests treatment for postmenopausal cancer patients who relapse

Breast Implant - De-epithelialized TRAM flaps are an alternative to autologous tissue use

Breastfeeding - Baby-friendly hospitals have positive impact on breastfeeding

Business and Finance - Tennessee insurers compete for customers

Cancer Biomarkers - Cytokine imbalances mark the pathogenesis of chronic lymphocytic leukemia

Cancer Cells - Antibody scFv fragments may be a nuclear delivery system in cancer cells

Cancer Immunotherapy - Diabody-based gene therapy represents a new strategy for cancer therapy

Cancer Metastasis - Prostate cancer invasion is influenced indirectly by TGF beta1 signals

Cancer Therapy - Carboxymethyl benzylamide dextran limits carcinomas in nude mice

Cancer Therapy - G-CSF raises GVHD but not mortality risk in matched sibling stem cell graft recipients

Cancer Therapy - ImClone, Bristol-Myers file application to approve Erbitux

Cancer Therapy - Isolated limb perfusion is feasible for treating cancer and other diseases

Cancer Therapy - Mitochondrial genes linked to tumor cell radiation resistance

Cancer Therapy - PEDF gene transfer suppresses angiogenesis and tumor growth

Cancer Therapy - The gef gene blocks the growth of breast cancer cells

Cancer Therapy - Vascular integrins are targets for cancer containment

Cancer Vaccine - Antibody fragments fused to IL-12 and to TNF-alpha exert anti-tumor effect

Cancer Vaccine - Current developments in cancer vaccines and cellular immunotherapy reviewed

Cancer Vaccine - IL-6 fused to antibody increases immune response against ovarian cancer

Cancer Vaccine - MUC1-derived glycopeptides are strong antigens for breast cancer vaccines

Cancer Vaccine - Peptide vaccine with adjuvant and CTLA-4 blockade elicits antitumor response

Cardiac Hypertrophy - Natural hormone could reverse heart damage

Cardiac Surgery - Intraoperative infusion of magnesium has beneficial effects on surgical outcome

Cardiology - Ex vivo gene transfer improves cardiac function in a swine ischemia model

Cardiology - Exogenous SERCA gene expression depends on CAR levels in cardiac myocytes

Cardiology - John Muir/Mt. Diablo selects TCS Symphony for cath image management/archiving

Cardiology - Premenopausal women have good outcomes after heart attacks with PTCA

Cardiovascular Disease - GATA4 mutation linked to congenital heart defects

Cataracts and Glaucoma - Cataract removal, nonpenetrating glaucoma surgery can be combined

Cell Biology - Endothelial cells overcome hypoxia-induced apoptosis because of CD105

Cell Biology - Scientists create new strain of yeast with 21-amino acid genetic code

Cervical Cancer - Genetically engineered plants produce vaccine components

Cervical Cancer - Papillomavirus E7 protein blocks pCAF's acetyltransferase, a p53 coactivator

Chemotherapy - Circulating VEGF levels change in response to therapy for metastatic cancer

Childhood Immunization - ACPM recommends research priorities for child and adolescent immunizations

Childhood Obesity - Peak heart rate low in obese girls

Chronic Hepatitis B - Thymosin-alpha 1 and interferon combination therapy controls HBV infections

Chronic Hepatitis C - Antigenic escape shifts the antibody balance in hepatitis C-infected patients

Chronic Lymphocytic Leukemia - Novel gene may be involved in CLL development

Chronic Myeloid Leukemia - Chronic-phase CML patients respond to imatinib, but questions remain

Citrobacter Braakii - LPS polysaccharide from strain PCM 1531 isn't same as others in group O6

Claims Management - Arkansas Blue Cross Blue Shield chooses Webify ClaimsNet

Clear Cell Carcinoma - Three immunohistochemical stains help distinguish clear cell cancer as ovarian or renal

Coagulation - Gln 192 from blood coagulation factor Xa plays key role in function

Cochlear Implant - CT can visualize temporal bone anatomic changes

Cognition - Amyloid-beta peptide impairs short-term but not long-term memory in rats

Cognitive Function - Creatine supplement boosts brain power

Collaborations - $50,000 development grant will support Oregon's bioscience industry

Collaborations - Alliance to deliver electronic clinical trial solution

Collaborations - Care management firm announces agreement with Carolinas HealthCare System

Collaborations - Chiropractic company enters agreements for Florida market

Collaborations - Liposome technology company initiates cooperative alliance

Collaborations - Partners HealthCare enters clinical research alliance

Collaborations - Research alliance centers on monoclonal antibody for inflammatory disease

Collaborations - ThinPrep imaging system agreement signed

Collection Management - Einstein Health Network to use HealthPay24 software to increase collections

Colon Cancer - Binding sites for Lewis antigens are expressed by human colon cancer cells

Colon Cancer - Immunochemical fecal occult blood testing can prevent advanced colorectal cancer

Colon Cancer - Moderate doses of vitamin B-6 suppress tumor growth in animal studies

Colorectal Neoplasms - Different genetic pathways may exist in the development of colorectal adenomas

Complementary and Alternative Medicine - Cordyceps pruinosa extract inhibits NF-kappaB gene expression

Complementary and Alternative Medicine - Study calls for major reforms in marketing of ephedra

Congestive Heart Failure - RABBIT trial started to evaluate b-type natriuretic peptide

Contact Lens - Contact lenses help poor visual acuity after unsuccessful refractive surgery

Contraception - Arabic language website launched on emergency contraception

Coronary Artery Bypass - Poverty increases risk of complications and death after CABG

Coronary Artery Disease - Study looks at role of intra-abdominal fat in heart disease in women

Coronary Grafting - Internal thoracic artery can be developed by an inferior epigastric AV fistula

Corporate Update - Chemistry-driven drug discovery company realigns business mission

Correctional Health - Tennessee company to provide healthcare to Pennsylvania prisoners

Crohn Disease - Anti-TNF-antibody therapy shows same results in IL-10 knockout mouse as humans

Cryogenics - Contract signed for exclusive provider for MRI magnet base

Cystinuria - Kidney stone patients can now be reliably tested, treated

Cytokine Control - Protein inhibitor of activated STAT3 and androgen receptor compete for STAT3

Cytomegalovirus - Host cell binding prevented for cytomegalovirus coated with AD-2 antibody

DNA Damage Response - Human Spy1 promotes survival of mammalian cells following DNA damage

DNA Research - Improved single nucleotide polymorphism-based genotype assays developed

DNA Research - Novel HIV-based cDNA cloning system may aid genetic research

DNA Testing - Amelogenin, 17 DNA loci effective as paternity markers in incest case

Dendritic Cell Function - Immature dendritic cells are largely unaffected by apoptotic T cells

Dermatology - Alpha-3-beta-1-integrin regulates hair follicle morphogenesis

Dermatology - EGF receptor may play critical role in suppressing keratinocyte inflammation

Developmental Biology - Clue found as to why small babies have increased risk of heart disease as adults

Diabetes Complications - Vascular endothelial growth factor is fundamental to diabetic retinopathy

Diabetes Epidemiology - Diabetes underdiagnosed in dialysis patients on renal transplant waiting list

Diabetes Epidemiology - Increased prevalence of diabetes - not all bad news

Diabetes Therapy - Allosteric activators of glucokinase show promise for diabetes therapy

Diabetic Nephropathy - Metabolic status affects markers for glomerular filtration rate

Diabetic Nephropathy - Prevention of the development and progression of renal disease reviewed

Diabetic Nephropathy - Study of genetic determinants of diabetic nephropathy launched

Diagnostic Markers - Trio of AFP, PIVKAII, GGTII increases accuracy of liver cancer diagnosis

Diagnostics - Effect of trabecular material on backscatter from cancellous bone reported

Diagnostics - Pediatric Lyme arthritis can be diagnosed using a recombinant IR6 assay

Diagnostics - Primary ocular lymphoma is often diagnosed late, following brain metastasis

Dialysis - Blue Cross unit decides to fully cover drug that prolongs patient survival

Diarrhea - Intestinal polypeptide antagonists considered as antidiarrhea agents

Diet and Nutrition - Some dietary fat reducing behaviors difficult to change in Arab women

Diet and Nutrition - The tendency to overeat predicts food consumption

Disease Management - Balanced outlook helps patients manage depression

Downsizing - Reduction in work force announced at lab-on-a-chip company

Drug Abuse Screening - Agreement signed for use of chemical assay

Drug Assistance Program - Pharmaceutical firm to help state AIDS programs

Drug Benefits - Congressional proposals offer little help to low-income Medicare recipients

Drug Delivery - Company's system helps reduce medication errors

Drug Design - Drugs must target particular compartment where protein they act upon is located

Drug Development - PEDF could potentially treat a variety of angiogenesis-related disorders

Drug Discovery - Inpharmatica secures ADME service agreement with European pharmaceutical company

Drug Importation - Montana moves to halt Canada drugs by mail

Drug Importation - Ohio county's prescription drug program halted

Drug Resistance - Epidemiology of sporadic bloody diarrhea in rural Western Kenya reported

Duodenal Carcinoma - Primary duodenal carcinoma can show divergent growth patterns

Early Learning - Babies determine shapes, objects at early age

Eating Disorders - Anorexia afflicting children as young as 8

Electronic Claims Processing - Claimsnet signs new contract with third party administrator

Electronic Medical Records - Michigan system selects company for connecting patient health data

Emergency Medicine - Dedicated trauma program improves patient outcomes

Emergency Medicine - Disaster relief fund in jeopardy

Emergency Medicine - Neighborhood factors are an independent risk for childhood injury

Employee Benefits - HealthMarket offers consumer driven health plans in Nevada

End-of-Life Care - Michigan group to review hospital "futile care" policies

Endocrine - Intermittent estrogen stimulates cell differentiation and bone formation

Endocrinology - Blue fox handling during pregnancy generates fetal gonadal stress

Endocrinology - First of three phase III exenatide studies achieves positive results

Endocrinology - Hormone replacement has no effect on the bladders of ovariectomized rats

Endometrial Cell Marker - Cold-inducible RNA-binding protein is downregulated in endometrial carcinoma

Environmental Health - Aerosolized mycobacteria may underlie respiratory disease outbreaks

Environmental Health - New method available for detecting toxic mold

Environmental Health - PAH exposure linked to DNA damage in human blood cells

Environmental Toxicology - The herbicide simazine may cause suppression of many immune system functions

Epidemiology - Black women still hardest hit by fatal breast cancer

Epidemiology - Risk of human ehrlichiosis in Germany present despite no clinical cases

Epidemiology - Sickness records can predict employee deaths

Epidemiology - Work done by Emerging Infections Programs outlined

Epilepsy - Foundation welcomes FDA approval of new monotherapy treatment for children

Epilepsy - Ketogenic diet raises cholesterol, lipid levels in children

Epstein Barr Virus - Inflammatory pseudotumor due to clonal EBV-infected cells can occur in spleen

Escherichia Coli - The StcE gene was probably acquired by E. coli O157:H7 via plasmid

Evolution - An MHC-like region of 19 genes is conserved between humans and fruit flies

Evolutionary Biology - Key genes prompt species to converge

Evolutionary Genomics - Pioneering study compares 13 vertebrate genomes

Expansion - Desert Medical Group to take larger role in FDA-based clinical research

Fat Substitute - FDA eliminates current label requirement on snack foods made with Olean

Fertility Medicine - Boston firm close to commercializing a way to freeze human eggs

Fetal Medicine - Midaortic syndrome and cardiomyopathy can give nonimmune fetal hydrops

Fetal Monitoring - Scientists develop greater accuracy in recording baby's heart rates in the womb

Fibroblasts - Autologous cellular therapy company receives license to manufacture in Australia

Finance - ADHD drug maker reports earnings of $0.31 per share

Finance - APF112 phase II submitted for FDA review; royalty income increases 11%

Finance - Actimmune sales increase; company meets guidance

Finance - Allergan collaboration leads to increased revenues for pharmaceutical company

Finance - American Physicians Capital reports income of $0.12 per share

Finance - Biosurgical device company reports net loss of $22.3M

Finance - Biotech company reports $0.36 per share loss

Finance - Biotherapeutics company reports loss of $0.24 per share

Finance - Board authorizes $1B share-repurchase program at medical products firm

Finance - Body monitoring device company raises $4M

Finance - CRO announces second quarter results, reports steadily improving results

Finance - Cell imaging systems provider secures equipment financing line

Finance - Coagulation monitoring systems company closes latest funding round

Finance - Company provides second quarter update, reports on CCR2 receptor antagonist program

Finance - Company receives extension of waivers from EPIL noteholders

Finance - Company updates Cialis progress, reports results for second quarter of 2003

Finance - Company's second quarter marked by record revenues, improved operating results

Finance - Corvas acquisition helps strengthen company's second quarter

Finance - Cross Country Healthcare reports 5% increase in revenue

Finance - Development of Affinitak contributes to company's decreased revenues

Finance - Device company reports 129% increase in net income

Finance - Dialysis company reports net loss of $0.19 per share

Finance - Dialysis company reports second quarter and 6-month results for 2003

Finance - Drug delivery company reports $0.47 per share loss

Finance - Drug discovery company meets second quarter expectation, initiates trials

Finance - Drug discovery firm meets analysts' estimate for revenues, earnings

Finance - Electrophysiology company achieves several milestones in second quarter

Finance - Epilepsy device maker reports 16% increase in sales

Finance - Equity firm to buy stake in nurse staffing company

Finance - Expenses to commercialize PowerLink AAA technology affect 2Q results

Finance - Genomics technology company provides update on its second quarter

Finance - Gentiva reports second quarter net revenue growth of 6.6% and diluted EPS of $0.19

Finance - German biotech reports 11% revenue increase in first half of 2003

Finance - Gliadel Wafer sales increase; company reports net loss in second quarter

Finance - Grants to fund rapid, portable detection systems for HIV, blood lead

Finance - Health Care Property Investors to redeem 7.875% series A preferred stock

Finance - Health Grades reports strong ratings and advisory revenue for second quarter

Finance - Health Net's second quarter EPS climbs 24% to $.63 per diluted share

Finance - Health system cites improved financials as basis for rating upgrade

Finance - HealthSouth sells Florida hospital to generate cash

Finance - Healthcare consulting, management services firm announces 2Q 2003 financial results

Finance - Healthcare supplier reports second quarter diluted EPS up 18% to $0.74

Finance - Hearing-care company has second consecutive quarter of profitable operations

Finance - Heart valve company raises $12.3M in private placement of common stock

Finance - Hormone therapy company raises $10.3M in private placement

Finance - Humana completes offering of $300 million of senior notes

Finance - Imaging company pleased with third quarter progress

Finance - Immunology company reports financial results, discusses Aventis collaboration

Finance - Information technology company pays dividend, launches product

Finance - Information technology company reports fourth quarter of profitability

Finance - Lab services company has a record-setting second quarter

Finance - Lab testing service reports increased patient volumes, revenues in second quarter

Finance - MDE acquisition highlights medical device company's fourth quarter

Finance - Massachusetts HMOs' profits up or about even in 2Q 2003

Finance - NeighborCare helps drive third quarter growth for Genesis Health

Finance - New products contribute to second quarter increases for medical products company

Finance - Oncology drug maker reports 66% increase in revenue

Finance - Pharmaceutical company reports net loss of $0.01 per share

Finance - Pharmaceutical distributor reports earnings of $0.29 per share

Finance - Pharmaceutical firm reports earnings of $2.43 per share

Finance - Pharmaceutical firm reports loss of $0.14 per share

Finance - Phoenix firm completes new $275 million credit facility

Finance - Pneumo Sleeve maker reports second quarter loss of $536,000

Finance - Pricing of note financing announced by occupational health firm

Finance - Pulsatile drug company files with SEC for IPO

Finance - Ribapharm parent reports second quarter 2003 net income of $14.9 million

Finance - Robotics company has profitable second quarter, thanks to record sales

Finance - Rosacea drug maker increases guidance for 2003

Finance - Status of stock offering reported by laser company

Finance - Strong Euro affects urological device maker's second quarter results

Finance - Ther-Rx branded pharma business contributes to increased first quarter revenues

Finance - Venture capital group invests in chloroplast DNA company

Finance - Women's health drug maker reports loss of $0.12 per share

Financing - Series B financing raises $26.4M to fund infectious disease program

Fish Immunomodulator - Shark cartilage has proteoglycans that stimulate macrophage and B, not T cells

Fitness - Counseling helps older adults add exercise to their lives

Fitness - Exercise may prolong men's sex lives

Fitness - People over 40 need frequent exercise to prevent or treat type 2 diabetes

Food Allergy - Pediatric hypersensitivity requires full elimination of the suspected food

Food Allergy - Recent recommendations for food allergen avoidance in children are reconciled

Food Allergy - Treatment for peanut-induced anaphylaxis may soon involve anti-IgE

Food-borne Disease - Vibrio vulnificus strains vary seasonally in the Galveston Bay estuary

Food-borne Disease - All Vibrio vulnificus isolates from market oysters are virulent

Food-borne Disease - Antimicrobial cocktail may reduce bacteria in fresh-cut produce

Food-borne Disease - Bacteriophage: Poultry's welcome virus

Foot Ulcers - OrCel data results published

Fungal Therapy - Caspofungin is first approved agent in new class of antifungals

Gastric Wall Tumors - One trocar method can be used for endo-organ resection of gastric wall tumors

Gastroenterology - Hepatitis C virus patients often form elevated serum lipase levels

Gastroenterology - Organelles of Giardia lamblia trophozoite contain cathepsin C activity

Gastroparesis - Data show Enterra therapy reduces persistent nausea, vomiting

Gene Delivery - The new nonviral GE7 vector system takes advantage of overexpressed receptors

Gene Probes - Spotted long oligonucleotide arrays allow for larger scale gene analysis

Gene Regulation - Specific factors direct iNOS-targeted antisense knockdown in endothelial cells

Gene Therapy Vectors - pTF-FC2 plasmid efficiently transfers genes to plants

Gene Transfer - Adenoviral fiber knob modifications overcome refractory transgene expression

Generic Antibiotic - Cefuroxime axetil tablets - generic equivalent of Ceftin - launched

Genetic Disorders - CAIS may be caused by androgen receptor gene disruption

Genetic Disorders - Folic acid food fortification may not reduce Down syndrome risk

Genetic Disorders - Visual-spatial deficits suitable for neurofibromatosis type-1 diagnosis

Genomics - Tumor and drug-resistant genomes can be shaped by instability and selection

Genomics Agreement - Human Genome Sciences announces license agreement

Genomics and Genetics - Evolutionary history of Australian and New Guinean aborigines described

Genomics and Genetics - Human autosomal nonsyndromic male infertility gene, CATSPER2, identified

Genomics and Genetics - Murine Cyp3a gene locus mapped

Genomics and Genetics - Novel retroviral plasmid library may improve genome research

Genotyping - Hopkins is first U.S. institution to obtain powerful technology

Geriatric Influenza Risk - Influenza A recurrence in myocarditis may cause cardiogenic shock

Geriatrics - Proteins that signal amyloid changes in Alzheimer disease are found in PEX

Glioma - SLIT2 may be glioma tumor suppressor gene

Glucose Control - Open label extension study of Metformin GR reinforces positive phase III results

Guillain Barre Syndrome - Acute flaccid paralysis may be caused by West Nile virus infection

Gynecology - Estradiol implants don't improve the urge syndrome in postmenopausal women

Gynecology - Estrogen receptor expression is differential in gynecological tissues

Gynecology - Oxytocin and estrogen receptor mRNAs change during the rodent estrous cycle

Gynecology - Patient position affects the analysis of pelvic organ prolapse

Gynecology - Spinal neurons involved in the urethrogenital reflex have been identified

Gynecology - Women with urinary tract dysfunction may have bouts of constipation

HIV/AIDS - Kappa-opioid, prostanoid EP3 receptors mediate HIV gp120-induced allodynia

HIV/AIDS Animal Models - Novel SHIV chimera may improve simian HIV models

HIV/AIDS Coinfection - SPECT imaging may replace liver biopsies in HIV/HCV coinfected patients

HIV/AIDS Diagnosis - Finger-stick HIV test is accurate and acceptable to women in Thailand

HIV/AIDS Diagnosis - Novel less-sensitive EIA may improve HIV infection tracking

HIV/AIDS Drug Resistance - Resistance mutation patterns different in subtype B and E HIV strains

HIV/AIDS Gene Therapy - Small interfering RNAs protect stem cells from HIV infection

HIV/AIDS Immunotherapy - Anti-gp41 antibody and interleukin-16 have synergistic anti-HIV effects

HIV/AIDS Neurotoxicity - Neuronal heat shock defenses not activated by HIV gp120

HIV/AIDS Opportunistic Infection - EGFR is a human cytomegalovirus receptor

HIV/AIDS Opportunistic Infection - Neutralizing antibodies don't prevent gB2 CMV reactivation in HIV patients

HIV/AIDS Opportunistic Infection - Substance P expression linked to diarrhea severity during cryptosporidiosis

HIV/AIDS Pathogenesis - Downregulation of cell surface CD4 needed for efficient HIV replication

HIV/AIDS Pathogenesis - HIV nef gene linked to vertical transmission

HIV/AIDS Pathogenesis - No direct interaction between Sp1 and HIV Tat proteins

HIV/AIDS Risk Factor - Sexual behavior labels usefulness limited in sexually active gay men

HIV/AIDS Risk Factor - TNF-alpha-inducible mutation in interferon gamma gene linked to rapid HIV progression

HIV/AIDS Therapy - HIV p24 levels linked to CD4 count change in successfully treated patients

HIV/AIDS Therapy - Markers of abacavir allergy versus influenza virus infection identified

HIV/AIDS Therapy - Novel HEPT analogs show improved antiretroviral activity

HIV/AIDS Therapy - Novel stavudine derivatives synthesized

HIV/AIDS Therapy - Proflavine disrupts HIV Rev protein activity

HIV/AIDS Transmission - Means of HIV transmission does not affect disease course

HIV/AIDS Tuberculosis - Active case-finding needed to identify HIV patients with TB in Africa

HIV/AIDS Vaccine - BlockAide trial to begin in fourth quarter; scientific advisory board formed

HIV/AIDS Vaccine - Tat-expressing Sendai viral vector-booster does not increase protection

Head and Neck Cancer - Endostatin also effective for head and neck cancer

Headache Management - Migraine management program appears to be effective while cutting costs

Health Coverage Tax Credit - Displaced workers in Virginia to get insurance help

Healthcare Access - Aetna signs contract with Cleveland Clinic Florida

Healthcare Access - Insured people with usual source of care are more likely to seek healthcare

Healthcare Access - OHSU sees spike in uninsured emergency visits

Healthcare Access - South Africa's health ministry to work up plan for distributing AIDS drugs

Healthcare Insurance - Task force in Wyoming tackles insurance problem

Heart Disease Risk - Most CHD patients have at least one major risk factor

Heart Failure - CardioPass synthetic coronary artery bypass graft implanted in baby

Helicobacter Pylori - VirB8 homologue essential to secretion system of H. pylori analyzed

Helicobacter Pylori - Mechanisms of action of Helicobacter pylori virulence factors studied

Helper T Cells - Inducible costimulator ICOS is involved in T cell activation, IL-4 production

Hematology - Acute myeloid leukemia responds to thalidomide in some patient cases

Hematology - Factor VII gene intronic mutation in a lethal factor VII deficiency studied

Hematology - Novel suicide fusion genes stem T cell reactions after transplantation

Hemodialysis - PMA approval granted for ProCol vascular bioprosthesis

Hepatic Lesions - Researchers propose guidelines for liver imaging with multidetector CT

Hepatitis C Virus - TNF-alpha -308 genotype does not affect HCV infection risk or treatment efficacy

Hepatitis Vaccine - Hepatitis vaccines: Recent advances

Hepatocyte Antigen - Hepatocyte antigen may be a marker of intestinal metaplasia

Hepatology - PHKA2 gene analysis useful for X-linked liver glycogenosis diagnosis

Hernia Repair - Laparoscopic repair of paraesophageal hernia with mesh has good results

Herpes Simplex Virus - The HSV ICP8 DNA-binding protein becomes altered upon viral replication setup

Herpesvirus - Herpes simplex virus VP16-induced complex investigated

Herpesvirus - Herpesvirus 8 infection linked to hepatitis B and HIV infections in Ugandans

Hip Arthroplasty - Preoperative planning needs improvement for patients with deformities

Hip Arthroplasty - Spiral CT technique can measure bone defects adjacent to acetabular components

Hippocampal - Poly(ADP-ribose) polymerase reduction occurs during stress-related cell death

Hirschsprung Disease - Stem cell defect underlies common genetic disorder

Histamine Receptor Function - Histamine receptors can bind many molecules, resulting in diverse actions

Hospital Acquisition - Dynacq agrees to acquire hospital in Dallas, Texas, area

Hospital Approval - HMA gets recommendation for approval for proposed Florida hospital

Human Tumors - Cyclin E is overexpressed and amplified in many different human tumor types

Huntington Disease - Degree of movement loss reflects brain damage

Hypercholesterolemia - FDA approves new therapy

Hypertension Risk Factor - Activation of central baroreceptor pathway sustained in hypertension

Imaging - Cardius-1, upgradable single-head gamma camera, released

Imaging - Eline Entertainment Group announces formation of imaging sub

Imaging - Researchers distinguish between kinds of dementia using brain imaging

Imaging Purchase - InSight completes purchase of mobile imaging assets in eastern U.S.

Imaging Trends - PET census shows fast growth in PET procedures

Immune Evasion - Peptostreptococcus magnus protein L has immunoglobulin binding domains

Immunology - "Macrophageless" mice have near-normal wound healing

Immunology - Hoxa5 gene loss linked to transient setback in murine thyroid development

Immunology - Chromatin antibodies associate with autoimmune hepatitis pathology

Immunology - Inactivated parapoxvirus ovis protects against hepatitis and herpes viruses

Immunology - Patent granted for ISA247, a calcineurin inhibitor

Immunology - Shark cartilage protein stimulates antitumor immunity in murine models

Immunosuppression - Bone marrow transplant has characteristic risks for pulmonary complications

Immunosuppression Risk - Embryonal rhabdomyosarcoma can occur following liver transplant

Infection Control - Company expands Ramoplanin program with launch of infection control study

Infection Control - E Med Future begins NeedleZap distribution in Uganda

Infection Susceptibility - Mannose-binding lectin quantity, thus infection resistance, may be genetic

Infectious Disease - Aeromonas pathogens carry cagA gene from H. pylori

Infectious Disease - Clostridium species not significant cause of pediatric diarrhea in Brazil

Infectious Disease - Dengue virus serotype 3 viral evolution elucidated

Infectious Disease - Gilead inks nonexclusive HCV licensing agreement, initiate research programs

Infectious Disease - Integron-bearing but drug-susceptible E. coli strains found in Rio Grande

Infectious Disease - New patents granted on oral-dosed, broad-spectrum immune activators

Infectious Disease - The structure of a key enzyme solved

Infectious Disease Diagnostics - Dried blood suitable for immunological RNA testing

Infectious Disease Diagnostics - Novel molecular assay improves E. coli detection in beef products

Infectious Disease Therapy - Improved bacteriophage construction methods developed

Infertility - Different techniques can manage ovarian hyperstimulation syndrome

Infertility - Sperm mobility and oocyte number predict multinucleate formation in human IVF

Inflammatory Immunoglobulin - Triggering receptor on myeloid cells can cause sepsis, acute inflammation

Inflammatory Responses - Sex differences in asthma and atopy may relate to hormones

Influenza - Biostatisticians demonstrate method to bolster accuracy of vaccine studies

Influenza - GHRH receptor gene involved in NREMS response to influenza infection in mice

Information Technology - Cancer research organization selects Blue Coat for secure proxy appliance

Information Technology - Children's Hospital of Pittsburgh converts to SET oximetry

Information Technology - Courion delivers identity management support for healthcare applications

Information Technology - Drug information available in handheld database

Information Technology - Foundation Surgery Affiliates to deploy SunriseXA financial solutions

Information Technology - LanVision announces new product installations at medical center

Information Technology - Lee Memorial Health System chooses Sprint for gigabit ethernet system

Inherited Disease - The cathepsin C gene now has 2 mutations linked to Papillon-Lefevre syndrome

Insect Sting Allergy - Insect sting anaphylaxis appears related to mastocytosis, urticaria pigmentosa

Interlukin Expression - IFN-alpha induces binding of IRF-1 and Stat3 to the IL-10 promoter

Interstitial Cystitis - Study finds limited benefit from two oral drugs

Intracranial Aneurysms - FDA approves expanded use of MicroCoil System family of embolic coils

Joint Replacement - Nailed hip fracture patients should receive individualized thromboprophylaxis

Kidney Disease - Anemia prevalence is extremely high in renal transplant recipients

Kidney Disease - Autosomal recessive Alport syndrome can be a cause of different kidney problems

Kidney Transplant - The use of IVIG in renal transplant may help suppress panel reactive antibodies

Laparoscopic Instruments - Baylor Medical Center commits to AEM surgical instruments

Laryngeal Cancer - Components of fibrinolytic pathways occur in situ in laryngeal cancer

Laser Imaging - Kodak inks global sales agreement for imaging products

Left Ventricular Hypertrophy - New treatment for enlarged heart effective

Legal Issues - Florida investigates Tenet for hospital ties

Legal Issues - Pharmacy groups sue prescription managers

Leishmaniasis - Leishmania major chromosome 3 contains two gene clusters

Leptin Studies - Ins and outs of leptin receptor activation reviewed

Leukemia - Childhood survivors not receiving radiation have same life expectancy as general population

Leukemia - Targeted approaches may lead to better treatment of chronic lymphocytic leukemia

Leukemia - Tumors with a high proliferation index have a poor prognosis

Leukemia - User-defined assays may have applicability in management of leukemia

Leukemia Therapy - AML karyotype strongly influences benefits of pre-HSCT consolidation chemotherapy

Lipoprotein Testing - Doctors Laboratory to offer VAP expanded cholesterol test

Liver Cancer - Organ allocation criteria for hepatocellular carcinoma need review

Liver Failure - Hybrid artificial liver support systems can stem hepatic decline

Liver Lesions - Method for quantifying volumetric lesion change in liver CT scans discussed

Liver Transplantation - Left liver grafts are successful for patients with MELD score less than 15

Liver Transplantation - Monitoring blood samples may be a better way to optimize cyclosporine A dosage

Liver Transplantation - Sonography has poor sensitivity in detecting hepatocellular carcinoma

Liver Tumors - Coded harmonic imaging, Levovist can differentiate hepatocellular carcinoma

Longevity - Brain cell research spawns hope for longer life

Lung Cancer - ALG-2 may be a player in survival pathways in lung cancer

Lung Cancer - New test improves chance of survival

Lung Cancer - Surgical resection of liver metastases may be justified in certain cases

Lung Cancer - Surgical techniques, perioperative care permit more resections in lung cancer

Lung Cancer - Tumor-associated antigen L6 is involved in cancer invasion and metastasis

Lymphoma - Brief chemotherapy plus rituximab is an option for elderly patients with NHL

Lymphoma - Mesenteric malignant lymphoma detected by routine color Doppler ultrasonography

Lymphoma - The anti-CD20 monoclonal antibody rituximab is generally well tolerated

Lymphoma Therapy - R-HDS regimen with stem cell autografting effective against mantle cell lymphoma

Macular Degeneration - Cholesterol lowering drugs may prevent degenerative eye disease

Macular Degeneration - Clinical trial: Squalamine improves vision in wet AMD

Malaria - Exoerythrocytic stages of Plasmodium inui shortti shown in new world monkeys

Malaria - Novel activated C kinase receptor helps regulate plasmodial life cycle

Malaria Diagnosis - Neutrophil lipocalin levels linked to malaria severity

Malaria Pathogenesis - P. falciparum hastens red blood cell senescence

Malaria Therapy - Amodiaquine with SP superior to chloroquine for first-line malaria treatment

Malaria Therapy - Antimalarial action explained by new report

Mandibuloacral Dysplasia - Researchers identify second gene responsible for rare syndrome

Market Analysis - Burn injury management product sales will double

Market Analysis - Coronary heart disease market to reach $23B in 2012

Mathematical Modeling - There are three different models for schistosomiasis transmission

Medicaid - Nebraska must resume payments

Medicaid - New national and state-by-state fact sheets released

Medicaid - Report finds spending rules hurt California, Florida, New York

Medical Equipment - FDA approves stair-climbing wheelchair

Medical History - Genetic risks for disease often missing from patient charts

Medical Malpractice - Doctors, politicians wait to see if plan works

Medicare - CAMC participates in bonus program

Medicare - CMS proposes new rules to pay appropriately for covered drugs

Medicare - Coverage boosts disease screening for previously uninsured adults

Medicare - Federal funding preserved for hospital pharmacy residencies

Medicare+Choice - Enrollees face continued cost increases in 2003

Medulloblastoma - Cancer research center reports that retinoids kill childhood brain tumor cells

Memory T Cells - Killing is much more efficient than previously thought, upon virus re-exposure

Meningitis - CIE, LA are best tests for pneumococcal antigen detection

Meningitis - West Nile possible, but not probable, cause of aseptic meningitis

Menopause - Grape components lower triglycerides and cholesterol levels in menopause models

Mental Health - APOE genotype joins fetal or neonatal malnutrition as a risk for schizophrenia

Mental Health - Stress moderation model variables provide clues to surgery-related psychology

Mental Health - Structure of schizophrenia-linked gene characterized

Mental Stress - Stress can affect heart rate, NK cell numbers, and subsequent cytokine release

Mergers and Acquisitions - Baptist Health to purchase HealthSouth Doctors' Hospital

Mergers and Acquisitions - Community Health Systems acquires hospital in Petersburg, Virginia

Mergers and Acquisitions - FTC clears Biogen merger

Mergers and Acquisitions - Gen-Probe announces acquisition

Mergers and Acquisitions - Genesis Bioventures announces merger

Mergers and Acquisitions - Home health nursing company acquires home care agencies

Mergers and Acquisitions - Letter of intent signed for merger with diagnostics company

Mergers and Acquisitions - Pharmaceutical research company buys Clinical Pharmacology Associates

Mergers and Acquistions - InnaPhase finalizes acquisition of laboratory automation operations

Metastatic Cancer - Interferon-gamma suppresses S100A4 transcription

Microfluidic Device - Microfluidic device can be programmed for adsorption and release of proteins

Microfluidics - Big pharma orders make for successful commercial launch for Dynaflow

Middle Ear Imaging - MRI of the ear is important for preoperative work-up and diagnosis

Midwifery - Study shows that midwives provide equivalent maternity care for less money

Migraine Headache - Screener found highly reliable in undiagnosed patients

Minority Health - Hemoglobin levels affect outcomes in pregnant African-American adolescents

Molecular Biology - Scientists report why taste and smell differ among individuals

Monkeypox - Researchers to take blood samples from victims for study

Morphogenesis - Class 3 semaphorins mediate vascular growth through integrin inhibition

Mosquito-borne Disease - Aedes albopictus mosquitos do not spread dengue virus

Mosquito-borne Disease - Maize pollen improves Anopheles development

Multicellular Spheroids - Thermo-reversible gelation polymer is very useful for three-dimensional cultures

Multiple Myeloma - Myeloma cell contamination minimal in melphalan-mobilized stem cell grafts

Multiple Myeloma - Thalidomide has been found to be effective for relapsed or refractory myeloma

Mutagenesis - Baculovirus expression vector system allows mutant actin protein studies

Mutagenesis - Deletion in endocytic receptor gene Endo180 impairs collagen uptake

Mutagenesis - Enzyme changes cause different abnormalities in oocytes and bone marrow cells

Mutagenesis - SOX9 gene mutation effects are not necessarily linked to XY sex reversals

Mutagenesis - Suppressor mutations define Cbp1 protein regions important for mRNA stability

Myocardial Infarction - Antidepressant reduces clotting factors after heart attack

Myocardial Infarction - FDA clearance granted to market defibrillator

Myocardial Infarction - Healing the heart with stem cells

Myocardial Infarction - Preliminary results of phase III PRIMO-CABG trial reported

Nasal Reconstruction - Results vary for nasomaxillary epithelial inlay skin graft for saddle nose

National Health Insurance - Thousands of doctors support proposal of single-payer system

National Healthcare Insurance - Louisiana joins push against federal insurance regulation

Neonatology - A modified variance index provides clues about preterm infant development

Neurodegenerative Disease - Scientist links brain disorders to tradition of eating bats

Neurological Activity - CART peptides can act as psychostimulants and reduce some cocaine effects

Neurology - Early endosomes carry nerve growth factor retrograde signals

Neurology - Stroke group announces new program in Dallas

Neuropsychiatric Drugs - Phase I clinical testing of ACP-103 complete

Neuroscience - Hoxb1-expressing neural crest cells play key role in glia development

Neuroscience - Gli2 required for Shh signaling and oligodendrocyte maturity in spinal cord

Neuroscience - MCK-driven dystrophin ameliorates muscular dystrophy in murine fast muscles

Neuroscience - Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3

Neuroscience - RhoG activates Rac1 by interaction with Dock180-binding protein Elmo

Neuroscience - Serial analysis of gene expression provides insight into nervous system

Neurotransmission - The central portion of Bassoon is involved in synaptic targeting, CAZ anchoring

Non-Hodgkin Lymphoma - Delaying chemotherapy could be best treatment option

Nutrition - Cereal maker cites study: Eating breakfast shown to help manage weight

Nutrition - Eating fish may lower heart rate, reduce risk of sudden death

Nutrition - Peanuts that keep hearts healthy on way to grocery stores

Obesity Risk Factor - Children just as likely to choose toys as candy on Halloween

Obesity Therapy - Exendin-4, a GLP-1 receptor agonist, suppresses food intake in rats

Obesity Therapy - Inverse agonism provides insight into obesity control

Obesity Therapy - Medicare and Medicaid pay half of costs for overweight and obesity

Obstetrics - Delaying treatment for an ectopic pregnancy is unethical

Obstetrics - Factors influencing choice of prenatal genetic screening by Israeli women identified.

Obstetrics - Leptin and hCG modulate new vessel growth at the maternal/fetal interface

Obstetrics - Lifestyle changes aid pregnant women with nausea and vomiting

Obstetrics - Monoamine transporters are involved in several reproductive processes

Obstetrics - Physical activity during pregnancy improves psychological well-being

Obstetrics - Taking painkillers during pregnancy increases risk of miscarriage

Obstructive Sleep Apnea - Hyoid myotomy with suspension under local anesthesia is safe and effective

Oncogenesis - Collagen XVII expression is reduced, then increased en route to oral cancer

Oncogenesis - Host angiotensin II type 1 receptor signals foster tumor angiogenesis

Oncology - Assay sensitivity sways the results of gene distribution analysis

Oncology - COX-2 causes prostaglandin E2 to modulate pancreatic cancer angiogenesis

Ophthalmic Therapy - Company announces submission of second Vitrase NDA to the FDA

Oral Lichen Planus - Infiltrating CD8+ T cells express CCR5, CXCR3 and their chemokine ligands

Osteogenesis - Hydroxyapatite particles promote osteogenesis

Osteoid Osteoma - Tibialis spastic varus foot can be caused by osteoid osteoma of the calcaneus

Osteoporosis - Ten surprising facts about bone health every woman should know

Osteoporosis - Therapy that prevents bone loss also reverses cholesterol transport

Outsourcing - South Carolina hospital selects business office outsourcer

Ovarian Cancer - Autoschizis is the principal form of cell death from in vitro vitamins

Ovarian Cancer - Bcl-2 down-regulation is a novel mechanism of paclitaxel resistance

Ovarian Cancer - Model developed for radioimmunotherapy of ovarian cancer micrometastases

Ovarian Cancer - Transcriptional and transductional targeting improve gene delivery to ovaries

Pain Management - Well-designed trials are needed to determine management of opioid side effects

Pain Medicine - Compound that acts on peripheral receptors may be promising treatment

Pain Medicine - First Flexogan order delivered to Canadian retailer

Pain Medicine - Study: Patient-controlled analgesia in hospitals must be made safer

Pancreatic Cancer - Novel targets for aberrant methylation in pancreatic carcinoma found

Pancreatic Islets - Islet volume increased while islet number remains unchanged in ob/ob mice

Pancreatitis - Acute pancreatitis can occur during painful sickle cell vaso-occlusive crisis

Pancreatitis - Mutation in SPINK1 gene linked to idiopathic pancreatitis in Italian patients

Parasitic Disease - Schistosomiasis symptoms in Nigeria include gynecological manifestations

Parasitology - Trypanosomes lacking pre-mRNA, gRNA still form functional RNA-editing complexes

Parkinson Disease - New drug reduces advanced disease symptoms

Parkinson Disease - Role of c-jun N-terminal kinase in Parkinson disease investigated

Parkinson Disease - Some over-the-counter pain relievers may reduce risk

Patents - Patent pending for antibodies to treat solid organ, cell transplant rejection

Pathogenic Microorganisms - Burkholderia cepacia complex and other pseudomonads are phage-infectable

Patient Safety - Results of utilization management and patient safety study released

Pediatric Endosurgery - Port-site recurrence of malignancy is rare after pediatric endosurgery

Pediatric Radiology - Causes of lower-extremity bowing must be distinguished for proper management

Pediatrics - Groups collaborate in development of pediatric core measures

Personnel - Anderson joins scientific advisory board at cancer drug firm

Personnel - Bernard Questier becomes chief business officer of drug discovery company

Personnel - Buccal drug delivery company hires GunnAllen Financial as advisor

Personnel - Daniel Levitt named VP, chief medical officer of biopharmaceutical company

Personnel - Dr. Farkad Ezzet joins science/IT consulting firm

Personnel - Durrant named president of pediatric drug firm

Personnel - First Coast Service Options announces new medical director

Personnel - Martone appointed head of medical affairs at pharmaceutical firm

Personnel - McClanathan named VP for behavioral health firm

Phagocytosis - Bacterial threat must be gauged during recognition, destruction by macrophages

Pharmaceutical Care - Pharmacist-physician partnership reduces healthcare costs, bad drug interactions

Pharmaceutical Marketing - Physicians using online marketing content, spending less time with sales reps

Pharmaceutical Research - NIH awards grant to Florida A&M

Pharmacokinetics - FDA incentive program improves study of medications for children

Pharmacy - Web-based self-assessment tool helps pharmacy managers improve quality

Pharmacy Management - Kodak to provide service and support to Parata customers

Photodynamic Therapy - Sulfonamide derivatives of porphycene are candidates for treating nasal cancers

Physician Compensation - Several specialties saw decline in 2002

Physiology - Findings in frog oocytes may help study of chromosomes

Plasmodium Falciparum - Study reveals genetic activity of key step in malaria parasite's cycle,

Pneumococcal Vaccine - 23-Valent polysaccharide pneumococcal vaccine not effective in Navajo adults

Prader-Willi Syndrome - Surgery successful in morbidly obese Prader-Willi syndrome patient

Pregnancy Complications - Hormone imbalance and anti-thyroid antibodies may cause postpartum depression

Pregnancy Complications - Placental villotrophoblastic pulmonary emboli can occur following abortion

Pregnancy Tests - Human chorionic gonadotropin is used to test pregnancy but has complications

Preventive Medicine - Macrophage migration inhibitory factor acts in septic shock, may be good target

Prion - Small interfering RNAs inhibit pathological prion protein accumulation

Product Marketing - Imaging company establishes direct sales in Europe's largest markets

Prostate Cancer - Beta-catenin induces hyperplasias and squamous transdifferentiation

Prostate Cancer - Chronic prostatitis may increase risk of BPH and prostate cancer

Prostate Cancer - Chronic zinc oversupply may play a role in prostate carcinogenesis

Prostate Cancer - Drug that mimics vitamin D hormone may boost effectiveness of treatment

Prostate Cancer - Gene profiling and clinical data can predict prostate cancer recurrence

Prostate Cancer - Improvements in radical prostatectomy yield better results

Prostate Cancer - Osteoporosis needs to be managed in men with prostate cancer

Prostate Cancer - Rare MSR1 mutations related to increased prostate cancer in African-American men

Prostate Inflammation - Chronic pelvic pain syndrome could be produced by pressure, nerve aggravation

Proteomics - Egr-1 expression elevated during hyperoxia

Proteomics - late expression factor-8 gene necessary for optimal baculovirus function

Proteomics - Analysis of E. coli W3110 expressing heterologous sigma factor reported

Proteomics - Annexin I interaction "unmasked" from structure of apo-S100A11

Proteomics - Bax and Bak localize to endoplasmic reticulum to initiate apoptosis

Proteomics - Casein kinase 2 is found in brain cell extracts; it binds occludin

Proteomics - FMRP interacting protein shows intracellular localization

Proteomics - Human protein TIN2 stimulates interactions between telomeric DNA tracts

Proteomics - Increase in NO production by bradykinin mediated by protein kinase A pathway

Proteomics - Oxidative stress induces 1-cys peroxiredoxin expression in lung cells

Proteomics - Phosphinic acid-based MMP-13 inhibitors spare MMP-1 and MMP-3

Proteomics - Proteasome-interacting motif found in ubiquitin-like domain of parkin

Proteomics - Researchers search for new cyclic AMP-binding proteins

Proteomics - Sum1 and Ndt80 proteins compete for binding to sporulation element sequences

Proteomics - Target selection and function determination in structural genomics outlined

Proteomics - The true bioactive conformation of anginex is the beta sheet

Proteomics - Up-regulation of elastin gene expression related to increase in transcription

Pseudomonas Syringae - Leading bacterial pathogen is sequenced

Psoriasis - FDA gives green light to U.S. phase I clinical trials for Psoraxine

Psoriasis - Treatment passes Phase II clinical trials

Psoriasis Research - VitD₃ downregulates CXCR2, thus inhibiting keratinocyte proliferation

Public Health - Death rate from heart disease improving, but is still higher among black Americans than white

Public Health - Illiterate and poor in Brazil have lower life expectancy

Public Offering - Biotech company announces common stock offering, second quarter results

Public Offering - MRI pharmaceutical company announces pricing of 4,300,000 shares of common stock

Pulmonary Tuberculosis - Adjunctive interleukin-2 does not improve anti-TB treatment efficacy

Quality Assurance - Critics say call center's staff unqualified

RNA Research - Reverse Hoogsteen base pair 54-58 important for tRNA function

RNA Research - Translational efficiency helps regulate expression of RNA binding protein

Rabies - Rabies reported among infrequently affected mammalian carnivores in U.S.

Radiology - Beer-derived beta-pseudouridine protects against radiation-induced chromosome damage

Radiotoxicity - Aegle marmelos extract prevents radiation damage in blood cells

Receptor Signaling - Different adapter proteins help create different microbe-specific TLR signals

Receptor Signaling - Toll-like receptor 4 has MyD88-independent pathway for inducing interferons

Receptor Signaling - Toll-like receptor signaling is dependent on adapter proteins such as MyD88

Recurrent Breast Cancer - Whole-body PET imaging can detect distant metastasis in breast cancer

Regulatory Issues - FDA pledging get-tough stance with drug over-promotion

Reimbursement - PET equipment supplier comments on proposed APC rates for 2004

Renal Artery Aneurysm - Nephrectomy, ex vivo repair, autotransplantation are safe, successful

Reporting - Activists oppose state proposal to report names of HIV patients

Reproductive Medicine - "Minisequencing" can improve detection of genetically defective embryos

Reproductive Medicine - Fertility specialists back warnings on human reproductive cloning

Reproductive Medicine - Identification of allele drop-out risk factors may aid single-gene disorder PGD

Reproductive Medicine - Novel PGD strategy improves muscular dystrophy diagnosis

Research Funding - Breast, prostate cancers focus of new Cancer Society research professorships

Research Funding - Lipids get the spotlight in new NIGMS "glue grant"

Respiratory Disease - Nasal vaccine may increase protection

Respiratory Medicine - Both gender and race influence nasal breathing during exercise

Respiratory Syncytial Virus - Respiratory syncytial virus fusion inhibitor escape mutants characterized

Restenosis - Happy Valley Medical strikes deal to evaluate Ceracor

Rheumatology - Propolis has stronger effects against IL-1 beta in cartilage than indomethacin

SARS - Did rats spread disease in apartment complex?

SARS - Virus will appear again, as will other viruses incubating in "Pandora's boxes"

Sales - Genesis Technology launches drug registration program with U.S. sales force

Schizophrenia - A treatable form of the psychosis was found in Hashimoto thyroiditis patient

Schizophrenia - Illness could cause patients to forget their medication

Schizophrenia Therapy - Mood stabilizers do not affect GSK-3 beta protein levels or GSK-3 activity

Sepsis - NF-kappa B increases occur with organ failure; targeting it may reduce risk

Sexually Transmitted Diseases - Pregnancy centers initiate program to reduce spread of STDs

Sexually Transmitted Diseases - Report finds low condom use, HIV testing in NYC

Sleep Disorders - Report tells older Americans how to fight sleeplessness

Slide Adhesive - Novel microscope slide adhesive for poorly adherent tissue sections is developed

Smallpox - Vaccine provides lifelong immunity

Smallpox - Voluntary shots may not protect

Smallpox Vaccine - Encephalitis is complication of smallpox vaccination

Smallpox Vaccine - Many aspects of smallpox vaccination reviewed

Solid Tumors - Manipulation of the vasculature with TNF improves response

Spinal Disorders - FlexiCore Intervertebral Disc clinical trial begins

Staffing - Small hospitals struggling to recruit, retain pharmacists

Statistics - "Diamond graph" corrects long-standing errors of 3-D bar graphs

Stem Cell Research - Bone marrow cells aid repair of necrotic renal tubules

Stem Cell Research - Bone marrow derived cells could heal organs through wound entry

Stem Cell Research - Diclofenac is toxic to neural stem cells

Stem Cell Research - Hypoxia enhances bone marrow hematopoietic cell activity

Stem Cell Research - Novel P2Y receptor regulates primitive hematopoietic cell activity

Stem Cell Research - Slug transcription factor needed for SCF/c-kit-mediated stem cell radioresistance

Stem Cell Research - TCRbeta enhancer activity characterized in T-cell progenitors

Stem Cell Transplantation - Airflow obstruction common after myeloablative stem cell transplants

Stem Cell Transplantation - Common lymphoid progenitors enhance immune recovery in stem cell graft recipients

Stem Cell Transplantation - Donor DNA chimerism monitoring useful in high-risk stem cell graft recipients

Stem Cell Transplantation - Donor memory T cells do not induce graft-versus-host disease

Stem Cell Transplantation - GVHD, glucocorticoid treatment impair IPC recovery in stem cell recipients

Stem Cell Transplantation - Murine hematopoietic stem cells engraft with near-absolute efficiency

Stem Cell Transplantation - Proteasome activity underlies alloimmune response to HA-3 antigen in stem cell recipients

Stem Cells - First U.K. line generated

Stem Cells - Scientists find that stem cells in the bone marrow become liver cells

Stock Market - Biotech firm reports conditional continued listing on NASDAQ SmallCap

Stock Market - Infectious disease-focused company approved for AMEX

Stock Sale - Biopharmaceutical company raises $2.7 million in private placement financing

Streptococcus - Gene linked to Streptococcus pyogenes in asymptomatic carriers

Stroke - Brain patterns the same whether doing or just watching

Stroke - Penicillin may help prevent strokes in the elderly

Substance Abuse - Legal hallucinogen a dangerous "roll of the dice," warns expert

Substance Abuse - Researchers urge advances in methamphetamine abuse treatment

Suicide - Parents may be less likely to take their own lives

Suicide - Same-sex twins have lower risk than general population

Systemic Lupus Erythematosus - A wide variety of treatments being researched for lupus are more targeted

T Cell Function - CD30 is not only in lymphoma, it is an important regulator of T cell functions

T-Cell Activation - Rho kinase is involved in structural and related activation functions of T cells

T-Cell Epitopes - Proteasomal cleavage sites of proteins for cytotoxic T cells may soon be fully predictable

Targeted Therapy - Complement inhibitor-CR fusion proteins inhibit complement activation better

Technology - DNA beats human challenger in tic-tac-toe

Technology - Hardware, software will enable immunology collaboration

Thoracic Cancer - Spinal cord circulation is an important consideration for thoracic surgeons

Thrombin Inhibition - Ximelagatran is safe given twice daily in a fixed dose regimen

Thromboembolism Risk - Thrombosis risk varies according to primary tumor site

Thrombogenesis - Beta-2-glycoprotein I is higher in lupus, antiphospholipid syndrome macrophages

Thromboprophylaxis - Are patients with cancer receiving adequate thromboprophylaxis?

Thromboprophylaxis - Dalteparin reduces the risk of recurrent thrombosis in cancer patients

Thromboprophylaxis - Some cancer patients do not receive adequate treatment for thrombosis

Thromboprophylaxis - There is an expanding role for antithrombotic therapy in cancer patients

Thrombosis - Drug-coated red blood cells destroy blood clots from within

Thrombosis - Inhibitors of tissue factor VIIa complex designed as antithrombotic drugs

Thrombosis - Thrombosis risk is higher due to increased apoptosis during treatment

Thyroid Cancer - Using cytology with histology has practical predictive value

Total Hip Arthroplasty - Cementless Spotorno tapered titanium stems have excellent 10-15 year survival

Total Hip Arthroplasty - Hydroxyapatite may have no benefit over porous-coated stems

Total Hip Arthroplasty - New multilayer coating system improves strength of the cement metal bond

Total Hip Arthroplasty - ROBODOC system reduces the incidence of intraoperative pulmonary embolism

Total Joint Arthroplasty - Melagatran/ximelagatran effective in preventing VTE after orthopedic surgery

Transplant Medicine - Absolute lymphocyte count recovery at 30 d associated with CD34+ graft survival

Transplant Medicine - Complement C4d in graft capillaries may mean rejection; it may be controllable

Transplant Medicine - Homograft endocarditis can be caused by Rhodotorula mucilaginosa

Transplant Medicine - Researchers developing new ways to store tissue, organs

Transplant Medicine - Study to rate methods of kidney storage

Transplant Risk - Intestinal transplant recipients can develop calicivirus enteritis

Trends - Devices and prescription drugs driving growth in U.S. pain management market

Trends - Early-stage pharmaceuticals: R&D spending doubles, NDAs plummet

Tuberculosis Diagnosis - MRI may improve osteoarticular TB diagnosis

Tuberculosis Enzymology - Mycobacterial RecA intein acts as DNA-, Mn2+-dependent ATPase

Tuberculosis Genomics and Genetics - DNA repair gene mutations may improve mycobacterial adaption

Tuberculosis Therapy - Mangosteen-derived agents have potent anti-TB activity

Tuberculosis Vaccine - Recent progress in development of vaccines against tuberculosis reviewed

Tumor Suppressor Gene - Identifying Rb function loss may help researchers understand tumor development

Type 2 Diabetes Therapy - Management of obese diabetic patient discussed

Type 2 Diabetes Therapy - Thiazolidinediones play increasing role in metabolic syndrome therapy

Umbilical Cord Blood - Differences identified in T- and B-cell activity from adults and neonates

Upper Airways - Pain, itch, and perhaps other nociceptive nerve types exist in the upper airway

Urban Pollutants - Diesel fumes in particulate air pollution linked to increased atopy and allergy

Ureaplasma - Ureaplasma multiple banded proteins exhibit phase-shifting mechanism

Urinary Tract Infection - Crystallization, calculus formation depend on type of Proteus endotoxin

Urinary Tract Infection - Toll like receptors and IL-8 receptors are involved in disease pathogenesis

Urogynecology - Moderate cystocele patients are the best candidates for four-corner correction

Urologic Symptoms - Prostatitis and interstitial cystitis may have similar symptoms

Urology - A new animal model will further the study of stress urinary incontinence

Urology - Female urethra perception threshold evaluations yield valuable data

Utilization - Aging boomers drive up doctor visits

Vaccine Adjuvant - Mixture of CpG oligodeoxynucleotides may be needed for effective vaccine

Vaccine Delivery - Bacillus spores show promise for vaccine delivery

Vaccine Development - Effort to develop vaccines against helminth diseases reviewed

Vaccine Efficacy - HIV-1-infected children have impaired immunological memory

Vaccine Efficacy - Implications of genetic traits on vaccine efficacy outlined

Vascular Medicine - The matrix protein Del-1 initiates angiogenesis in ischemic tissues

Vault Prolapse - Burch procedure with abdominal sacrocolpopexy is less effective than Burch alone

Vector Development - Better gene expression can be attained with modified adeno-associated virus

Vector Development - Polyethylene glycol FGF2 conjugates retarget adenoviruses to select domains

Vector-borne Disease - Heterologous flaviviruses alter the outcomes of human yellow fever infections

Vectors - Fundamental patent gained for lentiviral gene therapy technology

Viral Epidemiology - Hepatitis B virus genotypes on India's islands arrived with penal settlers

Viral Hepatitis - GBV-B infections in marmosets closely resemble human hepatitis C virology

Virology - Combinatorial approaches enhance the selection of receptor-specific vectors

West Nile Virus - Clinical trial cleared for NeuGene against virus; financial results reported

West Nile Virus - Vaccine said to be effective in mice

Wound Care - Nutritional and pharmacological strategies can enhance wound healing

Wound Care - Ultrasound aids wound bed preparation of chronic wounds

Wound Repair - Duke investigators develop a clinical model of dermal wound angiogenesis

Wound Treatment - V.A.C. Therapy GranuFoam Heel Dressing launched at APMA meeting

Yttrium-90 - Company improves global security of isotope supply

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