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Diagnostic Markers

Trio of AFP, PIVKAII, GGTII increases accuracy of liver cancer diagnosis

Published in Health and Medicine Week, September 1st, 2003

Diagnosis of hepatocellular carcinoma is easier using not only alpha-fetoprotein, but protein induced by vitamin K absence and gamma glutamyl transferase as markers, too.

"Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and alpha-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) and 90 patients with cirrhosis," scientists writing in the British Journal of Cancer report.

"The mean serum concentration of PIVKAII in HCC patients was higher than that in cirrhotic patients. A total of 53.3% of patients (64/120) with...

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