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TSLC1 gene in human lung cancer is probably a cell adhesion molecule
September 1st, 2003
The mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is found to be a cell adhesion molecule that may be expressed more to slow metastasis. According to recent research from Japan, "RA175, a new immunoglobulin superfamily member, is preferentially expressed during differentiation of P19 embryonic carcinoma (EC) cells induced by retinoic acid. "In the present study, we isolated mouse RA175 cDNA in its entirety and showed that RA175 is the mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer. RA175/TSLC1 was localized in the adherent region of human lung squamous carcinoma cells and in the differentiated P19 EC...
Source: Health & Medicine Week (2003-09-01)
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