Gene Transfer
Adenoviral fiber knob modifications overcome refractory transgene expression
Published in Health and Medicine Week, September 1st, 2003
According to published research from the United States, "genetic manipulation of the adenovirus type 5 represents one strategy to modify viral transduction properties in vitro and in vivo. In the majority of studies to date, reporter gene activity has been monitored to assess transduction efficiency. BRCA1 is a gene whose protein product is clinically important, biologically toxic, difficult to overexpress, and difficult to detect as an untagged protein species."
"Thus, it represents an attractive candidate from which to evaluate the efficacy of a gene delivery system. In...
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