Health & Medicine Week
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Asthma
Airway epithelium is in constant repair; allergens create cyclic Th2 response
September 1st, 2003
Asthmatic airway epithelium is in constant repair mode, and a cycle of Th2 responses due to contact with environmental allergens. "Epithelial cells in the airway wall actively interact with environmental antigens/allergens, both in healthy individuals and patients with asthma. In patients with (allergic) asthma the epithelium is abnormal, showing damaged structures and continuous activation similar to a repair phenotype cell. Epithelial cells bind allergens by a diversity of innate receptors, similar and in part identical to the Toll-like receptor family, which can induce the release of cytokines, chemokines, and growth factors," investigators in Netherlands...
Source: Health & Medicine Week (2003-09-01)
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