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Autoimmune Disease
Autoreactive B lymphocytes may be removable by recombinant fusion proteins
September 1st, 2003
Autoantigen Fcgamma1 fusion proteins appear to selectively eliminate autoreactive B lymphocytes. According to a study from Germany, "Antigen-specific B cells are key players in many autoimmune diseases through the production of autoreactive antibodies that can cause severe tissue damage and malfunction. "We have designed and expressed a fusion protein, referred to as MOG-Fc, composed of the extracellular Ig-like domain of human myelin oligodendrocyte glycoprotein (MOG) and the C(H)2 and C(H)3 domains of the human IgG1 heavy chain. The dimerized fusion protein was capable of mediating cytotoxicity against a MOG-reactive...
Source: Health & Medicine Week (2003-09-01)
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