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Acute Leukemia
Targeting TNF pathway along with ATRA may represent route to treat leukemias
September 1st, 2003
Targeting TNF pathway along with ATRA may represent route to treat leukemias. According to a study from Canada, "The nuclear receptor ligand all-trans retinoic acid (ATRA) causes dramatic terminal differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients, but it is less active in other malignancies. "However, downstream mediators of the effects of ATRA are not well understood. We used a cDNA microarray to search for ATRA-regulated genes in the APL cell line NB4 and found that ATRA regulated several members of the tumor necrosis factor (TNF) pathway," wrote M. Witcher and colleagues, McGill University, Lady Davis Medical...
Source: Health & Medicine Week (2003-09-01)
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