Health and Medicine Week
Susan Hasty, Publisher
Table of Contents . . . October 6th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Health and Medicine Week | Other Publications
Developmental Biology - Sensory cells for hearing and balance are fast developing
Performance Review - JCAHO creates two options to address legal disclosure concerns
Antibiotic Resistance - HHS, public health partners unveil campaign to promote proper antibiotic use
Breast Cancer - North American mammographers prone to more false positives, study finds
Epidemiology - Teams will integrate genomic, clinical, and epidemiological data
Healthcare Management - Client-nurse practitioner interactions drive resource exchanges
AIDS Prevention - Smallpox vaccines may protect against HIV
AIDS Prevention - Study will test antiviral drug tenofovir to prevent HIV infection
AIDS Therapy - Incyte enters licensing agreement for a phase II HIV drug
AIDS Therapy - Study: Patients can benefit from simplified antiretroviral treatments
Acanthamoeba Taxonomy - Some Acanthamoeba strains are different enough to need reclassification
Acne - FDA clears BLU-U Blue Light Photodynamic Therapy Illuminator
Acne - Peptide studied in acne patients
Acute Care - Abington Memorial Hospital earns magnet designation
Acute Myeloid Leukemia - Functional FAS promoter polymorphisms are associated with increased risk of AML
Acute Myocardial Infarction - Antibiotics don't help heart in study
Acute Myocardial Infarction - Chest pain units improve the treatment of heart attacks
Acute Myocardial Infarction - Heart may heal with help from oxygen-sensitive genes, new study suggests
Acute Respiratory Disease - TT virus load corresponds with disease and immune cell imbalance in children
Addiction Medicine - Role of signal regulation by G-proteins in opioid dependence reviewed
Addiction Medicine - Young women who take ecstasy face the risk of extremely low sodium levels
Adenovirus - Adenovirus type 11 uses CD46 as a cellular receptor
Advance Directives - Study to examine effectiveness for mentally ill patients
Adverse Drug Effect - Vaginal natamycin treatment during pregnancy does not harm the fetus
Age-related Macular Degeneration - Rheopheresis reduces vessel-linked eye disease
Aging - Longevity's healthcare costs reassessed
Alcohol Consumption - Alcohol drinking patterns differentially affect central adiposity
Alcoholism - Chronic drinking increases cortisol during intoxication and withdrawal
Alcoholism - Researchers study effects of alcohol abuse on lungs through $7 million NIH grant
Allergic Rhinitis - Experimental drug for allergic rhinitis studied in multidose safety trial
Allergy - New research in allergic inflammation and anti-IgE therapy unveiled
Allergy - SOCS-3 expression is tied to asthma, allergy, IgE production, TH2 response
Allergy Medicine - NOS1 polymorphism linked to atopy, but not exhaled NO levels in healthy children
Allergy Medicine - Experts concerned about insurance coverage of second-generation antihistamines
Allergy Medicine - Murine CRTH2 is functional orthologue of human receptor
Alzheimer Disease - Alzheimer disease hypothesis based on transcriptional dysregulation
Alzheimer Disease - Biochemicals in spinal fluid may aid in diagnosis
Alzheimer Disease - Brief telephonic questionnaire detects early signs of dementia
Alzheimer Disease - Structure of fibrous crystals formed by Alzheimer's peptide reported
Amyotrophic Lateral Sclerosis - Novel drug candidate shows promise in treating neurodegenerative diseases
Angina - Bypass surgery may relieve chest pain better than angioplasty plus stent
Angina - Heart patients may benefit from VEGF gene transfer
Angiology - Fibrinolytic factors are not useful in predicting risk of thromboembolism
Angiology - Fucoidan and heparin enhance growth factor-induced tube formation
Angiology - Myocardin "necessary and sufficient" for vascular smooth muscle cell development
Angiotensin - Basis of lisinopril-binding specificity in human ACE reported
Animal Models - Adult human blood stem cells can build human blood vessels in mice
Anorexia Nervosa - Fasting plasma ghrelin levels examined in subtypes of anorexia nervosa
Anti-infective Development - Innovative Medical enters partnership to develop, market Axenohl-based products
Anti-inflammatory Agents - Clarithromycin has no effect on inflammatory markers in atherosclerosis
Antibiotics - Initiative achieves significant antibiotic prescription cost savings
Antibody Purification - Heat elution chromatography is a new antibody purification method
Anticancer Drugs - Marine-derived anticancer agents are evaluated in clinical trials
Anticancer Immune Response - Immunotherapeutic approaches to prostate cancer therapy are improving
Antigen Presentation - T-cell receptor signaling for hours is necessary for maximal immune response
Antimicrobial Chemotherapy - Actinonin might be useful in increasing neutrophil response against bacteria
Antimicrobials - Costs of antibacterial resistance outlined
Antioxidants and Cancer - Consuming dietary antioxidant supplements has pros and cons for any population
Antipsychotic Drugs - Antipsychotic drugs linked to type 2 diabetes
Antiretroviral Therapy - Up to 10,000 Ugandans with AIDS to receive antiretroviral medications
Antisense Technology - Company announces discovery of positively charged cardiolipin
Antiviral Therapy - Limitin is similar to but distinct from interferon-alpha as hepatitis C therapy
Aortic Aneurysm - High blood pressure, fatty deposits are "bit players" in bulging arteries
Apoptosis - Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
Apoptosis - PS-341 enhances TRAIL-induced apoptosis by increasing the cleavage of caspase 8
Apoptosis - Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells
Apoptosis - Rel/NF-kappa B regulates B-cell apoptosis dependent on signals, cell stage
Arterial Catheters - Invasive arterial catheter use reduced due to blood pressure monitoring systems
Articular Cartilage - Engineered collagen scaffolds induce different growth rates of chondrocytes
Aspergillosis - Better outcomes and cost savings for life-threatening fungal infections
Assurance Quality - Report finds healthcare system's "quality gaps" cause 57,000 deaths annually
Asthma - Amelioration of asthma symptoms reported with anti-C5 therapy
Asthma - Asthma attacks at school are disruptive to routine, under-diagnosed
Asthma - Farm life may inhibit development of allergies and asthma
Asthma - Improved air quality reduces asthma
Asthma - Link to behavioral problems in children found
Asthma - Long-term use of inhaled steroids may increase risk of cataracts
Asthma - Nocturnal asthma may be worsened by melatonin
Atherosclerosis - Discovery points to new way to control atherosclerosis
Atrioventricular Canal Defect - New insight offered into the genetics of congenital heart disease
Autoimmune Disease - Autoimmune enteropathy can have autoantibodies to intestinal goblet cells
Autoimmune Disease - Minocycline therapy for acne can induce cutaneous polyarteritis nodosa
Awards - Folkman honored for hypertension research
Awards - HIV researcher at Rush awarded grant from Doris Duke Foundation
Awards - SinusPharma recognized as a top Rising Star company by Deloitte & Touche
B-Cell Lymphoma - Prior lymphoplasmacytic lymphoma is linked to diffuse large B-cell lymphoma
Bacillus - Bacillus subtilis extracytoplasmic function protein examined
Bacteriology - Osmotic pressure inhibit ejection of DNA from phage
Behavioral Health - Tennessee seeks new service organizations for mentally ill TennCare enrollees
Benefits Management - Medix resources announces agreement with CarePoint
Benign Prostate Hyperplasia - Company updates stent technology developments
Biliary Cirrhosis - Eta-1/osteopontin polymorphisms not related to biliary cirrhosis
Bilingual Healthcare - Anthem Blue Cross and Blue Shield provides e-tools to Spanish-speaking members
Biomaterials - Platelet-rich plasma does not improve hydroxyapatite sinus grafting
Bioterror Agent Detection - NIAID grant to awarded to develop phenotype microarray technology
Biowarfare - Select agents and toxins interim final regulations released
Blood Flow Measurement - Company receives marketing clearance for Quantix/OR in United States
Blood Substitute - Hemodilution with hemoglobin vesicle solutions can improve ischemic tissue oxygenation
Bone Disease - Novel techniques enable clinicians to detect bone microdamage
Brain Cancer - Radiation potentiates the effects of antiangiogenic agents on neuroblastoma
Brain Cancer - Researchers identify cancer stem cell for brain tumors
Brain Damage - Study findings suggest strategy for regeneration of tissues in damaged brains
Brain Tumors - Population pharmacokinetics of low-dose paclitaxel evaluated in brain tumors
Brain Tumors - Survivin, an apoptosis inhibitor, is widely expressed in brain tumors
Breast Cancer - BMI and c-erbB-2 expression may be risk factors for contralateral breast cancer
Breast Cancer - Breast cancer mortality in the Netherlands has been decreasing since 1997
Breast Cancer - Brk promotes breast carcinoma cell proliferation
Breast Cancer - Can healthy bones help prevent metastasis?
Breast Cancer - Chest wall ports can be placed ipsilateral to axillary lymph node dissection
Breast Cancer - Docetaxel and capecitabine improve survival in metastatic breast cancer
Breast Cancer - Genetic clues may show which women face risk from HRT
Breast Cancer - Glitazones' mechanism of inhibiting tumor growth determined
Breast Cancer - Low fat/high fiber diet doesn't appear to reduce risk
Breast Cancer - Malathion alters cell adhesion of cultured breast carcinoma cells
Breast Cancer - Mammographic screening program in Australia evaluated
Breast Cancer - Patients offer recommendations for care to their physicians
Breast Cancer - Patients treated by low-workload surgeons had poorer survival
Breast Cancer - Phase II clinical trial of MDX-010 launched
Breast Cancer - Positive results of preclinical trials of AZ-CINN 310 released
Breast Cancer - Some types of tumors behave in an unexpected way
Breast Cancer - Study tests examestane for use after 5 years of preventive tamoxifen
Breast Cancer - The potential for cytogenetic effects may persist with low-energy X-ray use
Breast Cancer - cDNA microarray profiling identifies 5-fluorouracil-inducible target genes
Breast Implants - PIP receives European regulatory approval for titanium-coated implants
Bubonic Plague - Case reopens on Black Death cause
Burkholderia - Burkholderia pseudomallei protein promotes bacterial invasion
Burn Treatment - European production facility for CellSpray awaits regulatory approval
Campylobacter Jejuni - Guillain-Barre syndrome can occur following Campylobacter infection
Cancer - Sodium salicylate may be used to protect cells against deleterious stressors
Cancer Immunotherapy - GeneMax Corp. announces agreement for the production of TAP cancer vaccine
Cancer Initiation - Chromosomal instability is an early driving force of cancer progression
Cancer Metastasis - Zoledronic acid is effective in managing metastatic bone disease
Cancer Metastasis - Zoledronic acid is the preferred therapy for treatment of bone metastases
Cancer Outcomes - Longer commute for cancer treatment associated with better survival
Cancer Predisposition - Genetic differences revealed by SNPS play a role in risk, prevention, outcomes
Cancer Progression - Lysophosphatidic acid signaling has role in cancer progression
Cancer Registries - Method to keep track of comorbidities is successful
Cancer Research - Epimmune earns milestone payment under cancer epitope license
Cancer Suppression - Forced expression of early growth response factor-1 generates apoptosis
Cancer Therapy - Baicalein and baicalin are strong angiogenesis inhibitors
Cancer Therapy - Certain enzyme inhibitors show promise
Cancer Therapy - Company adds Paclitaxel Injection to its U.S. product line
Cancer Therapy - Ethics of phase 1 oncology studies examined
Cancer Therapy - Javlor (Vinflunine) enters in phase III clinical trials
Cancer Therapy - New data presented on 1D09C3 in combination with rituxan
Cancer Therapy - Radiation and celebrex combination therapy reduces lung and breast tumor growth
Cancer Therapy - Sphingosine kinase inhibitors may hold key to halting growth of some tumors
Cancer Therapy - Starve a tumor or feed a tumor?
Cancer Therapy - Tubercin being tested on mice with cancer
Cancer-related Anemia - Fatigue is common complaint of patients with cancer
Cancer-related Genes - DVL-1 appears to be involved in cervical squamous cell cancer
Cardiac Arrest - Defibrillators save lives also in lay volunteers' hands
Cardiac Arrest - Hypothermia - good for both brain and heart?
Cardiac Arrhythmia - FDA grants approval to start atrial fibrillation study
Cardiac Arrhythmia - Patient enrollment completed in cryoblation study
Cardiac Catheterization - Intravascular MRI catheter for coronary arteries set for clinical trial
Cardiac Monitoring - Pharmaceutical company spends $1.5M in cardiac safety monitoring for studies
Cardiac Rehabilitation - U.K. nurses may be best choice to advise patients about driving restrictions
Cardiology - DNA microarray enables cardiac myocyte transcriptome study during heart failure
Cardiology - Targeted enzyme deletion attenuates left ventricular rupture after infarction
Caregiver Health - Learning skills greatly limits stress for family caregivers, study finds
Cartilage Repair - Clinical update provided on BST-CarGel
Cataracts - Nuclear cataract caused by lack of DNA degradation in mouse eye lens
Cell Death - Research aims to understand how mistakes in DNA replication lead to disease
Cell Signaling - Researchers discovering new regulators of the immune system
Central Motor Disorder - Weakness, hand spasm can be multifocal motor neuropathy, treatable by IVIG
Central Nervous System - Cysteinyl leukotrienes exhibit novel neurohormone functions
Central Nervous System - FDA needs for cellular therapies for spinal cord injury outlined
Central Nervous System - FDA requirements for spinal cord injury drug development reported
Cerebral Palsy - New ultrasound technique for diagnosis
Cervical Cancer - P16 inactivation may be associated with development of uterine cervical cancers
Cervical Cancer - Researchers design a novel applicator for low-dose-rate brachytherapy
Cervical Cancer - Study shows overweight, obesity linked to increased cancer risk
Childbirth - Continuous labor support offers benefits to mothers, babies
Chiropractic Care - Banyan opens chiropractic clinics nationwide
Cholecystokinin - Food intake can be inhibited by cholecystokinin independently of IL-1 beta
Chondral Lesions - Deep hyalin cartilage defects may be treated with perichondrial grafts
Chronic Fatigue Syndrome - Condition is rare in children
Chronic Hepatitis C - Adenovirus-mediated interferon-alpha gene transfer blocks HCV replication
Cirrhosis - Hepatocyte growth factor gene delivery attenuates liver disease
Claims Management - GHN-Online teams with UHC to offer integrated revenue transaction solutions
Clostridium Perfringens - CaCo-2 cells have concentration-dependent responses to CPE enterotoxin
Cochlear Implants - There are very few contraindications for cochlear implants in adults
Collaborations - Agreements signed for cardiac safety monitoring, information distribution services
Collaborations - Alliance with CryoVascular Systems for cardiology device technology
Collaborations - Engineered antibodies may expedite development of therapeutic oncology agents
Collaborations - Hospital and technology company join forces to reach "performance excellence"
Collaborations - New marketing and sales agreement reached for hydrophilic catheters
Collaborations - Oral drug delivery research alliance signed
Collaborations - Research agreement focuses on central nervous system and metabolic disease agents
Colon Cancer - A low but significant number of colorectal carcinomas are positive for EMR2
Colon Cancer - Calcium, vitamin D, and folate may inhibit colon cancer
Colon Cancer - Detection of hepatic disseminated tumor cells is a powerful prognostic factor
Colon Cancer - Doctor's urging may boost screening for those at risk
Colon Cancer - Function of APC may be regulation of caspase activity, other apoptotic proteins
Colon Cancer - Microsphere design holds promise for the colonic delivery of 5-fluorouracil
Colon Cancer - PEITC may play an important role in cancer cell killing
Colon Cancer - Poloxamer-containing liposomes can be used for heat-sensitive drug delivery
Colorectal Cancer - A medical nutriment has supportive value in the treatment of colorectal cancer
Colorectal Cancer - CRAC1 is unlikely to be implicated in the development of colorectal cancer
Colorectal Cancer - FDA approves clinical trial to test therapeutic vaccine Collidem
Colorectal Cancer - Noninvasive stool test for colorectal cancer now available
Complementary and Alternative Medicine - Genetic transformation of figwort feasible with Agrobacterium tumefaciens
Congenital Birth Defects - Babies of diabetic mothers have fivefold increase in structural heart defects
Constipation - Enrollment complete for efficacy study of constipation treatment drug
Consumer Marketing - Pharmaceutical DTC marketing costs will reach up to $80 million by 2005
Consumer-driven Healthcare - Preliminary study results show overall employer & employee satisfaction
Contaminants - U.S. Congress is urged to protect environment from methyl tertiary butyl ether
Contraception - FDA approves Barr's SEASONALE, an extended-cycle oral contraceptive
Coronary Artery Bypass - Preoperative plasma fibrinogen levels predict mortality after CABG
Crohn Disease - Intranasal vitamin B-12 supplement approved by FDA
DNA - Mitochondrial DNA detector commercialized to mark adverse effects of therapy
DNA - Peptide mass signature genotyping can detect TP53 mutations in tumor DNA
DNA Research - MutS-based protein chip improves DNA mutation detection
DNA Research - T3 DNA polymerase TBD insertion enhances Taq DNA polymerase processing
DNA Research - Telomere shortening in dental pulp DNA useful for forensic age estimation
Dementia - New class of drug helps people with severe dementia and their careers
Dementia - Scientists describe how HIV infection kills brain cells
Demographics - Key healthcare statistics about U.S. population now online
Demyelinating Disease - Chronic inflammatory demyelinating polyradiculoneuropathy is prone to relapse
Depression - Generic version of Paxil launched
Depression - Screening at primary level could be next trend in health care
Depression Therapy - Lithium upregulates hippocampal IMPA1 mRNA and MIP synthase
Dermatology - Clearer skin may result with new ACNE results
Dermatology - New topical immunomodulators for use in dermatology
Diabetes Pathogenesis - Protein histidine phosphorylation defective in diabetic rat islets
Diabetes Risk Factor - Fetal and early postnatal growth restriction lead to diabetes
Diabetes Survival and Mortality - Cardiac neuropathy contributes to high mortality in diabetic patients
Diabetes Survival and Mortality - Losartan protects against sudden cardiac death in people with diabetes
Diabetes Therapy - Beta-cellulin improves glucose metabolism in diabetic mice
Diabetes Therapy - Pharmacology of diabetic complications reviewed
Diabetic Nephropathy - Angiotensin II blockers useful for treatment of diabetic nephropathy
Diabetic Retinopathy - Wound healing in human diabetic corneas resembles that of cultured tissues
Diagnostics - Microfluidics company gets $2M NIST grant
Diagnostics - Multiplex PCR differentiates Cyclospora from Eimeria species
Diarrhea - Trial shows Probactrix is effective for treating diarrhea caused by antibiotics
Diet and Nutrition - Pancreatic polypeptide reduces appetite and food intake in humans
Diet and Nutrition - Unbalanced maternal diets affect offspring stress hormone later on
Disease Management - Consensus group develops 18 criteria for clinical guidelines
Disease Management - Eighteen sites selected to evaluate effectiveness of eHealth technologies
Disease Prevention - First lady urges women to take care of their hearts
Disinfection - Mexican distributor granted exclusive rights for Microcyn 60
Drug Binding - RU49953 inhibits drug binding to Saccharomyces cerevisiae ABC exporter
Drug Coverage - Health Alliance Medical Plans covers new OTC drugs
Drug Delivery - AERx pain management system study data published
Drug Development - $2M grant awarded for development of drug research software
Drug Development - Biotechnology and pharmaceutical companies co-developing new anticancer drug
Drug Development - Merck enters alliance to apply RNA interference for human therapeutics
Drug Development - Pharmaceutical corporation anticipates up to four new investigational drugs
Drug Development - Ubiquitin-like peptide with anticancer and immunostimulatory activity isolated from mushroom
Drug Discovery - New information management system available for pharma, biotech firms
Drug Discovery - Phages point the way to novel targets for antimicrobials
Drug Interactions - Investigational protease inhibitor can be taken with Maalox TC, Zantac, or Lipitor
Drug Resistance - "Forgotten" malaria still kills millions
Drug Resistance - Effects of mutant Neisseria penA on encoded penicillin-binding protein clarified
Drug Resistance - Pretreatment HCV hypervariable region 1 status predicts treatment outcomes
Drug Resistance - VIM-1 metallo-beta-lactamase-producing K. pneumoniae found in Greek hospitals
Drug Utilization Reviews - Study: Mandated programs don't reduce prescription errors or improve care
Dry Eye - FDA accepts Diquafosol NDA filing
Eating Disorder - Adolescent girls with anorexia nervosa have higher osteoprotegerin levels
Eating Disorders - Metabolic disorders in bulimia nervosa and binge eating described
Emerging Diseases - WHO chief warns SARS not the last epidemic of the 21st century
Endocrinology - Clinical disorders related to thyroid hormone deiodinases reviewed
Endocrinology - Cyclooxygenase-2 expression levels rise in benign pituitary tumors
Endocrinology - Gadd45 gamma expression is reduced in anaplastic thyroid cancer
Endocrinology - Insulin regulates angiogenesis by controlling VEGF expression
Endocrinology - Insulin-like growth factors mediate breast cancer growth and proliferation
Endocrinology - New reference values alleviate parathyroid hormone false positives
Endocrinology - Triphasic oral contraceptive decreases bone turnover in premenopausal women
Endocrinology - Women with irregular ovulation, some excess hair, may have androgen imbalance
Endometrial Cancer - Akt may have a pivotal role in regulating endometrial cancer cell survival
Endometrial Cancer - Insensitivity to growth suppression signals might be a mechanism of cell immortality
Environmental Toxins - More than 6500 join 9-11 World Trade Center health study
Enzymology - Glucose-6-phosphate dehydrogenase modulates VEGF-induced angiogenesis
Enzymology - Human alpha-1 antitrypsin plasma levels persist after nonviral DNA injection
Enzymology - TR-FRET assays enable high-throughput screening for angiogenesis inhibitors
Epilepsy - Device company gets NIH grant for neurological surgery technology
Epilepsy - FDA grants Alpharma subsidiary final approval for gabapentin capsules
Epilepsy - Study confirms the low prevalence of psychiatric adverse events with Keppra
Epithelioid-Cell Tumors - A uterine PEComa case confirms this rare cancer has metastatic potential
Esophageal Cancer - PBR-specific ligands cause apoptosis and cell-cycle arrest
Facilities - Florida HealthSource to acquire two Broward County physical therapy clinics
Facilities - New facility offers stertactic radiosurgery to treat malignant tumors
Factor XI Deficiency - Genetics to clinical management of factor XI deficiency reviewed
Factor XII Deficiency - Coagulation factor XII deficiency characterized in a Japanese family
Fanconi Anemia - OHSU scientists uncover key protein for susceptibility
Fertility - Economic stress in Germany linked to decline in male births
Finance - Acquisition of pharmaceutical company completed
Finance - American Stock Exchange lists oncology company's stock
Finance - Angiotech to change fiscal year end financials to calendar year
Finance - Biological-mechanism discovery firm completes $6.5 million series A financing
Finance - Corrective lens maker reports operating margin up 1.9 points for first 6 months
Finance - Diagnostic product manufacturer offers shares of common stock
Finance - Dialysis company calls 7% convertible notes, authorizes share repurchase
Finance - Disease management company acquires StatusOne Health Systems
Finance - Gene transcription company raises $47 million in private placement
Finance - Hawaii/California-based pharmaceutical company sees continued improvement in Q3
Finance - Med-eMonitor developer completes bridge financing
Finance - Medical device company raises $13.6M in second round financing
Finance - Net sales up 34% for cardiothoracic surgery device manufacturer
Finance - Nucleic acid testing products company announces stock split
Finance - Pharmaceutical company declares 3-for-2 stock split
Finance - Pharmaceutical company's stock listed on AMEX
Finance - Revised financial expectations reported by pharmaceutical company
Finance - Skin substitute manufacturer emerges from Chapter 11 protection
Finance - Specialized polymer and hydrogel company reports 10% revenue increase
Finance - Supplement maker reports 12% revenue increase for fiscal 2003
Finance - Tampa-based pharmaceutical company reports second quarter revenue of $84,049
Finance - Topical drug company announces $3.25 million private placement
Finance - Venture financing round completed with Emerging Technology Partners
Financing - $4M financing advances antithrombotic agent into clinical development
Financing - $6M in funds helps biotech company develop psychiatric disease treatments
Fitness - Poor fitness increases risk of death in women more than in men
Fitness - Researchers find caffeine reduces muscle pain during exercise
Food Allergy - Protein hydrolysate study may result in formulations to prevent food allergies
Food Allergy - Research from WAO Congress brings new insight about allergic reactions to food
Food Science - Genetic assay can detect foie gras adulteration
Food-borne Illness - Imaging system detects contaminants on poultry
Fractures - Osseous FDG uptake is normal 3 months after traumatic or surgical fractures
Fungal Infection - Calmodulin from Paracoccidioides brasiliensis characterized
Fungal Therapy - Chickpea-derived peptide has potent and durable antifungal activity
GI Tumors - Classification of neuroendocrine tumors must consider location within GI tract
Gallbladder - ABCG5 and ABCG8 are expressed in gallbladder epithelial cells
Gastric Cancer - H. pylori increases proteasome-mediated degradation of p27(Kip1)
Gastric Cancer - Activation of transcription factors may contribute to stomach cancer development
Gastroenterology - CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults
Gene Recombination - Fusogenic membrane glycoproteins enhance the efficacy of virus-based therapy
Gene Therapy Vectors - HIV-based vectors do not require rev gene
Gene Transfer - Gold nanoparticles enhance polyethylenimine-mediated plasmid DNA transfer
Generic Drugs - FDA approves generic Midazolam syrup
Generic Drugs - FDA grants approval for midodrine hydrochloride tablets
Generic Drugs - GSK makes announcement regarding launch of generic paroxetine hydrochloride
Genetic Analysis - Genetic link found between gene segments in common rotavirus strains
Genetic Disorders - Fungal model may aid research on lethal human CACT gene mutations
Genetic Disorders - Monoamine oxidase A gene mutations may affect autism severity in males
Genetic Disorders - Nine genes linked to hereditary spastic paraplegias
Genetic Variation - New bioconsumable kits aid in genetic variation discovery and detection
Genetics - Antimicrobial peptides in our bodies have evolutionarily conserved functions
Genome Analysis - Optical mapping system offers rapid whole genome analysis
Genomics - Telomere dysfunction could contribute to genomic instability in human tumors
Genomics and Genetics - Comprehensive haplotype map of human genome still needs work
Genomics and Genetics - Maximum haplotype diversity best criterion for SNP site selection
Genomics and Genetics - Mutations arise independently of transcription in non-dividing bacteria
Genomics and Genetics - Type II transmembrane serine proteases identified
Geriatrics - Alzheimer drug trials should include a brain biopsy for beta-amyloid level
Geriatrics - Hepatic inflammatory pseudotumor can occur with primary biliary cirrhosis
Geriatrics - Low trauma fractures in older patients warrant a check for osteoporosis
Glaucoma - Oxidative stress inhibits proteosomes in trabecular meshwork cells
Glucose Monitoring - Pros and cons of various glucose monitoring technologies weighed
Gynecologic Cancer - Clinical findings, treatment, outcome of endometriosis-related malignancies reviewed
Gynecology - Candida strains linked to recurrent vaginal infections show genetic variety
Gynecology - Introital and transvaginal ultrasound foster urogynecological diagnosis
HIPAA - Medical privacy laws frustrate police
HIV Diagnostics - HIV-1 antibody tests approved for distribution in the Republic of Uganda
HIV Prevention - Genetically enhanced bacteria may prevent HIV infections in women
HIV Testing - FDA approves venipuncture whole-blood claim for OraQuick HIV-1 antibody test
HIV Therapy - Study assessing abacavir in a once daily art regimen presented at ICAAC
HIV/AIDS - DNA immunization enhances immune response to fowlpox-based SIVmac vaccine
HIV/AIDS Diagnosis - Consecutive HIV testing strategy suitable for use in developing countries
HIV/AIDS Diagnosis - New HIV-1 enzyme immunoassay used to estimate HIV seroincidence
HIV/AIDS Gene Therapy - Lentiviral vectors can protect transduced cells from HIV infection
HIV/AIDS Gene Therapy - Novel assay detects replication-competent lentiviral vectors
HIV/AIDS Genetics - Yeast-based HIV cloning system useful for research
HIV/AIDS Immunology - Cytidine deaminase with potent but Vif-abolished antiretroviral activity identified
HIV/AIDS Lipodystrophy - Antioxidant treatment may do more harm than good
HIV/AIDS Lipodystrophy - Leptin replacement can ameliorate protease inhibitor-induced lipid abnormalities
HIV/AIDS Pathogenesis - Role of Tsg101 in HIV Gag trafficking and release clarified
HIV/AIDS Pathogenesis - Through ESCRT recruitment, Hrs helps regulate endosomal multivesicular body formation
HIV/AIDS Pathogenesis - To recruit cytoplasmic Tsg101, HIV Gag mimics human Hrs protein
HIV/AIDS Pathogenesis - Virus assembly takes place in late endosomes in HIV-infected primary macrophages
HIV/AIDS Prevention - Successful negotiations by Zimbabwean women increase male condom use
HIV/AIDS Therapy - Baseline serum IL-7 levels do not predict immunologic HAART outcome
HIV/AIDS Therapy - High-performance LC assay improves measurement of plasma tenofovir levels
HIV/AIDS Therapy - Metal chelation underlies anti-HIV integrase activity of beta-diketo acids
HIV/AIDS Therapy - Novel MKC-442 analogues show potent antiretroviral activity
HIV/AIDS Therapy - Nuclear protein phosphatase-1 helps mediate HIV transcription
HIV/AIDS Therapy - Prophylactic single-dose nevirapine linked to low rate of HIV V106M mutations
HIV/AIDS Therapy - Some antiretroviral drugs induce PBMC P-glycoprotein expression
HIV/AIDS Therapy - T-cell apoptosis overwhelms proliferation during structured HIV treatment interruptions
HIV/AIDS Tuberculosis - Vitamin A deficiency common in HIV, tuberculosis patients in Africa
HIV/AIDS Vaccine - AIDS vaccine protects against infection in a macaque AIDS model
HLA Alleles - HLA B*2714 and B*2708 alleles relate to spondarthritis and hemophilia
Hairy-Cell Leukemia - Hairy-cell leukemia can have CD10 positivity in a patient subset
Head Lice - Recommendations provided for back-to-school head lice problem
Head and Neck Cancer - Celecoxib will be a useful biological modulator in treating head and neck cancer
Head and Neck Cancer - Faster radiotherapy more effective
Head and Neck Cancer - Sentinel lymph node biopsy in head and neck cancer is experimental
Head and Neck Tumors - [F-18]FDG PET with hybrid PET scanners is diagnostically superior to CT and MRI
Headache - Resource provides access to latest information on headache conditions
Health Economics - Insurance rates rise in Vermont, Wisconsin
Health Economics - Poor health affects businesses' bottom line
Health Insurance - Aetna announces 2004 Medicare+Choice markets
Health Insurance - Blue Cross and Blue Shield of Florida increases enrollment
Health and Fitness - Jump exercises strengthen rodent bones regardless of hormone status
Healthcare Access - Report suggests ways to evaluate physician access in public insurance programs
Healthcare Coverage - Report: Insurers won't reimburse weight-loss treatment; cite lack of data
Healthcare Insurance - Company offers guaranteed private health insurance in Alabama
Healthcare Insurance - Study finds more New Yorkers lack health coverage
Heart Attack - Japanese government expands use of automated external defibrillators
Heart Disease - Acetaminophen may be best for patients on cardioprotective aspirin therapy
Heart Failure - DECREASE-HF study to find best cardiac resynchronization therapy
Hematology - Hemostatic risk factors predict thrombosis during pregnancy and the puerperium
Hemochromatosis - Old drug works new tricks for iron overload heart disease
Hemodialysis Risks - Skin eruptions, tongue papules can occur as a form of autoreactive amyloidosis
Hemodynamics - New technology permits bedside assessment of cerebral hemodynamics
Hemoglobin Monitoring - FDA clearance granted for new D-10 Hemoglobin testing system
Hemophilia A - Agreement signed with Baxter for Advate distribution
Hemophilia A - U.S. commercial availability of Advate announced
Hemophilia B - Clinical trials of Coagulin-B to resume
Hepatitis - Hepatitis vaccine approved for sale in Argentina
Hepatitis B and C - Risk posed by discarded needles and syringes
Hepatitis C Diagnosis - The MagNA pure LC reduces laborious HCV sample preparation
Hepatology - Normal and tumor human and murine liver NKT cells are dissimilar
Hepatoma - PEITC potently induces apoptosis and cell-cycle arrest in HepG2 cells
Herpesvirus - Herpesvirus protein is B-cell-associated antigen important for latency
Herpesvirus - KSHV transcription factor K-bZIP prolongs cell cycle transition in infected cells
Herpesvirus - Peptide epitopes from herpes simplex virus glycoprotein confer immunity
Hip Replacement - 80% of patients eligible for minimally invasive surgery
Hirschsprung Disease - A new candidate gene for Hirschsprung disease discovered
Hodgkin Disease - Routine CT scan is of little value in following patients with Hodgkin's disease
Hormone Replacement Therapy - Group issues position statement on HRT use
Hormone Replacement Therapy - Nurse practitioners help FDA educate women on hormone therapy
Hospitalists - IPC enters into three new consulting agreements
Human Antimicrobial Proteins - Leukocyte calprotectin has antimicrobial activity vs. Borrelia burgdorferi
Human Neoplasms - Oncogenic transformation by BK virus may lead to human tumors
Human Papillomavirus - Regulations on molecular diagnostic testing of HPV outlined
Human Pheromones - The existence of human pheromones has not been proven conclusively
Huntington Disease - Huntingtin and associated proteins stimulate NeuroD activity
Hyperglycemia - Final FDA approval received for generic Glucotrol XL 5mg tablets
Hyperparathyroidism - New drug application submitted for cinacalcet HCl
Hypertension - Benicar HCT now available in U.S.
Hypogonadism - FDA approves new manufacturing site for injectable testosterone product
IV Feeding - Changes in IV formula can reverse neurological problems in bowel failure patients
Ig-Like Receptors - MAIR-I, MAIR-II have roles in mast cell, macrophage, B-cell function
Imaging - PET scans could provide insight into HIV-1 progression
Immunocytochemical Detection - Cyclin E increases in G1 in growing cells, using cell protein content method
Immunoglobulin Y - IgY can be purified best from egg yolk by using preparative electrophoresis
Immunological Memory - T memory-cell homeostasis may occur by density-dependent fratricide
Immunology - Antiangiogenic mechanisms may be responsible for interleukin-12 tumor control
Immunology - Corixa Corp. signs research, development, and license agreement
Immunology - Estrogen receptor modulates the anti-inflammatory activity of estradiol
Immunology - Liver memory CD8 cells protect after treatment with irradiated plasmodial sporozoites
Immunology - Monoclonal antibody to activated murine lymphocyte domain blocks liver damage
Immunology - Multiple T cell subsets control Francisella tularensis growth
Immunology - New patent broadens company's JNK intellectual property estate
Immunology - Persistent infection impairs the immune system
Immunology - Scientists invent search-and-destroy method to flush HIV out of hiding places
Immunology - Two phase II clinical trials for Vitaxin begin
Immunotherapy - Guillain-Barre syndrome has most treatments based on symptom attenuation
Infectious Disease - Biodefense grant to aid continued development of the GeneCode System
Infectious Disease - First VEB-1-producing Acinetobacter baumannii strain found in French hospital
Infectious Disease Diagnosis - EVIGENE assay provides accurate and convenient MRSA identification
Infectious Disease Diagnosis - Molecular assay can detect and distinguish fecal Giardia duodenalis
Infectious Disease Diagnosis - Molecular blood test suitable for CMV monitoring
Infectious Disease Therapy - Antibiotics that bind to S. aureus 30S ribosomal subunit also block subunit assembly
Inflammatory Myopathies - New therapeutic options for difficult to treat inflammatory myopathies
Influenza - Adults with asthma fail to follow flu vaccine guidelines
Information Technology - Alliance to bring added automation to Oracle clinical users
Information Technology - Diabetes care moves online
Information Technology - Gentiva launches CaseMatch software
Information Technology - German pharma company to use DataCore to improve storage availability
Information Technology - Grant to be used to study technology for cancer treatment
Information Technology - Merge eFilm enters partnerships with four European resellers and distributors
Information Technology - Navigant and Ontario Systems partner to provide revenue cycle management
Information Technology - New U.S. Health & Human Services project will use MicroStrategy technology
Information Technology - Pharmaceutical company implements Phoenix sample accountability services
Information Technology - Rockford Clinic enhances medical transcription services
Information Technology - Software provides new surgery center with coding compliance
Injury Prevention - U.K. doctors voice concern over rise in pedestrian and cyclist injuries
Insulin Delivery - Collaborative effort to develop inhaled insulin
Insulin Delivery - NIH provides grant for oral insulin development
Insulin Sensitizer - Label language finalized for Sucanon release in Mexico
Insurance Costs - Healthcare premiums to rise 13% in 2004; rate of increase high but slowing
Interferon - ISG15, an ubiquitin-like protein, may be involved in regulating interferon
Intravenous Immunoglobulins - Antibody-deficient IVIg-treated patients have a rate of adverse effects of 0.8%
Investments - Partnership to hold investments in two medical device companies
Ischemia-Reperfusion Injury - Heavy chain ferritin inhibits apoptosis, damage in experimental liver transplant
Ischemic Hepatitis - Hypotension-related liver disease clears upon hemodynamic support
Kidney Disease - Amgen submits NDA for cinacalcet HCL
Kidney Disease - Pregnant patients with chronic renal insufficiency can have good outcome
Kidney Stones - FDA grants clearance for percutaneous urology access device
Laparoscopic Surgery - Data lacking on venous thromboembolism prophylaxis
Legal Issues - Composition patent for Sinusol filed
Legal Issues - Health plan company seeks inquiry into Minnesota cancer center
Legal Issues - Healthcare appeals process working, New York administration says
Legal Issues - Ohio attorney general to investigate Medicaid claims related to equipment
Legal Issues - Patent issued covering cremophor-free taxanes
Legal Issues - Report urges laws, practices to address needs of incapacitated elderly patients
Legionnaires Disease - Link found to hot water pipes
Leishmania Donovani - Hepatic granuloma may be antileishmania defense; IL-4, receptor may be involved
Leptin Studies - Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men
Letter to the Editor - Phthalates and children
Leukemia - Anthocyanidins induce apoptosis in human promyelocytic leukemia cells
Leukemia - Grants fund research on leukemia, lymphoma, and myeloma treatments
Leukemia - p15 Methylation has a poor prognostic impact on disease-free survival
Leukemia Therapy - High-dose hydroxyurea shows promise for treatment of high-risk AML patients
Licensing Agreement - Rights to Loestrin oral contraceptive obtained
Lipid Research - Company launches metabolic pathway maps and Signature flux equations
Liver Cancer - Laser therapy offers alternative to surgery for liver tumors
Liver Disease - Thioredoxin transfection protects liver cells from apoptosis and necrosis
Low Birth Weight - Women with family history of early heart death at greater risk of having small babies
Lumbar Disc Prosthesis - Shock absorption is compared between lumbar disc prostheses
Lung Cancer - $464,000 Grant given to conduct research on lung cancer immunotherapy
Lung Cancer - COX-2 inhibitors might improve the efficacy of cancer radiation therapy
Lung Cancer - Combined CPT-11 and ifosfamide is effective in relapsed SCLC
Lung Cancer - Loss of PDCD4 expression correlates with tumor progression and prognosis
Lung Cancer - Low levels of chromium(VI) selectively activates Src family kinases, JNK
Lung Cancer - Lung cancer vaccines yield promising results in clinical trials
Lung Cancer - New blood test could detect disease in its earliest stages
Lung Cancer - Tc-99m-MIBI scintigraphy might be valuable in detecting recurrent lung cancer
Lung Cancer - Ultrasound-guided endoscopy may have role in evaluation of mediastinal lesions
Lung Cancer - Vitamin K2 may be used for lung cancer therapy
Lyme Disease - Peripheral nerve disorder may be from reaction with anti-Borrelia antibodies
Lymphocyte Activation - Quiescence enforcers for lymphocytes may be therapeutically useful
Lymphoma - Mutation of the BIK gene is a frequent feature of B-cell lymphomas
Lymphoma Therapy - Telomere shortening seen after chemotherapy in NHL patients
Macular Degeneration - Nonprofit organization receives proceeds for macular degeneration research
Magnetic Resonance Imaging - New shortest high-field MRI system provides more openness and less noise
Malaria - Telomerase assay detects activity in P. falciparum
Malaria Therapy - Hydroxychloroquine should not be used to treat chloroquine-resistant malaria
Malaria Therapy - Novel culture augments Artemisia annua artemisinin production
Malaria Therapy - Polyamine analogues active against resistant P. falciparum
Malaria Therapy - Quinacrine binds to cellular prion protein's C-terminal helix
Malignant Glioma - Oncolytic adenovirus may accelerate radiation-induced tumor fibrosis
Management Systems - Electronic medical record technology offered to physician offices
Market Analysis - Antidepressant, proton pump inhibitor lead first half 2003 in drug promotion
Market Analysis - Driving market uptake through successful physician messaging
Market Analysis - Drug-eluting stents improve outcomes in heart stent procedures
Marketing Research - Study: Market research critical to blockbuster launches
Mast-Cell Disease - Imatinib may inhibit the growth-promoting role of wild-type ckit
Measles - Edmonston measles virus prevents expression of MHC proteins
Medicaid - Governors ponder dilemma of soaring costs
Medicaid - HMS continues to administer estate recovery for Colorado program
Medicaid - Study blasts privatized Medicaid program; data questioned
Medical Ethics - AMA will provide electronic ethics alerts to physicians
Medical Malpractice - As healthcare problems persist, alliance breaks down
Medicare - Arkansas Blue Cross and Blue Shield to process, pay claims in Rhode Island
Medicare - HMO announces Medicare plans for 2004
Medicare Fraud - New efforts aimed at stopping abuse of the power wheelchair benefit
Melanoma - Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo
Melanoma - Knowledge of genetics has generated optimism for prevention program development
Melanoma - Phase II study demonstrates vaccine effectiveness in half of patients
Melanoma - Positive results reported in phase III trial of Genasense plus chemotherapy
Melanoma - Systemic treatment for advanced melanoma reviewed
Melanoma - Two clinical milestones achieved for Vitaxin
Men's Health - Cordyceps sinensis stimulates testosterone production
Meningioma - Brain neoplasms with a malignant phenotype express higher levels of COX-2
Menopause - Estradiol replacement affects face recognition exercises in female monkeys
Menopause - Some anticoagulant therapies interact with hormone replacement therapy
Mental Health - Affectivity model provides best expanation of genetic influence on job satisfaction
Mental Health - Antisaccade performance normal in relatives of schizophrenia patients
Mental Health - Off-label uses for selective serotonin reuptake inhibitors outlined
Mental Health - Screening for osteoporosis should be done before electroconvulsive treatment
Mental Health Coverage - Industry study reveals behavioral health benefits pay off
Mergers and Acquisitions - Acquisition offers company methods to fight bioterrorism
Mergers and Acquisitions - American Medical Security sells Accountable Health Plan network
Mergers and Acquisitions - Assets of Physicians Nutraceutical Laboratories acquired
Mergers and Acquisitions - Company plans to acquire generics manufacturer and diagnostic test kit company
Mergers and Acquisitions - Genzyme completes tender offer
Mergers and Acquisitions - H-Net.Net advances acquisition strategy
Mergers and Acquisitions - Hillenbrand Industries plans to acquire the maker of The Vest
Mergers and Acquisitions - Imaging company to be acquired
Mergers and Acquisitions - Martek completes acquisition of South Carolina company
Mergers and Acquisitions - Pain management company acquires assets of its distributor
Mergers and Acquisitions - Peoples Genetics' technologies acquired for genetic analyses
Mergers and Acquisitions - U.K. consumer dermatology business sold to Ferndale Pharmaceuticals
Mesothelioma - Wnt signaling plays a role in the pathogenesis of mesothelioma
Metabolic Disease - Hammerhead ribozymes facilitate the production of deficient enzymes
Metapneumovirus - Newly discovered bug ubiquitous in society
Microanalysis - A nanoinjector for microanalysis has better than 1.2% repeatability
Microarray Technology - Nanogen teams to develop infectious disease diagnostics
Migraine Headache - Link found to behavioral disorders in children
Migraine Headache - Understanding migraines may lead to better compliance, reduced medical interventions
Mitral Valve Stenosis - The 3D TEE enables a better description of the mural valvular anatomy
Monoclonal Antibodies - Novel mAb may aid glycoprotein VI research
Monoclonal Antibodies - The anti-HLA-A monoclonal LGIII-147.4.1 has broadest spectrum of reactivity
Mortality - Study: Low-calorie diet can extend life
Mosquito-borne Disease - Anopheles gambiae GST gene mutations can confer DDT resistance
Multiple Pregnancy - Rare conjoined twins in triplet pregnancies present management challenges
Multiple Sclerosis - Stress makes symptoms worse
Muscular Dystrophy - SK3 is expressed in myotonic muscular dystrophy; may not cause symptoms
Mycobacterium - Two o-quinone reductases isolated from pyrene-degrading Mycobacterium
Mycotic Aneurysm - Fungal infection can cause aneurysm of the extracranial internal carotid artery
Myeloma - Researchers find genetic variations may predict treatment responses
Myocardial Ischemia - Hypoxia-inducible VEGF gene delivery may treat ischemic heart disease
Nanotechnology - DuPont Electronic inks agreement for carbon nanotubes in field emission displays
Natural Killer Cells - There are two types of liver-restricted NKT cells for immune surveillance
Necrosis Factor Receptor - TRAF2 controls cell sensitivity to apoptosis
Needle Safety - Safety-engineered needle technology receives FDA patent
Neovascularization - Medicare panel supports Visudyne therapy for use in patients with occult AMD
Nerve Fibers - PACAP is coexpressed with CGRP in rat, VIP in human tooth pulp nerve fibers
Neuroimmunology - Many paraneoplastic neurologic syndromes may be immune mediated
Neuroscience - Circadian tryptophan hydroxylase expression in brainstem varies by isoform
Neuroscience - Multimerization of PSD-95 is lipid- and protein-mediated
Neuroscience - Nervous tissue development relies on vascularization for nutritional support
Neuroscience - Potassium channel gene therapy prevents neuron death
Neuroscience - Scorpion venom toxin inhibits potassium currents in hippocampal neurons
New Facilities - International consortium appointed to develop two surgical hospitals in England
Non-Hodgkin Lymphoma - Medicare coding instructions issued for Bexxar
Nutrition - Increase in forearm fractures seen among adolescents
Nutrition - Study: Multivitamins linked with reduced risk of heart attack
Nutritional Supplements - Oat bran product available to consumers
Obesity Genomics and Genetics - Obesity risk linked to carbohydrate intake in certain genotype
Obesity Risk Factor - Enteral tube feeding did not suppress food intake in healthy men
Obesity Risk Factor - Selectively bred Sprague-Dawley rats respond differently to diet
Obesity Treatment - New obesity drug in phase III development
Obstetric - Progesterone may regulate calbindin-D-9k mRNA expression during late pregnancy
Obstetrics - Doctors need to know alcohol, pregnancy don't mix
Obstetrics - Family history of early death from heart disease increases risk of LBW babies
Obstetrics - Massachusetts plan will cover pregnant women
Obstetrics - Physical burden is the major cause of slower movement during pregnancy
Occupational Exposure - Mercury may induce autoimmune disease by interfering with apoptosis complex
Oligodendrogliomas - Cyclins other than D1 are expressed in higher grade oligodendrogliomas
Oncogene - P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein
Oncogenesis - Human prostate cancers lack evidence of KLF6 tumor suppressor gene mutations
Oncogenesis - Powerful new method helps reveal genetic basis of cancer
Oncogenesis - Survivin is expressed in premalignant lesions, more in oral squamous cancers
Oncology - Lutein blocks murine tumor growth through antiangiogenesis and apoptosis
Oncology - Tumor-specific gene therapy diminishes thyroid cancers without adverse effects
Oncology Research - Grant to help fund cancer research
Ophthalmology - Fibroblast growth factors are important modulators of ocular vascularization
Ophthalmology - Virus-mediated gene transfer slows the loss of photoreceptors in rodent models
Opportunistic Infection - T-cell costimulatory molecule function may determine PCP susceptibility
Oral Mucositis - Study demonstrates CG53135's activity in two animal models
Orthodontics - Cervical vertebral bone age predicts mandibular growth potential
Orthostatic Intolerance - Melatonin supplements may make standing hazardous for some
Osteoarthritis - Territory expanded for Orthovisc to Germany and France
Osteomyelitis - Intracellular Staphylococcus basis of indolence of osteomyelitis
Osteopontin - Osteopontin of different sizes can be purified from human milk
Osteoporosis - Antioxidants play a crucial role in estrogen-deficiency bone loss
Osteoporosis - Balance between bone-building protein and inhibitor expression is critical
Osteoporosis - Cathepsin K inhibition is feasible for the treatment of bone loss
Osteoporosis - Enzyme evaluations reveal how glucocorticoids stymie bone health
Osteoporosis - Fracture risk is marked by vitamin D and estrogen receptor genotype interactions
Osteoporosis - Genetics company, UCSF to collaborate on osteoporosis genetics
Otitis Media - Augmentin ES-600T more effective than Zithromax in study
Outbreaks - High-dose steroids, CPAP, strict quarantine helped control Chinese SARS outbreak
Ovarian Cancer - Immunotherapeutic approaches in ovarian cancer reviewed
Ovarian Cancer - Paclitaxel temporarily adds to the sensory neurotoxicity of cisplatin
Ovarian Cancer - Royalty rights to R1549 obtained by U.K. biotech company
Ovarian Tumors - Tumors of the gonadal stroma are potentially malignant
Pain Management - New educational tool launched to fight "epidemic" of untreated pain
Pain Medicine - Proteins modulate stress-induced antinociception in the mouse
Pain Relief - NWT 4000 preparing for clinical trials, expects to seek FDA approval
Pain Therapy - Positive phase III results for bicifadine, a novel, non-narcotic analgesic, announced
Pancreatic Cancer - FDA gives orphan drug approval to REXIN-G
Pancreatic Cancer - Link found to developmental cell signaling pathway
Pancreatic Cancer - Obesity increases risk of pancreatic cancer
Pancreatic and Prostate Cancer - Financing secured for the development of cancer vaccines
Parkinson Disease - Company to assist Neurologix in management of gene therapy trial
Parkinson Disease - FDA response provided on special protocol assessment for Altropane
Parkinson Disease - Mutations in hemochromatosis gene linked to Parkinson disease
Parkinson Disease - New clinical research study evaluates novel cell therapy
Parkinson Disease - New drug application submitted to FDA for drug to treat Parkinson's disease
Parkinson Disease - Therapeutic cloning tried in Parkinsonian mice
Pathogen Detection - Genetic assessment company announces FDA purchase of Smart Cycler II
Patient Care - Academy recognized for enhancing physician-patient communication
Patient Education - Horizon BCBS to educate parents about infant immunizations
Patient Trends - Forrester Research highlights attitudes and behaviors of the uninsured
Pediatric Leukemia - Clofarabine gets fast track designation
Pediatric Obesity - Best, worst snacks for kids listed
Pediatric Vaccine - Haemophilus influenzae antibodies present in vaccinated infants
Pediatrics - As budget woes threaten children's access to dental care, states get creative
Pericardial Repair - CardioWrap pericardial film wins FDA approval
Periodontal Disease - Periodontal disease associated with lower antioxidant capacity
Peripheral Artery Disease - Phase II drug shows promise for treating peripheral arterial obstructive disease
Personnel - Biotech company appoints Sachs to board of directors
Personnel - Board strengthened with addition of new chairperson at device firm
Personnel - Canadian biopharma announces new board members
Personnel - Device firm names Swank chief financial officer
Personnel - Drug discovery company names John A. Keller executive VP, chief business officer
Personnel - Frank A. D'Amelio joins Humana board of directors
Personnel - Generics association names Bruce Lott senior director of state affairs
Personnel - Genetics testing company organization names Thomas Goralski as lab director
Personnel - Gennevois named VP of medical affairs at cardiovascular device company
Personnel - HMO announces new president
Personnel - HealthSouth names Lee S. Hillman as new board member
Personnel - IntelliClaim names Kathleen Connolly president
Personnel - John H. Capobianco named president of MEDecision
Personnel - Kimberly K. Dennis named vice president, corporate services
Personnel - Laser maker names new CEO
Personnel - Levin named to scientific advisory board at infectious disease firm
Personnel - Lloyd G. Glenn joins pharma company as VP marketing and corporate development
Personnel - Management change reported after CEO goes on medical leave
Personnel - Martin B. Leon, MD, interventional cardiologist, joins scientific advisory board
Personnel - Medical device manufacturer names new vice president of international sales
Personnel - Michael R. Dougherty steps down from board of directors
Personnel - New officer, board member, chairman named at diagnostics company
Personnel - Oxygen delivery company shareholders elect board's nominees
Personnel - Peter U. Feig, Caron D'Ambruso join healthcare company
Personnel - Pharmaceutical company's chief executive officer resigns
Personnel - Richard Schoenfeld named VP, marketing and business development
Personnel - Zelefsky named to board of directors at pharmaceutical firm
Pertussis Vaccine - Bordetella pertussis isolates in Russia compared to vaccine strains
Pharmaceutical Approvals - European Union approves Humira; FDA approves Depakote ER
Pharmaceutical Marketing - Launching blockbusters: Early investments fuel maximum impact
Pharmaceutical Marketing - R&D and commercial teams unite during drug development to cut spending
Pharmacological Effects - Neuropeptides CGRP, substance P increase with Hange-shashin-to, not Rikkunshi-to
Pharmacy Benefits Management - Generic drug program adds OTCs for two therapeutic groups
Physician Incentives - Blue Cross of California pays out $28M in doctors' bonuses
Pneumococcus Vaccine - Novel vaccine strategies reported with Streptococcus pneumoniae antigens
Polio - Virulent highly divergent vaccine-derived polioviruses circulating
Poliovirus - Structure of internal loop in poliovirus 3'-UTR reported
Polymerase Chain Reaction - Quantitative PCR assay for detecting Ehrlichia chaffeensis reported
Pompe Disease - Myozyme development program expanded
Post-Transplant Infections - CMV DNA assessment may help early diagnosis in pediatric liver transplant
Prescription Drug Benefits - Illinois mulls buying drugs from Canada
Prescription Drug Benefits - Indian Nation, unions, team up with seniors in drug-cost coalition
Prescription Drug Benefits - Iowa wants drug rules extended to all nursing home patients
Prescription Drug Benefits - Wisconsin businesses create drug purchasing pool
Preterm Labor - Overview of therapeutics for preterm labor provided
Primary Immunodeficiency Disease - Product approved to treat primary humoral immune deficiency disease
Prion Diseases - Allograft inflammatory factor-1 is found in macrophages, neurons of CJD brains
Product Launches - Brand teams allocate 41% of staffing resources to drug launch period
Product Sales - Pharmaceutical companies share tactics for increasing sales productivity
Prostate Cancer - Bombesin may act as a mitogen in prostate cancer
Prostate Cancer - Brachytherapy seed supplier now sells direct
Prostate Cancer - Cdc37 is necessary for normal human prostate epithelial cell survival
Prostate Cancer - GST genotype not linked to increased prostate cancer risk, but may have protective effect
Prostate Cancer - Grape seed extract may be an effective therapeutic agent for prostate cancer
Prostate Cancer - PPARalpha can be induced or inhibited by ARA70, depending on tissue type
Prostate Cancer - Polymorphism in codon 10 of ERalpha may be a risk factor for prostate cancer
Prostate Cancer - Promising results reported on new protease activated therapy
Prostate Cancer Markers - Oncofetal protein p65 may be useful added marker in prostate cancer
Proteomics - Clues found on ability of protein toxins to form pores in membranes
Proteomics - Importin beta contains nucleoporin binding region
Proteomics - Localization of proteins bound to replication origin of DNA reported
Proteomics - PDE2 and PDE4 inhibitors reduce VEGF-inspired cell growth and migration
Proteomics - Rab3B and Rab13 play distinct roles in transport of membrane proteins
Proteomics - Role of scaffolding proteins in disease discussed
Proteomics - Talin forges links between integrins and actin
Proteomics - The leech Hirudo medicinalis responds to VEGF by growing new vessels
Proteomics - The von Hippel-Lindau protein targets hsRPB7 to regulate angiogenesis
Pseudomonas - CadR from Pseudomonas aeruginosa characterized
Pseudomyxoma Peritonei - Pseudomyxoma peritonei is reviewed
Psoriasis - Clinical trials for Psoraxine initiated
Psoriasis - Committee recommends approval for Raptiva as a potential treatment for plaque
Psoriasis - Design of trials in psoriasis provides lessons for clinical practice
Psoriasis - Psoriasis may be due to growth defects, differentiation transcription factors
Psychology - Educational achievement can overcome problematic parenting
Psychology - First year of widowhood most harmful to mental health, large study finds
Psychology - Recurrent brief depression is prevalent among the young people of Italy
Psychology - Women satisfied in their marriage appear to reap health benefit
Public Health - Lack of funding threatens to derail WHO's Roll Back Malaria program
Public Offering - Biosciences company announces pricing of 3.75 million share public offering
Pulmonary Embolism - Emergency rooms can rule out pulmonary embolism rapidly by following protocol
Pulmonary Fibrosis - Idiopathic pulmonary fibrosis appears to arise from improper wound healing
Pulmonary Fibrosis - Idiopathic pulmonary fibrosis is linked to a complement receptor 1 polymorphism
Pulmonary Medicine - Prenatal screening impacts cystic fibrosis prevalence in Brittany, France
Q Fever - An animal model is found for Q fever endocarditis
Quality of Care - Physicians don't follow guidelines for women's heart care, study finds
RNA Research - RNA pol II CTD C-terminus motif needed for transcription, splicing and 3' end processing
RNA Research - Role of HIV nucleocapsid protein zinc fingers in reverse transcription clarified
RNA Research - Ubiquitin plays non-proteolytic role in HIV Tat-mediated viral transactivation
Radiation Poisoning - FDA encourages new applications for drugs to treat internal contamination
Radiology - Math tool promises to cut dose calculation time
Recombinant - Hepatitis B virus X protein disturbs calcium signals to stimulate apoptosis
Rectal Cancer - Endosonograpy and MRI are important in staging rectal cancer
Regulatory Process - Expression Analysis submits microarray-based gene expression data to FDA
Reimbursement - Adaptis partners with Q Mark for HEDIS reporting
Reimbursement - Companies offer additional reimbursement coverage for capsule endoscopy
Renal Transplantation - A transplanted kidney can be interpreted as a malignant lesion on FDG PET
Reproduction Medicine - Novel strategy for beta-globin gene mutation analysis improves PGD
Reproductive Health - IntegraMed America reaches agreement with North Carolina fertility center
Reproductive Medicine - High doses of the COX-2 inhibitor DuP-697 changes rodent fetal development
Reproductive Medicine - Neural signals sent to the CNS from the ovaries seem to dictate ovarian function
Reproductive Medicine - New methods detect the gene for spinal muscular atrophy before implantation
Research Funding - $85 Million awarded for research on human immunity and biodefense
Research Funding - Devices could help diagnose precursors to cancer
Research Funding - NIGMS funds Centers of Excellence to unravel complexities of living systems
Research Funding - Researchers continue AIDS vaccine research with $15 million grant
Restenosis - Angioplasty device company starts clinical studies of catheter
Restenosis - Restenosis rates drop to 5.1% in sirolimus-eluting coronary stent trials
Restless Leg Syndrome - sNDA filed for Requip for the treatment of RLS
Restructuring - First Consulting Group announces organizational changes
Rheumatoid Arthritis - British scientists receive Lasker Prize for discovering new treatment
Rheumatoid Arthritis - Novel therapeutic target identified
Rheumatoid Arthritis - RA autoantibodies appear after peptide citrullination increases by PADI4
Rheumatoid Arthritis - Some HLA microsatellites can indicate RA risk, others show no risk
Rheumatology - Chondroepiphyseal angiogenesis studies will advance research on several fronts
Rosacea - Dyspeptic, anti-Helicobacter pylori patients have high rosacea risk
SARS - Chinese province designates 158 hospitals for treating possible future victims
Schizophrenia - Apolipoprotein D plays role in psychiatric disorders
Schizophrenia - FDA approves ABILIFY (Aripiprazole) sNDA
Schizophrenia - Interneurons play important roles in schizophrenia
Schizophrenia - New program will pursue gene leads
Schizophrenia - UGA, MCG study impact of long-term use of drugs
Sclerosis - Diffuse, limited systemic sclerosis are distinct, steroid-treatable diseases
Sepsis - CE Mark issued for test that aids in sepsis risk assessment
Septic Shock - Therapy to combat septic shock mortality is based on limiting immune reactivity
Septicemia - Statin drugs may protect against sepsis
Sexually Transmitted Disease - Chlamydia and gonorrhea retests would mitigate false-positives
Sexually Transmitted Disease - Gastricsin processes hCAP-18 in semen to antimicrobial ALL-38, at vaginal pH
Sexually Transmitted Disease - Routine gonorrhea, Chlamydia screening at HIV clinics may slow HIV spread
Sexually Transmitted Disease - SD amplification detects comparable numbers of STD cases with vaginal swabs
Sexually Transmitted Disease - Sexually transmitted diseases treatment guidelines explained
Sexually Transmitted Disease - Virus-associated growths might be prevented with sexual education
Short Root Anomaly - Short root anomaly gingival crevicular fluid is high in MMP-9
Sickle Cell Anemia - Children's Hospital of Pittsburgh reports successful bone marrow transplant
Sinusitis - Ketek tablets active in treatment of acute maxillary sinusitis
Skin Cancer - Two UN agencies and partners launch campaign to prevent overexposure to sun
Skin Infections - Cutaneous T-cell lymphoma patients do not show association with Chlamydia
Skin Infections - FDA approves first in new class of antibiotics
Sleep Apnea - Nasal-Aire II hits market
Smallpox - Licensing deal signed with Gilead Sciences for smallpox drug
Smallpox - SBIR grant awarded to develop anti-smallpox therapeutics
Smallpox Vaccine - Modes of protection against infection shared by smallpox vaccine viruses
Smallpox Vaccine - New generation of cell culture assay for smallpox vaccine potency developed
Social Anxiety Disorder - Drug market to triple sales volume by 2012
Speech Disorders - Harcourt launches tests to identify speech and language disorders in children
Spinal Cord Injuries - Biotechnology company receives grant to continue spinal cord injury research
Spinal Tuberculosis - First report of combined spinal subdural tuberculous empyema and intramedullary tuberculoma
Spine Surgery - A new technique for implanting prosthetic disc-nucleus devices is introduced
Spine Surgery - Classification of heterotopic ossification in artificial disk replacement proves reliable
Spine Surgery - Preliminary results with ProDisc II are encouraging
Spine Surgery - SB Charite disc replacement improves function
Staph Infection - New antibiotic compound has activity against drug-resistant bacteria
Staphylococcus - Company successfully completes StaphVAX immunogenicity study
Staphylococcus - Phase I study of Aurexis finished
Statins - Genaissance Pharmaceuticals enters pharmacogenomics-based agreement
Stem Cells - Demand for cord blood bank rapidly growing in Taiwan
Stem Cells - Mouse sperm cells generated
Stem Cells - Patents issued for the therapeutic use of stem cells in gene therapy
Stem-Cell Research - Allergy-induced CCR3 expression may stimulate bone marrow stem-cell migration
Stem-Cell Research - Bone morphogenetic protein-7 regulates Runx2/Cbfa1 promoter transcription
Stem-Cell Research - Cystatin-B is expressed by both neural stem cells and mature neurons
Stem-Cell Research - Mesenchymal stem cells can regenerate craniofacial bone in animals
Stem-Cell Research - VEGF disruption affects tumors derived from stem cells and oncogenes differently
Stem-Cell Transplantation - Erythropoietin reduces transfusion needs during aggressive lymphoma treatment
Stem-Cell Transplantation - Granisetron effective as antiemitic for bone marrow transplant recipients
Stem-Cell Transplantation - T cell-depleted stem cell autografts can trigger CVID in genetically predisposed patients
Stents - European surgeons implant new nonvascular stents
Stock Market - AMEX accepts pharmaceutical company's plan to regain compliance
Stock Market - IMPATH announces commencement of formal SEC investigation
Stock Market - Predictive medicine company listed as "IME" on American Stock Exchange
Stock Martet - Healthaxis announces NASDAQ approval of continued listing
Streptococcus - Expanded distribution and promotion for Strep A test
Streptococcus Pneumoniae - Neurogenesis may be induced in hippocampus soon after bacterial meningitis
Streptococcus Pneumoniae - New vaccine reduces antibiotic-resistant infections and protects families
Stress Incontinence - New class of incontinence products introduced
Stroke - Cranberry component linked to reduced stroke damage
Stroke - Gene associated with susceptibility to common form
Substance Abuse - Hepatitis C on the increase among injecting drug users
Substance Abuse - Link between cannabis and death still not established
Substance Abuse - Male injecting-drug users at greater risk of drug-related death
Sudden Cardiac Death - Distribution agreement announced for sudden cardiac death risk stratifier
Sudden Cardiac Death - New drug therapies improve outcomes
Suicide - Different approaches required for monitoring trends
Supply Chain - Global Healthcare Exchange introduces The Content Center
Surgical Equipment - Radiation/oncology company signs provider contract
Surgical Menopause - Testosterone patch improves sexual desire in women whose ovaries were removed
Systemic Lupus Erythematosus - IL-4 exerts differential effects in peptide-induced autoimmunity
Systemic Lupus Erythematosus - Lupus can affect children with sickle cell disease
T-Cell Activation - Fas ligand is involved in positive selection of thymocytes
T-Cell Function - Fas ligand regulates different aspects of T -function, homeostasis
TLR Signaling - PI3K is an early negative regulator of Toll-like receptor signaling
Telemedicine - Georgia county receives funding for rural healthcare program
Telemedicine - Home care trial planned for heart failure patients
Thromboembolism - Many British oncologists unaware of cancer clot risk
Thrombosis - Central line thrombosis in patients with cancer is a common complication
Thrombosis - Deep vein thrombosis may be related to acute cytomegalovirus infection
Thrombosis - Thrombin upregulates ICAM-1 in human monocytes, THP-1 cells, and in pregnancy
Thymic Environment - Group selection potential in the thymus determines individual CD4, CD8 lineages
Thymus Development - Mesenchyme provides fibroblast growth factors 7, 10 for thymic maturation
Thyroid Cancer - Radioiodine improves prognosis for patients with pulmonary metastases
Thyroid Disease - VEGF-C overexpression is detected in papillary thyroid cancer
Thyroid Dysfunction - Thyroid antibodies increase risk of miscarriage
Tobacco Use - Cigarette smoking may affect multiple organs in addition to lungs and airways
Tobacco Use - Deaths due to smoking-related disease are increasing among women
Tongue Cancer - Tumor thickness predicts cervical nodal metastases and survival in early disease
Tooth Injury - TGF-beta 1 induces accumulation of immature dendritic cells in tooth pulp
Toxicology - Rodent fetuses demonstrate congenital defects after maternal MBeP exposure
Toxoplasma - Host cell penetration by Toxoplasma gondii investigated
Transfusion Medicine - Blood platelets may last longer on shelf
Transfusion Medicine - Suboptimal treatment contributes to bone loss in youth with beta-thalassemia
Transplant Medicine - Complement from renal allograft tubules may play largest role in rejection
Transplant Medicine - Mycophenolate mofetil added to a regimen with cyclosporine A will lower CsA
Transplant Medicine - Pediatric kidney transplantation improved in areas of infant survival, rejection reversal
Transplant Medicine - Racial groups fare equally well in kidney transplant using combination therapy
Transplant Medicine - Renal transplant artery stenosis reviewed
Transplant Medicine - Should living liver donation be available in the British National Health Service?
Trauma - Paper highlights blood substitute for trauma patients
Trypanosoma Brucei - T. brucei has interrelated editosome proteins
Tuberculosis - Isoniazid effective for latent tuberculosis infection
Tuberculosis Immunology - Platelet-activating factor not involved in immune response to TB infection
Tuberculosis Immunology - Role of CCL2 in host tuberculosis defense clarified
Tuberculosis Immunology - Valpha14 NK T cells may help control inflammation during TB infection
Tuberculosis Pathogenesis - M. tuberculosis capable of gene-selective suppression of IFN-gamma-induced transcription
Tuberculosis Proteomics - Mycobacterial Nudix hydrolase characterized
Tuberculosis Screening - TB not always evident at arrival in new country
Tuberculosis Therapy - Anti-tuberculous efficacy of fluoroquinolones compared
Tuberculosis Therapy - Fresh-frozen allografts suitable for spinal tuberculosis treatment
Tularemia - Study evaluates "rabbit fever" as part of biodefense research plan
Tumor Histology - Noninvasive bladder cancer has microinvasion; may affect recurrence, progression
Tumor Metastasis - Use of in vivo radiolabelled cytokines can help locate inflammation, metastasis
Tumor Necrosis Factor - Complexity in TNF and receptor family related immunology involves coevolution
Tumor Response - SPET and PET have a role in monitoring tumor response to therapy
Tumor Suppression - SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability Smad4
Type 2 Diabetes Therapy - Polypeptide analogs offer potential for treating type 2 diabetes
Typhoid Models - Enterocolitis diarrheal symptom may result from expression of chemokine GROalpha
Ultraviolet Radiation - TARC/CCL17 is inhibited for days in human keratinocytes following UVA
Uninsured Children - Centers could help find kids eligible for healthcare, study says
Urinary Tract Infection - Research confirms safety of phone call diagnosis
Urology - PTEN gene therapy suppresses tumor growth and sensitizes cells to doxorubicin
Vaccine Safety - Facts and speculation on vaccine safety reviewed
Varicella - CDC: Chickenpox rates drop in 4 states
Varicose Veins - Radiofrequency treatment offers faster recovery, less discomfort
Vascular Endothelial Growth Factor - Partnership to develop, commercialize the VEGF Trap
Vector Development - External controllers would improve the efficacy of cancer gene therapy
Vectors and Zoonoses - Wild mammals harbor human-pathogenic Enterocytozoon bieneusi
Venous Thromboembolism - Low-molecular-weight heparins are safe and effective for cancer patients
Ventricular Fibrillation - New drug for ventricular disorders receives ANDA
Vesnarinone - Analysis of differentiation therapy might provide targeted molecules for therapy
Viral Genomics - Hepatitis C virus subgenomes replicate in nonhepatic human and murine cells
Viral Genomics - The INNO-LiPA assay can quickly identify hepatitis B virus variants
Viral Proteomics - Hepatitis B virus X protein triggers survival signals by activating enzyme
Virology - Hybrid amplicons change the way adenoviral genes are delivered
Virology - Recombinant variants protect against CTL escape and viral persistence in mice
Virulence Factors - Listeria monocytogenes has a virulence-related gene homologous to AgrA
Visual Impairment - New hand-held obstacle detection device launched
Vitamin C - Vitamin C supplementation reduces constitutive ICAM-1 expression
Waste Collection - CE Mark awarded for gastrointestinal device
Weight Loss - Overweight Americans don't believe they are at risk for diabetes
West Nile Virus - Clinical trial of West Nile virus patients begins
West Nile Virus - National study planned to evaluate treatment
West Nile Virus - Recent developments in West Nile virus vaccine reported
West Nile Virus - Test helps protects the nation's blood supply
Wiskott-Aldrich Syndrome - Heterozygotic mothers of Wiskott-Aldrich syndrome children express WASP fully
Women's Health - Hormonal contraceptives don't affect course of HIV infection
Wound Repair - Heat shock protein 47 antisense therapy stops collagen overproduction
Zoonosis - Subclinical hepatitis E virus prevails among humans and swine in Korea
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