Occupational Exposure

Mercury may induce autoimmune disease by interfering with apoptosis complex

Published in Health and Medicine Week, October 6th, 2003

Mercury may induce autoimmune disease by interfering with an apoptosis signaling complex.

"Inorganic mercury (Hg²⁺) modulates several lymphocyte signaling pathways and has been implicated as an environmental factor linked to autoimmune disease. From the standpoint that autoimmune diseases represent disorders of cell accumulation, in which dysregulated apoptosis may be one mechanism leading to the accumulation of autoreactive lymphocytes, we have been investigating the influences of Hg²⁺ on CD95-mediated apoptosis," investigators in the United States report.

"We demonstrate here that low and noncytotoxic concentrations of...

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Source: Health and Medicine Week (2003-10-06)

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