Dendritic-Cell Vaccine
Genetic tagging shows longevity of antigen-presenting dendritic cells
Published in Health and Medicine Week, October 20th, 2003
"Dendritic cells (DCs) are key regulators of immune responses that activate naive antigen-specific T lymphocytes. In draining lymph nodes, antigen-bearing DCs are reported to be rare and short-lived. How such small numbers of short-lived DCs can activate rare antigen-specific T cells is unclear," scientists writing in the journal Nature Immunology report.
"Here we show that after immunization of mouse skins by gene gun, the number of antigen-bearing DCs that migrate to draining lymph node is 100-fold higher than previously...
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