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Sclerodoma

Study offers genetic clues to causes of mysterious skin disease

Published in Health and Medicine Week, October 20th, 2003

People suffering from scleroderma, a debilitating, sometimes-fatal skin disease, may one day benefit from a study that gives doctors their first look at the genes behind the poorly understood disease.

A team of scientists, including Princeton geneticist David Botstein and led by his postdoctoral fellow Michael Whitfield (now at Dartmouth), found more than 2700 genes with an unusual level of activity in people with scleroderma, which causes painful thickening of the skin, swelling and other tissue damage. The results could greatly improve doctors' ability to diagnose the disease and may reveal possible avenues for treating it.

A surprising result of...

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