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Acute Myeloid Leukemia
Mutations in FLT3 are the most common genetic lesions in AML
October 27th, 2003
Mutations in FLT3 are the most common genetic lesions in AML. "Normal hematopoietic cells use complex systems to control proliferation, differentiation and cell death. The control of proliferation is, in part, accomplished through the ligand-induced stimulation of receptor tyrosine kinases, which signal to downstream effectors through the RAS pathway," scientists in the United States report. "Recently, mutations in the FMS-like tyrosine kinase 3 (FLT3) gene, which encodes a receptor tyrosine kinase, have been found to be the most common genetic lesion in acute myeloid leukemia (AML), occurring in approximately 25% of cases," wrote D.L. Stirewalt and...
Source: Health & Medicine Week (2003-10-27)
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