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Adverse Drug Effects
Apoptosis precedes necrosis in acetaminophen-induced liver injury
October 27th, 2003
Apoptosis precedes necrosis in acetaminophen-induced liver injury. "The role of apoptosis in acetaminophen (AAP)-induced hepatic injury was investigated. Six hours after AAP administration to BALB/c mice, a significant loss of hepatic mitochondrial cytochrome c was observed that was similar in extent to the loss observed after in vivo activation of CD95 by antibody treatment. AAP-induced loss of mitochondrial cytochrome c coincided with the appearance in the cytosol of a fragment corresponding to truncated Bid (tBid)," scientists in England reported. "At the same time, tBid became detectable in the mitochondrial fraction, and concomitantly, Bax was...
Source: Health & Medicine Week (2003-10-27)
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