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Allergy Medicine
Alpha-melanocyte-stimulating hormone kills mast cells; NF-kappa B can stop it
October 27th, 2003
Mast cell death can be caused by alpha melanocyte stimulating hormone and controlled by NF-kappaB and expression of alpha-MSH receptors. According to a study from India, "Mast cells play a major role in the initiation of inflammation and allergic reactions. As cell numbers are tightly controlled by the interplay of factors affecting cell proliferation, development, and death, the regulation of mast cell number may be important. "Melanocyte-stimulating hormone inhibits most forms of inflammation by an unknown mechanism. In the present study, we have found that the alpha-melanocyte-stimulating hormone (alpha-MSH) inhibited endotoxin-mediated nuclear...
Source: Health & Medicine Week (2003-10-27)
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