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Allergy Medicine
Mast cell mediator increases bronchial macrophage-derived chemokine
October 27th, 2003
Prostaglandin D-2 released by mast cells upregulates mouse macrophage derived chemokine (MDC), which appears to accelerate the immune response to antigen; human MDC may therefore be a good target for asthma reduction. "PGD2 a lipid mediator released from mast cells, is known to participate in allergic reactions. However, the mechanism by which PGD2 contributes to such reactions remains unclear. We established a novel experimental model of asthma that permitted direct assessment of the role of PGD2 in airway inflammation," investigators in Japan report. "Antigen-sensitized mice were exposed to aerosolized...
Source: Health & Medicine Week (2003-10-27)
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