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Angiology
c-Jun N-terminal kinase inhibitor protects against cerebral ischemia
October 27th, 2003
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. "Neuronal death in cerebral ischemia is largely due to excitotoxic mechanisms, which are known to activate the c-Jun N-terminal kinase (JNK) pathway. We have evaluated the neuroprotective power of a cell-penetrating, protease-resistant peptide that blocks the access of JNK to many of its targets," scientists in Switzerland report. "We obtained strong protection in two models of middle cerebral artery occlusion (MCAO): transient occlusion in adult mice and permanent occlusion in 14-day-old rat pups," stated Tiziana Borsello "In the first model,...
Source: Health & Medicine Week (2003-10-27)
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