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Antibiotics
Ribosome binding thiazole antibiotics exhibit contrasting activities
October 27th, 2003
The structural basis for the contrasting activities of ribosome binding thiazole antibiotics has been published in a recent issue of the journal Chemistry and Biology. "Thiostrepton and micrococcin inhibit protein synthesis by binding to the L11 binding domain (L11 BD) of 23S ribosomal RNA. The two compounds are structurally related, yet they produce different effects on ribosomal RNA in footprinting experiments and on elongation factor-G (EF-G)-dependent GTP hydrolysis. Using NMR and an assay based on A1067 methylation by thiostrepton-resistance methyltransferase, we show that the related thiazoles, nosiheptide and siomycin, also bind to this region,"...
Source: Health & Medicine Week (2003-10-27)
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