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Antibody Production
Immunoglobulin class switch recombination requires AID to affect dsDNA breaks
October 27th, 2003
Immunoglobulin class switch recombination requires AID to affect many double stranded DNA breaks. "Affinity maturation of the Ab repertoire in germinal centers leads to the selection of high affinity Abs with selected heavy chain constant regions," scientists in France report. "Ab maturation involves two modifications of the Ig genes, i.e., somatic hypermutation and class switch recombination. The mechanisms of these 2 processes are not fully understood. As shown by the somatic hypermutation and class switch recombination-deficient phenotype of activation-induced cytidine deaminase (AID)-deficient patients (hyperIgM type 2 syndrome) and mice, both...
Source: Health & Medicine Week (2003-10-27)
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