Hepatology
Upregulated transactivating factor may play a role in liver metabolism
Published in Health and Medicine Week, October 27th, 2003
"The mRNA expression profile in control and clofibric acid (CLO)-treated mouse, rat, and human hepatocytes was analyzed using species-specific oligonucleotide DNA microarrays (Affymetrix). A statistical empirical Bayes procedure was applied in order to select the significantly differentially expressed genes. Treatment with the peroxisome proliferator CLO induced up-regulation of genes involved in peroxisome proliferation and in cell proliferation as well as downregulation of genes involved in apoptosis in hepatocytes of rodent but not of human origin," researchers in France reported.
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