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Antigen Presentation
Recognition of antigens presented by HLA-A2 involves binding site recognition
October 27th, 2003
Recognition of antigens presented by HLA-A2 does also depend on recognition of the structure of the peptide binding site. According to recent research published in the Journal of Immunology, "T cell recognition by peptide-specific alphabeta TCRs involves not only recognition of the peptide, but also recognition of multiple molecular features on the surface of the MHC molecule to which the peptide has been bound. "We have previously shown that TCRs that are specific for 5 different peptides presented by HLA-A2 recognize similar molecular features on the surface of the alpha1 and alpha2 helices of the HLA-A2 molecule. We next asked whether these...
Source: Health & Medicine Week (2003-10-27)
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