Health & Medicine Week
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Antigen-Presenting Cells
Even short rises to temperature increase hsp90, dendritic cell maturation
October 27th, 2003
A rise in temperature level, even a short one, increases hsp90 and causes dendritic cells to mature. According to a study from the United States, "Fever is a phylogenetically conserved biological phenomenon and a common consequence of infection. Here we examine in vitro and in vivo, the effect of febrile temperature on dendritic cells (DC), a key antigen-presenting cell (APC) in the immune system. "Elevated temperatures are observed to cause immature DC to mature, specifically through elevation of intracellular levels of hsp90. Surprisingly, even brief exposure to elevated temperatures has a powerful effect on the immunostimulatory capacity of DC,"...
Source: Health & Medicine Week (2003-10-27)
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