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Antimicrobial Resistance
Multidrug transporters of E. coli play role in resistance to beta-lactams
October 27th, 2003
Scientists have described the roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams in a recent issue of the journal Antimicrobial Agents and Chemotherapy. According to researchers in Japan, "AcrAB exports some beta-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC." "In this study, the roles of the drug exporters of E. coli in beta-lactam resistance were examined," said Kunihiko Nishino and colleagues at Osaka University. "We found that five of five...
Source: Health & Medicine Week (2003-10-27)
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