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Antimicrobial Resistance
Resistance to tiamulin caused by mutation of ribosomal protein L3
October 27th, 2003
Resistance to the peptidyl transferase inhibitor tiamulin is caused by mutation of ribosomal protein L3. According to recent research from Denmark, "The antibiotic tiamulin targets the 50S subunit of the bacterial ribosome and interacts at the peptidyl transferase center. Tiamulin-resistant Escherichia coli mutants were isolated in order to elucidate mechanisms of resistance to the drug. No mutations in the rRNA were selected as resistance determinants using a strain expressing only a plasmid-encoded rRNA operon." "Selection in a strain with all seven chromosomal rRNA operons yielded a mutant with an A445G mutation in the gene coding for...
Source: Health & Medicine Week (2003-10-27)
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