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Antisense Technology
Loop swapping changes the direction of helix progression in paired RNA
October 27th, 2003
Loop swapping changes the direction of helix progression in paired RNA. "The binding pathway of the natural antisense RNA CopA to its target CopT proceeds through a hierarchical order of steps. It initiates by reversible loop-loop contacts followed by unidirectional helix progression into the upper stems. This involves extensive breakage of intramolecular base pairs and the subsequent formation of two intermolecular helices, B and B'," investigators in Sweden report. "Based on the known tRNA anticodon loop structure and on results from the Sok/Hok antisense/target RNA system, it had been suggested that a U-turn ( or pi-turn) in the loop of CopT might...
Source: Health & Medicine Week (2003-10-27)
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