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Antitumor Agents
Combretastatin A-4 analogues show potential as antimitotic antitumor agents
October 27th, 2003
Combretastatin A-4 analogues show potential as antimitotic antitumor agents. According to published research from the United States, "Tubulin protein is a major target for anticancer drug discovery. As a result, anti-mitotic agents constitute an important class of the current anticancer drugs. "Hundreds of tubulin inhibitors, naturally occurring, semisynthetic or synthetic, have been reported. Among these, combretastatin A-4 (CA-4), isolated from a South African tree Combretum caffrum is one of the most potent anti-mitotic agents," wrote N.H. Nam and colleagues, University of Rhode Island, Department of Biomedical Science. "CA-4...
Source: Health & Medicine Week (2003-10-27)
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