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Apoptosis
Melatonin inhibits serum deprivation-induced apoptosis in rat hepatoma cells
October 27th, 2003
Melatonin inhibited serum deprivation-induced apoptosis in rat hepatoma cells. According to a study from Canada, "Growth factor deprivation-induced apoptosis has been shown in various cell systems and is recognized as one of the standard models for the study of programmed cell death. The mechanism of induction of apoptosis by serum deprivation is still not clear. The objective of the present study was to investigate if serum-deprivation causes oxidative stress, which then leads to apoptotic death." "We have demonstrated that indeed, there was a significant increase in reactive oxygen species following serum deprivation of 5123tc hepatoma cells,"...
Source: Health & Medicine Week (2003-10-27)
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