Proteomics
Perlecan play role in skeletal development and diseases
Published in Health and Medicine Week, December 1st, 2003
According to published research from the United States, "Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization."
"Recent studies with gene knockout mice and human diseases revealed critical in vivo roles of perlecan in cartilage development and neuromuscular junction activity," wrote John Hassell at Shriners...
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