Scleroderma Diagnostics

Pulmonary fibrosis, hypertension may be due to anti-endothelial antibodies

Published in Health and Medicine Week, December 1st, 2003

Reactivity of sera from scleroderma patients to endothelial cells is linked to pulmonary fibrosis and hypertension.

"We recently reported on the use of an indirect immunofluorescent method designated the rodent lung assay; this test assesses for the presence of circulating antibodies directed at components of the microvasculature. Serum samples from 49 patients with scleroderma were incubated with rodent lung tissue sections and visualized with fluoresceinated human anti-IgG. The assay also was performed on samples from a control group," researchers in the United States report.

"Western blot analysis was performed with endothelial cell protein...

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Source: Health and Medicine Week (2003-12-01)

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