Health and Medicine Week
Susan Hasty, Publisher
Table of Contents . . . January 5th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Health and Medicine Week | Other Publications
Behavioral Medicine - Health behavioral change models helpful in preventing weight gain
Abortion - Lawyer to appeal court ruling on late-term procedure
Breast Cancer - Battery-powered gamma detection probe available for lymph node mapping
Breast Cancer - Chemotherapy advance reported for women with node-positive early breast cancer
Breast Cancer - Contract entered for the purchase of US$3.4M in BreastCare product
Breast Cancer - Data from Theratope Vaccine trial presented
Breast Cancer - Fewer than half of patients with early-stage disease get full chemotherapy dose
Breast Cancer - Mammograms don't reach all communities equally
Breast Cancer - Oral drug shows promise for prevention of ER-negative disease in mouse model
Breast Cancer - Positive Abraxane phase III data released
Breast Cancer - Positive data reported on phase II breast tumor cell proliferation study
Breast Cancer - Post-tamoxifen use of Femara reduces risk of breast cancer recurrence by 43%
Accreditation - Medco receives perfect score, full accreditation from JCAHO
Breast Cancer - Randomized trial examines second-line endocrine therapy in advanced breast cancer
Breast Cancer - Researchers develop a mathematical modeling of comedo DCIS of the breast
Breast Cancer - Residential magnetic field exposure does not increase risk of breast cancer
Breast Cancer - SAFB1 and SAFB2 may be novel breast tumor suppressor genes
Breast Cancer - Shc proteins are prognostic markers for primary breast cancer
Breast Cancer - Short-term postmenopausal hormone therapy does not measurably increase breast cancer risk
Breast Cancer - Some patients may benefit from endocrine therapy alone
Breast Cancer - Study data indicate promise for investigational compound GW572016
Breast Cancer - Study supports tailoring adjuvant therapy for early-stage disease
Breast Cancer - Study to provide more data on targeted 5-day radiotherapy for DCIS patients
Acute Myeloid Leukemia - Genasense plus chemo demonstrates enhanced activity for older AML patients
Breast Cancer - Tailored dosage of chemotherapy is effective treatment, study shows
Breast Cancer - Urokinase-type plasminogen activator receptor marks metastatic breast cancer
Breast Implant - Company files FDA submission for breast implants
CNS Function - MrgX2 is the dorsal root ganglion receptor for cortistatin
Cancer Anorexia - Nutrition counseling, drug therapy recommended for anorectic cancer patients
Cancer Cell Migration - Requirement discussed for Arf6 in cell adhesion, migration, cancer cell invasion
Cancer Detection - Company receives CE Mark for Nipple Endoscope
Cancer Epidemiology - EUROCARE-3 publishes new childhood cancer survival figures
Cancer Market - Non-small cell lung cancer drug market to exceed $4.1 billion in 2012
Cancer Metastasis - Homocysteine thiolactone is a proangiogenic agent
Addiction Medicine - Basis of methamphetamine-induced neuronal apoptosis reviewed
Cancer Pain - Company reports on phase II meeting with FDA on Oravescent Fentanyl
Cancer Pain - Differential documentation of pain may be noted when hospice is involved
Cancer Pain - The effect of donepezil in patients receiving opioids for cancer pain
Cancer Prevention - Organosulfer compounds stop liver cancer invasion, migration, and angiogenesis
Cancer Prognosis - Cyclooxygenase-2 is a prognostic indicator of oral squamous cell carcinoma
Cancer Research - Teratomas from stem cells provide a platform for studying cancer mechanisms
Cancer Screening - Information interventions may help people make screening decisions
Cancer Symptoms - Modified Rotterdam Symptom Checklist is reliable, valid for cancer patient use
Cancer Therapies - New way to lock DNA-slicing enzyme onto chromosomes could lead to novel drugs
Cancer Therapy - Angiotensin II receptor blockers staunch prostate cancer growth
Addiction Medicine - Life priorities of HIV-seropositive injection drug users revealed
Cancer Therapy - Data: LPAAT-beta has potential use in myeloid and lymphoid malignancies
Cancer Therapy - INEX releases Onco TCS data from three clinical trials
Cancer Therapy - Inhibiting DNA replication-initiation protein induces apoptosis
Cancer Therapy - Novacea licenses anticancer product candidate
Cancer Therapy - P-glycoprotein and Mrp1 protect bone marrow from vincristine-induced toxicity
Cancer Therapy - Researchers analyze model of a virus that replicates selectively in tumor cells
Cancer Therapy - Study: Multiple mechanisms of action make INGN 241 a promising approach
Cancer Therapy - VGA1155 inhibits vascular endothelial growth factor binding
Cancer Vaccine - Tumor growth inhibited by vaccination with Her-2/neu peptides
Cancer Vaccine - Vaccines for leukemia therapy reviewed
Adolescent Health - Teenage pregnancy may put girls at risk for osteoporosis
Candidiasis - Anti-idiotypic antibody fragment effective against candidiasis
Candidiasis - Oral sex, masturbating - but not men - linked to recurrent infections
Carcinogenesis - Multiple mechanisms contribute to the carcinogenicity of cadmium
Cardiac Arrest - Hypothermia may offer protection when heart and brain are at risk
Cardiac Catheterization - Hemostasis device launched
Cardiac Surgery - The first 50 years of cardiothoracic surgery in the southern U.S. reviewed
Cardio-Respiratory Diseases - Engineers develop technologies to measure ultrafine specks of air pollution
Cardiology - Beta-adrenergic signaling regulates cardiac NDPK activity
Cardiology - Cardiac Ca2+-activated K+ channel discovered and characterized
Adrenomyeloneuropathy - Phase IIa data reported from clinical study of Immunokine in AMN
Cardiology - Invasive measures of pulmonary artery pressure complement Doppler assays
Cardiovascular Disease - Baseline lipid profiles determine relative efficacy of fenofibrate and simvastatin
Cardiovascular Disease - Circadian pattern seen for CHF mortality in elderly heart attack survivors
Cardiovascular Disease - Diastolic function determinants in hypertensive myocardial hypertrophy identified
Cardiovascular Disease - Distribution of the NPY 1128C allele determined
Cardiovascular Disease - Fetal aortic stenosis diagnosed with echocardiography
Cardiovascular Disease - High heart rate linked to increased mortality risk in disabled older women
Cardiovascular Disease - Hydrophobic statins induce apoptosis in rat pulmonary vein endothelial cells
Cardiovascular Disease - L-ascorbic acid may ameliorate vascular dysfunction
Cardiovascular Disease - Losartan may reduce risk of platelet-induced pulmonary thromboembolism
Adverse Drug Effects - Guinea pig assays not effective for drug hypersensitivity testing
Cardiovascular Disease - Moderate hypertension linked to significantly heightened mortality risk in Japan
Cardiovascular Disease - New drug submissions filed to market Niaspan and Advicor in Canada
Cardiovascular Disease - Paraoxonase gene cluster mutations can predict heart disease risk
Cardiovascular Disease - Protein kinase C changes RKIP target from Raf-1 to GRK-2
Cardiovascular Disease - Thoratec ventricular assist device can be effectively used in small children
Carotid Artery - Delayed complications of endovascular stenting for carotid blowout examined
Cell Biology - Autophagy active in tumor suppression
Cell Biology - Channel structure improves understanding of protein transport
Cell Biology - Functions of p53 equally important in halting for cancer cell growth
Cell Biology - Inflammation of fat cells linked to obesity-related insulin resistance
Age-Related Disease - Age-related disease susceptibility may depend on complement regulatory proteins
Cell Metabolism - The immunomodulator FTY720 bars VEGF-induced vascular permeability
Cell Signaling - Nomadic outposts of transplanted stem cells tracked
Central Nervous System - Myelin-associated inhibitors of axon regeneration reviewed
Cerebral Cavernous Malformations - Discovery of brain disorder gene paves way for genetic test
Cervical Cancer - Educating women about disease link to smoking persuades more to quit
Cervical Cancer - Eighty-one percent of surveyed women want noninvasive cervical cancer test over Pap test
Chemotherapy - Additional patent issued for Tocosol Paclitaxel cancer drug
Chest Wall Tumors - CT, MRI help in delineating location, extent of chest wall tumors
Childhood Diseases - Pediatric measles-like rash may be separate or coinciding HHV-6, HHV-7 infection
Chronic Angina - Cardiovascular trial for Angiogenix begins
Age-Related Macular Degeneration - Preferred specialty distributor chosen for AMD treatment
Chronic Angina - Phase II study of Acclaim initiated
Chronic Hepatitis B - Patient and viral factors correlate with pediatric response to lamivudine
Chronic Hepatitis C - Impaired interleukin-15 production impedes the effectiveness of interferon
Chronic Myelogenous Leukemia - Abnormal bone marrow angiogenesis persists after stem cell transplantation
Chronic Pain - Anti-inflammatory cytokine technology licensed
Cloning - Company releases two new sets of ORF expression clones of human genes
Coagulation Therapy - Efficacy of regional citrate anticoagulation during SLED evaluated
Cocaine Addiction - Baclofen holds promise for cocaine treatment
Cognition - cGMP-dependent protein kinase I ablation impairs cerebellar learning
Colitis - Clinical trial initiated for Visilizumab in severe ulcerative colitis
Sarcopenia - Weight training in older people fights the muscle loss condition
Alcohol Abuse - Ethanol lowers serotonin synthesis; may cause some related psychiatric disorders
Collaborations - Aetna signs contract renewals with two northern Virginia hospitals
Collaborations - Agreement signed to acquire noncancer assets from Cadherin
Collaborations - Alliance formed to develop an automated test to monitor transplant drug
Collaborations - Alliance to advance whole transcript analysis
Collaborations - Deal signed for generic oral contraceptive products
Collaborations - Deal signed for solid-tumor cancer treatment development
Collaborations - Genaissance enters pharmacogenomics agreement
Collaborations - Global reach expanded with formation of two marketing partnerships
Collaborations - MedAssets and Chamberlin partner to reduce losses from self-pay patients
Collaborations - Multiyear contract awarded for IV solutions, sets to veterans hospitals
Alcoholism - Alcoholics with antisocial personality have blunted emotional reactivity
Collaborations - President to finalize Sucanon marketing agreement for Mexico
Collaborations - Wellbutrin XL global marketing status updated
Colles Fractures - Palmar plating for unstable Colles fractures yield excellent results
Colon Cancer - A3 adenosine receptor agonist inhibits colon cancer growth
Colon Cancer - Activation of PPAR gamma in colon tumor cell lines
Colon Cancer - Dendritic cell vaccine to be used in trial for new cancer treatment
Colon Cancer - Total energy and macronutrients associated with colon cancer risk
Colon Cancer Screening - Risk factors determine need for colonoscopy
Colorectal Cancer - 15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer
Colorectal Cancer - Calcium and vitamin D collaborate to reduce cancer risk
Alcoholism - Frat guys drink more in college, cut back afterward
Colorectal Cancer - Knudson's theory can explain diverse experimental situations
Colorectal Cancer - Phase II clinical trials of KOS-862 initiated
Colorectal Cancer - Study projects colorectal cancer drug sales to reach $2.1B in 2012
Company Expansion - Device company opens new Canadian subsidiary
Complementary and Alternative Medicine - A variety of vegetables, fruits, and other foods stop bone resorption
Complementary and Alternative Medicine - Companies announce $239 million medical venture
Complementary and Alternative Medicine - The natural calcium source Coral calx prevents bone loss
Complementary and Alternative Medicine - Zinc and antioxidants limit the injury some xenobotics may cause the liver
Computer Vision Syndrome - Survey: Americans concerned about vision problems from computer use
Congestive Heart Failure - FDA 510k clearance granted for fluid removal system
Alcoholism - Research findings suggest compound might help in fight against alcoholism
Congestive Heart Failure - FDA grants clearance to NT-proBNP for prognosis of congestive heart failure
Consumer-Driven Healthcare - Hospital association selects program provider
Contraception - Cultural factors underlie oral contraceptive use by Hispanic women in the U.S.
Contraception - FDA advisory panel backs easier morning-after pill
Coronary Revascularization - More selective cardiac stress protocol has little effect on morbidity, mortality
Corynebacterium - Analysis of the Corynebacterium diphtheriae DtxR regulon reported
Creutzfeldt-Jakob Disease - Report appears to confirm blood-borne transmission of Creutzfeldt-Jakob disease
Critical Care - Company introduces two new CPAP devices
Critical Care Medicine - Deoxyhemoglobin nitrite reduction contributes to vasodilation
Cryptosporidium - Cryptosporidium surveillance provides outbreak insights
Alcoholism - Significant reduction in heavy drinking seen in phase III trial Of Vivitrex
Cystic Fibrosis - Tiny nanowire could be next big diagnostic tool for doctors
DNA Repair - DNA-mediated charge transport involved in DNA repair
Deep-Vein Thrombosis - Coalition established to raise awareness of deep-vein thrombosis
Deep-Vein Thrombosis - Study suggests 1% risk of DVT for long-distance travelers
Degenerative Disc Disease - Patient enrollment begins in U.S. IDE study
Dengue Fever - Dengue 4 virus glycoprotein induces resistance to Dengue 4 virus
Depression - Pentapeptide antidepressant shows some promise in clinical trials
Depression - Survey reveals stress, anxiety prevent many women from enjoying the holidays
Dermatitis - Gloves help improve skin, relieve dermatitis
Dermatitis - Topical tacrolimus effective against CAD with idiopathic leukopenia
Allergen Research - Some IgE epitopes to cedar allergens map to a conserved pectate lyase site
Dermatology - Interleukin-15 blockade resolves psoriasis in murine xenografts
Dermatology - Proteinase-activated receptor-2 increases skin inflammation in humans and mice
Dermatology - The antifungal ketoconazole may cause liver injury
Dermatology - Up to five co-occurring types of physical urticaria can exist and persist
Dermatology - User fee not required for Extina new drug application
Dermatomyositis - Myelodysplastic syndrome with autoimmune symptoms may benefit from methotrexate
Developmental Biology - Chemical gradient steers nerve growth in spinal cord
Diabetes Complications - Changes in diabetes comorbidity from 1980s to 1990s reported
Diabetes Pathogenesis - Bone marrow-derived cells help prevent islet cell loss
Allergic Rhinitis - Experimental allergic rhinitis treatment achieves positive safety data
Diabetes Pathogenesis - Glucokinase mutations can cause hyper- and hypoglycemia
Diabetes Pathogenesis - Islet amyloid levels elevated in Chinese patients with type 2 diabetes
Diabetes Risk Factor - Chronic exposure to interleukin-6 causes hepatic insulin resistance
Diabetes Risk Factor - Permanent neonatal diabetes caused by glucokinase deficiency
Diabetes Therapy - Positive phase III results reported with Metformin GR
Diabetic Retinopathy - American Indian males are more apt to require therapy for diabetic eye disease
Diagnostic Medicine - Organotypic raft cultures typify spectral analysis of in vivo tissues
Diagnostics - Fluorescent dyes used as probes to study lipid-binding proteins
Diagnostics - Gen-Probe inks cross-licensing agreement for nucleic acid testing technologies
Diagnostics - Peptide and protein de novo sequencing by mass spectrometry reported
Allergic Rhinitis - Repeat rhinitis therapy with omalizumab is safe for a second ragweed season
Diagnostics - The Chemagic viral DNA/RNA kit improves viral extraction
Diet and Nutrition - Children accept ready-to-eat sweet potato breakfast cereal
Diet and Nutrition - Gender drives lipoprotein response to saturated fat and cholesterol restriction
Diet and Nutrition - Results of dietary survey in primary school children reported
Disease Management - Modified commercial software available for remote health monitoring
Disease Management - New Medicare law boosts chronic care
Disease Pathway Detection - Early research advances field of proteasome biology
Divestiture - Kindred acquires for resale 10 unprofitable facilities from Ventas
Drug Allergies - Patients with aspirin, NSAID allergy can get angioedema from COX-2 inhibitors
Drug Costs - Canadian drug savings calculator available online
Allergy Medicine - Asthma mediator LTE4 is still excreted in urine of steroid-treated asthmatics
Drug Costs - RxPricePoint to provide competitive drug pricing on a handheld device
Drug Delivery - Biodegradable particles mimic white blood cells, target inflamed tissue
Drug Delivery - Company extends its Xcelodose showcasing agreement
Drug Delivery - Company initiates feasibility study with Acertus of RapidMist system
Drug Delivery - Preclinical data on microbubble drug delivery reported
Drug Delivery - Studies highlight aerosol generator technology in infant mechanical ventilation
Drug Development - Antiviral pronucleotides improved through cycloSal system
Drug Development - Circadian rhythms reveal when antiangiogenic therapy should be administered
Drug Development - HIV RNase H activity characterization leads to novel anti-HIV agents
Drug Development - Markovian model can aid anti-HIV drug design
Allergy Medicine - Food allergies may be treatable with immunotherapy, anti-IgE antibodies, herbs
Drug Development - New drug approvals rise 20% as pharma R&D and marketing unite
Drug Development - Novel computational approach aids HIV protease inhibitor design
Drug Development - Oxygenated xanthones show antimalarial activity in vivo
Drug Development - Patch maker provides product development update
Drug Development - Pharma-biotech alliances present lower risk opportunities
Drug Development - Phenanthrene alkaloids strongly inhibit Ang-II-induced leukocyte adhesion
Drug Development - Study shows early commercialization drives product success
Drug Development - Suramin analogues block P. falciparum MSP1 secondary processing
Drug Discovery - Companies sign anti-inflammatory drug discovery deal
Drug Discovery - Super-quenching fluorescence-based assay for HTS released
Failure to Thrive - Scientists investigate childhood nutrition mystery's causes, effects
Allergy Medicine - Inhaled endotoxin increases lung surfactant protein A, lowers it in lavage fluid
Drug Toxicity - Company adds GPCR CloneSet to TrueClone Collection
Ebola Virus - NIH begins human Ebola vaccine trial using Biojector 2000
Ebola Virus - WHO: Ebola outbreak death toll stands at 29
Echinococcosis - Advanced and refractory human alveolar echinococcosis responds to amphotericin B
Electronic Medical Records - ChartMaxx selected by Canadian Hospital Cite de la sante de Laval
Embryonic Research - Modulators of HAND factor function identified
Emergency Medicine - Company enters emergency department software market with EDNet
Emergency Medicine - Elderly men and women in Tehran have a similar mortality rate after falling
Emerging Epidemics - 2003 begins with SARS, ends with flu
Employer-Sponsored Health Insurance - Judge bars referendum from California's March 2004 ballot
Allergy Medicine - Researchers find connection between poinsettia and latex allergies
End-of-Life Care - Good evidence improves design of programs for children, young adults
Endocrinology - Estrogen receptor-alpha and beta are differentially expressed in the uterus
Endocrinology - Lack of ovulation can be counteracted with a variety of therapies
Endocrinology - Large dimeric ligands possess PPAR agonist activity in vivo
Endocytosis - Proteins defining new alpha-adaptin ear-binding motif identified
Endocytosis - Proteins ubiquitinate in response to endoplasmic reticulum mutations
Endometrial Cancer - A systematic and practical approach to the endometrial biopsy outlined
Enlarged Prostate - Uroxatral offers early results in relieving urinary symptoms
Environmental Health - Pregnant women in Russia avoid chemical exposures by filtering drinking water
Environmental Health Research - Compounding issues become more complex with introduction of new bio-technologies
Alzheimer Disease - Identity and function of gamma-secretase reported
Environmental Toxins - Air pollution's impact on the heart is as bad as having been a smoker
Environmental Toxins - FDA announces comprehensive foods advisory on methylmercury
Environmental Toxins - Homes should be smoke-free zones soon after baby's birth
Enzymology - Amino acids of Cdc37 critical for protein kinase binding identified
Enzymology - Early-stage human endothelial cells constitutively express proangiogenic enzyme
Enzymology - EndoPDI protects endothelial cells exposed to hypoxia
Enzymology - Labor does not alter the expression of placental nitric oxide synthase isoforms
Enzymology - Surfactant developed for in-solution enzymatic digestion of proteins
Enzymology - When the Src family of kinases are shut down, angiogenesis ceases
Epilepsy - $1.2M raised for research at UC Davis
Alzheimer Disease - More positive results reported for Alzhemed
Epilepsy - Cardiac sympathetic modulation and MIBG uptake can predict outcome of epilepsy surgery
Epilepsy - Topiramate is detectable in saliva; concentration is slightly less than serum
Esophageal Cancer - An invagination technique treats esophagogastric end-to-end anastomoses
Exam Gloves - Exam gloves now available with anatomically correct fitting
Exercise - Strength training induces different early and late changes in muscles
Experimental Zygomycosis - Posaconazole is most effective against the zygomycete Rhizopus microsporus
Facilities - Boehringer Ingelheim selects vendor to automate new plant in Germany
Factor V Inhibitors - Intravenous immunoglobulin may resolve acquired factor V inhibitor complications
Femoral Artery Puncture - Matrix VSG System pivotal clinical trial commences
Fetal Medicine - Sonography shows that fetal hip joints mature at 34 weeks gestation
Alzheimer Disease - Novel murine AD model reveals link between atherosclerosis and beta-amyloidosis
Fever - Doctor discovers noninvasive way of taking temperature
Fibroids - Study shows acceptance of UFE as treatment for symptomatic uterine fibroids
Fibromyalgia - Treatment of fibromyalgia-related pain is distinct from treatment of mood
Fibrosis - Low levels of serum amyloid P are implicated in chronic inflammatory disorders
Finance - Biotech announces share repurchase program
Finance - Biotech company announces $8M financing
Finance - Biotech company completes second financing round
Finance - Boston Scientific permitted to acquire up to 20% of device firm's shares
Finance - C.K. Cooper named investment banker; will advise on restructuring
Finance - Cancer therapy maker announces $5.62 per share loss for third quarter
Alzheimer Disease - Presenilin mutation in AD may produce lower activity of dimer in gamma-secretase
Finance - Cancer vaccine company reports $10M net loss; provides clinical update
Finance - Capital raised for two medical device companies
Finance - Cardiothoracic device maker reports revenues up 108% in second quarter
Finance - Company announces private placement of $27.4 million of common stock
Finance - Company expects strong double-digit growth in coming year
Finance - Company raises EUR 13.8 million in third round of private financing
Finance - Company reports 33% increase in sales and 50% increase in net income in Q2
Finance - DNA technology company completes initial bridge financing
Finance - Device company raises $17 million from sale of exchangeable notes
Finance - Diagnostic kit company reports first operating profit since 1998
Alzheimer Disease - Relation between cholesterol trafficking and amyloid beta explored
Finance - Diagnostics company receives $3.5 million private placement
Finance - Drug development company upgraded to buy by independent researcher
Finance - Genesis Healthcare reports 3.5% revenue growth in fiscal 2003
Finance - Glycoproteins company secures $10M in series C financing
Finance - IT company announces $5 million financing
Finance - Kaiser selects KPMG as independent auditor
Finance - Laser technology company reports record sales growth
Finance - Milestone payment made for needle-free technology
Finance - NeighborCare reports strong fiscal 2003 results
Finance - Operating capital helps position device firm for 2004
Alzheimer Disease - Researchers isolate Alzheimer-fighting gene
Finance - Oxygen therapeutics company reports loss of $0.30 per share
Finance - Pharmaceutical announces interim funding and filing of patent application
Finance - Pharmaceutical company announces $252M closing of series D financing
Finance - Pharmaceutical company closes $21 million Series A financing
Finance - Pharmaceutical company completes two rounds of fundraising
Finance - Pharmaceutical company files shelf registration statement
Finance - Pharmaceutical firm's redeemable warrants expire
Finance - Pricing of follow-on offering announced by pharmaceutical firm
Finance - Private placement to advance skeletal targeted radiotherapy phase III trial
Finance - Report shows thriving biotech community in New Jersey
Amphetamines - Stress, amphetamines make neurons with glucocorticoid receptors express Fos
Finance - Trial management software company closes on $1.5 million tranche
Fitness - Can the mode of training affect the hormone response to different modes of exercise?
Fitness - HealtheTech announces supply and services agreement
Fitness - New findings can help parents looking to combat number of kids' sick days
Fitness - Treadmill tests gauge future fitness
Food Contamination - Spatial technology company launches food safety system
Food-borne Disease - Salmonella enterica serovar Enteritidis YafD protects against egg albumen
Food-borne Illness - Exposure to UV irradiation kills off harmful bacteria in food
Food-borne Illness - U.K. scientists create medical and food safety tool from virus
Food-borne Illness - U.S. agency launches $53 million cow genome project
Amyotrophic Lateral Sclerosis - High ciliary neurotrophic factor in ALS patients unrelated to disease severity
Fundus - Sophisticated new camera systems are available for documenting ocular fundus
Fungal Infection - Surgery still the best option for allergic fungal sinusitis in atopic patients
Gastroenterology - Phase I study evaluates S-1 combined with cisplatin for metastatic GI cancer
Gastrointestinal Motility - Positive ITAX phase II results reported
Gene Dectection - Lung cancer and fibroblast cocultures reveal genes linked to cancer progression
Gene Delivery - Recombinant histone H1.4F ensures nucleic acids reach their destinations
Gene Expression - Optimized adenovirus directs genes to designated cells
Gene Silencing - Two siRNA libraries launched
Gene Therapy - Lentiviral vectors efficiently transduce HLECs
Genetic Disorders - Coloboma and similar disorders in young children may be early sign of Kabuki syndrome
Geriatrics - Persons 80 and older make up the largest growing surgical population in U.S.
Aneurysm - Doctor says a ripped aorta can result from intense weight training
Genetics - Researchers have identified XY genes in a female marmoset
Genetics and Genomics - Gene-trap screen identifies Wnk1 kinase as blood pressure regulator
Genetics and Genomics - Mutations affecting lipoprotein phenotype in South European FH patients identified
Genomics - Company produces whole genome map of Francisella tularensis
Genomics - Human MutY genetic mutations detected in cancer
Genomics - Metabolon announces founding scientific advisory board
Genomics - Mutations at the MECP2 gene link to non-syndromic X-linked mental retardation
Geriatrics - Dependent older patients may cost hospitals more
Geriatrics - Gender and kinship reflect the ambivalence adult children feel towards parents
Geriatrics - Older women who receive home-delivered meals may not get adequate nutrients
Angioedema - Diagnosis and management of hereditary angioedema reviewed
Glaucoma - Proprietary Factor 5A1 shows promise for controlling glaucoma
Glucose Intolerance - Perinatal alcohol exposure may cause insulin resistance later in life
Glycopeptide Research - Carbohydrate-protein ligand screening can be done with NMR spectroscopy
Graft-versus-Host Disease - Agreement signed with NIH to develop Theralux device
Gynecological Cancer - Proteomics is the newest, most promising direction for gynecologic cancer
Gynecology - Gallup survey reveals female ob-gyns benefit from "insider knowledge"
Gynecology - MR imaging of disorders associated with female infertility
Gynecology - Self-care kits could help deployed military women with genitourinary infections
HIV Prevention - Advantages of rectal vaccination against HIV described
HIV/AIDS DNA Studies - Recombinant DNA model enables HIV-2 gene analysis
Angiology - Attenuated adenovirus induces thrombocytopenia in rhesus monkeys
HIV/AIDS Diagnostics - "Mega-PCR" assay lowers detection limit of HIV DNA
HIV/AIDS Immunology - FIV induces phenotypical changes in CD8 cells
HIV/AIDS Neurological Disorders - Low HDMT scores may not indicate HIV neurodegeneration
HIV/AIDS Opportunistic Infection - Pneumocystis carinii mt LSU rRNA gene in SIV-infected macaques examined
HIV/AIDS Opportunistic Infection - Solid phase cytometry test provides rapid Aspergillus fumigatus detection
HIV/AIDS Pathogenesis - HIV-exposed but uninfected IDUs have heightened NK-cell activity
HIV/AIDS Pathogenesis - Viral replication does not lead to SIV disease progression in sooty mangabeys
HIV/AIDS Proteomics - HIV Tat interacts with Notch protein EGF-like repeats and the EGF precursor
HIV/AIDS Receptor Studies - Molecular assay enables accurate measure of CCR5 mRNA
HIV/AIDS Risk Factor - Nucleic acid tests increase safety of blood products
Angioplasty - Stents with cell-cycle inhibitors show promise for further reducing restenosis
HIV/AIDS Therapy - Growth hormone treatment can improve NK-cell function
HIV/AIDS Therapy - Mediators of protease inhibitor-induced bone resorption identified
HIV/AIDS Therapy - Modified p24 antigen assay useful for disease monitoring in HIV patients
HIV/AIDS Therapy - Nelfinavir does not cause reproductive toxicity in rats
HIV/AIDS Therapy - Prophylactic antiretroviral treatment reduces T-cell apoptosis
HIV/AIDS Therapy - Small-molecule CCR5 inhibitor effective in macaques
HIV/AIDS Therapy - Thymosin alpha1 shows promise for improving immune recovery
HIV/AIDS Transmission - HIV-1 viral load influences risk of mother-to-child HIV transmission
HIV/Hepatitis Diagnosis - Clinical trials begin for Procleix Ultrio assay
Head and Neck Cancer - Met Y1253D mutations prevail in many patients with radioresistant cancers
Anthrax - U.K. company to work with U.S. Naval Medical Research Center on oral anthrax vaccine
Head and Neck Cancer - Patients with throat cancer should have endoscopic ultrasound examination
Health Information Management - Delaware hospital facility selects medical transcription service provider
Health Policy - Financial incentives affect the smoking practices of women considering pregnancy
Health Statistics - U.S. teen birth rate continues to decline, particularly among African Americans
Healthcare & Politics - Merger complete, AAHP-HIAA looks ahead to 2004
Healthcare & Politics - Town council votes itself lifetime healthcare benefits
Healthcare & Politics - Vermont Democrats say they'll pursue health economics agenda
Healthcare Access - Patients at rural Mississippi hospitals linked to state's largest ER
Healthcare Benefits - Hospitals may cut costs for uninsured
Anthrax Vaccine - Human antibodies from immunized donors protect against anthrax
Healthcare Costs - Costs for kids with behavioral disorders similar to those with physical ones
Healthcare Costs - Study: International pricing/reimbursement policies to challenge the industry
Healthcare Economics - Insurance inadequate for more than one in three people with disabilities
Healthcare Economics - More Wisconsin communities seek to create municipal health insurance trust
Healthcare Economics - Newspaper reports on families' struggles with tough choices to pay for health
Healthcare Economics - Push on for hospitals to disclose costs of procedures
Hearing Loss - Univ. of Buffalo, military collaborate on design, testing of first drug to prevent deafness
Heart Disease - Study shows heart disease risk factors reduced by 90% with drug-free program
Heart Disease Prevention - Fitness in young adulthood protects heart health in middle age
Heart Disease Risk Factor - Fat distribution differences affect cardiovascular disease risk
Anthrax Vaccine - Lymphocytic vasculitis associated with anthrax vaccine
Heart Failure Therapy - Beta-blockers have agonist and inverse agonist activity at beta2 -adrenoceptor
Heart Failure Therapy - LC-MS/MS assay enables vesnarinone monitoring in dialysate
Helicobacter Gastritis - IL-4 reduces Helicobacter gastritis, increases somatostatin, lowers gastrin
Helicobacter Pylori - Reinfection with new H. pylori strains is common after antibiotic therapy
Helicobacter Vaccine - Helicobacter pylori vaccines spiral into the new millennium
Hematology - Hemostatic potential of factor VIII-heparin cofactor II proteins assessed
Hematology - Peroxynitrite induces changes in thiol groups of human blood platelets
Hematuria - Multidetector row CT urography may permit evaluation of hematuria
Hemolysis - Orphan drug designation granted in U.S., Europe for Eculizumab
Hemophilia - Application filed for approval of Bio-Set drug delivery device for Kogenate
Anti-Infectives - Amphotericin B lipid complex used to treat invasive fungal infections
Hemophilia - Line-1 insertion in Factor IX gene segregates with hemophilia B in dogs
Hemophilia Therapy - Data support safety, efficacy of Advate
Hepatitis - A key hepatitis C virus protein modulates apoptosis in liver cells
Hepatitis A Vaccine - Hepatitis A vaccine does not promote atherogenesis in murine model
Hepatitis C Virus - AIDS therapy less risky than assumed
Hepatitis C Virus - Company announces positive test results for A4+L
Hepatology - Calcitonin gene-related peptide involved in hepatic cytoprotection
Hepatology - Liver biopsies provide clues for the management of liver diseases
Hepatology - Metalloproteinases involved in regenerating rat liver after injury
Herpes Simplex 2 - New or old Pap smears can be destained and used to test for HSV-2 viral DNA
Anti-Infectives - Therapy of intestinal protozoa outlined
Herpes Simplex Virus - Immunotherapy company provides update on late-stage adjuvant programs
High Content Screening - Software combination addresses IT storage issues
Hodgkin Disease - Results of phase I/II clinical study of MDX-060, targeting CD30, reported
Honors - Regeneration Technologies selected as a 2004 Technology Pioneer
Hospitalization - Editorial highlights gap between medical care and patients' emotional needs
Human Enterovirus - Human enterovirus 71 contains a type I IRES element similar to other enterovirus
Huntington Disease - Research community website for Huntington disease planned
Huntington Disease - Transcriptional dysregulation mechanisms in Huntington disease reviewed
Hypertension - More evidence needed for "salt assault"
Hypertension - Once-at-bedtime hypertension therapy experiences rise in prescription rate
Anti-Inflammatory Agents - Doxycycline inhibits T cell cytokine reaction to staphylococcal exotoxin
Hypertension - Pre-eclampsia correlates with reduced plasma coenzyme Q10 levels
Hypertension Therapy - Effects of apomorphine in hypertensive rats clarified
Hypertension Therapy - Thiazide diuretics may help prevent stroke
Ileoinguinal Tumors - Ileoinguinal tumors should be considered for primary excision, reconstruction
Imaging - Johns Hopkins University to participate in DIS leasing program
Imaging - New technology designed to improve diagnosis of arm/hand injuries and disease
Imaging - Whole-body PET/CT scan appears useful for determining tumor stage
Immobility - Proning Therapy Kit Option added to TriaDyne critical care therapy system
Immunodeficiency - Use of corticosteroids, cyclosporine may stop GVHD in some human SCID patients
Immunoglobulins - Genetic data manipulation by exegesis maps immunoglobulin superfamily better
Geriatrics - Physicians make house calls to New York City's elderly
Antibiotc Prescribing - California partnership takes lead on simplifying guidelines
Immunology - Functional deficits in cord blood B cells elucidated
Immunology - Ikaros proteins discovered in hagfish and urochordate
Immunology - John Weinstein, MD, PhD, appointed to scientific advisory board
Immunology - Neutrophils underlie pathogenic cardiac CD8 cell activity
Immunology - Non-organ-specific autoantibodies prevail in nonalcoholic fatty liver disease
Immunology - Positive results reported for IRHs in models of neutropenia
Immunology - Researchers uncover pathway that could lead to plant generation of human-like protein
Immunology - Virological responders to hepatitis C virus therapy have more CD8+ cells
Immunostimulants - Centella asiatica S3A derivatives are mildly immmunostimulatory; S3A is not
Immunosuppression - Anti-ICOS plus cyclosporine enhances cardiac but not islet allograft survival
Antibiotic Resistance - V. cholerae's resistance genes can leave host, integrate into new one
Immunosuppression Risk - Cutaneous extramedullary plasmacytoma can occur following heart transplant
Infections - FDA grants approval for Piperacillin injection
Infectious Disease - Common TLR5 mutation linked to heightened Legionnaires disease risk
Infectious Disease Diagnostics - Molecular assay detects norovirus, Sapovirus and astrovirus
Infertility - Sperm retrieved from the epididymis or testis have different characteristics
Influenza - Among high-risk adults, flu shots less likely for blacks than whites
Influenza - CDC activates center to deal with flu
Influenza - Company reports positive preclinical data against variant influenza strains
Influenza - Fluvirin influenza vaccine production increased by 50%
Influenza - Health plan expands flu vaccine coverage
Antibiotics - Daptomyclin effective for treating resistant Gram-positive infections
Influenza - Integra syringe maximizes current flu vaccination supply
Influenza - New flu test for physician offices launched
Influenza - Patient, doctor attitudes can affect rate of flu shots
Influenza - Scientists agonized over choosing less-than-perfect flu vaccine
Influenza - Scientists warn of coming flu pandemic
Influenza - Shipment of about 43M doses of influenza vaccine completed
Influenza - Some New Jersey insurers expand coverage to include nasal flu vaccine
Influenza Vaccine - AmeriHealth to cover FluMist due to vaccine shortage
Influenza Vaccine - Cross-reactive H1N1 antibody responses to influenza vaccine reported
Information Technology - ASPeN EMR services agreement inked with Pattie A. Clay Regional Medical Center
Antibiotics - Generic amoxicillin with clavulanate potassium launched
Information Technology - CDC launches e-journal to connect public health research and practice
Information Technology - Carolinas Healthcare implements MercuryMD's mobile solution
Information Technology - Cincinnati Children's purchases pharmacy IV automation technology
Information Technology - New Healthwise Knowledgebase API delivery option allows for more customization
Information Technology - New pharmacy automation system launched
Information Technology - Technology collaboration with FDA extended
Information Technology - U.N. health agency launches virtual school for public health information
Insomnia - Positive results reported for indiplon
Insulin - SPE-CE method for determining insulin derivatives developed
Insulin Regulation - New understanding of insulin's complexities needed to conquer diabetes
Antifungal Proteins - Penicillium chrysogenum can inhibit some aspergilli with PAF protein
Insulin Therapy - Positive data presented on inhaled insulin
Ischemia - Humanin prolongs survival of serum-deprived human lymphocytes
Ischemia - Shock is an underlying factor in hypoxic hepatitis only half of the time
Kidney Cancer - Research shows cancer can be diagnosed in urine
Kidney Diagnostics - Retinol in urine may indicate renal dysfunction in multiple myeloma patients
Kidney Disease - Early kidney disease identification cost effective only when directed at high-risk patients
Knee Replacement - Data presented on oral anticoagulant after total knee replacement surgery
Knee Synovitis - Arthroscopy is a valuable tool in the diagnosis and treatment of LPVNS
Leber Congenital Amaurosis - Protein linked to Leber congenital amaurosis aids protein processing
Legal Issues - Company licenses more generic AIDS drug sales in South Africa
Antigen Receptors - V(D)J recombination is controlled by methylation and demethlation of DNA
Legal Issues - HMO fined for violations in Maine
Legal Issues - West Virginia court dismisses claims against pharmacy benefits management firm
Leishmaniasis - Leishmania P4 nuclease protects mice against leishmaniasis
Leukemia - Abstracts report on drug-induced apoptosis in cultured cancer cells
Leukemia - Clofarabine active in combination with Ara-C for adult acute myeloid leukemia
Leukemia - Data from numerous studies cite activity of Nipent combination therapy
Leukemia - Data reported in trials of heat shock protein-based cancer vaccines
Leukemia - Drug prolongs lives of chronic lymphocytic leukemia patients
Leukemia - Initial leukemia diagnosis should include eye exam
Leukemia - Interim data reported from phase II trial of GVAX vaccine
Antimicrobial Activity - Varying antimicrobial activity in follicular fluids may be due to lysosyme
Leukemia - Nelarabine works in aggressive, resistant forms of childhood T-cell malignancies
Leukemia - Qualitative methods in environmental health research
Leukemia - Rituximab leads to substantial but transient down-modulation of CD20 expression
Licensing Program - InterfeRx licensing program launched for RNAi therapeutics
Liver Cancer - Preclinical results reported on the use of ThermoDox
Liver Cancer - Transgastric fine-needle biopsies sample high risk patients for malignancy
Liver Disease - Interferon-gamma is lower in HCV-positive patients with liver fibrosis
Liver Transplantation - Antibodies to biliary epithelial cells important in liver transplants
Lung Cancer - COX17 is a therapeutic target for the treatment of non-small cell lung cancer
Lung Cancer - Randomized evidence in chemotherapeutic regimens for some NSCLC biased
Antimicrobial Proteins - Gastric epithelial cells produce beta-defensins after H. pylori infection
Lung Cancer - Risk model with intermediate endpoints needed for new lung cancer chemo studies
Lung Cancer - Surgery can now successfully treat lung cancers once deemed inoperable
Lyme Disease - FDA clearance granted for Lyme test kit
Lyme Disease - Lyme borreliosis is a risk to zoo visitors; there are infected animals and ticks
Lymphocyte Chemotaxis - Noradrenaline and MHPG metabolite inhibit thymus, spleen lymphocyte chemotaxis
Lymphography - Old lymphography technique retains its usefulness
Lymphoma - Radiographic-MR imaging depicts soft-tissue metastasis in primary bone lymphoma
Malaria - DB289 demonstrates potent antimalarial results in human clinical trial
Malaria - Grant allows research on vaccine for pregnant women to continue
Malaria - Raman imaging of hemozoin in malaria-infected RBC achieved
Antimicrobial Proteins - Lactoferrin-derived peptides have antimicrobial activity beyond iron depletion
Malaria Diagnostics - Abbott Cell-Dyn 4000 useful for therapeutic monitoring of malaria patients
Malaria Pathogenesis - Pyruvate kinase deficiency may protect against malaria
Malaria Proteomics - Crystal structure of plasmodial PfGST characterized
Malaria Proteomics - Subunit fusion plays key role in Plasmodium glyoxalase evolution
Malaria Therapy - Amodiaquine treatment effective for children in chloroquine-resistance area
Malaria Vaccine - Crossreactive antibodies against Plasmodium protein induced
Male Infertility - Global gene expression analysed in testicular biopsies from infertile men
Malignant Hematopoiesis - RTK classes, known to be expressed on normal hematopoietic tissue, summarized
Market Analysis - Adjunctive imaging technologies help with early detection of breast cancer
Market Analysis - Certain tactics can increase awareness of disease, treatment options
Antisense Technology - Vectosomes improve the delivery of antisense oligonucleotides
Market Analysis - Emerging viral diseases present opportunities for niche diagnostics
Market Analysis - Positron emission tomography industry faces reduction in growth
Marketing - Research identifies five ehealth-consumer trends
Medicaid - Judge's order temporarily halts cutoff for some in Texas
Medical Device Regulations - Diagnostics firm announces ISO 13485 audit complete
Medical Malpractice Insurance - Pennsylvania doctors again threaten to close offices over high rates
Medical Research - Developments in cancer, heart disease lead year's medical breakthroughs
Medicare - Provisions for ehealth-based chronic care promise higher quality at lower cost
Medicare & Medicaid - New interim CMS chief named
Medulloblastoma - Continuing research should improve, may achieve cure of common neoplasms
Prostate Cancer - Risk of prostate cancer is associated with family history of disease
Antiviral Compounds - Adenovirus proteinase is inhibited by NO from NONOates; viral infection lowered
Melanoma - Fibroblasts may control melanoma cell invasion after start of tumor progression
Memory - Concord grape juice improves memory and neuro-motor skills in animal study
Meningitis - Study yields new findings about bacterial meningitis
Meningitis Vaccine - Subtype immunogenicity in Neisseria vaccine not dependent on form
Meningococcal disease - PCR can diagnose and type antibiotic-treated invasive meningococcal disease
Menopause - Sequential hormone replacement therapy ameliorates menopausal complaints
Mental Healthcare - Regional centers in Nebraska could stay open under new plan
Mergers and Acquisitions - Accent Rx mail service pharmacy acquired
Mergers and Acquisitions - GNC announces completion of acquisition
Antiviral Therapy - A new heterocyclic HCV replicon RNA synthesis inhibitor has distinct kinetics
Mergers and Acquisitions - High-resolution cell imaging technologies acquired from Q3DM
Mergers and Acquisitions - Pharmaceutical company acquires nutritional supplement manufacturer
Mergers and Acquisitions - Post-acquisition status reported by pharmaceutical testing firm
Metabolic Syndrome - Strong link found to heart attack and stroke
Microbiology - Antisense peptide nucleic acid offers strain selection without antibiotics
Minimal Residual Disease - Campath (alemtuzumab) achieves significant responses, molecular remissions
Mitochondrial Disease - Drosophila model of human mitochondrial disease developed
Molecular Biology - Millibiology provides a framework for studying neurovascular networks
Molecular Biology - Researchers solve structure of water channel from E. coli
Molecular Biology - Study profiles the genes that make stem cells
Aplastic Anemia - Abnormal stem-cell adhesion molecule expression may underlie aplastic anemia
Molecular Diagnostics - Alliance to establish molecular center for diagnostic testing
Morbid Obesity - Bioimpedance analysis predicts basal metabolic rate in obese patients
Mosquito-borne Disease - High oxidative stress in An. gambiae can prevent Plasmodium development
Mosquito-borne Disease - Mating does not affect Anopheles gambiae biting behavior
Multiple Myeloma - Data from SGN-30 clinical trials shows antitumor activity
Multiple Myeloma - Data suggests Quadramet provides pain relief for certain cancer patients
Multiple Myeloma - New data announced on the effects of telomerase inhibitor drugs
Multiple Myeloma - Opportunities to get more patients into clinical trials being missed
Multiple Myeloma - Promising clinical data on Actimid presented at ASH
Apoptosis - Monoclonal antibody-based alternative to small-molecule drugs announced
Multiple Myeloma - Velcade demonstrates activity in previously untreated multiple myeloma
Multiple Sclerosis - AVR118 suppresses progression of disease in animal model
Multiple Sclerosis - Anti-IFNbeta, neutralizing antibodies don't affect response to IFNbeta in MS
Multiple Sclerosis - Phase I trial of small molecule drug for MS begins
Musculoskeletal Sarcoidosis - MRI reveals a range of musculoskeletal abnormalities in sarcoidosis patients
Mycobacterium Tuberculosis - Scientists discover new pathway critical to pathogen survival
Myelodysplastic Syndromes - Additional data presented on Revimid at hematology meeting
Myocardial Infarction - Women less likely to get lifesaving drug during heart attack
Nanotechnology - Tissue culture dish enables direct electron microscopy of wet specimens
Nausea - Antiemetic regimen improved control of chemotherapy-induced nausea, vomiting
Arthritis - Database study yields new insights into arthritis drug
Nemaline Myopathy - Toadfish help in muscular disease fight
Neuroblastoma - Risk of second malignant neoplasms increased after childhood neuroblastoma
Neuropathic Pain - Phase I clinical trial commences for pain drug T-62
Neuroscience - CBL:clathrin complex involved in nerve growth factor signaling
Neuroscience - Modified cells foster spinal system regeneration following cord injury
Neuroscience - NF2 gene overexpression thwarts schwannoma cell growth
Neuroscience - The protein limitrin demarcates blood-brain barrier integrity
Neurotoxin - Polyvalent snake antivenom treats envenomation by Micropechis ikaheka
Neurovirology - Diffusion imaging and proton MRI can aid HSE diagnosis in AIDS patients
Nicotine Addiction - Most popular snuff brands also have big nicotine doses
Arthritis - Knee treatment value questioned
Non-Hodgkin Lymphoma - Data presented from study of Rituxan as front-line and maintenance therapy
Non-Hodgkin Lymphoma - MyVax Personalized Immunotherapy shows promise in mantle cell lymphoma
Non-Hodgkin Lymphoma - Phase III trial of non-Hodgkin lymphoma therapy reaches endpoint early
Non-Hodgkin Lymphoma - Pixantrone induces major tumor response in relapsed aggressive lymphoma
Obesity Pathogenesis - Serum resistin (FIZZ3) protein is increased in obese humans
Obesity Risk Factor - Maternal attitude and attachment style affects obesity risk in children
Obesity Therapy - ERR protein ligand expression promotes energy use and weight loss
Obstetrics - Alcohol exposure during early postnatal period may result in insulin resistance
Obstetrics - Exploding elective labor induction rates provoke a call for action
Obstetrics - Micronutrients other than iron and folic acid don't enhance hematologic status
Assisted Reproduction - Pregnancy achieved from frozen donor egg at New Jersey institute
Obstetrics - Optimal delivery conditions call for a shorter pushing phase during labor
Obstetrics - Preconception body mass associates with birth outcomes among Chinese women
Obstetrics - Pregnancy wantedness in the Philippines often depends on spousal communication
Obstetrics - Pregnant women request influenza vaccine to protect self and baby
Obstetrics - Quick action improves maternal and fetal odds during intrapartum emergencies
Obstetrics - Researchers warn pregnant women to be wary of flu outbreak
Obstetrics - Umbilical plasma kininase I activity grows where fetal hypoxia abounds
Ocular Diseases - SBIR grants awarded for PEDF protein research in macular degeneration
Oncology - Antisense suppression of proapoptosis genes limits melanoma angiogenesis
Oncology - Breast cancer coexpresses tumor specific VEGF-A and VEGFR2/KDR protein
Assisted Reproductive Technology - CDC issues 2001 summary of ART trends and success rates
Oncology - Interventional strategies that decreasing rate of clonal expansion preferred
Oncology - Many factors affect how oncolytic adenoviruses transfect tumors
Ophthalmology - Free eye exams available to those at increased risk of glaucoma
Oral Mucositis - Phase III data show that Palifermin improves oral mucositis in cancer patients
Osteoarthritis - Human osteoarthritic cartilage, chondrocytes have functional mu-opioid receptors
Osteomyelitis - Staphylococcus lugdunensis may be the cause of some vertebral osteomyelitis
Osteoporosis - Iron levels associate with bone mineral density in postmenopausal women
Osteoporosis - Society pays a high cost for vertebral fractures
Osteoporosis - Standardized grading schemes allow clinicians to recognize vertebral fractures
Osteoporosis - Study: Older women with fractures not receiving recommended testing, treatment
Asthma - Acetaldehyde activates NF-kappa B and upregulates GM-CSF in human bronchi
Osteoporosis - The recombinant therapy teriparatide restores bone mass
Osteoporosis - Vertebral fractures are indicative of the need for preventive therapy
Otitis Media - FDA approves marketing of Dispermox
Ovarian Cancer - Women at high risk for ovarian cancer aren't getting the care they need
Ovulation Test - FDA-approved, reusable, ovulation management test now available nationwide
Pain Medicine - Collaborative approaches to pain management have changed labor analgesia
Pain Medicine - Neurogen corrects media report on alliance
Pancreatic Cancer - A phase II trial investigates glufosfamide for advanced pancreatic cancer
Pancreatic Cancer - RNA interference of focal adhesion kinase makes cancer chemosensitive
Parasitic Disease - People with T. solium asymptomatic neurocysticercosis have a TH2 profile
Asthma - Monocyte-derived chemokine is elevated in asthmatic's BAL, as are leukocytes
Paratesticular Cancer - CT, MRI findings helpful in evaluating and narrowing paratesticular neoplasms
Parkinson Disease - Mutation analysis of the neurofilament M gene in Parkinson disease
Patent Ductus Arteriosus - Team travels to perform newborn heart surgery at regional hospitals
Patents - Additional patent granted on cartridge technology for DNA analysis
Patents - Broad use patent issued for Ampakine for enhancement of memory, cognition
Patents - International patent application filed for herpes treatment
Patents - Patent granted for compositions, kits for compounding pharmaceuticals
Patents - Patent granted for method of tissue oxygenation
Patents - U.S. patent granted covering fully automatic defibrillator for public use
Patient Safety - Web site for healthcare workers aims to reduce medication errors
Women's Health - Female ob-gyns name leading health problems for women; obesity heads list
Asthma - Occupational asthma, rhinitis could be brought on by many enzymes, isocyanates
Peanut Allergies - Prevalence of peanut and tree nut allergies on the rise in children
Pediatric Cancer - Thalidomide antagonizes neuroblastoma vessel growth
Pediatric Obesity - Polls show parents and teachers agree on solutions to childhood obesity
Pediatric Obesity - Race, income, insurance all influence obesity rates among children
Pediatrics - The impact of multiple micronutrient deficiencies on cognition remains unknown
Perinatal Medicine - Argon plasma coagulation, fibrin glue effective for treating chylothorax in premature infant
Peripheral Vascular Disease - New technique enables patients to avoid risky surgery and amputation
Personnel - Beier named senior VP, global government affairs at biotech firm
Personnel - Benefits management company expands senior management team
Personnel - Biotech company appoints new president
Asthma - Secondhand smoke exposure increases adult asthma risk
Personnel - Canadian biotech appoints Andrew R. Jordan to its board of directors
Personnel - Company names new executives to guide orthotic and prosthetic expansion
Personnel - David Arkowitz becomes CFO
Personnel - Disease management company appoints chief medical officer
Personnel - Gregory L. Weaver elected to WBBA board of directors
Personnel - Hawkins named to board of directors at viral disease drug company
Personnel - Igor Gradov named new global VP of research and development
Personnel - Jay M. Green named executive VP and director of corporate development
Personnel - Jeffrey Klar, new COO, tapped to build solid platform for rapid growth
Personnel - Jim Manzi named chairman of instrument company
Asthma - Serum levels of urinary trypsin inhibitor are higher during pediatric asthma
Personnel - Karen Auditore-Hargreaves named president of cancer therapeutics company
Personnel - Krishna Sudhir, MD, PhD, joins management team of biotech company
Personnel - Lab equipment company announces that CEO retires
Personnel - MedeFinance appoints Katherine Glassey as VP, business development
Personnel - New director joins cardiovascular diagnostics company's board
Personnel - Ovation Research Group names Dave Miller as director, statistical analysis
Personnel - Pharmaceutical company appoints new CEO, president
Personnel - Rolf A. Classon named vice chairman of board
Personnel - Senior R&D executive to lead product development
Personnel - Senior management team strengthened at pharmaceutical firm
Asthma - Xopenex effective treatment for children with acute attacks
Personnel - Slepian, Wehberg named to board of directors at device company
Personnel - Surgical robotics company makes changes in board of directors
Pertussis - bvgR expression in Bordetella pertussis analyzed
Pharmaceutical & Drug Development - A new improved culture system scales up gene vector production
Pharmaceutical & Drug Development - Challenges and opportunities in animal drug development outlined
Pharmaceutical Marketing - ImpactRx expands to provide decision support on dermatology market
Pharmacokinetics - Single-trough concentrations analyzed using mixed-effects modeling
Phytotherapy - Plant extracts containing zeaxanthin might treat age-related eye disease
Placental Malaria - High hemozoin levels linked to low PGE2 output in pregnant women
Pneumonia - Phase II study of aerosolized amikacin completed in critical care setting
Atherosclerosis - Company to expand HDL Therapy development program
Policy - AIDS group releases white paper urging new HIV prevention strategies
Policy - Americans want more money directed to cancer research
Population Research - Canadian university receives US$11.7 million grant from Gates Foundation
Postoperative Fever - Following total knee arthroplasty, IL-6 levels are related to a febrile state
Pouchitis - InKine enters copromotion agreement for gastrointestinal Probiotic VSL#3
Prescription Drug Benefits - Auto industry nudging work force, retirees toward mail-order drugs
Prescription Drug Importation - As New Hampshire, Massachusetts go, so goes Maine?
Prescription Drug Importation - Iowa seniors say savings are worth the legal risk
Prescription Drug Importation - U.S. may overwhelm Canadian pharmacies
Preventive Medicine - Arkansas officials launch health initiative
Atherosclerosis - Geriatrics disease firm secures license for discovery of cardiovascular treatments
Preventive Medicine - Calendar encourages African Americans to adopt better health practices
Preventive Medicine - Group encourages patient-provider partnership in healthcare decisions
Prostate Cancer - Alpha-methylacyl-coenzyme A racemase may be an important prostate cancer marker
Prostate Cancer - Androgen receptor involved in resistance to drugs
Prostate Cancer - Biology of prostate-specific antigen reviewed
Prostate Cancer - Black men should be screened for prostate cancer at younger age
Prostate Cancer - Heavy metal-metabolizing proteins involved in human prostate homeostasis
Prostate Cancer - Improved tools for analyzing prostate cancer genes are needed
Prostate Cancer - New targets for therapy in prostate cancer discussed
Prostate Cancer - Older patients may face age bias
Attention Deficit Disorder - Research in animals reveals possible long-term effects of stimulants on brain
Prostate Cancer - Phase II study shows citrus fruit nutrient combats prostate cancer
Prostate Cancer - Researchers identify molecular cause of drug-resistant disease
Prostate Cancer - Signaling pathway of prostate cancer profiled using protein arrays
Prostate Cancer - Vitamin D should be a priority for men of all ages
Prostate Disease - Combination therapy significantly delays progression of benign prostatic hyperplasia
Prosthetic Vision - Functional replacement of photoreceptors by a retinal prosthesis examined
Prosthetics - Titanium prosthetic components available for obese patients
Proteomics - Exons in protein domains have implications for protein modeling
Proteomics - NaSi-1 deficits cause seizures, infertility, and low body weight in mice
Awards - Scientist wins one of 14 grants that mark next phase of genome investigation
Proteomics - Novel associations between O-mannosyl glycans and disease reported
Proteomics - Physics of protein conformational changes described
Proteomics - Protein function predicted from redundancies in protein networks
Proteomics - Protein microarrays are effective molecular profiling technologies
Proteomics - RNA extraction from limited samples yields useful microarray results
Proteomics - Spontaneous MinE ring and MinD polar zone formation in E. coli reported
Proteomics - Tropomodulins bind to actin filaments
Psoriasis - Group warns that psoriasis "cures" are being peddled on Internet
Public Offering - LCA-Vision completes public offering
Pulmonary Embolism - Combo imaging has potential to provide single comprehensive study of acute PE
Bacteriology - Friendly bacteria shut down inflammation
Quality Management - Radiopharmaceutical facility receives ISO 9001 certification
Radiology - Cancer's love-hate relationship with proteins offers new treatment window
Radiosurgery - Growth of extracranial radiosurgery highlighted at CyberKnife Users' Meeting
Radiotherapy - Microbeams point to future of radiotherapy
Rasmussen Encephalitis - Refractory Rasmussen syndrome may be treatable by thalidomide
Rectal Cancer - New developments in radiology and oncology may further increase patient survival
Rectal Cancer - Preliminary results of laparoscopic resection for rectal cancer are promising
Rectal Cancer - Rectal cancer outcome dependent on diagnostic, oncologic, technical principles
Regulatory Issues - Drug company fees for FDA reviews haven't accelerated approvals
Reimbursement - Medicare increases reimbursement coverage for DeBakey LVAD
Reimbursement - North Carolina health plan to cover cost of FluMist
Renal Artery Angioplasty - Kissing balloon method reliable for bifurcation stenosis of renal artery
Renal Lesions - Color Doppler sonography is a standard method renal artery stenosis screening
Renal Medicine - Link between hyperhomocysteinemia and cardiovascular disease in renal patients reviewed
Renal Tumor - Multiple roles of the tuberous sclerosis complex genes reviewed
Reproductive Medicine - 'Suicide proteins' contribute to sperm creation
Reproductive Medicine - Infertility and involuntary childlessness heighten psychological distress
Reproductive Medicine - Recombinant human luteinizing hormone can be individualized for infertile women
Research Collaborations - Alliance formed for oncology therapeutics development
Respiratory Syncytial Virus - Research suggests more needs to be done to protect at-risk infants from RSV
AIDS Epidemiology - Nearly 6000 AIDS deaths in Malaysia since 1985
Bioengineering - Chinese biotech to apply for listing on primary U.S. stock exchange
Restenosis - Drug-coated biomaterials prevent artery reblockage
Restenosis - Drug-eluting stents unmask device fractures
Retinopathy of Prematurity - Breakthrough protocol reduces infant eye damage
Rheumatoid Arthritis - Phase I study of SC12267 initiated
Rhinosinusitis - New chronic rhinosinusitis guidelines released from SAHP
Rhinosinusitis - Resistant rhinosinusitis may indicate another underlying condition
Rickettsiae - Phospholipase D-superfamily gene in rickettsiae characterized
SARS - Compound for influenza tests positive in preliminary in vitro SARS study
SARS - Non-viral factors play key role in SARS severity
SARS - Outbreak in Beijing spread rapidly, was controlled fairly quickly
Biological Rhythms - Change in biological rhythms may cause early deaths from premature aging, cancer
SARS - Preliminary report suggests combination therapy may help treat SARS
SARS - Spilled lab sample likely infected Taiwanese scientist
SARS - Study: Coronavirus part bird, part mammal
Sarcoma - Leg lengthening should be offered only to long-term sarcoma survivors
Schizophrenia - Calcium signaling dysfunction central to schizophrenia pathogenesis
Schizophrenia - Phase II clinical trial initiated for Secretin in refractory schizophrenia
Sensory Studies - Some areas of thermosensation and perception are marked by gender differences
Septicemia - LPS-binding domain of cathelicidin linked to IgG is protective against sepsis
Septicemia Susceptibility - Mannose-binding lectin polymorphisms are linked to sepsis, related mortality
Sickle-Cell Disease - Passive tobacco smoke increases complications in pediatric sickle cell patients
Biomaterials - Nanotech-based hydrogel launched
Sinusitis - Survey shows antibiotics initially ineffective in some sinusitis patients
Sjogren Syndrome - Patients with neuropathy may have sicca, autoantibodies, or a positive biopsy
Sleep Apnea - C-Flex sleep apnea home treatment now available
Small Bowel Cancer - Small intestinal carcinoid tumors have a favorable prognosis
Smallpox - Pharmaceutical and USAMRIID collaborate on molecule-screening program
Smallpox - Vaccine victims can seek payment
Smoking - New anti-smoking ad campaign appeals to parents through children
Smoking Cessation - Financial payoff for quitting smoking may take years
Smoking Cessation - Quitting reduces risk of death from coronary heart disease by more than a third
Sociology - In India children's genders have a strong influence on parents' divorce risk
Biomonitoring - Alabama clinic merges technology, low costs
Solid Tumors - Vascular targeting agents granted European patent
Spasticity - Popular epilepsy drug also effective in controlling debilitating MS symptom
Spinal Cord Injury - First U.S. site tests ProCord for the treatment of spinal cord injuries
Spinal Disk Repair - Companies extend relationship for development of spinal disc repair product
Spinal Injury - Proof-of-principle data for nerve repair program presented
Spinal Muscular Atrophy - Valproic acid increases SMN levels in spinal muscular atrophy cells
Staph Infection - Company provides update on StaphVAX development program
Staphylococcus - Electrophoresis pattern database of Staphylococcus isolates created
Staphylococcus - High-level vancomycin-resistant Staphylococcus aureus isolated
State-Sponsored Health Insurance - Tax referendum could mean the demise of the Oregon Health Plan
Biotechnology - Biodegradable nanofibrous structure shows promise for blood vessel engineering
Stem-Cell Biology - Researchers get stem cells to form blood vessels
Stem-Cell Research - B-cell development requires flt3- and IL-7Ralpha-mediated signaling
Stem-Cell Research - Cost-effective method for producing chimeric animals from ES cells developed
Stem-Cell Research - Hematopoietic stem cells can become muscle as well as blood cells
Stem-Cell Research - Human-shaped mandibular condyle tissue-engineered from rat MSCs
Stem-Cell Research - JSAP1 protein needed for early embryonic neurogenesis
Stem-Cell Research - Osteogenic capacity of mesenchymal stem cells does not decline with age
Stem-Cell Research - STO feeder cells can support human embryonic cell lines
Stem-Cell Technology - Researchers growing stem cells without help from mice
Stem-Cell Transplantation - Amotosalen-treated T cells prevent CMV infection without inducing GVHD
Bladder Infection - Escherichia coli adheres to bladder epithelium with fimbriae, sialic acid
Stem-Cell Transplantation - Fetal bone marrow stem cells best for transplantation
Stem-Cell Transplantation - Humanized and chimeric anti-CD25 mAbs effective for GvHD prevention
Stem-Cell Transplantation - Intracoelomic route shows promise for in utero SCT
Stem-Cell Transplantation - New stem-cell transplantation drug addresses unmet need in cancer patients
Streptococcus - Available rapid streptococcal-A-antigen assays still need backup culture
Streptococcus - M protein gene subtypes from invasive group A streptococcus recovered
Streptococcus - Pneumococcal surface adhesin A of Streptococcus pneumoniae analyzed
Stress Proteins - Heat shock proteins 70 and 40 are upregulated in many gastric cancer tissues
Stroke - Carotid stenting may cut stroke risk in half
Stroke - Pick your poison: Rat poison vs. cobra venom for stroke prevention
Blood Clots - New version of catheter introduced for peripheral arterial use
Substance Abuse - Scripps gets $3 million for addiction research
Sudden Deafness - Immune-mediated inner ear disease has recurrences like some autoimmune diseases
Systemic Lupus Erythematosus - Company inks autoimmune-therapy agreement with the University of Michigan
Systemic Lupus Erythematosus - Heart attack caused by delayed heparin-induced thrombocytopenia
Systemic Lupus Erythematosus - Lupus patients at increased risk for atherosclerosis
T-Cell Immune Synapse - TCR stimulation induces phosphodiesterase 4B2 activity, movement during synapse
T-Cell Malignancies - Results of BCX-1777 phase I study reviewed
Teratogenesis - Murine malformations offer a way to assess retinoid-induced teratogenicity
Therapeutic Proteins - Platform technology to be developed for delivery of therapeutic proteins
Thoracic Aortic Aneurysms - FDA grants approval for investigation of Zenith TX2 graft
Blood Product Management - Wyndgate signs $1.2 million contract with California hospital
Tinea Pedis - FDA approves ERTACZO (sertaconazole nitrate) Cream, 2%
Tobacco Use - Payoff for quitting smoking may take years
Tolerance Induction - FOXP3 can be used as a CD4+ regulatory T cell marker to study immune tolerance
Total Hip Arthroplasty - Frozen section histology recommended for diagnosing total joint infection
Total Joint Arthroplasty - Ultrasound screening for DVT is not beneficial after major orthopedic surgery
Total Knee Arthroplasty - Accuracy of current TKR instrumentation is questioned
Total Knee Arthroplasty - Extraarticular impingement can be avoided by careful removal of excess cement
Total Knee Arthroplasty - Patella fracture surgery has a high complication rate, avoid if possible
Total Knee Arthroplasty - Patellar options in revision total knee arthroplasty reviewed
Total Knee Arthroplasty - Predicting total knee replacement pain
Blood Substitutes - Catalase coencapsulation enhances efficacy of hemoglobin vesicles
Total Knee Arthroplasty - Studies favor patellar resurfacing over retaining the native patella
Total Knee Arthroplasty - Use of LCS meniscal-bearing prosthesis appears unjustified
Toxoplasmosis - Sulfadiazine presents risk of kidney failure during pregnancy
Toxoplasmosis Vaccine - MIC3 gene of Toxoplasma gondii is potent vaccine candidate
Transforming Growth Factor - Targeting of TGF-beta may control cell growth, apoptosis in cancer cells
Transplant Medicine - Early promise seen for steroid-free liver transplantation in children
Transplant Medicine - Idiopathic colitis after pediatric cardiac transplantation can cause morbidity
Transplant Medicine - Kidney recipients with high pretransplant CD30 benefit most from HLA matching
Transplant Medicine - Kidney transplant patients given tacrolimus have lower risk of osteonecrosis
Transplant Medicine - Stem cells allow tolerance for allogeneic islets but do not regenerate pancreas
Blood Substitutes - Veterinary use of Oxyglobin reviewed
Transplant Medicine - The new JNK inhibitor SP600125 blocks interleukin 6-induced angiogenesis
Transplant Medicine - U.S. liver allocation plan is a better ranking method for transplant patients
Transplant Medicine - Vascular and thrombotic complications compromise living donor liver grafts
Transplant Medicinie - Growth hormone therapy affect on renal allograft function needs further study
Trends - Report asks: Has the pharmaceutical blockbuster model gone bust?
Tuberculosis - Laboratories not following recommendations for tuberculosis testing
Tuberculosis DNA Research - Molecular analysis performed on Koch bacillus
Tuberculosis Diagnosis - Tanzanian rats, who already sniff out landmines, now poised to detect TB
Tuberculosis Epidemiology - TB transmission among Canadian Inuits characterized
Tuberculosis Immunology - M. tuberculosis-specific CD8 cells recognize heavily infected cells
AIDS Therapy - Company issues statement on antiretroviral treatment study
Blood Supply Safety - National Blood Service in England begins nucleic acid testing
Tuberculosis Immunology - Novel CD8 cell epitope shared by M. tuberculosis ESAT-6 proteins
Tuberculosis Pathogenesis - Differential mycobacterial gene expression seen in mice and humans
Tuberculosis Pathogenesis - Function of M. tb MprAB signaling system clarified
Tuberculosis Therapy - Molecular assay can aid detection of M. tuberculosis isoniazid resistance
Tuberculosis Vaccine - Advances in tuberculosis research offer novel vaccine strategy insights
Tumor Growth - New eco-evolutionary model of tumor dynamics described
Tumor Suppressor Gene - Haploinsufficient genes requiring inactivation of only one allele
Tumors - Data on next-generation VEGF cancer agent presented at ASH
Tumors - Model for the early growth of DCIS of the breast is formulated
Type 1 Diabetes - Functional insulin-producing cells derived from bone marrow stem cells
Body Composition - Body composition of Aboriginal Australian and Caucasian women compared
Type 2 Diabetes Therapy - Computerized exercise program for type 2 diabetic patients developed
Ulcerative Colitis - Salix announces initiation of granulated mesalamine clinical trials
Ulcers - Americans seeking relief from pain medication can be at fatal risk
Ultrasonography - Invasive ductal carcinomas appear larger on viscoelastic scan than B-mode image
Urinary Tract Infections - Doripenem meets primary endpoints in phase II clinical trial
Urology - Universally effective therapy for interstitial cystitis is still lacking
Uterine Enlargement - MR imaging allows specific diagnosis of diffusely enlarged uterus
Vaccine Safety - Report: Additives and preservatives in childhood vaccines are not harmful
Vascular Targeting Agents - Companies sign agreement to humanize vascular targeting agent antibody
Vector Development - Double-stranded adeno-associated virus vectors produce rapid transduction
Bone Cancer - Bisphosphonate suppress growth and induces apoptosis in cancer cells in culture
Vector Development - Micelle formation is key to how chlorpromazine augments retroviral transduction
Vein Stenosis - Stenosis, occlusion accelerated in hemodialysis patients with pacemakers
Venous Thromboembolism - Guideliness on venous thromboembolism prophylaxis reconsidered
Venous Ulcer - Sixty-four percent improvement over standard of care therapy in trial of OrCel
Violence - Sexual assault evidence collection by trained nurse examiners is more accurate
Viral Genomics and Genetics - South American dengue-1 viral genotypes determined
Virology - Adenovirus serotype 35 vector has an attractive distribution profile
Virology - Analysis of iridoviruses based on protein and DNA sequences reported
Virology - De novo methylation patterns are common to papillomavirus DNA
Virology - Effects of GBV-C co-infection on HIV progression reviewed
Bone Injuries - Micro-CT can correlate a bone injury to an injury-causing instrument
Virology - Lassa virus signal peptide acts as a trans-acting maturation factor
Virology - Modified adeno-associated virus type 2 circumvents human antibodies
Virology - Purdue biologists expose the inner workings of viral machine
Virology - Short hairpin RNAs inhibit hepatitis B virus replication
Virology - Tagged baculovirus capsids are new tools for analyzing transduction
Water-borne Disease - Novel assay improves detection of Cryptosporidium in water
Weight Control - Self-regulation of food intake not enough to prevent obesity
Weight Loss - FDA to list studies on obesity drug label
Weight Loss - Key appetite regulator may be identified
Weight Loss - Stress management important in treating obesity
Bone Marrow Transplantation - Repifermin reduces the severity of graft-versus-host-disease
Women's Health - The global cancer burden in women appeared to be increasing quickly
Wound Healing - Company announces extension of Wound Gel shelf life
Yellow Fever - BLA filed for Arilvax vaccine
Bone Regeneration - FDA approves expanded use of INFUSE Bone Graft with fusion device
Botulism - Outbreak of botulism linked to food sold at salvage store in Texas
Brain Cancer - Bone marrow-derived endothelial progenitor cells are marginal to gliomas
Brain Tumors - A delivery system for targeting anticancer drugs to the brain developed
Breast Cancer - Altered cyclin E protein linked to genetic instability, endocrine resistance
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