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Health and Medicine Week

Susan Hasty, Publisher

Table of Contents . . . January 19th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Health and Medicine Week | Other Publications

Depression - Research reveals social isolation boosts teen girls' suicide thoughts

Acne - New drug application submitted for Actiza

Bone Health - Inhaled corticosteroids found safe

Botulinum Toxin - Electrophoresis method to evaluate botulinum toxin activity developed

Bovine Spongiform Encephalopathy - FDA issues statement on new measures against BSE

Bovine Spongiform Encephalopathy - FDA issues statement on rendered products derived from BSE cow in Washington

Brain Injury - Depression, other psychiatric illnesses common following brain injury

Brain Tumor - Matrix metalloproteinases are tumor-specific markers in glioma patients

Brain Tumors - Individualized chemotherapy appears promising for glioblastoma multiforme

Brain Tumors - White matter fiber tracking is important for neurosurgical planning

Breast Cancer - Breast cancer patients of lower socioeconomic status may have poorer survival

Breast Cancer - Declining estrogen receptor-beta expression defines progression of breast cancer

Acute Myeloid Leukemia - PCR analysis can aid Aspergillus niger endocarditis diagnosis in AML patients

Breast Cancer - Exercise may reduce disease risk

Breast Cancer - Hemoglobin level may be related to tumor hypoxia and treatment resistance

Breast Cancer - Her-2/neu gene amplification in familial breast cancer predicts worse outcome

Breast Cancer - Higher dietary fat intake is associated with an increased breast cancer risk

Breast Cancer - Major milestone achieved in molecular diagnostics oncology program

Breast Cancer - Novobiocin reverses breast cancer resistance protein BCRP/ABCG2

Breast Cancer - Research paves way for individualized treatment

Breast Cancer - Tamoxifen has no effect on p27 protein expression in endometrium

Breast Cancer - The TGFB1 L10P polymorphism is not associated with breast cancer risk

Breast Cancer - Tumor size is likely unrelated to risk of recurrent breast cancer

Addiction Medicine - Amphetamines and cocaine regulate dopamine transporter function

Breast Cancer Therapy - Tumor cell contamination of stem-cell apheresis products has little clinical effect

Breast Tumors - Segmentation of breast tumor in 3-D ultrasound can obtain tumor volume

Breastfeeding - Advocacy groups in Oklahoma propose legislation

Breastfeeding - Continuing to nurse while dealing with viral infection is okay

Burkitt Lymphoma - Epstein-Barr virus is necessary for the survival of Burkitt lymphomas

Business & Finance - Healthcare provider launches online renewal service

Business & Finance - Insurer announces new physician advisory committee

Business & Finance - Two Passaic, New Jersey, hospitals consolidate

CNS Disease - Extracellular phospholipase A2 inhibitors can inhibit inflammation in CNS

Cancer - Phase III study for kidney cancer vaccine analyzed

Addiction Medicine - Bilirubin is a simple marker for alcoholic hepatitis treatment response

Cancer - Results from new cancer therapeutic published

Cancer Incidence - Parental exposure to the atomic bomb has not increased cancer in offspring

Cancer Mortality - Researchers report cancer incidence and mortality in the Netherlands

Cancer Prevention - College receives $10 million for cancer prevention trials

Cancer Prevention - National survey finds U.S. public enthusiastic about cancer screening

Cancer Risk - Cancer risks attributable to low doses of ionizing radiation reviewed

Cancer Therapy - Data presented on treatment to combat effects of chemotherapy

Cancer Therapy - Rho pathway inhibition produces glioma radiosensitization and oxygenation

Carcinogenesis - The major polyphenol from green tea may contribute to preventing carcinogenesis

Cardiac Rhythm Disorders - Alliance formed to offer broad electrophysiology solutions

Addiction Medicine - TWEAK identifies where intervention for alcohol use during pregnancy is needed

Cardiac Surgery - Company announces blood substitute studies for cardiac surgery

Cardiology - Biotech begins new Phase I study of cardiovascular drug

Cardiology - Cells with endothelial phenotypes have diverse origins

Cardiology - HDL therapy receiving heightened interest

Cardiology - Hypoxia-inducible factor 1 regulates several factors to control angiogenesis

Cardiology - Invasive measures of pulmonary artery pressure complement Doppler assays

Cardiology - New agreement signed for cardiac safety information services

Cardiovascular Disease -  MTHFR mutation significantly raises hyperhomocysteinemia risk in children

Cardiovascular Disease - Biopharmaceutical company acquired to develop cardiovascular disease treatments

Cardiovascular Disease - Changes in skeletal muscle gene expression during CHF elucidated

Adenocarcinoma - Lung adenocarcinoma may be associated with atypical adenomatous hyperplasia

Cardiovascular Disease - Distribution of the NPY 1128C allele determined

Cardiovascular Disease - Genetic and environmental risk factors for extremely high cholesterol levels identified

Cardiovascular Disease - Losartan may reduce risk of platelet-induced pulmonary thromboembolism

Cardiovascular Disease - Novel transthyretin mutation linked to heart failure

Cardiovascular Disease - Paraoxonase gene cluster mutations can predict heart disease risk

Cardiovascular Disease - Protein kinase C changes RKIP target from Raf-1 to GRK-2

Cardiovascular Disease - Selenium may protect against heart attacks in men

Cardiovascular Disease - Study shows multivitamin offers cardiovascular risk factor protection

Cardiovascular Disease Therapy - Current and future antiarrhythmic treatment reviewed

Cardiovascular Disease Therapy - Prevention of SR alterations may underlie beneficial effects of heart failure treatments

Aesthetic Surgery - Cosmetic foot surgery to beautify feet has serious risks

Cardiovascular Disease Therapy - Suppression of cardiomyocyte apoptosis has little effect on efficacy of MI treatments

Cardiovascular Risk - Trial studies best ways to prevent heart problems in type 2 diabetes patients

Cartilage Repair - Fibrin-chondrocyte constructs can be used to perform cartilage repair

Cataracts - Zinc may play role in development of diabetic senile cataractous lenses

Catheter Insertion - Peritoneal dialysis catheters can be inserted via a peritoneoscope

Celiac Disease - Knowledge of gluten-processing path should help celiac disease therapy emerge

Cell Biology - A big surprise: Young nerve cells can rewind their developmental clocks

Cell Biology - Endothelial cell-specific response characterizes VEGF receptor stimulation

Cell Biology - Method could detect protein-binding events, without fluorescent labeling

Cell Biology - Nitric oxide modifies how low oxygen levels impact cell physiology

Aging - Pneumonia-caused cellular immunity damage is reversible

Cell Biology - Transcriptome and glycome regulation prepare endothelial cells for death

Cell Counting - An SAP staining procedure is equal or better than IF for HbF cell counting

Cell Death - Endoplasmic reticulum pathways contribute to apoptosis

Cellular Senescence - Cellular senescence may be a trustworthy tumor suppressor mechanism

Central Nervous System - Ap-1 targets in the brain reviewed

Charcot-Marie-Tooth Syndrome - Late onset Charcot-Marie-Tooth 2 syndrome caused by mutations in MPZ gene

Chemokine Receptors - The E3 ubiquitin ligase AIP4, Hirs, and Vps4 coordinate CXCR4 ubiquitination

Chemotherapy - Cellular pH regulators may be promising molecular targets for chemotherapy

Childhood Obesity - Nutritive factors influencing development of childhood obesity outlined

Childhood Obesity - Obesity in 3- to 7-year-old New Zealand children is serious concern

Agriculture - Federal court trumps local township restrictions on use of biosolids

Chlamydia - Delay in cell death may lower Chlamydia infection but increase pathology

Chronic Berylliosis - Beryllium is detected lung tissue using electron probe X-ray microanalysis

Chronic Hepatitis C - Hepatic reserve marks survival in those with HCV-related liver cancer

Chronic Hepatitis C - Sepsis heightens mortality after retransplantation for recurrent HCV infection

Chronic Pancreatitis - Bilateral thoracoscopic splanchnicectomy most effective surgery for pancreatitis

Chronic Pancreatitis - Pylorus-preserving pancreaticoduodenectomy is effective but not superior

Class Switch Recombination - Class switch recombination has unique DNA recognition structures for enzymes

Clinical Trials - New central lab business created

Clinical Trials - Update released on investigational device exemption for drug stent

Cocaine Testing - An anti-BZE coated sensor can detect residual cocaine vapor plumes in the air

Allergic Rhinitis - Pranlukast reduces levels of cytokines, eosinophils in rhinitis nasal mucosa

Cochlear Implants - Software tool can analyze multichannel cochlear implant signals

Collaborations - Agreement signed with Mitsubishi for irritable bowel syndrome compound

Collaborations - Alliance pledges to serve people with alpha-1 antitrypsin deficiency

Collaborations - Antibody deal with Amgen restructured

Collaborations - Biotech software company announces deal to distribute database

Collaborations - Cardiac safety monitoring, information distribution services deal signed

Collaborations - Cornerstone signs exclusive agreement with Amerinet

Collaborations - Deal signed for development of sustained release generic product

Collaborations - Deal with Johnson & Johnson expanded to include obesity

Collaborations - Intellectual property for antibodies binding to IL-12 licensed

Pediatrics - U.S. CDC releases annual summary of pediatric vital statistics for 2002

Allergy - Survey shows more allergy sufferers seek medical attention for symptom relief

Collaborations - License, supply agreement signed for osteoarthritis product

Collaborations - Marketing, communications contract extended with ChainDrugStore.net

Collaborations - Purchasing agreement signed for electrophysiology systems

Collaborations - Rights assigned from complement research to pharmaceutical company

Collaborations - VaxImmune vaccine adjuvant licensed to Chiron

Colon Cancer - Colorectal tumors are not caused by germline deletions of EXO1

Colon Cancer - Phenethylisothiocyanate induces GADD gene activation in colon cancer cells

Colon Cancer - Positive ursodiol disulfate study results reported

Colon Cancer Screening - Gastrointestinal specialists comment on new study on "virtual" colonoscopy

Colorectal Adenomas - Cigarette smoking and colorectal adenomas are associated

Allergy Medicine - Allergy to goat, sheep milk, but not cow, is due to greater casein homology

Colorectal Cancer - Four-drug regimen is feasible in advanced colorectal cancer

Colorectal Cancer - Study to evaluate photodynamic therapy for liver metastases from colorectal cancer

Complementary and Alternative Medicine - Green tea reduces body fat accretion caused by high-fat diet in rats

Complementary and Alternative Medicine - Licorice extract may stop cancer

Complementary and Alternative Medicine - Swaziland: AIDS toll leads to flood of bogus "miracle" cures

Complementary and Alternative Medicine - U.S. bans ephedra, drug linked to deaths

Conferences - Company announces participation in healthcare conference

Congestive Heart Failure - Encouraging signs follow muscle cell transplantation into damaged hearts

Coronary Artery Bypass - Coronary artery bypass graft patients have higher plasma, surface CD163 levels

Coronary Artery Bypass - Modified ultrafiltration benefits dialysis patients undergoing CABG

Allergy Medicine - Childhood allergies can be induced by the environment early in development

Coronary Artery Bypass - Study: Coronary bypass on beating heart results in more failed grafts

Coronary Artery Disease - European phase II trial of Hemopure initiated in angioplasty patients

Coronary Artery Disease - FDA panel underscores need for greater understanding of aspirin's benefit

Coronary Artery Disease - Utility of myocardial perfusion imaging for analysis of CAD patients reviewed

Corporate Update - Biotech company announces 2004 strategic initiatives

Corporate Update - Pronova Biocare sale announced

Correctional Health - Report says Ohio needs to improve inmate healthcare

Cough - Chronic cough is due to abnormal release of inflammatory mediators within the airway

Cowden Syndrome - Human Lhermitte-Duclos disease may be caused by mutation, dysfunction in PTEN

Cranial Lesions - Stereotactic radiosurgery is a viable option for performing neurosurgery

Allergy Medicine - Electrotransfer of interleukin-10 prevents bronchopulmonary hyperreactivity

Creutzfeldt Jakob Disease - "Human" mad cow usually not tied to diet

Creutzfeldt-Jakob Disease - In cerebellum of Creutzfeldt-Jakob patients, nestin increases with severity

Creutzfeldt-Jakob Disease - U.S. quarantines calves from diseased cow

Critical Care Medicine - Respirator weaning with adaptive support ventilation effective after heart surgery

Crystallography - Complement protein C1q has a trimeric, spherical shape that may aid binding

Cystic Fibrosis - The A561E cystic fibrosis mutation is a class II, protein trafficking defect

Cystitis - Pharmaceutical company receives second milestone payment for launch of Uracyst-S

Cytotoxic Drug Contamination - Low-level cytotoxic drug contamination found on the outside of drug vials

DNA Vaccine - Plasmid DNA activates dendritic cells via toll-like receptor 9

Deep Vein Thrombosis - Study finds 1% of air travelers develop injurious blood clots

Allergy Medicine - Five IgE epitopes in chicken egg ovalbumin cause allergy

Dendritic Cell Function - Cyclosporine may induce tolerogenesis by reducing dendritic cell IL-2, IL-12

Dental Healthcare - Kansas program to offer low-cost dentistry services in 3-year project

Depression - Depression may be linked to proinflammatory cytokine-serotonin interaction

Depression - Psychiatrist awarded grant to study effects of parental suicide

Depression - Study: Depression doesn't affect Chicanos

Dermatology - Vascular changes signal squamous cell carcinoma progression

Dermatology - Verapamil inhibits interleukin-6 and angiogenic growth factor in fibroblasts

Developmental Biology - New roles for protein modifications in cell migration

Developmental Biology - Sticky uterine coating helps embryo implant in uterus

Allergy Medicine - Gluten intolerance no longer considered rare

Diabetes - Magnesium may reduce risk for type 2 diabetes

Diabetes - Weight loss drug may reduce threat of type 2 diabetes

Diabetes Complications - Methods for preventing complications of diabetes reviewed

Diabetes Genetics - Researchers identify gene that causes insulin resistance in Mexican Americans

Diabetes Genomics & Genetics - Genetic predisposition to obesity and type 2 diabetes linked

Diabetes Pathogenesis - Beta cell death triggers priming of self-reactive T cells by dendritic cells

Diabetes Pathogenesis - Muscle-specific Pparg deletion causes insulin resistance

Diabetes Prevention - Diet high in magnesium lowers diabetes risk

Diabetes Risk Factor - No link found between preeclampsia or cesarean section and type 1 diabetes

Diabetic Retinopathy - Drugs capable of controlling angiotensin II may halt diabetic eye disease

Allergy Medicine - Job syndrome can be relieved by long-term oral penicillin treatment

Diagnostics - FDA approves molecular diagnostic test for sexually transmitted diseases

Diagnostics - TaqMan PCR suitable for quantification of EBV DNA in blood

Diet and Nutrition - Phenol levels and antioxidant activity measured in Turkish food

Disease Management - Study offers new findings on disease management effectiveness

Disease Prevention - Female OB/GYNs name obesity the greatest threat to women's health

Disease Tracking - New system provides disease and pathogen detection in food

Drug Abuse - Survey shows decline in teen drug abuse over past 2 years

Drug Delivery - "Smart bomb" destroys tumors in mice

Drug Delivery - Screening can identify chemicals that improve effectiveness of skin patches

Drug Development - Furamidine aza-analogues show promise as antiprotozoal agents

Allergy Medicine - Prevention of allergies by antigen avoidance may not always prove beneficial

Drug Development - New antibody collaboration announced

Drug Development - Nitric oxide donor-metronidazole hybrids have potent anti-H. pylori activity

Drug Development - Numbers of fish used in acute ecotoxicity testing of pharmaceuticals reduced

Drug Research - The norligan cis-Hinokiresinol curtails angiogenic response

Drug Resistance - Adefovir dipivoxil elicits a response in HBV-positive liver graft recipients

Drug Resistance - FLICE inhibitory protein supports chemoresistance in cervical cancer

Drug Resistance Reversal - Understanding drug resistance reversal may be complex and multifactorial

Embryonic Research - Slit3 protein involved in heart, kidney and diaphragm development

Employer-Sponsored Health Insurance - City workers in Gillette, Wyoming, unhappy with change in benefits

Employer-Sponsored Health Insurance - New Hampshire law changes health insurance rules for small-businesses

Allergy Medicine - Research suggests inverse relationship between rheumatoid arthritis and rhinitis

Employer-Sponsored Health Insurance - Plan to improve health insurance coverage stymied

Encopresis - Researcher finds that Internet-based treatment of childhood problem is effective

End-of-Life Care - Family members say dying patients need better emotional, medical support

Endocrinology - Ectopic ghrelin expression enhances growth

Endocrinology - Gravitational load modulates mammary metabolic function

Endocrinology - Hypoxia causes pituitary adenoma cells to stimulate new vessel growth

Endocrinology - Progesterone metabolite levels rise in women with chronic fatigue syndrome

Endocrinology - Skin temperature reflects changes brought on by hormones

Endometriosis - Nasal leuprolide product could offer noninvasive treatment for endometriosis

Enterobacter Sakazakii - Environmental presence of pathogen dangerous to infants is widespread

Alzheimer Disease - Abeta(1-42) can oligomerize into neurotoxins; Ginkgo extract inhibits it

Environmental Exposure - Atrazine contamination in water can be detected with a sensitive immunoassay

Environmental Health - Rice strains genetically engineered for mercury resistance may clean water

Environmental Toxins - Changes needed to reduce migrant farm worker exposure to pesticides

Enzymology - Calcineurin anchoring and cell signaling reviewed

Enzymology - Extracellular matrix signals collaborate to govern angiogenesis

Enzymology - Lipoxygenase makes transgenic tobacco less vulnerable to parasitic infection

Epilepsy - Companies enter broad agreement covering topiramate

Escherichia Coli - Latex agglutination, EIA are comparable tests for shiga toxin-E. coli

Esophageal Cancer - Aspirin trial launched to block heartburn's switch to cancer

Esophageal Candidiasis - EMEA marketing application filed for anidulafungin

Ethics - Study examines issues related to research involving prisoners

Alzheimer Disease - Cerebrospinal fluid markers function as predictors of Alzheimer disease

Exercise - Physical activity reduces depression in former elite athletes

Facilities - Maryland designated its first accredited chest pain center

Familial Cancer Risk - Familial risk of cancer is calculated

Fatty Acids - Omega-3 fats benefit people of many ages and health conditions

Fetal Medicine - Early recognition and treatment of fetal alcohol syndrome improves outcomes

Fetal Medicine - Infection prophylaxis improves odds after a prolapsed chorioamniotic membrane

Finance - Acquisition of cancer information registry business completed

Finance - Benefits management firm raises $8.6M

Finance - Biopharmaceutical company completes stock redemption; files shelf registration

Alzheimer Disease - HSPG2 A, APOE epsilon 4 alleles combined increase risk for Alzheimer disease

Finance - Cardiology company announces sale of Paulson stock

Finance - Cardiology company completes $3.1M private placement

Finance - Coventry Health Care announces three-for-two stock split

Finance - Credit facility renegotiated for health information company

Finance - DNA expression technology company to trade on Berlin Stock Exchange

Finance - Health technology and software company approves stock split

Finance - Home healthcare company revises quarterly outlook

Finance - Imaging company issues financial guidance for first quarter

Finance - Medical device company closes $12 million series B financing

Finance - Medical device company secures $2.2 million in financing

Alzheimer Disease - Imaging study pinpoints brain's myelin insulation as a key to AD

Finance - Medical device manufacturer announce closing of $12M total financing

Finance - Medical technology company to sell 3D visualization business

Finance - New registration statement filed for initial public offering

Finance - Pharmaceutical company announces change to earnings guidance

Finance - Pharmaceutical company announces exercise of over-allotment option

Finance - Pharmaceutical company announces year-end results

Finance - Pharmaceutical company completes $35M private placement

Finance - Pharmaceutical company files universal shelf registration statement

Finance - Shelf registration filed with SEC

Finance - Small protein company raises $1.2 million

Alzheimer Disease - In vivo reduction of amyloid-beta promoted by mutant copper transporter

Finance - Spinal access company announces research coverage by financial research group

Finance - Supply chain company pays off remaining debt

Finance - Taste receptor research company expands financing

Finance - Ultrasound systems manufacturer secures $25.6M in venture financing

Fitness - Full-bodied models highlight fitness ads

Fitness - Increased physical activity called priority for Americas

Fitness - Keeping resolutions for the new year

Food Allergy - Brownie mix recalled for pecan content

Food Supplements - NMR used to quantify ephedrine analogues from Ephedra species

Food Supply Safety - FDA and CBP announce their transitional compliance policy on food imports

Alzheimer Disease - Mayo Clinic receives $10 million gift to accelerate research

Food-borne Illness - Major cause of painful gastroenteritis under study at the Medical College of Georgia

Funding - 50 Washington, DC-area nonprofits receive health impact grants

Funding - Council would strengthen European research

Funding - Public-private collaboration to target new treatments for depression, nicotine addiction

Fungal Infection - Mycosis fungoides has changes in T-cell chemokine receptors that depend on stage

Fungal Infection - Severe alveolar echinococcosis can be controlled for years with benzimidazoles

GI Perforation - Radiologic approaches to diagnosing a variety of gastrointestinal perforations

Gastric Cancer - Cyclooxygenase-2 contributes to gastric carcinogenesis

Gastric Ulcer - Receptors play role in vascular effects of adrenomedullin in gastric ulcers

Gastroenterology - Carbon monoxide combines with nitric oxide to protect liver cells

Alzheimer Disease - No link found between TrkA polymorphisms and Alzheimer disease in Japanese

Gastroenterology - Estradiol treatment improves the healing of gastric and colonic injuries

Gastroenterology - Glucagon-like peptide-2 is not the only enterotrophin

Gene Expression - Companies renew commitment to gene expression tool

Gene Expression - Researchers describe a global toolkit for testing gene function

Gene Mutations - Polish families with ovarian and stomach cancer often have BRCA2 mutations

Gene Regulation - Non-small cell lung cancer cells are ideal targets for p53 gene transfer

Gene Suppression - Extended peptide nucleic acid conjugates have a greater capacity to bind DNA

Gene Therapy - Therapy containing hepatocyte growth factor gene improves hearing in rats

Gene Transfer - DNA encapsulation within polymeric sponges improves transfer efficiency

General Health - Survey shows flu tops germ concerns for 2004

Ambulatory Care - National standards sought for ambulatory care performance

Generic Drugs - Litigation status updated; FDA approves generic metolazone

Genetic Disorder - Familial Mediterranean fever with amyloidosis linked to mutation of MEFV gene

Genetic Disorder - Kinesin KIF21A mutations linked to congenital fibrosis

Genetic Disorder - Mutations in polyglutamine binding protein 1 gene cause mental retardation

Genetic Disorder - PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic

Genetic Engineering - Reengineered dendritic cells readies cytotoxic T cells for select epitopes

Genital Herpes - Antibodies to HSV-2 glycoprotein G are not always there during primary infection

Genital Herpes - Researchers: Pill stops spread of herpes

Genomics - License for patented gene targeting technology granted

Genomics and Genetics - Mutations affecting lipoprotein phenotype in South European FH patients identified

Amycolatopsis - Cinnamaldehyde derivative inhibits nicotinoprotein alcohol dehydrogenase

Genomics and Genetics - Oxidative DNA damage underlies mitochondrial effects of cancer, HIV drugs

Geriatrics - Alliance to offer elder care program

Germ Cell Tumors - Infertility rates are low after chemotherapy for germ cell tumors

Glioma - P-glycoprotein mediates multidrug resistance in malignant glioma cell lines

Glucose Metabolism - Metabolism of D-glucose anomers in pancreatic islets reviewed

Gonorrhea - Louisiana has worst gonorrhea rate, in top 10 in two other STDs

Gout - New drug application submitted for Oxyprim

Gynecology - Adenovirus-mediated suicide gene therapy destroys ovarian cancer cells

Gynecology - Transvaginal ultrasound aids the diagnosis and treatment of urological disorder

Gynecology - VEGF-Trap is a potent ascites suppressor in ovarian cancer models

Amyloidosis - C-terminal of beta 2-microglobulin plays role in amyloid fibril formation

HIV Diagnosis - FDA OKs U.S. sale of 10-minute HIV test

HIV Epidemiology - Name-based reporting leads to better information in New York City

HIV Progression - Having a stable partner delays AIDS in HIV patients

HIV Testing - Uni-Gold Recombigen HIV test receives FDA approval

HIV Therapy - Best treatment for new HIV patients to be studied

HIV/AIDS - Infection with multiple HIV strains hastens disease progression

HIV/AIDS - Substantia nigra lesion-induced parkinsonism can mark AIDS onset

HIV/AIDS Cancer - Epidemiology of Kaposi sarcoma in Israel elucidated

HIV/AIDS Cancer - HAART improves outcome of HIV-related non-Hodgkin lymphoma

HIV/AIDS Coinfection - HIV coinfection does not alter efficacy of hepatitis C treatment

Amyotrophic Lateral Sclerosis - ALS disease stage related to changes in tau protein and S100 beta

HIV/AIDS Epidemiology - HIV-1 seroprevalence rates in women and relinquishment of infants to the state in Russia

HIV/AIDS Obstetrics - HIV testing acceptable to pregnant women and their husbands in India

HIV/AIDS Opportunistic Infection - Molecular blood test detects Penicillium marneffei

HIV/AIDS Opportunistic Infection - Pathogenesis and treatment of candidiasis-associated HLH reviewed

HIV/AIDS Opportunistic Infection - Solid phase cytometry test provides rapid Aspergillus fumigatus detection

HIV/AIDS Pathogenesis - Immune response to SIV infection in African green monkeys investigated

HIV/AIDS Proteomics - HIV Tat interacts with Notch protein EGF-like repeats and the EGF precursor

HIV/AIDS Proteomics - HIV Vif induces G2 /M arrest in feline and bovine cells

HIV/AIDS Proteomics - Mechanisms of HIV Vif-induced APOBEC3G degradation identified

Infertility - Men and women in infertile unions benefit from psychosocial intervention

Anesthetics - Protein kinase C plays role in action of volatile anesthetics

HIV/AIDS RNA Research - Homology requirements for optimal antiretroviral shRNA activity clarified

HIV/AIDS Therapy - Distal mutation cooperation needed for HIV multiprotease inhibitor resistance

HIV/AIDS Therapy - High viremia at start of triple-drug ART linked to increased mortality risk

HIV/AIDS Therapy - LC-MS method for measuring zidovudine and lamivudine in mice developed

HIV/AIDS Therapy - Levels of anti-p24 IgG1 may mark HAART efficacy

HIV/AIDS Therapy - Thymidine analogue mutation patterns identified

HIV/AIDS Tuberculosis - Rifampicin does not affect enfuvirtide pharmacokinetics

HIV/AIDS Vaccine - Antigen engineering promotes induction of HIV-neutralizing antibodies

Aneurysm - Neuroform stent shows good results for cerebral aneurysms

HIV/AIDS Vaccine - Candidate HIV-1 subtype C DNA vaccine for South Africa characterized

Haplotypes - Close look at gene shuffling spots copying

Head Trauma - Low-dose radiation in infancy may affect intellect

Health News - WebMD Health releases their top ten health stories of 2003

Health Statistics - Teen birthrate drops 7% in Arkansas

Healthcare Access - Church project would establish clinic and free medical care

Healthcare Access - Cut in Colorado medical fund has immigrant advocates concerned

Healthcare Access - New foundation supports healthcare for residents of Indiana

Healthcare Benefits - Study finds working Oklahomans uninsured

Healthcare Economics - Study tallies high costs of health-related lost work productivity

Aneurysm - Nonsurgical treatment may be most beneficial for older adults

Healthcare Economics - Vanderbilt study explores new ways to cut costs

Healthcare Economics - Working-age minorities face greater prescription drug affordability problems

Healthcare Information - Low-income Internet users in California benefit from online medical searches

Healthcare Insurance - BENU Washington expands products and access

Healthcare Reform - Maine's universal health plan takes shape

Hearing - New strategic plan in place for communications service provider for the deaf

Heart Attack Risk Factor - Platelet reactivity increased in patients with diabetes

Heart Disease - Primary endpoints met in phase I/II clinical trial of DX-88

Heart Disease Risk Factor - Time from diabetes diagnosis to therapy related to carotid artery thickness

Heart Failure - Triage B-type natriuretic peptide test approved for use on Beckman Coulter platforms

Angina - U.S. Food and Drug Administration advisory committee evaluates Ranexa

Heart Surgery - Proton magnetic resonance spectroscopy useful for pediatric brain imaging

Heart Transplantation - Questions about the safety and efficacy of cardiac gene therapy persist

Hematology - Elevated cobalamin levels may indicate severe liver disease

Hematology - Gene regulation could modify autosomal-dominant giant platelet syndromes

Hematology - Thrombin interaction with platelet membrane glycoprotein Ib alpha discussed

Hematology - Vectors encoding the heavy and light chains of FVIII correct hemophilia A

Hematology/Oncology - Effect of aging on hematopoietic system reviewed

Hemophagocytic Lymphohistiocytosis - Familial hemophagocytic lymphohistiocytosis has mutated hMunc13-4

Hepatitis B Vaccine - Immunity persists 4 years after hepatitis B vaccination

Hepatitis B Virus - Rates on the decline in the United States but not among adults

Angiology - Elastin induces myofibrillogenesis via VGVAPG domain

Hepatitis B Virus - Study will compare two antivirals for lamivudine-resistant disease

Hepatitis C Virus - Persistently abnormal liver function tests: Marker of liver disease?

Hepatitis Virus - Antiseptic hand spray formula proven to kill hepatitis A, B and C viruses

Hepatocellular Carcinoma - A novel lipophilic platinum complex is effective in treating HCC

Hepatocellular Carcinoma - Gemcitabine is equivalent to other cytotoxic agents when used alone for HCC

Hepatocellular Carcinoma - Growth of hepatocellular carcinoma cells is arrested by troglitazone

Herpes Simplex Virus - Myeloid, not hepatic, C3 controls effectiveness of antibody response to HSV

Hormone Replacement Therapy - Compound discovered that lacks estrogen's risks

Hormone Replacement Therapy - FDA teams up with women's health organizations to raise awareness about HRT

Hormone Replacement Therapy - Study results have altered how physicians prescribe, women use HRT

Animal Models - Heart and eye disorders in murine MPS IV model identified

Huntington Disease - Could a protein have saved Salem's witches from burning at the stake?

Hypertension - High blood pressure may cause increased sE-selectin, sVCAM-1 in serum

Hypertension - Remodulin receives preliminary notice of approval in Switzerland and Australia

Hypertension - Two milestones achieved in the development of DNA-based diagnostic tests

Hypertension - Use of drug declined following release of trial results

Hypertension Therapy - Effects of apomorphine in hypertensive rats clarified

Hypertension Therapy - Lipid-lowering drugs have limited efficacy in Japanese hypertensives

Hypertension Therapy - Pharmacokinetics of irbesartan examined in aortic coarctated rats

Hypoparathyroidism - Researchers discuss the diagnosis and treatment of iatrogenic hypoparathyroidism

Hypothalamic Tumors - Researchers describe tanycytomas, a newly characterized tumors

Anopheles - Synergy of insecticide applied to mosquito nets described

Hypothalamus - Chromatin-derived acidic peptide exert effects in hypothalamus

Hysterectomy - Nerve-sparing radical hysterectomy is promising in preserving bladder function

Imaging - Ultrasound allows better visualization of hyperthermia technique

Immune System Function - Study of the unique mechanisms in ocular immune privilege may help other areas

Immunology - Heat shock protein 70 gene therapy and hyperthermia boost antitumor immunity

Immunology - Leptin has differential effects on monocyte ROS activity during HIV infection

Immunology - Natural killer cell functions mediated by neuropeptide substance P

Immunology - New label-free immunosensor for proteins is based on imaging ellipsometry

Immunology - Phagocytosis accelerates maturation of polymorphonuclear leukocytes

Immunology - Phase I trials initiated for a compound to combat several inflammatory conditions

Anthrax - Anthrax mounts nuclear attack on glucocorticoid signaling

Immunology - Protein makes LIGHT of cancer

Immunology - Regulatory T cells play a role in hepatitis C virus persistence

Immunology Research - $1 Million gift helps establish immunology center

Infection - Sale of ocular infection drug completed

Infection Control - Rubbing hands with antiseptic may help prevent nosocomial urinary tract infections

Infectious Disease - Immunologic features during different stages of Chagas disease characterized

Inflammatory Bowel Diseases - Bowel disease complications can affect the eye; problem can be better managed

Influenza - BCBSNC gives North Carolina Health Departments $300,000 for flu vaccines

Influenza - Flu outbreak tests new federal law limiting release of medical information

Influenza - Flu treatment options offered

Anthrax - Calcium may play role in folding pathway of anthrax protective antigen

Influenza - Influenza virus envelope cholesterol is required for virus entry, infectivity

Influenza - Nasal spray flu vaccine may help prevent influenza in healthy children

Influenza - Officials hope break brings flu downturn

Influenza - Sales of thermometers up 20% due to flu epidemic

Influenza Vaccine - Aggregate content influences Thl/Th2 response to influenza vaccine

Information Technology - ER information system selected by California healthcare provider

Information Technology - Maine health alliance to uses telemedicine to share data

Information Technology - New partnership helps with HIPAA compliance

Information Technology - Orthopedic outcomes software provided to Minnesota Clinic

Information Technology - Physicians use the Internet to remotely monitor heart failure patients

Anthrax - FDA clears lab culture test for anthrax

Information Technology - Smokers get cutting edge technology to help kick the habit

Inhaled Insulin - Human trials of Alveair insulin pulmonary technology about to begin

International Health - Paternal status affects pediatric mortality in Mozambique

Jaundice - Chinese herbal preparation speeds clearance of bilirubin

Kidney Transplant - Antibody-mediated kidney rejection can now be diagnosed, may soon be treatable

Klebsiella -  Klebsiella oxytoca harbors carbapenem-hydrolyzing beta-lactamase KPC-2

Lactation - Several factors determine whether urban women elect to breastfeed or not

Laparoscopic Ureteral Injury - Researchers review laparoscopic ureteral injury occurring during pelvic surgery

Leg Ulcers - Premarket approval application to be filed for venous leg ulcer treatment

Legal Issues - Biotech patent dispute settled

Pediatrics - Strategies for assessing child neglect reported

Anthrax - FDA issues final order on safety of bacterial vaccines and toxoids

Legal Issues - Doctors, employees seek to keep Philadelphia hospital open

Legal Issues - Insurer fires back at state claims in lawsuit

Leptin Studies - Rats have defective central leptin signaling before obesity onset

Leukemia - ALL leads to reduced bone volume and trabecular thickness in children

Leukemia - LISA set to transform children's cancer care

Leukemia - One-fifth of infectious deaths in children with ALL are due to fungal infections

Leukocyte Function - Tetraspanins form functional cell surface microdomains in leukocytes

Liver Cancer - A high percentage of liver cancers have elevated liver-intestine cadherin

Liver Disease - Caveolins regulate bile salt and cholesterol metabolism

Liver Transplantation - ICAM-1 is not linked to liver allograft ischemia-reperfusion injury

Anthrax Vaccine - Flow cytometric assay for responses to anthrax vaccine developed

Liver Transplantation - Imaging can detect complications of liver transplantation

Liver Transplantation - Splenic aneurysm after liver transplant may be treated by embolization, glue

Long QT Syndrome - New genetic "hit list" may underlie susceptibility to sudden cardiac death

Low Birth Weight - Heart rate irregularities in some babies may signal the onset of sepsis

Lumbar Spine Density - Researchers evaluate the clinical utility of dual-energy vertebral assessment

Lung Cancer - Aspirin use does not reduce lung cancer risk in men

Lung Cancer - Certain GST genetic polymorphisms are related to increased lung adenocarcinoma

Lung Cancer - Clinical trial under way for patients with brain metastases

Lung Cancer - NSCLC tumor response to chemotherapy can be assessed using RECIST guidelines

Lung Cancer - Researchers detect lung cancer in plasma with multiple genetic markers

Anti-Infectives - FDA approves manufacturing and marketing of Cefaclor Tablets, Chewable

Lung Cancer - Risk factors for acute lung injury after lung cancer surgery are identified

Lung Cancer - SOCS-3 is suppresses cell growth in human lung cancer

Lymphocyte Activation - Paracaspase is involved in B cell and T cell NF-kappa B-dependent activities

Lymphocyte Maturation - Activated Notch2 is involved in CD8 T-cell maturation, selects for B1 B cells

Lymphocyte Migration - IL-16 acts on CD4 associated with CCR5, inducing Th1 cell migration

Lymphoma - BRAF mutation may aid tumor development in some non-Hodgkin lymphoma

Lymphoma - Researchers assess expression of B-cell markers in classical Hodgkin lymphoma

Malakoplakia - Cervical malakoplakia is treatable by excision, antibiotics for E. coli

Malaria Diagnostics - Abbott Cell-Dyn 4000 useful for therapeutic monitoring of malaria patients

Malaria Drug Resistance - Novel pfcrt mutations seen in P. falciparum from the Philippines

Anti-Inflammatory - Binding site for anti-inflammatory tripeptide feG identified

Malaria Enzymology - Lipid-binding domain of PfCCT characterized

Malaria Immunology - In asymptomatic patients, IL-12 suppresses parasitemia and NOS activity

Malaria Therapy - Antiviral effects of chloroquine reviewed

Malaria Therapy - Combination drug therapy offers hope for millions

Measles - Health official plays down reports of Central African Republic epidemic

Measles Vaccine - ELISA and virus neutralization assay yield same measles antibody titers

Medical Devices - New agreement signed for "smart pump" devices

Medical Malpractice Insurance - Insurer raises malpractice rates in Florida by 45%

Medical Malpractice Insurance - Pennsylvania doctors to continue paying insurance

Medical Malpractice Insurance - University hospital, doctors form malpractice insurance company in Kentucky

Anti-Inflammatory Agents - CX-659X uracil compounds have topical anti-inflammatory potency like tacrolimus

Medical News - Harvard rates top 10 health/medical stories of 2003

Medical Technology - Global healthcare technology company chooses parts management company

Medical Technology - High technology trade fair to be held in Germany

Medical Waste - Joint venture negotiations for diagnostic software initiated

Melanoma - Agents directed at actin assembly would stop tumor aggression

Melanoma - Carboplatin and temozolomide have high toxicity in advanced melanoma patients

Melanoma - PET scanning can assess extent of disease in patients with metastatic melanoma

Meningioma - RT-PCR assay can rapidly identify telomerase RNA in intracranial meningiomas

Meningococcal Meningitis - BLA submitted for approval of Menactra

Menopause - Aromatase activity helps to maintain bone health after menopause

Antibiotic Research - Study of E. coli given cecropin B reveals antibiotic's mode of action

Menopause - Parathyroid hormone gene therapy may stop osteoporosis in postmenopausal women

Menopause - Some women turn to antidepressants to quell hot flashes

Mental Health - FDA approves medication for bipolar depression

Mental Health - Gestational stress harms maternal behavior in rodent models

Mental Health - Milestone payment resulting from depression and anxiety drug collaboration

Mental Health - The GHQ-12 assessment tool can't score pregnant and postpartum women adequately

Mergers and Acquisitions - Biopharmaceutical service company acquired

Mergers and Acquisitions - CRC Health Group acquires National Specialty Clinics

Mergers and Acquisitions - Drug discovery companies announce merger

Mergers and Acquisitions - European pharmaceutical sales, marketing business sold for $120M

Antibody Drug Conjugates - Exclusive antigen license taken under antibody drug conjugate collaboration

Mergers and Acquisitions - Express Scripts, CuraScript announce acquisition agreement

Mergers and Acquisitions - Healthcare management and healthcare services companies announce $80 million merger

Mergers and Acquisitions - Implant product manufacturer announces termination of acquisition negotiations

Mergers and Acquisitions - Insurer acquires provider of health insurance coverage to college students

Mergers and Acquisitions - Lab services and instrumentation company makes acquisition

Mergers and Acquisitions - Nutrition company completes acquisition

Mergers and Acquisitions - Pharmaceutical firms receive FTC request for information on transactions

Metabolic Syndrome - Genetic markers may signal a predisposition to metabolic syndrome

Metastatic Melanoma - Nitric oxide-mediates hypoxia-induced B16F10 melanoma metastasis

Molar Pregnancy - High-resolution vaginal ultrasonography may detect molar pregnancy

Antifungals - Terbinafine HCl Tablets receives tentative FDA approval

Monoclonal Gammopathy - IgM monoclonal gammopathy increases the risk for lymphoma and other diseases

Mosquito-borne Disease - Marsupials help prevent establishment of Japanese encephalitis in Australia

Multiple Myeloma - Breakthrough discovery puts researchers closer to cure for multiple myeloma

Multiple Myeloma - Survey shows low enrollment of multiple myeloma patients into clinical trials

Multiple Myeloma - Thalidomide Pharmion approved in New Zealand

Multiple Sclerosis - A genome screen of multiple sclerosis reveals 22 associated markers

Multiple Sclerosis - A genome-wide screen in HLA-DRB1*1501 positive MS patients yields three new links

Multiple Sclerosis - A genomic screen reveals 191 genes, 11 in the MHC region, linked to MS

Multiple Sclerosis - A linkage disequilibrium screen reveals 12 possible multiple sclerosis markers

Antigen Presentation - Full T-cell expansion, function require days of exposure to antigen complex

Multiple Sclerosis - A whole genome screen including families reveals only one sure gene linked to MS

Multiple Sclerosis - A whole genome study associates 91 markers with multiple sclerosis

Multiple Sclerosis - A whole genome study reveals 108 markers associated with multiple sclerosis

Multiple Sclerosis - A whole genome study reveals 46 genes associated with multiple sclerosis

Multiple Sclerosis - Confounding factors need to be worked out of MS whole genome linkage mapping

Multiple Sclerosis - Genetic screens reveal nine markers potentially related to multiple sclerosis

Multiple Sclerosis - Genomics research reveals 10 genes associated with multiple sclerosis

Multiple Sclerosis - Linkage analysis of families with MS shows chromosome 10, 10p15 involved

Multiple Sclerosis - MMP-9 degrades endogenous, therapeutic IFNbeta in MS; may be therapeutic target

Multiple Sclerosis - MS patient PBMC have decreased mRNA of apoptosis regulators CD95, caspase-8

Antigen Presentation - Uptake of polioviral RNA creates antigen by neosynthesis, specific CTL result

Multiple Sclerosis - Targeting of chemokine receptors may be able to control multiple sclerosis

Multiple Sclerosis - Two genome-wide screens of high risk Sardinians show five genes linked with MS

Multiple Sclerosis - Whole genome study of consanguineous Turkish MS families finds linked regions

Mumps - Mumps can be detected by IFA or shell vial culture of throat swab, urine

Murine Ehrlich Ascites Tumor - Tumor growth was delayed 4-6 days by treatment with 5-FU and ultrasound

Murine Melanoma - Fyn and cortactin cooperate in cell migration of metastatic murine melanoma

Muscle Diseases - Mixed connective tissue disease may have pathology due to lymphoid follicle

Myelodysplasia - Study looks at immune-suppressing treatments

Myelodysplastic Syndrome - Enrollment stopped for myelodysplastic syndromes monotherapy trial

Myelodysplastic Syndrome - New drug application submitted to market myelodysplastic syndromes therapy

Reproductive Biology - Researchers find gene key to production of egg and sperm

Antigen-Presenting Cells - APC-expressed indoleamine 2,3-dioxygenase degrades tryptophan; lowers atopy

Myelodysplastic Syndrome - Trial will compare Daclizumab to ATG to treat the cytopenia of myelodysplastic syndrome

Myocardial Infarction - Company seeks new drug indication for treatment of heart attack survivors

Nanoscience - University lands role in $70 million network for nanotechnology research

Narcolepsy - Hypocretin receptor 2 may be attacked in high-axon regions in human narcolepsy

Nausea - Addition of aprepitant to cisplatin improves chemo patients' quality of life

Nearsightedness - Review date set for phakic intraocular lens premarket approval application

Necrotizing Vasculitis - Respiratory problem testing for ANCA may find early Wegener granulomatosis

Needlestick Injury - LiftLoc safety infusion set product receives ISO Certification and CE Mark

Needlestick Prevention - ECRI, Novation team up to provide needlestick prevention information

Neurodegeneration - Role of CREB in neurodegeneration reviewed

Antimicrobial Peptides - Cathelicidins vary in resistance to proteolysis; some have sustained activity

Neurology - Epilepsy drug candidate begins phase I clinical development

Neurology - Lumbar epidural hematoma, falling, other trauma can cause acute paraparesis

Neurology - Neurotrophic and angiogenic growth factors augment electroconvulsive therapy

Neurology - Research may help stroke survivors with uncontrolled emotions

Neuroscience - Anoxic births foreshadow dopamine-related behaviors after puberty

Neuroscience - Gender and employment environment correlate with Parkinson disease epidemiology

Neuroscience - Layering defect linked to improper neuronal-glial interaction

Neuroscience - Neuropsin is novel opsin identified in mammalian neural tissue

Neuroscience - Overexpressed antioxidant enzymes protect nerve cells from necrotic insults

Neuroscience - Sickle red blood cells prefer to accumulate in tumor vessels

Antimicrobials - Analyst report recommends pharma company

Neutrophil Cytotoxicity - SLP-76 is essential for reactive oxygen intermediate formation in neutrophils

Norovirus - CDC: Nearly 65 passengers on cruise ship get stomach illness

Nutrition - Nearly one in four women make New Year's resolution to eat healthier

Obesity - Researcher gets $1 million to study thin people

Obesity - Researcher links rising tide of obesity to food prices

Obesity - Role of ectopic lipids in the metabolic syndrome reviewed

Obesity Diagnosis - Screening recommendations for obesity in adults released

Obesity Risk Factor - Early intrauterine exposure to tobacco increases obesity risk

Obesity Surgery - New techniques available for open-surgery management of morbid obesity

Obesity Therapy - Peripheral GLP-2 has no effect on gastric emptying or satiety

Antimicrobials - Lentivirus lytic peptide derivatives selectively toxic to airway pathogens

Obstetrics - Full placenta previa worsens pregnancy outcomes

Obstetrics - More episiotomies performed by private doctors than residents, hospital faculty

Obstetrics - Short-term exercise has little impact on fluid regulation during pregnancy

Obstetrics - Social and psychological factors predict alcohol use during pregnancy

Obstetrics - The Cambridge Worry Scale is reliable for assessing pregnant women

Obstetrics - Two midwives to run center in Iowa

Obstetrics - Urgent action required to prevent half a million maternal deaths annually

Occupational Safety - Hands may contain clues about fluorine poisoning

Oncology - Antisense inhibition of VEGF blocks leukemia angiogenesis and growth

Oncology - Cyclooxygenase 2 and survivin are often coexpressed in lung cancers

Antimicrobials - New classes of antibacterial oxazolidinones reported

Oncology - Multimodal therapy works well for treating caudate hepatocellular carcinoma

Ophthalmology - Different eye area DC have different abilities to react, be tolerant of antigens

Ophthalmology - FDA issues approval letter for dry eye treatment

Ophthalmology - Gender-specific gene polymorphisms associate with uveitis symtomatology

Ophthalmology - Intact sensory nerves are required for vascular remodeling after sympathectomy

Ophthalmology - Laser system selected for LASIK centers nationwide

Ophthalmology - Study: Primary care physicians not sending children with vision problems to the eye doctor

Ophthalmology - Vitamin E may combat macular degeneration

Opportunistic Infection - Etest suitable for Aspergillus voriconazole resistance testing

Oral Cysts - MR imaging of oral and maxillofacial cysts gives more information than X-rays

Antineoplastic Agents - A closed-system protective device reduces exposure to antineoplastic agents

Osteoarthritis - Chondrocyte HO-1 is regulated by cytokines depending on inflammatory properties

Osteoporosis - ANDA submitted for hormonal nasal spray that may combat osteoporosis

Osteoporosis - Agreement extended to collaborate on selective androgen receptor modulators

Osteoporosis - Calcium and sodium regulation supports osteoporosis and hypertension therapies

Osteoporosis - Extracts of Cortex Eucommiae augment bone growth and suppress bone loss

Otology - Major developments to improve hearing health reported

Outbreaks - Enrichment culture could aid laboratory detection of C. perfringens

Outbreaks - Rate and severity of serogroup X meningococcal meningitis in Niger clarified

Ovarian Cancer - Oral capecitabine is safe and effective in recurrent ovarian cancer

Ovarian Tumors - B-scan ultrasound is effective in evaluating ovarian masses

Antisense Technology - Antisense oligodeoxynucleotides to p53 and p21 augment cancer radiotherapy

Pain Management - FDA approves generic oxycontin

Pain Medicine - A woman's beliefs about childbirth rules labor anesthesia choices

Pain Medicine - Economic impact of back pain substantial

Pancreatic Cancer - Irinotecan plus cisplatin in advanced pancreatic cancer had severe toxicity

Pancreatic Carcinoma - Pancreatic head carcinoma may be difficult to differentiate from pancreatitis

Pancreatic Islets - Interactions of polymeric sulfonylurea with pancreatic islets examined

Parkinson Disease - Alpha-synuclein interacting protein gene and Parkinson disease studied

Patents - Patent announced for chewable oral contraceptive

Pediatric AIDS - More effective prenatal care could halt perinatal transmission of AIDS

Antitumor Agents - Vitamin E succinate may be a prototype for selective antitumor activity

Pediatric Obesity - Panel set to rid Florida schools of junk food

Pediatric Obesity - U.S. has highest prevalence of overweight teens in 15-country study

Pediatrics - Parental alcohol abuse has long-term consequences for offspring

Pediatrics - Reduced vitamin K doses would still benefit premature infants

Peptides - Vasoactive intestinal peptide blocks chemokine receptors

Perinatal HIV - Rapid HIV tests for women in labor studied

Perinatal Medicine - Neonatal care and practices have improved over the last 25 years

Personnel - Administration changes made at trade association

Personnel - American Physicians Capital board appoints new president, CEO

Personnel - Biopharma announces two executives

Antitumor Therapy - RNA aptamers can bind and inhibit CTLA-4, increasing antitumor activity

Personnel - Biotech firm appoints renowned biochemist to scientific advisory board

Personnel - Cardiovascular drug development company announces election of directors

Personnel - Chief financial officer resigns from biotech firm

Personnel - Cron named VP of surgical division at device firm

Personnel - Healthcare information management firms announced board resignation

Personnel - Imaging company technology officer steps down

Personnel - Medical device manufacturer announces new member to board of directors

Personnel - New consultant in transfusion science appointed

Personnel - New executive named for Illinois foundation

Personnel - New genomics executive named

Anxiety - Effexor XR provides long-term treatment of generalized anxiety disorder

Personnel - New health information company executive named

Personnel - New president named for biometric signature authentication firm

Personnel - Oregon BCBS announces executive changes

Personnel - Pain management company announces executive appointments

Personnel - Pharmaceutical company announces new chief business officer

Personnel - Pharmaceutical company founder and chairman steps down to nonexecutive role

Personnel - Risk management company names head of investigative services

Personnel - Rosa named VP, strategic development at molecular fingerprinting company

Personnel - Silverstein joins board of directors at pharmaceutical company

Personnel - Spineology names Jim Rybicki as vice chairman of the board

AIDS Epidemiology - American Indians see rapidly climbing AIDS infection rates

Apoptosis - Peptide increases arachidonic acid release and apoptosis of muscle cells

Personnel - Surgical company announces change in board of directors

Personnel - Therapeutics company announces management changes, promotions

Personnel - Tissue regeneration company appoints new board member

Personnel - Two new board members named at drug delivery company

Personnel - U.S. Dept. of Health & Human Services appoints National Advisory Council member

Pharmaceutical & Drug Development - The lambda-dynamics method improves analysis of HCV protease inhibitors

Photomedicine - Early-stage photodynamic therapy doesn't harm outer retinal function

Podiatric Surgery - Study shows reduced pain and narcotic use following foot and ankle surgery

Policy - Mozambique: U.N. human rights expert decries discrimination against AIDS patients

Population Descendance - Genetic markers show Iranian speakers in Azerbaijan related most to Azerbaijanis

Apoptosis - Targeting lipid raft protein distribution may control apoptosis

Preeclampsia - High PLA2 levels in decidual tissue may underlie acute atherosis

Pregnancy Complications - Mast cell degranulation supports anaphylaxis as result of amniotic embolism

Premature Birth - Alliance to provide care management for high-risk neonates

Prescribing Practice - Researchers update Beers criteria for medications to avoid in the elderly

Prescription Drugs - Companies announces new prescription information alliance

Prion Disease - Helix 1 peptide elicits antibodies against prion protein in mice

Professional Development - Cultural training increases competence of nonminority psychologists

Prostate Cancer - Adenoid cystic/basal cell carcinoma of the prostate requires ablative treatment

Prostate Cancer - CHEK2 gene variants play a role in hereditary prostate cancer

Prostate Cancer - Canadian company announces Phase II clinical study of prostate cancer treatment

Arthritis - Study identifies biological markers among patients with high risk of joint damage

Prostate Cancer - Cancer vaccine manufacturer obtains rights to Biogen Idec LFA-3 patents

Prostate Cancer - Erectile dysfunction affects quality of life after radical prostatectomy

Prostate Cancer - Green tea may be protective against prostate cancer

Prostate Cancer - Mayo Clinic presents results from the familial prostate cancer study

Prostate Cancer - Repeating the measurement of PSA symptomatic men can avoid unnecessary biopsy

Prostate Cancer - Scan of hereditary prostate cancer families finds dominant locus at 6p22.3

Prostate Cancer - Too much, too little vitamin D both increase prostate cancer risk

Prostate Cancer - p300 is important in prostate cancer proliferation and progression

Prosthetics - Hydraulic knee frame reintroduced to market

Proteomics - Approach to unnatural insertion of amino acids into proteins proposed

Arthritis Pathogenesis - Arthritis-regulating quantitative trait locus on rat chromosome 6

Proteomics - JNK and ERK activation in rabbit hippocampus is regulated by lithium

Proteomics - Neovastat stimulates tissue plasminogen activator activity

Proteomics - RACK1 gene regulated by nuclear factor-kappa B and promotes cell survival

Proteomics - Screening platform for protein analysis in intact cells developed

Proteomics - The death effector domain protein family may control life and death of cells

Pseudomonas - Scaffolds increase activity of efflux pump inhibitors against Pseudomonas

Psoriasis - Immunotherapeutic treatment for psoriasis discontinued

Psoriasis - PVAC program is discontinued due to lack of clinical benefit

Psoriasis - Study may indicate a new direction for psoriasis research

Psychology - Demographics link alcohol consumption risk and use by pregnant women

Assisted Reproduction - A CD16+CD56DIM NK cell increase may lead to idiopathic infertility

Psychology - Negative marriage interaction prefaces inadequate transition to parenthood

Psychology - Sense of Coherence surveys of college students lead to questions of validity

Pulmonary Embolism - MR angiography is useful for diagnosing pulmonary embolism

Pulmonary Medicine - Death certificate underestimates impact of obstructive lung disease on mortality in U.K.

Rabies - Disease remains a costly public health threat, says virologist

Receptor Studies - Gastrointestinal functions of proteinase-activated receptors reviewed

Receptor Studies - Role of proteinase-activated receptors in nervous system reviewed

Regulatory Issues - Paper: U.K.'s new National Health Service act will restrict choice of treatment location

Rehabilitation Medicine - Running a-fowl: Researchers measure energy used by leg muscles

Renal Medicine - Link between hyperhomocysteinemia and CVD in renal patients reviewed

Asthma - Corticosteroids do not appear to prevent early bronchial remodeling

Renal Transplantation - Renal transplant patients with headache may have intracranial hypertension

Reproduction Medicine - More use of sex-diagnostic techniques might change the gender ratio in India

Research Bias - Researchers find bias in radiologic studies

Respiratory Illness - Human metapneumovirus is responsible for many respiratory tract illnesses

Respiratory Syncytial Virus - Palivizumab and RSV-IGIV indications for respiratory syncytial virus revised

Restenosis - Positive phase II clinical results reported in trial of Resten-NG

Retinopathy - Thrombospondin-1 is essential for appropriate retinal vascular remodeling

Rheumatoid Arthritis -  HLA-DRB1*04 mutations disrupt stem-cell function

Rheumatoid Arthritis - Heat shock proteins for immunotherapy of rheumatoid arthritis reviewed

Rheumatoid Arthritis - Long-term study suggests vitamin D may help reduce older women's risk

Asthma - Exposure of babies to mite, cat can lead to asthma; repeat rhinitis lowers risk

Rosacea - Finacea 15% gel approved in E.U. countries

SARS - Angiotensin-converting enzyme 2 acts as receptor for SARS virus

SARS - Researchers assess putative protein targets derived from the SARS genome

SARS - Severe acute respiratory syndrome -associated coronavirus vaccine shows promise in monkeys

SARS - WHO wants China's suspected SARS case tested overseas

Saccharomyces -  Saccharomyces cerevisiae transcription factor defective in spt7 mutants

Salmonella Enterica - SopE, encoded outside the Salmonella SPI-1, is still chaperoned by InvB

Salmonellosis - U.S. outbreak of Salmonella enterica linked to mango consumption

Sarcoidosis - Refractory sarcoidosis may improve with infliximab therapy

Asthma - Long-term childhood asthma is likely to carry into adult asthma or wheezing

Schizophrenia - Human frizzled-3 gene on chromosome 8p21 linked to schizophrenia

Schizophrenia - Yeast two-hybrid screens implicate DISC1 in brain development and function

Senior Fitness - Pennsylvania insurance plan offers senior fitness program

Short Bowel Syndrome - Cell proliferation and survival occur via activation of GLP-2 receptors

Simian Immunodeficiency Virus - Development of SIV in sooty mangabey monkeys characterized

Simian Immunodeficiency Virus - Origins of mandrill- and drill-derived SIV reviewed

Sinusitis -  Trichoderma longibrachiatum can be a cause of sinusitis, atopy, and asthma

Sinusitis - OTC nasal wash shown helpful in treatment of sinus sufferers

Skin Cancer - Researchers measure daily UVB exposure in students using digital dosimeters

Skin Cancer - Winter outdoors fans urged to use sunscreen

Asthma - Recurrent wheezing higher in infants who show reduced interferon, plus less IFN-gamma

Smallpox - Researchers intrigued by century-old smallpox scabs

Sociology - Gender influences perceptions of social support

Spine Lesions - F-18FDG PET is highly predictive for spinal metastases or benign lesions

Squamous Cell Carcinoma - Smad7 cooperates with oncogenic ras in malignant conversion of murine SCC

Stem-Cell Research - Artemisinin staunches angiogenic effects in murine embryoid bodies

Stem-Cell Research - Candidate genes for maintenance of embryonic stem cell pluripotency identified

Stem-Cell Research - Embryonic stem cells can replace ear "hair" cells

Stem-Cell Research - Hematopoietic stem cells provide superior repopulation in mice

Stem-Cell Research - Main-population cells account for vast majority of Sk-34 cell activity

Atherosclerosis - Gene worsens artery disease

Stem-Cell Research - Modified stem cells relieve motor symptoms in a Parkinson disease model

Stem-Cell Research - P-selectin and ICAM-1 influence regulatory T-cell development

Stem-Cell Research - Serum-free medium with SCF can produce mature cord blood-derived mast cells

Stem-Cell Research - Thrombopoietin regulates early neutrophil differentiation

Stem-Cell Research - Types and activity of mammary epithelial progenitor cells reviewed

Stem-Cell Transplantation - Rhinolalia can mark dangerous post-SCT pulmonary complications

Stroke - Intra-arterial clot-dissolving therapy improves results of early stroke treatment

Systemic Lupus Erythematosus - Knowledge of the genetic basis for SLE has helped analysis of complex disease

AIDS Prevention - Mauritania: Imams join low-key campaign against AIDS

Atrial Fibrillation - ACP and AAFP release joint clinical guidelines to manage common heart condition

Systemic Lupus Erythematosus - Thromboembolism in pediatric lupus linked to anticoagulant

T-Cell Function - Venezuelan EEV replicons increase CD56+ T cells with NK-like activity

T-Cell Proliferation - T-cell apoptosis can be induced by cell cycle regulator p21 or peptide DQ 65-79

Testicular Cancer - Testicular microlithiasis is associated with germ cell tumors

Thrombosis - FDA approves lab tests for genetic clotting risk

Thrombus - Pronto extraction catheter receives 510(k) clearance from FDA

Thyroid Cancer - PP1 inhibitor targets RETMEN2A and RETMEN2B oncoproteins

Thyroid Cancer - Radioiodine increases risk of solid tumors, leukemias in thyroid cancer patients

Thyroid Cancer - Well-differentiated thyroid cancer can transform into an anaplastic tumor

Thyroid Tumors - Hurthle cell tumors composed of onocytes remain to be defined

Autoimmune Disease - Autoreactive B cells infected with EBV may be key to chronic autoimmune disease

Thyroid Tumors - Researchers explore the molecular basis of thyroid epithelial tumorigenesis

Tonsillar Cancer - HPV is not found in all tonsillar squamous cell carcinoma patients

Total Joint Arthroplasty - Researchers analyze ground reaction forces before and after TKA & THA

Total Knee Arthroplasty - Bone cement induces an increase in serum astroglial S-100B protein in TKA

Toxicology - "Homegrown" relief may aid victims of arsenic poisoning in South Asia

Toxicology - Bisphenol A metabolite levels in urine are gender-dependent

Transplant Medicine - Synthetic "antifreeze" could better preserve human cells and tissues

Transplant Medicine - Tacrolimus levels increase as a result of steroid withdrawal

Transplant Medicine - Transplant clinic expands services

Transplantation - Donations of both blood and tissue may yield better liver graft results

Autoimmune Disease - CNS autoimmune disorders may benefit from the statin anticholesterol drugs

Transplantation - Maintenance lamivudine lowers risk from HBV antibody-positive liver grafts

Transplantation - Refractory acute rejection thwarts some living liver graft implantations

Travel Medicine - U.K. public health agency issues reminder to travelers over malaria

Trypanosoma - Structure of thioredoxin from Trypanosoma brucei brucei determined

Trypanosomiasis - Diagnosing sleeping sickness outside Africa is difficult

Tuberculosis -  M. tuberculosis ethA and inhA gene mutations linked to ethionamide resistance

Tuberculosis - Lupus vulgaris can mimic wide array of conditions

Tuberculosis - TB-induced gastroduodenal artery pseudoaneurysm reported

Tuberculosis Genomics & Genetics -  M. tb strains have differential PE, PE_PGRS gene expression

Tuberculosis Immunology - Novel CD8 cell epitope shared by M. tuberculosis ESAT-6 proteins

Autoimmune Disease - EEA1 has many B cell epitopes; neurological disease may occur if at C terminal

Tuberculosis Pathogenesis - Differential mycobacterial gene expression seen in mice and humans

Tuberculosis Pathogenesis - Factors involved in failure of anti-TB immunity identified

Tuberculosis Therapy - CDC study will compare short versus long-term TB treatment regimens

Tuberculosis Therapy - Voltammetric assay provides accurate measure of isoniazid levels

Tuberculosis Vaccine - recA deletion mutant of M. bovis BCG confers protection

Tumor Angiogenesis - Delivering cationic liposomes to tumors improves antiangiogenic therapy

Tumor Growth - Small molecule shown to inhibit tumor growth in preclinical models

Tumor Necrosis Factor - There are several multimeric forms of RANKL involved in osteoclastogenesis

Tumorigenesis - The Bcl-2 family primarily determines cell survival

Type 1 Diabetes - Lymphocytic choriomeningitis virus infection stops diabetes in mice

Autoimmune Disease - Parasite lipids could be used against asthma or diabetes

Ulcers - The nitrite anion has role in mucous production

Urinary Tract Infections - Phase III trial begins with Doripenem in complicated urinary tract infections

Uveal Melanoma - MC1R variants do not appear to be related to uveal melanoma

Vaccine Adjuvant - CpG-containing oligodeoxynucleotides increase adjuvant effects

Vaccine Development - Tumor cell vaccines containing nonviral vectors offer cancer prevention

Vaccine Efficacy - Cost-utility analysis of vaccine strategies in Switzerland released

Vaccine Safety -  Vibrio cholerae toxins activate proinflammatory immune response

Vaccines - Investigational new drug application to be filed for HIV vaccine

Varicella Vaccine - Incidence of herpes zoster in children reported

Vascular Endothelium - Activated lymphocyte, neutrophil migration may be regulated by L-selectin

Autopsy - Autopsy imaging may provide more precise information about final diagnosis

Vector Development - Moderate retroviral transduction limits the potential for multiple insertions

Vectors and Zoonoses - Genetic variation in Aedes aegypti characterized

Vectors and Zoonoses - Single gene encoding VDAC protein identified in Anopheles gambiae

Venous Thromboembolism - New drug application submitted to FDA for Exanta

Viral Genomics - Common antivirals can't totally block hepatitis B virus infection

Viral Genomics & Genetics - South American dengue-1 viral genotypes determined

Viral Hepatitis - Estrogen exposure may confer protection against liver cancer

Viral Proteomics - Antivirals are tools for analyzing hepatitis B virus genomic replication

Viral Proteomics - Hemagglutinin uses "leash in the groove" mechanism for membrane fusion

Virology - Effects of GBV-C co-infection on HIV progression reviewed

Awards - Thompson honored for his contributions to medicine, public health

Waste Treatment - Recycling company looks to expand business in China

Water-borne Disease - Novel assay improves detection of Cryptosporidium in water

Weight Loss - Pilates and paella: Gyms selling food plans to help members lose weight

Wound Care - Oxygen exposure improves wound healing rate

Bacteriology - Amino acids and peptides may help protein removal and innate lung defense

Bacteriology - Chemical signaling among bacteria and its inhibition reviewed

Bacteriology - DNA-membrane interactions can localize bacterial cell center

AIDS Therapy - DSMB recommends continuation of phase I trial with VRX496 modified T cells

Bacteriology - Needle length of bacterial injectisomes determined by molecular ruler

Behavior - Kids exposed to violence have more behavioral problems

Behavioral Medicine - Factors affecting validity of self-reports among adolescents determined

Biodefense - Landmine sensor to be tested by U.S. Army

Biodefense - Safe room kit available for home protection

Bioengineering - Continuous delivery of microencapsulated interleukin-1 diminishes angiogenesis

Bioengineering - VEGF gene transfer enhances the function of implantable sensors

Blood Pump - Researchers test a centrifugal blood pump with a magnetic bearing

Blood Safety - Japanese transfusion recipient infected by HIV-tainted blood

Blood Substitute - Patient enrollment begins for urban ambulance/blood substitute trial

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