Leptin Studies
Rats have defective central leptin signaling before obesity onset
Published in Health and Medicine Week, January 19th, 2004
According to published research from the United States, "Rats selectively bred to develop diet-induced obesity (DIO) were compared with those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin signaling and blood-brain barrier (BBB) transport. Peripheral leptin injection (15 mg/kg ip) into lean 4- to 5-week-old rats produced 54% less anorexia in DIO than DR rats."
"DIO rats also had 21, 63, and 64% less leptin-induced immunoreactive phosphorylated signal transducer and activator of...
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