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Health and Medicine Week

Susan Hasty, Publisher

Table of Contents . . . February 9th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Health and Medicine Week | Other Publications

Nutrition - Eggplant found to have an antioxidant kick

AIDS Infection - Bulgarian medics trial postponed

Breast Cancer - Increased Bim mRNA and protein can cause apoptosis in breast cancer cells

Breast Cancer - Magnetic resonance imaging detects more tumors

Breast Cancer - Normal HC11 and ras-transformed mouse mammary cells are resistant retinoic acid

Breast Cancer - Pathologic study of reduction mammaplasty tissue should be performed routinely

Breast Cancer - Proteins and antibodies licensed for human cancer research

Breast Cancer - Radiotherapy improves survival after early stage, breast-conserving surgery

Breast Cancer - Review of patient-tailored cancer treatment completed

Breast Cancer - Symposium calls for improved access to screening, treatment across Europe

Breast Cancer - Trial seeks patients in Southern California

Breast Implants - Breast implant prosthesis may offer alternative to saline and silicone

AIDS Research - Thailand rejects criticism of AIDS vaccine trial

Breast and Lung Cancer - Salivary-type neoplasms of the breast and lung need further molecular study

Bronchogenic Carcinoma - Exercise testing may predict surgical risk of pneumonectomy

Burn Medicine - Pediatric burn patients need vitamin D supplements

Business & Finance - Blue Cross profits among fastest-rising in early 2003

Business & Finance - Firm acquires Nevada medical center from Tenet

Business & Finance - HMO's move could push more in Missouri, Kansas to high-risk insurance pools

Business & Finance - Managed care medical directors, execs rank drug firms by ability to meet needs

Business & Finance - NABN selects disease management programs and services provider

Business & Finance - Plan realizes major ROI with care-management decision support

Business & Finance - South Carolina healthcare nonprofit plans to file for bankruptcy

AIDS Therapy - IND application filed for protease inhibitor GS 9005

Business & Finance - Subsidiary question kills health insurance transfer

Business & Finance - Trustees reach agreement for company to operate Oklahoma hospital

Cancer Cell Biology - Scientists identify cell defects that limit immune system's impact on late-stage tumors

Cancer Databases - Center goal is to speed detection, treatment and prevention of cancer

Cancer Epidemiology - Using established epidemiological methods can best answer molecular questions

Cancer Fraud - Ohio woman sentenced for faking cancer and collecting donations

Cancer Incidence - Exposure to high levels of trichloroethylene may be increase risk of NHL

Cancer Metastasis - PTEN gene inactivation associates with breast cancer dissemination

Cancer Outcomes - Patients enrolled in cancer trials do not necessarily fare better

Cancer Research - U.K. program for clinical research launched in London

AIDS Treatment - AIDS activists fight for more affordable drugs

Cancer Surgery - Excisional surgery for cancer cure may have adverse effects

Cancer Symptoms - Researchers summarize mechanisms underlying cancer-induced symptoms

Cancer Therapy - CRADA inked for pancreatic, ovarian, and lung cancer antibody development

Cancer Therapy - Company reports on mechanism for immunotherapy cure of prostate cancer

Cancer Therapy - DFMO did not improve outcomes in superficial bladder cancer study

Cancer Therapy - Patent granted for humanized CEA antibody conjugates

Cancer Therapy - The cytocidal gene construct rexin-G arrests pancreatic tumor growth

Cancer Therapy - Therapies that control VEGF production look appealing for treating cancer

Cancer Vaccine - Cancer vaccine delivers antigen to dendritic cells

AIDS Treatment - Companies agree to drop price of AIDS-combating drugs sold to Brazil

Carcinogenesis - Arsenic is associated with increased cancer incidence

Cardiac Safety Testing - Company can help clients meet FDA cardiovascular requirements

Cardiac Surgery - Brain injury during adult cardiac surgery may be reduced

Cardiology - Clonal embryonic cardiac development characterized

Cardiology - Embryonic atrial function steers embryogenesis, cardiac growth, and angiogenesis

Cardiology - Enhanced permeability explains reduced calcium uptake in cardiac mitochondria

Cardiology - Function of FGF8 during embryonic development elucidated

Cardiology - GATA4 triggers cardiomyocyte development in Xenopus explants

Cardiology - Inotropic, chronotropic responses vary during dobutamine stress echocardiography

Cardiology - Nkx2.5 regulates Cx43 expression in neonatal cardiomyocytes

AIDS and HIV - Gene product restricts HIV-1 replication in resting CD4+ lymphocytes

Cardiology - Polyurethane implants deliver site-specific therapy with tethering systems

Cardiology - Sorcin gene therapy reverses cardiac function in diabetes-linked heart disease

Cardiovascular Disease - Aging, heart failure reduce cutaneous vascular reactivity

Cardiovascular Disease - Colchicine can cause kidney damage in heart failure patients

Cardiovascular Disease - D-dimer levels predict cardiovascular events in AF patients on OAT

Cardiovascular Disease - Late sequela of infective endocarditis possible

Cardiovascular Disease - NAD(P)H oxidase p22 phox mutations do not affect CVD risk

Cardiovascular Disease - Optimal CFVR cut-off for LAD stenosis diagnosis identified

Cardiovascular Disease - Role of P-selectin in atherogenesis reviewed

Catheter Systems - Company announces market release of two left-heart delivery systems

Accreditation - First Health receives URAC accreditation for health provider credentialing

Cell Biology - Angiomotin enables endothelial cells to respond to chemotactic cues

Cell Biology - Findings uncover workings of cell's energy machinery

Cell Biology - Gene causing tumors by "double-whammy" mechanism also reveals the key to a cure

Cell Biology - Vascular endothelial growth factor receptor-1 fosters matrix protein activity

Cell Biology - Wnt-1 signals could be major players in angiogenesis regulation

Cell Signaling - Complete picture of a human immune pathway revealed

Cell Transduction - A unique coculture system improves in vitro investigations of gene therapy

Cerebral Malaria - Misdiagnosis common in patients who die after coma

Cervical Cancer - Cervical cancer staging is based on clinical, anatomic disease extent

Cervical Cancer - Cervical neoplasia is an HPV-associated malignancy

Acute Myocardial Infarction - Research focuses on drug-free heart attack prevention

Cervical Cancer - Chemotherapy for carcinoma of the cervix has improved outcomes

Cervical Cancer - Clinical trial data show noninvasive technology could reduce false positives

Cervical Cancer - Combined therapy is standard treatment for Stage IIB-IVA cancer of the cervix

Cervical Cancer - DNA testing for HPV complicates management of atypical cervical cytology

Cervical Cancer - Hong Kong diva's death inspires Singapore women to screen for cervical cancer

Cervical Cancer - Role of injectable progesterones in cervical cancer remains unconfirmed

Cervical Cancer - System for cervical cytology reporting is updated

Cervical Cancer Screening - Self-sampling and direct sampling for HPV compared

Chemotherapy - Helsinn signs licensing agreement for palonosetron with Japanese firm

Child Protection - Utah legislators to make parents' rights an 'emotional' issue

Acute Myocardial Infarction - Scientists to study use of fat-derived regenerative cells for treating heart attack

Children's Health Insurance - Connecticut plan would drop kids from state insurance

Children's Health Insurance - Florida lawmakers haggle over funding care for uninsured children

Chiropractic Coverage - Insurers, chiropractic association meet to improve relations

Chlamydia - New screening programs launched in U.K. to reduce STD incidence

Cholera - First mass cholera vaccination begins

Chronic Liver Disease - Interferon-gamma-inducible protein 10 denotes HCV-linked liver status

Chronic Myeloid Leukemia - Marrow fibrosis indicates therapy failure in chronic myeloid leukemia

Clinical Trials - Patient recruitment company says its panel exceeds 6 million members

Clinical Trials - Proper metrics for clinical trials outlined

Addiction Medicine - Alcohol has a dose-dependent effect on endothelial adhesion molecules

Cloning - Leading researcher says anticloning bill would be a mistake

Coagulation Therapy - Is LAA elimination suitable for atrial fibrillation treatment?

Cochlear Implant - Tuning the noise level optimizes performance of tasks in cochlear implants

Cochlear Implants - Penetrating electrode auditory device successfully implanted

Cognition - Long-term progesterone deficits improve spatial performance in older rats

Collaborations - Agreement signed with Atria Genetics for tissue typing tests

Collaborations - Agreement signed with J&J to validate GPCR targets using aptamers

Collaborations - Alliance focuses on development of nanotechnology-based chemical sensors

Collaborations - Alliance targets development of protein activity profiles

Collaborations - Alliance with Baxter to discover anti-MIF antibody

Systems Biology - Science needs a model of complex living systems, Sorger says

Adolescent Health - New reproductive health program informs girls in Nairobi slums

Collaborations - Biomaterials products, services orders exceed $2M in fourth quarter

Collaborations - Biopharmaceutical company enters joint SARS clinical program with Vanderbilt

Collaborations - Companies join forces to accelerate clinical trial recruitment for drugmakers

Collaborations - Deal signed with Fujisawa to develop AGI-1096 for transplant rejection

Collaborations - Drug discovery partnership to collaborate on cardiovascular therapeutics

Collaborations - Fosrenol licensing agreement expanded with Shire Pharmaceuticals

Collaborations - GPC biotech announces achievement of new milestones

Collaborations - Genedata expands genomics-based drug discovery collaboration

Collaborations - Grant received for drug development; enzyme deal signed

Collaborations - KV Pharmaceutical adds to pipeline via development and marketing agreement

Adolescent Health - Rio's mayor nixes teen birth-control plan

Collaborations - M&H Informatics enters agreement to provide packaging solution

Collaborations - Medco, UnitedHealthcare renew strategic relationship

Collaborations - Metabasis joins forces to develop hepatitis C therapeutic

Collaborations - NIH research agreement signed to develop rapid vaccine production system

Collaborations - New cancer vaccine program launched

Collaborations - NextGen Healthcare added to AccuSoft's customer roster

Collaborations - Partnership with Wyeth to develop therapeutics for neurological disorders

Collaborations - Pharmaceutical company announces research milestone with AstraZeneca

Collaborations - Pharmaceutical company identifies SARS antisense drug candidates

Collaborations - Pharmaceutical firms sign deal to develop drugs for Alzheimer disease

Adolescent Health - Survey finds 8,000 clandestine abortions occur yearly in Burkina Faso capital

Collaborations - Program launched to create whole-genome arrays

Collaborations - Research alliance, licensing agreement targets RNA interference

Collaborations - Systems biology company to develop hematology model for Johnson & Johnson

Colon Cancer - Eloxatin approved in U.S. for treatment of metastatic colorectal cancer

Colon Cancer - Larger colon tumors need more injected dye to identify sentinel lymph nodes

Colon Cleaning - Phase II study to begin on new purgative product

Colorectal Cancer - Aggrus expression is frequently upregulated in colorectal tumors

Colorectal Cancer - BRAF mutations associated with sporadic colorectal cancers

Colorectal Cancer - Beta-catenin has a role in invasion and metastasis of colorectal carcinomas

Adolescent Health - Teen abortion, pregnancy rates declining in Washington state

Colorectal Cancer - Clinical trials use gene therapy for GI cancer

Colorectal Cancer - Increased fiber intake is associated with a smaller risk of colorectal adenomas

Colorectal Cancer - Tumor-related Rac1b not regulated by Rho-GDP dissociation inhibitors

Complementary and Alternative Medicine - Aromatherapy offers plant-based nurturing and soul soothing

Complementary and Alternative Medicine - CAM treatments could hinder cancer treatment

Conference Announcement - Medicare drug legislation among emerging issues at healthcare law conference

Constipation - Second phase II trial initiated for opioid-induced constipation treatment

Aging - Getting older tied to lower self-esteem

Constipation - Second phase III efficacy study for constipation treatment completed

Consumer-Driven Healthcare - Blue Cross launches new plan for small-group employers

Contraception - Large clinical trial launched to test "male Pill" in 14 European centers

Contraception - Low-dose levonorgestrel is an effective emergency contraceptive

Contraception - Virginia university resumes distribution of emergency 'morning after' pill

Cord Blood - Singapore to ask mothers to donate cord blood

Coronary Artery Bypass - Veterans' healthcare agency has more care problems than private sector hospitals

Coronary Artery Disease - $1M milestone payment received for initiation of Binodenoson trial

Coronary Artery Disease - Statins prevent AF in chronic stable CAD patients

Airway Dysfunction - Device to improve breathlessness is focus of innovative program

Coronary Bifurcations - CE Mark granted for the Axxess bifurcated stent system

Corporate Update - Biotech device company launches in San Francisco bay area

Corporate Update - Genome5000 program has yielded more than 40 drug discovery programs

Corporate Update - HealthSouth further strengthens corporate governance and compliance practices

Corporate Update - Macrofluidics, microfluidics company changes name

Corporate Update - Oncology drug maker reports initial guidance for 2004

Corporate Update - Significant increase in Levulan Kerastick end-user sales

Corporate Update - Supplement maker discusses progress in refocusing business

Corporate Update - Urological device maker restructures both operating divisions

Correctional Health - Inmates increasing medical bills create budget shortfall

Allergy Drug Trends - Popularity of OTC allergy meds puts prescription drugs under price pressure

Counterfeit Drugs - Millions of fake drugs seized

Courts - Victims of cancer drug dilution scheme to receive checks soon

Cutaneous Lymphoma - Researchers propose guidelines for managing primary cutaneous T-cell lymphomas

Cutaneous Melanoma - p53 Arg/Arg genotype linked to higher risk of cutaneous melanoma over age 50

Cystic Fibrosis - Gene conjugates can be delivered to the airway of fetal sheep in utero

Cytomegalovirus - RNAi program initiated to develop therapies for diseases associated with CMV

DNA Vaccine - Hepatitis delta antigens cause varied immunity in mice

DNA Vaccine - RANK-L gene improves the T cell immune response to infectious agents

Deep-Vein Thrombosis - Study shows DVT preventative treatment not implemented in high-risk patients

Dental - Company gets nod to sell Endopore dental implant in Mainland China

Allergy Medicine - Inactivated split influenza vaccine safe in children with asthma

Depression - Mental illness tied to hypertension by family history

Depression - Nurses can play role in helping cancer patients keep the blues at bay

Depression - Paxil CR receives Canadian approval

Dermatology - FDA clears phototherapy technology developed in Israel

Dermatology - Gene targeting alters keratin 17 expression in murine hair follicles

Dermatology - Inamed acquires license rights to Juvederm

Developmental Biology - Researchers describe cell activity leading to disruption of neuron migration

Diabetes - Overweight Hispanic youth face increased risk of diabetes, metabolic syndrome

Diabetes Complications - Models project links between diabetic retinopathy and kidney disease

Diabetes Pathogenesis - Autoantibodies target beta cell retroviral protein in diabetic mice

Alzheimer Disease - A-beta single chain Fv antibodies isolated from immune phage library

Diabetes Pathogenesis - Co-transfer system in young prediabetic BB rats developed

Diabetes Pathogenesis - IL-18 promotes diabetes development in young nonobese diabetic mice

Diabetes Pathogenesis - Insulin resistance found in offspring of rats using alcohol while pregnant

Diabetes Pathogenesis - Mechanisms of oxidative stress in diabetes reviewed

Diabetes Surgery - Maternal pancreatic islet transplant prevents hypothalamic defect in rat pups

Diabetes Therapy - Transfer of flt-3L-derived dendritic cells delays diabetes development

Diabetic Nephrology - Bosentan protects against diabetic nephrology in diabetic rats

Diabetic Neuropathy - Hyperbaric oxygen is effective adjuvant therapy for diabetic foot ulcers

Diabetic Retinopathy - Gene mutations correlate with proliferative eye disease in diabetes patients

Diagnostics - New method for rapid protein sequence analysis developed

Alzheimer Disease - Gamma Secretase HTS Assay may help further Alzheimer research

Dialysis Catheters - Researchers describe a technique to correct migrated Tenckhoff catheters

Diet and Cancer - Researchers report common and country-specific dietary patterns in Europe

Diet and Nutrition - Chongkukjang improves glucose, lipid levels in diabetic rats

Diet and Nutrition - Maternal diet influences offspring longevity, murine study shows

Diet and Nutrition - Some tomatoes have antithrombotic effects

Dietary Cancer Exposure - Polycyclic aromatic hydrocarbons in foods increase cancer risk

Distribution Agreement - Lifeline to distribute Hexalon bioabsorbable ACL/PLC screw

Drug Abuse - Abuse-resistant form of oxycodone undergoes clinical testing

Drug Approvals - FDA grants approval for generic contraceptive, manic disorder drug

Drug Costs - FDA says U.S. generics a better bargain than many Canadian drugs

Depression - Friendships can help prevent teen suicide

Alzheimer Disease - Gene technique targets memory loss

Drug Development - Antimicrobial agents isolated from Turkish Pimpinella plants

Drug Development - Company signs NIH agreement to develop vaccines

Drug Development - FDA approves generic drug manufacturer based in India

Drug Development - Lavendamycin analogues show promise as antiretroviral agents

Drug Development - Liminoids strongly inhibit HIV protease activity

Drug Development - Pharmaceutical company chooses preferred chemical supplier

Drug Development - Report: FDA will be pressed to do more with less

Drug Development - UMass medicine hunter tracks plants with healing promise

Drug Discovery - Microfluidics firm introduces system to increase analytical HPLC throughput

Drug Discovery - Microplate standards expected to accelerate, streamline industry

Alzheimer Disease - Grants to fund studies of families caring for Alzheimer patients

Drug Discovery - Research collaboration and technology transfer agreement expanded

Drug Resistance - Liposome-based approaches can target drugs to tumor tissue

Drug Resistance - New advance to combat antibiotic-resistant pneumonia and malaria

Education - Agreement to admit HIV-positive children into Nairobi's public schools approved

Elastomeric Medical Devices - Device master file submitted to FDA for absorbable elastomeric biomaterial

Electronic Medical Records - Electronic health records system proposed to improve healthcare

Employer-sponsored Health Insurance - Business leaders meet with senator's staff on healthcare pools

Employer-sponsored Health Insurance - Lawmaker says North Dakota Legislature should reconsider employee benefits

Employer-sponsored Health Insurance - Small business groups have mixed feelings about association health proposal

Employer-sponsored Health Insurance - West Virginia businesses on board with new health plan

Alzheimer Disease - Namenda now available nationwide

End-of-Life Care - Arizona bill would create online medical-directive registry

End-of-Life Care - Psychologists can be helpful for end-of-life decisions

End-of-Life Care - Study: Most Nebraskans wish to die at home; few do

Endocrinology - Endocrine factors underlie bone disease in cirrhotic men and women

Endocrinology - High estrogen levels may make the brain more vulnerable to stress

Endocrinology - Race has little impact on adrenal hormone response to submaximal exercise

Endometrial Cancer - Surgical staging directs appropriate use of radiotherapy

Enterococcus - Glycopeptide-resistant Enterococcus faecium found in ICU

Environmental Health - Method for dual measurement of urinary bisphenol A and alkylphenols developed

Environmental Health - Study: Agent Orange linked to cancer risk

Alzheimer Disease - Pittsburgh Compound B gives unique view of amyloid plaques in living human brain

Enzymology - Lack of matrix metalloproteinase-9 ensures faulty bone formation

Enzymology - Non-apoptotic functions of caspase-3 in nervous tissue reviewed

Enzymology - RhoA stimulates signals conductive to endothelial cell invasion

Ephedra - Methods of addressing potential risks associated with ephedra use reviewed

Epidemiology - Hepatitis B virus pre-S mutants flourish in countries with HBV endemicity

Epidemiology - Prevalence of mental, physical disorders varies within U.S. black population

Epilepsy - Expanded indication for Lamictal offers additional treatment options

Epilepsy - Rights to epilepsy drug, DP-VPA, reacquired from Shire

Escherichia Coli - Expression of N-formylated proteins in E. coli described

Evolutionary Biology - Oxygen triggered the evolution of complex life forms

Alzheimer Disease - Potential tool would aid diagnostic and therapeutic research

Fabry Disease - Biopharmaceutical company to ceases to seek U.S. approval of Replagal

Facilities - Global Life Sciences acquires property in Berlin, Germany

Fatty Liver Disease - The etiology of liver steatosis is often virus-related

Fecal Incontinence - Published trial data demonstrates safety and efficacy of Secca procedure

Fertility Risk - Family faces risks in birth of sextuplets

Fertility Services - IntegraMed America announces new contract

Finance - $135M credit facility positions ResCare for growth in 2004

Finance - Benemax's global insurance pool reduces benefit costs

Finance - Biopharmaceutical company concludes $30M second round of financing

Finance - Biotech company reports strong revenue growth for fourth quarter and 2003

Alzheimer Disease - Researchers begin unique study of brain's tangles

Finance - Biotechnology company closes on initial round of seed funding

Finance - Blood pressure company raises $5 million of additional capital

Finance - Blood safety products company announces $6.6 million private placement

Finance - Company completes sale of therapeutic plasma business

Finance - Company proposes increase in number of authorized common shares

Finance - CompuMed maker announces a 1-for-3 reverse stock split

Finance - Device company reports $0.02 per share loss

Finance - Diagnostics company announces closing of private offering

Finance - Diagnostics company reports loss of $0.12 per share

Finance - Endoscope maker announces fourth quarter 2003 revenues of $12.5 million

Alzheimer Disease - Two proteins may help prevent brain plaques

Finance - Genetics company announces $2.15M private placement

Finance - Genomic-marker company completes $5.4 million series A financing

Finance - Horizon Health Corp. announces first-quarter results

Finance - LCA-Vision provides 2004 guidance; expects increase over 2003

Finance - Life sciences fund closes year with $211M commitment

Finance - Medical device company sees fourth quarter sales increase of 15%

Finance - Medical device maker increases revenue, earnings guidance for 2003

Finance - Medical device maker reports 3Q earnings per share of $0.13

Finance - Metabolic-focused company raises $4M in second close of private financing

Finance - Molecular regeneration company raises $18.875 million in series B financing

Amyotrophic Lateral Sclerosis - AEOL 10150 clears toxicology hurdle; company makes initial draw on financing

Finance - Nanoparticle drug developer reports loss of $0.12 per share

Finance - Nanotechnology developer secures $5M in second-round venture capital financing

Finance - Ophthalmic laser company reports record fourth quarter

Finance - Orders for heparin-coated cardiopulmonary products generate $250,000

Finance - Period extended for acquisition of up to 20% of device company's shares

Finance - Pharmaceutical companies reinvest 10% of revenues to extend product lines

Finance - Pharmaceutical company announces $15M financing, deal with Intel

Finance - Pharmaceutical company announces closing of $50M round C financing

Finance - Pharmaceutical company gets listing on the Frankfurt Stock Exchange

Finance - Pharmaceutical company launches third venture capital fund

Aneurysm - Study confirms good results of coil treatment for aneurysms

Finance - Pharmaceutical company raises $14 million in private offering

Finance - Pharmaceutical company raises $3.7 million in private placement

Finance - Pharmaceutical company raises $41 million in series B financing

Finance - Pharmaceutical company retires over 46% of outstanding common stock warrants

Finance - Pharmaceutical company secures $12M under new management

Finance - Research organization reports 33% increase in operating income

Finance - Veronate maker completes $20 million private placement

Financial Planning - AHA selects Kaufman Hall to provide financial planning tools, services

Fitness - Record number of people ran marathons in 2003

Food-borne Illness - Main bacteria contributing to histamine formation in seafood identified

Angiogenesis - Patent granted for antiangiogenic treatments using VEGF inhibition

Food-borne Illness - Results from viral monitoring of oysters in polluted estuary reported

Food-borne Illness - Rugged LC-MS/MS survey analysis developed for acrylamide in foods

Food-borne Illness - Vitamin E may be key to listeria-free turkeys

Foot Ulcers - Initial dosing complete in phase I chronic diabetic neuropathic foot ulcer trial

Gastric Cancer - A PI3K inhibitor holds promise as an antitumor agent for gastric carcinoma

Gastroenterology - Effects of CDX2 on ileal bile acid-binding protein promoter outlined

Gastroenterology - Gemcitabine halts ascites formation in patients with pancreatic cancer

Gastroenterology - Thymidylate synthase antisense blocks the oncogenic properties of colon cancer

Gene Delivery - PPE-EA attains sustained gene expression in the central nervous system

Gene Expression - Company announces six human genomes on a single BeadChip

Geriatrics - Combined analysis identifies elderly women who are at risk for hip fracture

Animal Models - Diets with different levels of soy affect toxicity assessments in rats

Gene Expression - Gene-disabling technique simplified by medical school team

Gene Expression - Roche to license Eberwine linear RNA amplification technologies

Gene Mapping - Oxford joins HapMap project

Gene Therapy - HIV vector T-cell transduction efficiency is not pseudotype-dependent

Gene Therapy - Phase I/II HIV gene therapy trial initiated

Generics - Innovative Cos. announces first generic drug; human version in pipeline

Genetic Disorders - Malays with distal renal tubular acidosis have high rate of SE Asian ovalocytosis

Genetic Engineering - California county to vote on banning genetically engineered plants, animals

Genetic Research - Asians could benefit from education about genetic research

Genetic Research - Transgenomic to distribute NanoChip Molecular Biology Workstation

Anthrax - Contract signed with Pentagon to supply vaccine

Genital Herpes - Healthy women volunteers sought for final trial phase of herpes vaccine

Genomics and Genetics - Genetic interaction controls intestine length in PRM/Alf mice

Genotyping - Reagent, software product launched for use with genetic analyzers

Geriatrics - The relationship between gender and well-being among older people is complex

Germ-Cell Tumors - Genetic, environmental factors evaluated in germ-cell cancer of three brothers

Gerontology - Vasomotor function loss in elderly linked to eNOS phosphorylation

Glaucoma - Company reports updates in glaucoma, arthritis trials

Global Health - To tackle poverty: Empower women and educate girls, U.N. leader says

Glucose Testing - Florida Medicaid selects provider of monitoring system

Gynecologic Oncology - CYP1A1 polymorphism unrelated to gynecological malignancies in the Japanese

Anthrax - Small-molecule inhibitors of anthrax lethal factor identified

Gynecologic Oncology - New surgical blood ordering system is efficient and saves money

Gynecology - Gynecological practice must include continuing education in relational roles

HIPAA - 90 Days after deadline, payers rejecting more physician claims

HIV Diagnosis - Prototype of a portable detector for protein diagnosis developed

HIV Transmission - Jury finds Iowa City man guilty of criminal transmission of HIV

HIV Treatment - New drug class may enable body's immune system to halt HIV infection

HIV/AIDS - HIV identification bill moves through committee

HIV/AIDS - India's Catholic Church issues guidelines for treating HIV/AIDS

HIV/AIDS Cancer - Low B-cell counts linked to heightened Kaposi sarcoma risk

HIV/AIDS Cancer - Serum preferable to plasma for KSHV load testing

Antibiotic Testing - Pharmaceutical company begins phase I clinical trial of inhaled doripenem

HIV/AIDS Coinfection - Liver transplantation feasible in HIV/HCV-coinfected patients

HIV/AIDS Dementia - PMG augments glutamate output from infected macrophages

HIV/AIDS Enzymology - Yeast system facilitates study of HIV integrase

HIV/AIDS Immunology - Role of CD40L dysregulation in HIV-related APC impairment reviewed

HIV/AIDS Opportunistic Infection -  C. albicans cell wall adhesin identified

HIV/AIDS Opportunistic Infection - Molecular assay enables noninvasive PCP monitoring

HIV/AIDS Opportunistic Infection - Oral CMV therapy cost effective

HIV/AIDS Pathogenesis - HIV Nef activates macrophage STAT3 via soluble factors

HIV/AIDS Pathogenesis - Macrophages and lymphocytes have differential effects on anti-HIV RANTES activity

HIV/AIDS Pathogenesis - Nuclear transport of HIV integrase characterized

Anticancer Therapy - Recent developments in antitumor taxoids reviewed

HIV/AIDS Pathogenesis - Opioid-regulated lymphocyte genes identified

HIV/AIDS Pathogenesis - PKA signaling underlies gp120-induced T-cell anergy

HIV/AIDS Pathogenesis - Role of dendritic cell C-type lectin receptors in HIV pathogenesis reviewed

HIV/AIDS Pathogenesis - Serum SDF-1 inactivated during HIV infection

HIV/AIDS Prevention - Incorporating HIV prevention into the medical care of persons living with HIV

HIV/AIDS Proteomics - Nuclear targeting of HIV Rev transport signals clarified

HIV/AIDS Risk Factor - Transmission risk data lacking in HIV/AIDS surveillance system

HIV/AIDS Therapy - Phototherapy ameliorates nanobacteria-related peripheral neuropathy

HIV/AIDS Therapy - STAT1 blockade shows promise for clearance of latent HIV reservoirs

HIV/AIDS Therapy - Treatment-induced recovery of HIV-specific immunity more extensive in children

Antioxidants - Curcumin has properties known to shutter diabetes complications

HIV/AIDS Therapy - Viral AAC resistance mutations identified

HIV/AIDS Tuberculosis - MDR-TB common for HIV patients in Peruvian hospitals

HIV/AIDS Vaccine - Multispecific mucosal cytotoxic T cells fail to control SIVmac239

Head Injury - "Ding" concussions require removal from the game

Head and Neck Cancer - Audiotaped patient consultations are used to survey patient attitudes

Health Funding - Public health spending drops as anti-terrorism funds soar

Health Management - Mutual of Omaha chooses American Healthways for disease management

Healthcare Access - AIDS activists hail victory as U.S. drug company relinquishes patent

Healthcare Access - Foundation helps expand care for uninsured, low-income Massachusetts residents

Healthcare Access - Poor AIDS patients forced to make life-and-death choices

Antisense Technology - Antisense oligonucleotides depend on reliable delivery for therapeutic success

Healthcare Access - Survey says nation's healthcare system is ill

Healthcare Benefits - BCBS proposes options to reduce number of uninsured

Healthcare Benefits - Idaho counties receive $1 billion in healthcare fusion through state agency

Healthcare Benefits - Indonesia proposes plan to provide free insurance to its poor

Healthcare Benefits - More funds approved to expand benefits for Michigan's uninsured

Healthcare Benefits - North Dakota groups work to improve reach of public health insurance

Healthcare Branding - Highmark Blue Shield's HealthGuard now carries the "Blue" brand

Healthcare Economics - AP poll reveals Americans' top concerns; healthcare moves up the list

Healthcare Economics - Iowa officials say budget cuts could destroy long-standing program for poor

Healthcare Economics - Marylanders' healthcare spending was up 11% in 2002

Arthroplasty - Elbow replacements are effective for the rheumatic elbow joint

Healthcare Economics - Police working longer due to health insurance costs in retirement

Healthcare Economics - Vermont's governor proposes health spending initiatives

Healthcare Funding - Budget plans for space exploration instead of health, education questioned

Healthcare Reform - First steps in New Mexico plan controversial

Healthcare Reform - Kennedy proposes major federal expansion for U.S. healthcare

Healthcare Reform - Minnesota lawmakers aim to improve the system

Healthcare and Politics - Presidential candidate Clark would lift stem cell restrictions

Heart Attack - Carvedilol enhances mitochondrial function during myocardial ischemia

Heart Attack - NHE-1 blockade ameliorates postinfarction remodeling

Heart Attack - NIH grant awarded to study the use of adipose-derived regenerative cells

Heart Attack - National training agreement signed for defibrillator use

Heart Disease - Data shows hospital ER use for heart problems increases on snow days

Heart Disease - Registry demonstrates positive outcomes after heart valve implantation

Heart Disease Therapy - Rosuvastatin cost-effective for U.K. National Health Service

Heart Failure Therapy - Carvedilol may be superior to metoprolol tartrate

Heart Transplantation - Tolerogenic mechanisms of LF15-0195 characterized

Hematologic Disease - Platelet membrane glycoprotein mutations do not affect VWD severity

Hematology - Effects of gamma radiation on hemoglobin characterized

Hematology - Intracellular signal inhibitors block H2 O2 -induced platelet aggregation

Assisted Reproduction - Analysis shows babies conceived via ART face high risk at birth

Hematology - Lamivudine prevents HBV flare in leukemia patients treated with campath-1H

Hepatitis A Vaccine - Two-dose hepatitis A vaccine effective in Thai children

Hepatitis B Virus - CHO cell clones expressing hepatitis B surface protein screened

Hepatitis B Virus - Hepatitis B infection appears to trigger adult-onset Still disease

Hepatitis B Virus - Preliminary testing of hepatitis B test kit meets expectations

Hepatitis C Therapy - Hepatitis vaccine collaboration signed

Hepatitis C Therapy - Phase I trials of Actilon initiated

Hepatitis C Virus - Company announces development of two new molecules to battle virus

Hepatitis E Vaccine - HEV-neutralizing antibodies recognize antigen of ORF2 protein vaccine

Hepatology - Alcohol dehydrogenase 6 and apolipoprotein E constructs propel liver transgenes

Psycho-Oncology - Psycho-oncology now has a recognized role within the oncologic community

Assisted Reproduction - Trial begins in lawsuit over embryo pregnancy

Hereditary Angioedema - Positive phase II study results with Icatibant

Hodgkin Lymphoma - Increased serum levels IL-9 may contribute to Hodgkin lymphoma development

Human Papillomavirus - Vaccines for cervical cancer reviewed

Human Papillomavirus - Women's Health Connecticut adopts DNAwithPap test

Huntington Disease - Abnormalities develop early in R6/2 Huntington disease transgenic mice

Huntington Disease - Different phenotype found in monozygotic twins with Huntington disease

Hypertension - B-type natriuretic peptide levels have limited value for diastolic HF diagnosis

Hypertension - Genomic influence of angiotensin II elucidated

Hypertension - Glucocorticoids act in dorsal hindbrain to increase arterial pressure

Asthma - Asthma drug program licensed from Abbott Laboratories

Hypertension - Melatonin may have an effect on nocturnal blood pressure

Hysterectomy - Hysterectomy may not result in impaired sexual arousal

Idiopathic Myelofibrosis - Thalidomide yields success in patients treated for idiopathic myelofibrosis

Imaging - Ultrasound-guided liposomes boost imaging, target drug/gene therapy

Immune Reconstitution - Phase I trial of CYT 99 007 initiated

Immunology - Effects of TCR activation on naive cord blood T cells characterized

Immunology - Fat cells fight disease

Immunology - Hepatitis C virus NS4 uses subversive tactics to thwart Th1 response

Asthma - Controlled-release treatment for asthma and COPD to be developed

Immunology - Pathway for cell-associated antigens by dendritic cells characterized

Immunology - Peripheral blood should be used for flow cytometry T-cell counts

Immunology - Researchers retract part of paper on source of HIV defense

Immunology - Roles of TLR2 and -4 in antimycobacterial host defense characterized

Immunology - Soluble TLR2 isoforms present in plasma, breast milk

Immunology - Soluble adhesion factor marks microvascular changes in arthritis patients

Immunology - To avoid detection, HIV disrupts immune cell migration

Immunology - Viral interleukin-10 gene transfer suppresses genes upregulated by inflammation

Industry Certification - Device manufacturer achieves ISO quality system standard

Infection - Patent granted for nonlive FluINsure vaccine

Asthma - Disappointing phase IIa clinical trial results reported for oral asthma drug

Infection Control - Current hospital infection control methods merit updates

Inflammatory Bowel Disease - Depression may affect bowel disease relapse

Inflammatory Bowel Disease - Phase I trial of Traficet-EN initiated

Inflammatory Bowel Disease - Plantain extract may be future treatment

Inflammatory Diseases - Small molecule collaboration extended

Inflammatory Response - Interleukin-18-binding protein staunches inflammatory response in mouse livers

Influenza - Flu continues to decline; just five states now reporting widespread illness

Influenza - Flu shots last winter not perceived as effective prevention, surveys show

Influenza - Flu shots questioned in study of healthcare workers

Influenza - FluMist to be donated to public health agencies

Asthma - Doubling of steroids before severe asthma attacks ineffective

Information Technology - Anthem supplies tools to help members choose hospitals, prepare for treatments

Information Technology - Baylor Health Care selects DocuData to implement medical record digitization

Information Technology - CMS strengthens initiatives with clinical evidence-based criteria

Information Technology - Catholic Medical Center uses ibex PulseCheck ED system

Information Technology - Children's Hospital Boston, Cerner to deliver pediatric research to clinicians

Information Technology - Company launches S-PLUS validation and clinical reporting solutions

Information Technology - Company launches enhanced Drug Information Framework

Information Technology - Computer resources help doctors answer patient care questions

Information Technology - Computerized records surmount a medical emergency

Information Technology - Duke University Health System selects mobile computing infrastructure

Asthma - Pregnant smokers put babies at increased risk for asthma

Information Technology - Hoag Memorial selects Premier's Clinical Advisor

Information Technology - Horizon BCBS, AdvancePCS begin recruiting for electronic prescribing program

Information Technology - Hospitals choose picture archiving and communications system

Information Technology - Program helps improve ED patient throughput, documentation

Information Technology - Software helps Oklahoma heart hospital to securely install PCs in patient rooms

Information Technology - WellPoint jumpstarts physician participation in electronic medical community

Kidney Dialysis - Advanced glycation end product role in uremia and dialysis outlined

Kidney Stones - Project initiated for biodegradable stents in ureteral, prostate applications

Kinetic Research - Short rest periods stimulate some bone formation in active female mice

Laboratory Tests - LabOne to provide testing for Anthem Blue Cross and Blue Shield

Avian Flu - U.N. FAO seriously concerned about spread of avian flu in East Asia

Language - Monkey calls light language centers

Laparoscopic Nephrectomy - Hand-assisted laparoscopy reduces operative time and improves outcomes

Laryngeal Cancer - Angiotensin-converting enzyme might be a marker for laryngeal cancer

Leg Ulcers - Researchers discuss wound bed preparation for treating venous leg ulcers

Legal Issues - Colorado lawmakers want to head off barrage of fast food lawsuits

Legal Issues - Court to decide: Should murderer of pregnant mom be prosecuted for fetus' death?

Legal Issues - Florida court rules that fetuses can't have guardians

Legal Issues - HealthSouth sees 2004 revenue of $4 billion, says fraud at least $3.8 billion

Legal Issues - Husband plans court challenge in wife's cesarean delivery case

Legal Issues - Intuitive Surgical settles pending litigation

Avian Influenza - Bird flu vaccine not likely for 6 months

Legal Issues - Law firms, hospital agree to change website name

Legal Issues - Makers of OxyContin made unsubstantiated claims, report says

Legal Issues - Malpractice suit for botched appendectomy settled

Legal Issues - Oregon man files lawsuit against ephedra manufacturer, marketer

Legal Issues - R.J. Reynolds tries to overturn $15 million tobacco liability award

Legal Issues - Seven charged with diverting healthcare funds to campaign fund

Legal Issues - Sports doctors settle Medicare fraud suit for $2.6 million

Legal Issues - Switzerland investigators say two dozen patients murdered by male nurse

Legal Issues - Texas commission seeks to move Medicaid case to federal court

Legionnaires Disease - Type I secretion system in Legionella pneumophila described

Avian Influenza - Bird flu's rapidly changing genetic makeup likely behind its rapid spread

Legislation and Prevention - Bill proposed to prosecute those who spread HIV

Leprosy - Genetic underpinnings described

Leptin Studies - Leptin may play direct role in bone metabolism

Leptin Studies - Leptin overexpression decreases basal lipolysis, PKA activity, and perilipin

Leukemia - Adaphostin can damage both myeloid and lymphoid leukemia cells

Leukemia - Dosing commenced in trial of Clofarabine first line treatment

Leukemia - Hematopoietic reserve in B-cell CLL evaluated

Leukemia - High spontaneous colony growth in CMML predicts short survival

Leukemia - Rare combination of genes cause leukemia

Leukemia - Resistance to different classes of chemo agents indicates a poor outcome in ALL

Avian Influenza - Threat to humans is significant

Leukemia - SIN lentivectors can transfer the CD40L gene to leukemia precursor cells

Leukemia - Somatic mitochondrial DNA mutations are associated with adult-onset leukemia

Leukemia - TP53 is frequently altered in acute lymphoblastic leukemia

Leukemia Therapy - Dendritic cell recovery slow after allo-SCT

Leukemia Therapy - Filgrastim stem-cell mobilization safe and effective during imatinib treatment

Licensing Trends - Study looks at maximizing in-licensing opportunities in leading organizations

Limb Ischemia - Treatment for critical limb ischemia submitted to FDA

Lipid Studies - Intramyocellular lipid levels decrease during aerobic exercise

Lipid Studies - Lycopene enhances lipid accumulation in macrophages

Smoking Cessation - Cutting down on cigarettes promotes quitting, Yale study said

Avian Influenza - Vietnam last on vaccine list

Lipid Studies - Mice lacking ARID transcription factor Mrf-2 resist weight gain

Lipid Studies - Thiazolidinediones effective for dyslipidemia in type 2 diabetic patients

Liver Cancer - Antisense suppression of DDEFL1 blocks hepatocellular carcinoma cell growth

Liver Cancer - P-glycoprotein may have a role in liver cancer development

Liver Cancer - Preoperative transcatheter arterial chemoembolization may limit tumor recurrence

Liver Carcinoma - Osteopontin enhances metastatic behavior in hepatocellular cancer cells

Long-Term Care - Groups say national debate needed to set course for senior care

Long-Term Care - Hawaii lawmakers back to square one on tax-funded insurance program

Lung Cancer - Endostatin prevails in nonmalignant and malignant pleural effusions

Lung Cancer - Gemcitabine and vinorelbine combination has a high response rate in NSCLC

Avian Influenza - WHO says SARS helped Asia on bird flu

Lung Cancer - Hypermethylation of p16 in sputum and plasma may indicate lung cancer

Lung Cancer - Welding fumes cause lung impairment, including cancer

Lymphoma Therapy - Stem-cell transplantation is only known cure for CTCL

Malaria - Scientists accuse international agencies of approving useless malaria programs

Malaria Enzymology - Crystal structure of P. falciparum FabZ characterized

Malaria Proteomics - Expression of functional plasmodial fp2 in E. coli achieved

Malaria Therapy - Effects of PKC on artemisinin-induced leukemia cell differentiation clarified

Malaria Therapy - Trends in antimalarial drug deployment in sub-Saharan Africa reported

Market Analysis - "Flanking generics" enables drug makers to retain market share

Avian Influenza - WHO suggests quarantine for bird flu

Market Analysis - Big pharma, biotech look to combinatorial chemistry for future pipelines

Market Analysis - Drug companies spend 46% of marketing budgets on product launch

Market Analysis - Drug discovery spending declining in face of changing market dynamics

Market Analysis - Hesitancy to adopt new technologies restrains dressings market

Market Analysis - OTC switching could be a reality for statins

Marketing Agreements - ICU Medical announces amendments to Abbott agreement

Medicaid - Louisiana plan protects workers counting on Medicaid

Medicaid - Medicaid cuts would stop services to 84,000 Georgians

Medicaid - Montana begins new, 3-year, disease management program

Medical Devices - Transoesophageal echocardiography valuable during non-cardiac surgery

Bacterial Viruses - Bacteriophage genomics method to antimicrobial drug discovery published

Medical Error - Legal papers claim New York hospital gave child fatal mix of painkillers

Medical Errors - South Dakota neurosurgeon, already on probation, faces additional lawsuits

Medical Errors - Young cancer patient's family announces plans to sue Johns Hopkins

Medical Malpractice - Analysis shows premiums lower in states with caps on damage awards

Medical Malpractice - Demonstrators in Utah protest mandatory arbitration

Medical Malpractice - Doctors, victims in Maryland gather as debate heats up

Medical Malpractice - Families sue hospitals that employed a nurse charged with overdosing patients

Medical Malpractice - Follow-up audit in South Carolina finds changes to compensation fund

Medical Malpractice - Group says CBO study fails to consider full impact of rising liability costs

Medical Malpractice - Judge orders information on malpractice lawsuit data

Bacteriology - Accuracy of six systems for Vibrionaceae identification compared

Medical Malpractice - Kentucky's Senate passes malpractice amendment by minimum margin

Medical Malpractice - Minnesota ER doctors say they're facing insurance crisis

Medical Malpractice - New Jersey Democrats vow to address liability insurance, caps

Medical Malpractice - Pennsylvania lawmakers hope third time is charm for malpractice tort reform

Medicare - AHCA faults skilled-nursing facility recommendations again

Medicare - Discount card to emerge from new retail pharmacy, benefit manager alliance

Medicare - Drugstore chains seek discount card

Medicare - Organization's support for legislation leads at least 45,000 members to quit

Medication Compliance - 40% of American adults report difficulty in swallowing pills

Melanoma - Canvaxin therapeutic polyvalent vaccine shows promise against melanoma

Bacteriology - DNA damage recognized by Escherichia coli Fpg protein

Melanoma Vaccine - Allogeneic melanoma tumor cell lysate vaccine benefits patients

Melanoma Vaccine - Melanoma vaccines evaluated by monitoring of tumor-specific T cells

Memory - Scientists discover protein in brain affects learning and memory

Meningitis - Echovirus type 13 emerging as prominent enterovirus

Menopause - Clinical trial data reported for first, oral, plant-derived conjugated estrogen

Menopause - Mobility range holds implications for quality of life in women with osteoporosis

Menopause - Tail-temperatures of estrogen-deficient rats simulate menopausal hot flushes

Mental Health - National study indicates obesity is linked to major depression

Mental Health - State offers help to better identify Creutzfeldt-Jakob, other brain diseases

Mental Illness - Bill would aid children with mental illness

Bacteriology - Mycobacterial consumption of carbon monoxide, hydrogen reported

Mergers and Acquisitions - Acquisition enhances financial services firm's healthcare practice offerings

Mergers and Acquisitions - FTC closes review of Novazyme acquisition

Mergers and Acquisitions - IPVoice to acquire Medical Office Software

Mergers and Acquisitions - Invacare Corp. acquires the assets of ACS

Mergers and Acquisitions - KaloBios, therapeutics company, announce merger

Mergers and Acquisitions - Kimberly-Clark wound care assets acquired

Mergers and Acquisitions - NADAG and SiREEN merge to form drug discovery/development company

Mergers and Acquisitions - Pain relief company completes acquisition

Metabolism - Japanese men but not women carry gene polymorphisms for bone loss

Metastasis - New research technique may help scientists understand tumor spread

Bacteriology - Neutrophil activation regulates Forkhead transcription factors

Metastasis - Simple microbes give insight into the development and spread of cancer

Middle Ear Infection - Patient trials to begin with middle ear infection treatment

Minority Health - Racial, social events can impact healthcare of African American male homosexuals

Mitosis - Phase II trial launched for SB-715992

Molecular Biotechnology - Company acquires technology from Fraunhofer Center

Mosquito-borne Disease - Use of recombinant bacteria for mosquito control reviewed

Multiple Sclerosis - Collaboration to develop multiple sclerosis drug candidates

Multiple Sclerosis - Collaborative research initiative aims for new drugs in half the time

Multiple Sclerosis - Neurological disease not as progressive or disabling as once thought

Mutagenesis - Gene modification increases yields of a yeast used for astaxanthin production

Mutagenesis - Keratin polypeptide gene deletions heighten susceptibility to liver injury

Mycobacteria - Analysis of mycobacterial rpoB gene suitable for RGM identification

Mycobacteria - Clinical management of Mycobacterium fortuitum skin infection outlined

Mycobacteria - IFN-gamma autoantibodies can increase susceptibility to mycobacterial infection

Mycology - Antigens shared by Aspergillus and Penicillium species identified

Narcolepsy - Phase III trials on schedule for R-modafinil; NDA to be filed in 4Q

Nasopharyngeal Cancer - TSLC1 gene is one of the target tumor suppressor genes of nasopharyngeal cancer

Nerve Damage - Scientists reveal key part of nerve regeneration mechanism

Neurodegenerative Disorders - Bioscientists to lead research into brain diseases

Neuroendocrine Tumors - Study shows in vivo phosphorylation of the somatostatin 2A receptor in vivo

Basal Cell Carcinoma - Cancer treatment gets mixed review

Neurology - Alpha V beta 8 integrin is Schwann cell receptor for fibrin

Neuroscience - A new hybrid promoter enhances neuron-specific transgene expression

Neuroscience - Angiogenic growth factor could be used for the treatment of neonatal stroke

Neuroscience - Elevated GDNF levels increase nerve cell death after ischemic stroke in rats

Nutrition - Children at higher risk for hunger if mother has poor mental or physical health

Nutrition - Experimental product boosts immune function and reduces flu symptoms in elderly

Nutrition - One-size-fits-all approach to nutrition recommendations may soon be outdated

Nutrition - Schools asked to aid in ending junk food craze; implementing healthy diets

Nutrition - Utah students may get longer lunch periods

Obesity - CDC: Obesity costs states billions in medical expenses

Women's Health - Greater patient-doctor dialogue may improve a women's healthcare

Baylisascaris -  Baylisascaris procyonis found in metropolitan Atlanta area

Obesity - Physical fitness, nutrition are hot topics for West Virginia coalition

Obesity - U.S. Surgeon General calls obesity "the terror within"

Obesity Genomics & Genetics - -308 Nco I polymorphism of TNF-alpha does not affect weight loss

Obesity Genomics & Genetics - Analysis of obesity in diabetes confirms loci on chromosomes 1q and 11q

Obesity Genomics & Genetics - SLC6A14 gene linked to obesity

Obesity Prevention - Governments back WHO's anti-obesity plan

Obesity Surgery - Laparoscopic adjustable gastric banding effective for massive superobesity

Obesity Surgery - Massachusetts probing death of man following obesity surgery

Obstetrics - Combined prenatal exposure to second-hand smoke, urban air pollutants harmful

Obstetrics - Fertility experts' group strengthens commitment to reducing multiple births

Biosample Archiving - BioServices division wins contract to establish NIDDK biosample repository

Obstetrics - Researchers identify enzyme that helps make uterus stretchy

Obstetrics - Study calls for end to age thresholds for prenatal genetic testing

Occupational Health - The face and eyes provide a means for occupational acquisition of hepatitis C

Oncogenesis - Beta3Gal-T5 counteracts malignancy-related glycosylation in cancer cells

Oncology - A switch to the lymphangiogenic phenotype typifies CIN stage 3 cervical lesions

Oncology - Combined gene regulatory elements select for melanoma suicide gene expression

Oncology - Genes noted for aggressive phenotypes can be found within malignant melanoma

Oncology - Hepatitis B virus X protein is involved in the etiology of liver cancer

Oncology - Interleukins-1 alpha and beta have differential effects on tumorigenicity

Oncology - Thalidomide prolongs disease stabilization in those with recurrent glioblastoma

Biosensors - Artificial membranes can reveal biological weapons

Oncology - Viral gene therapy shows promise for treating sarcoma

Oral Health - Gene therapy in salivary glands could lead to promising applications in oral diseases

Oral Implants - Alveolar distraction can increase the height of the alveolar ridge

Oral Implants - Early loading of endosseous implants is 95.6% successful at 1-year

Oral Implants - Study compares direct digital and conventional intraoral radiography

Orbit Tumors - Definitive surgery is the goal for orbital schwannomas and neurofibromas

Organ Transplant - Grants to fund new organ transportation devices and cryopreservation methods

Osteoarthritis - Study confirms efficacy of Lyprinol in treating osteoarthritis

Osteoporosis - Angiogenic cytokine modulates bone remodeling in steroid-treated animal models

Osteoporosis - Folate has a strong link to bone mineral density in postmenopausal women

Bipolar Disorder - FDA approves Zyprexa to delay relapse into mania, depression

Osteoporosis - Microarchitectural changes explain the benefits of antiresorptive therapy

Osteoporosis - New phase III study shows positive results for oral monthly Boniva

Osteoporosis - Oral bone forming drug candidate acquired

Osteoporosis - Selenium, vitamin E, and vitamin C combinations prevent bone decline

Outbreaks -  Vibrio cholerae outbreak linked use of chlorinated water source

Ovarian Cancer - Data: Drug candidate MPI-176716 causes ovarian tumor remission

Ovarian Cancer - Fact/GOG-Ntx questionnaire offers valid assessment of neuropathy

Ovarian Cancer - Researchers study non-epithelial ovarian cancer in Mexican women

Oxygen Monitoring - Brigham and Women's Hospital implements SET oximetry hospital-wide

PET Imaging - Neuroimaging company inks agreement with GlaxoSmithKline

Bipolar Mania - FDA grants approval for Seroquel

Pain Management - Pain treatment decisions may be influenced by physician gender

Pain Management - Third-party billing program available for ambulatory surgery centers

Pain Medicine - FDA launches consumer campaign on safe use of OTC pain products

Pain Medicine - High bone mineral density associates with low back pain in middle-aged women

Palliative Care - Groups provide $300,000 grant to fund fellowships

Panic Disorder - Emotion-regulating protein lacking in panic patients

Parasitology - 14-3-3 Protein is key molecule in parasites as in other organisms

Parkinson Disease - Down-regulation of DJ-1 enhances cell death

Parkinson Disease - Parkin is recruited to centrosome in response to proteasome inhibition

Patents - Geron receives favorable ruling in nuclear transfer patent interference matter

Birth Defects - Ohio begins work on registry to track birth defects

Patents - MRI contrast agent patent strengthens company's proprietary position

Patents - Patent granted for treatment of psoriasis

Patents - Pharmaceutical company is issued U.S. patent for cancer therapy

Patient Education - Better info could help American Indians/Alaska Natives receive recommended care

Patient Education - Heart patients want more information from their doctors

Pediatric Cardiology - Fusion of technologies improves infant survival rates after heart surgery

Pediatrics - Development of rational therapeutics in children reviewed

Perception - Study shows that senses are tied to movement

Peri-Implant Bone Loss - Gelatinase B is associated with peri-implant bone loss

Periodontal Disease - Blood test may reveal factors that relate to gum disease, especially in men

Bladder Cancer - Smoking plus drinking water with arsenic increases risk of bladder cancer

Peripheral Arterial Disease - Diabetics are urged to check legs

Personnel - Aviel Faliks, PhD, majority stock holder, becomes new CEO

Personnel - Batkin joins board of directors at infection control device company

Personnel - Biopharmaceutical company names new vice president, clinical affairs

Personnel - Biotech company names senior VP, general counsel, secretary

Personnel - Biotechnology company appoints new chairman of the board of directors

Personnel - Blose named board director at microarray company

Personnel - Chip maker names executive to head new clinical diagnostics division

Personnel - Dennis M. Keane named CEO of CNS-focused pharmaceutical

Personnel - Drug discovery company names Frank Karbe CFO

Blood Transfusion - Prosecutors proceed cautiously with stabbing victim who refused transfusion

Personnel - Drug-eluting stent maker reports 15% increase in sales

Personnel - Five Star announces election of new director

Personnel - Former HIAA executive named URAC senior VP of planning and operations

Personnel - Gastroenterological expert joins board of nutraceutical company

Personnel - Genetic assessment company announces a change in board of directors

Personnel - Genomics company announces two new appointments

Personnel - Gregory S. Ballish named vice president of sales and marketing

Personnel - HMS strengthens leadership team, prepares for future growth

Personnel - Healthcare staffing company names CEO

Personnel - Healthcare veteran Patrick G. LePore joins board

Bloodstream Infections - Once-weekly Dalbavancin shows superiority for bloodstream infections in study

Personnel - Imaging company names Dennis Mulroy CFO

Personnel - John C. Parmigiani joins QuickCompliance as senior VP for consulting services

Personnel - John Hamer named VP of drug delivery company

Personnel - Kevin S. Moore named to board of neurological device company

Personnel - Kristina M. Johnson, PhD, elected to board of directors

Personnel - M. Renee Simar, director of pediatrics, becomes VP

Personnel - MacDonald named president, COO at biotech company

Personnel - Magnus Precht named president of Phyton, Inc.

Personnel - McCarthy joins IT firm as senior scientist, clinical consultant

Personnel - McGuire named chief medical officer at gene therapy company

Bone Cancer - Orthopedic implant designed to restore function

Personnel - Medical device company announces management succession

Personnel - Medical product manufacturer names new chief technology officer

Personnel - Medical products company appoints interim chief executive officer

Personnel - Nancy Larkin joins Courage Center as vice president of healthcare development

Personnel - New director appointed for Mississippi Medicaid program

Personnel - Osagie Imasogie named to board of directors of biotech company

Personnel - Pharmaceutical company adds two new board members

Personnel - Pharmaceutical company announces new member of board of directors

Personnel - Pharmaceutical company announces retirement of co-founder and CEO

Personnel - Pharmaceutical company appoints Theresa Bischoff to board of directors

AIDS - Man accused of falsely telling woman he gave her AIDS

Bone Density - Some bone sites in the humerus may provide stronger fixation for implants

Personnel - Pharmaceutical company names two new vice presidents

Personnel - President James T. Lenehan retires

Personnel - Robinson joins board of biotech company

Personnel - Swartz promoted to VP, controller at device firm

Personnel - Vogel named to biotech company's board of directors

Personnel - Winger named to board of directors

Peutz-Jeghers Syndrome - Antibiotics related to geldanamycin could promote development of carcinoma

Pharmaceutical Care - McKesson renews agreement with Omnicare

Pharmacy Management - Jackson Memorial selects Cardinal Health for pharmacy management services

Pineal Region Tumors - Researchers describe a new tumor forceps for removal of pineal region tumors

Bone Fractures - Bone graft clinical trial initiated at lead U.S. site

Pituitary Tumors - Researchers discuss mechanisms for pituitary tumorigenesis

Poliomyelitis - Nigerian state upholds ban on polio vaccinations

Poliomyelitis - WHO considers rapid response to halt polio spread in Africa

Postoperative Ileus - Results reported in Entereg phase III study

Practice Management - Orthopedic practice selects outsourced practice systems management solution

Prenatal Medicine - Prenatal diagnosis impacts the parental psyche

Prescription Benefits Management - Bills introduced in Michigan Legislature to lower drug costs

Prescription Benefits Management - Contract renewal has firm continuing to provide pharma distribution services

Prescription Drug Abuse - Petition requests FDA to require risk management plans for OxyContin generics

Prescription Drug Benefits - Program helps Louisiana seniors save on purchases

Bone Grafts - Endoskeleton structural device for the spine issued FDA 510k clearance

Prescription Drug Benefits - Program shows informed consumers decide to save on medication

Prescription Drug Importation - FDA scrutinizing county's plan to bring in drugs from Canada

Prescription Drug Importation - Iowa governor seeks HHS authorization for pilot program

Preventive Healthcare - Georgia hospital wins $100,000 prize for work in building coalitions

Prion Disease - Improved method for detecting PrPc in peripheral nerves developed

Prion Diseases - Physicists study mad cow-type diseases

Privacy Issues - Britain to end egg, sperm donor anonymity

Product Safety - U.S. regulators uphold ban on silicone gel breast implants to market

Prostate Cancer - Elderly men need more education about prostate-specific antigen screening

Prostate Cancer - Maximum tumor diameter is a predictor of tumor volume

Bone Grafts - Further studies of transplanted composite bone grafts-implants are needed

Prostate Cancer - Pan-European marketing partner named for prostate cancer products

Prostate Cancer - Provenge extends survival in advanced prostate cancer

Prostate Cancer - TRPS1 may play a role in androgen regulation of PSA gene expression

Protein Competition - Shifting protein signals allow VEGF receptor-1 to flourish on adult cells

Protein Synthesis - Scientists describe new strategy to make glycoproteins

Proteomics - Embryonic handedness in C. elegans involves G alpha protein

Proteomics - Novel member of protein phosphatase 2C family cloned

Proteomics - OX-43 deficits mark the invasive phenotype of endothelial cells

Proteomics - Structure and regulation of Che-1, a novel partner of Rb, reported

Proteomics - Thioredoxin stamps out microvascular endothelial capillary tubule formation

Bone Grafts - Vitoss bone graft material receives FDA clearance

Psychosomatic Medicine - Century of research confirms impact of psychosocial factors on health

Public Health - Study: Health gap between blacks and whites in Chicago widening

Public Health Practice - Viral hepatitis rates in Lower Saxony reflect common disease risk factors

Pulmonary Medicine - CRP testing cannot exclude pulmonary embolism

Quality Assurance - Hospital star ratings in U.K. are misleading the public, report says

RNA Research - Techniques for study of ribonucleoparticle complexes reviewed

Rabies Vaccine - DNA vaccine more effective against rabies than culture-derived vaccine

Rabies Virus - Novel lyssaviruses isolated from bats in Russia

Radiation Exposure - New study finds no link between cancer and cell phone use; more research needed

Radiopharmaceuticals - Company enters into $3 million supply agreement for oxygen-18

Bone Loss - Spinal and radial analyses are best for determining bone health

Rat Brain Tumors - Arsenic trioxide enhances radiation response of 9L glioma in the rat brain

Receptor Studies - Interaction of vasopressin analogs with vasopressin receptors modeled

Receptor Studies - Neutral histamine H-1-receptor antagonists synthesized

Receptor Studies - Structural organization of receptor associated protein characterized

Reconstructive Surgery - Osteocutaneous flap prefabrication preserves bone viability in rabbits

Rectal Cancer - Tumor treatment blocks blood vessels

Reducing Risk - 2004 cancer report card for California a mixed bag

Referrals - Florida HealthSource adds more than 25 providers to network

Regulatory Approval - Diagnostics company gets CE mark certification

Regulatory Issues - FDA implements broader requirements for tissue bank registration

Bone Marrow Transplant - Researchers discover secret for recalling stem cells

Regulatory Issues - FDA sees rebound in approval of innovative drugs in 2003

Regulatory Issues - FDA takes actions against illegal drug import operations

Regulatory Issues - Guidant CRM division deploys EDC and eResearch Community solutions

Regulatory Issues - Medical sanctions on rise in West Virginia

Regulatory Issues - Pennsylvania insurance agency orders Blues to justify large cash reserves

Renal Cell Cancer - Interim clinical results of GTI-2040 in combination chemotherapy announced

Reovirus - Histidines needed for reovirus guanylyltransferase activity identified

Reproductive Health - Experts examine Europe's population, health, and social concerns

Reproductive Medicine - Neurotrophin receptors are critical to female germ-cell survival

Research Technology - Computer application "reads" medical literature, finds significant data

Bone Repair - Angiogenic factors increase during distraction osteogenesis

Respiratory Distress - Kappa B may initiate respiratory distress in the septic surgical patient

Respiratory Therapy - Collaboration announces initiation of human trials for respiratory indication

Rheumatoid Arthritis - Does RA-related inflammation induce cardiovascular disease?

Rheumatology - Intravital fluorescence microscopy assesses angiogenesis in arthritic mice

Rheumatology - Osteoarthritis and pain constrict hand function in postmenopausal women

Robotics - Robotic mitral valve surgery reviewed

Rotavirus - Virulence region of rotaviral nonstructural protein NSP4 characterized

SARS - Flu season helps U.S. prepare for SARS

SARS - Real-time PCR enables rapid diagnosis

SARS - WHO finds evidence that animals play SARS role

Bone Tumors - Endoprosthetic extremity reconstruction in children can be successful

Salivary Duct Carcinoma - Salivary tumor features in 15 patients described

Salmonella -  Salmonella enterica isolated from humans and food animals characterized

Schistosomiasis - IL-10 regulates immune responses induced by schistosome vaccine

Schizophrenia - Common genetic influence found in mental illnesses

Seborrheic Dermatitis - Results reported from phase III studies of Sebazole

Sexually Transmitted Disease - Many men would rather cope with STDs than use condoms, study finds

Sinus Surgery - Sinus lift surgery is safe for regenerating the atrophic posterior maxilla

Sleep Apnea - Upper airway EMG responses to acute hypoxia impaired in diabetic rats

Smallpox - Smallpox vaccines to be delivered to CDC

Smoking - Inmate smoking ban moves ahead in California

Bone Tumors - Free vascularized fibular graft is an option for limb-sparing surgery

Smoking Cessation - Shopping-voucher system rewards quitters instantly

Social Attachments - Reward mechanism involved in addiction likely regulates pair bonds

Spinal Cord Injury - Scientists grow neurons using nanostructures

Spine Surgery - New anesthetic techniques for spinal surgery in adults are discussed

Staffing - Rural doctors in western Kentucky await reinforcements

Staffing - West Virginia nursing overtime bill still alive

State Medicaid - Budget proposal for New York could include higher rates for program recipients

State Medicaid - Medicaid losses in Michigan painful for some adults

Stem Cells - Human embryo stem cells produced in Japan

Stem-Cell Research - Bcl-xL-transduced stem cells provide better bone marrow transplantation

AIDS - Media organizations unite to fight HIV/AIDS

Bone Tumors - Rotationplasty is useful for tumors with a large soft-tissue component

Stem-Cell Research - CD41 expression defines hematopoiesis onset in murine embryo

Stem-Cell Research - Effects of NF-kappaB/Rel on leukemic cell apoptosis reviewed

Stem-Cell Research - Embryonic stem cell-derived glial precursors show promise for transplantation

Stem-Cell Research - IL-21 triggers rapid maturation of natural killer cell precursors

Stem-Cell Research - MEK-1/ERK signal effects on erythroid progenitor self-renewal clarified

Stem-Cell Research - Matrigel-based cultures promote neuronal differentiation of mesenchymal stem cells

Stem-Cell Research - Novel model of hematopoietic cancer cell kinetics proposed

Stem-Cell Research - STI571 inhibits mast cell development in vitro

Stem-Cell Research - Serum hepatocyte growth factor rises during stem cell mobilization

Stem-Cell Research - Ultraviolet light facilitates better transduction of bone marrow stem cells

Bone Tumors - Surgical role in treating primary malignant bone tumors under debate

Stem-Cell Transplantation - Risedronate prevents bone loss in allo-SCT survivors

Stock Market - Nutrition bioscience company faces possible NASDAQ delisting

Streptococcus - Enolase from Streptococcus sobrinus is immunosuppressive protein

Streptococcus - Researchers map pneumococcal surface protein A of strain Rx1

Stress - Grant funds stress reduction program for women cancer patients

Stress - Unemployment strikes a harder blow on men's mental health

Stroke - Anticlotting drug may be better than aspirin in preventing third stroke or heart attack

Stroke - Burden of plaque is lower in women than men

Stroke - Professional groups review best treatment and management of ischemic stroke

Stroke - Rising cholesterol levels in Asia may increase stroke risk

Bone Tumors - Telecommunication and telepathology optimizes treatment of malignant bone tumors

Subdural Hematoma - CO2 insufflation for chronic subdural hematoma helps recovery

Suicide - Suicide prevention, education services available in Washington county

Supply Chain Management - Medwave updates on progress for purchasing agreement

Surgical Infections - New system rapidly identifies patients with nasal colonization of S. aureus

TB Prevention - Plans underway to launch U.S. study of tuberculosis vaccine

TB Prevention - WHO launches program to curb TB/HIV co-infection

Telemedicine - Product gives patients access to pediatric specialty care without the drive

Testicular Cancer - Combination chemo offers high cure rates for most metastatic testicular cancer

Thyroid Cancer - Change of urinary glucocorticoids level may play a role in thyroid cancer

Tobacco Settlement - Counties want money for ill nursing home patients

Botulinum Toxin - Hemagglutinin element of toxin from Clostridium botulinum identified

Tobacco Settlement - Smoker's widow awarded $20 million in damages

Toxicology - A new in vitro assay tests earlier for toxic effects during oogenesis

Transfusion Medicine - Better treatment of porcine RBCs needed before human transfusion is feasible

Transgene Expression - Radiolabeled FIAU monitors the progress of cancer gene therapy

Transplant Medicine - Adult live-donor liver transplants resume at New York City hospital

Transplant Medicine - Drug prevents diabetes recurrence after islet cell transplantation

Transplant Medicine - Hospital resumes adult live-donor liver transplants 2 years after donor's death

Transplant Medicine - Issues related to donor altruism examined

Tuberculosis - Epidemiology of extrapulmonary TB in San Francisco clarified

Tuberculosis - Oklahoma seeks court order to keep TB patient isolated

Bovine Spongiform Encephalopathy - Premortum test for mad cow disease under development

Tuberculosis Animal Models - Lung cell responses in genetically resistant mice clarified

Tuberculosis Diagnostics - TaqMan PCR assay enables rapid mycobacteria counts

Tuberculosis Enzymology - Crystal structure of M. tuberculosis PPAT characterized

Tuberculosis Epidemiology - Genetic distance useful as measure of ongoing TB transmission

Tuberculosis Epidemiology - Size of TB clusters not linked to symptom duration

Tuberculosis Immunology - CD57+ CD4 cells play key role in host defense against TB

Tuberculosis Immunology - HLA class I-restricted CD8 cells help control TB infection

Tuberculosis Pathogenesis - CD44 expression affects type but not efficacy of anti-TB immune response

Tuberculosis Therapy - Isoniazid toxicity characterized

Tularemia - PCR assay for enhanced detection of Francisella tularensis developed

Brain Disorders - Program addresses disabling neurological, mental illness in developing world

Tumor Ablation - Radiosurgery company gets Japanese regulatory clearance for CyberKnife

Tumor Marker - Silenced MAT-8 genes make prostate cancer cell proliferation decline

Tumor Suppression - Heterozygous disruption of the beclin 1 autophagy gene promotes tumorigenesis

Ultrasound - Three-dimensional ultrasound technology available in Houston, Texas, area

Urethral Cancer - Report reviews the treatment of urethral cancer

Urinary Incontinence - Materials used for pubovaginal slings remain strong in rodent studies

Urinary Tract Infection - Scientists film bacteria changing, collaborating to defeat bladder cell defenses

Urinary Tract Infection - Video details how bacteria invade and overwhelm bladder cells

Urology - Bladder screening device approved in U.S.

Vaccine Delivery - Bacterial spores as heat stable vaccine vehicles reviewed

Brain Tumors - No environmental, chemical link found in Rohm and Haas brain tumor cases

Vaccine Safety - Infant develops Kawasaki disease after hepatitis B vaccination

Vaccines - Plant-based vaccines to be developed by Dow

Vector Development - Electroporation facilitates gene transfer into adult skeletal muscle myofibers

Vector Development - Magnetofection is a useful tool for transfecting endothelial cells

Vector Development - Vaccine adjuvant vector, CTA1-DD/ISCOM, designed

Vectors - One dose of "designer" gene therapy may target specific body area

Vectors and Zoonoses -  Anopheles funestus dinucleotide microsatellite markers identified

Vegetarian Diet - All-vegetable vitamin E pill introduced

Venous Bypass Grafting - Stent implantation better than balloon angioplasty in de novo saphenous vein graft

Veterans Affairs - Group is suing Veterans Affairs' secretary over "rationing" of healthcare services

Breast Cancer - Areola-sparing mastectomy with immediate reconstruction is feasible

Veterans Affairs - Tennessee men no longer have to give up smoking for Viagra

Viral Genomics - The INNO-LiPA HBV identifies mixed genotypes in difficult samples

Virology - Borna disease virus infection reported in immunocompromised patients

Virology - Recombinant constructs revive p53 tumor-suppressor activity in tumor cells

Virology - Scientists create chip that detects viruses quickly

Virology - Several genetic loci are known to regulate adenovirus-based gene therapy

Vulva Reconstruction - Modified VRAM flap can resurface a large vulvoperitoneal defect

Vulvar Pathology - Laser Doppler perfusion imaging can map vulva microcirculation

Weight Gain - Adolescents tend to gain excessive weight during pregnancy

Weight Loss - Dieting for weight loss decreases memory ability

Breast Cancer - CAD workstation reference library to aid in early breast cancer detection

Weight Loss - Ephedra alternatives reviewed

West Nile Virus - CDC: 2003 West Nile outbreak largest yet

Workers Compensation - Senator goes after compensation for Cold War-era nuclear workers

Wound Care - New dressing developed

Wound Healing - Mitogenic protein in latex from Carica candamarcensis identified

Wound Healing - Wound healing may be accelerated with a traditional scalpel blade

Wound Repair - Angiotensin peptides accelerate wound healing in diabetic mice

X-Ray Technology - SuperSpeedSolutions launched for materials research, nanostructure applications

Breast Cancer - FDA grants clearance to market Ariol HerSight

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