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Transplant Medicine

Drug prevents diabetes recurrence after islet cell transplantation

Published in Health and Medicine Week, February 9th, 2004

A new anti-inflammatory compound called lisofylline prevents diabetes from coming back after insulin-manufacturing islet cells are transplanted into diabetic mice, according to a new study by researchers at the University of Virginia Health System.

The study is published in Transplantation.

Pancreatic islet cell transplantation has become a promising treatment for type 1 diabetes in humans in recent years. But without several powerful immunosuppressive drugs, the body's immune system would destroy the engrafted islet cells in transplant patients leading to insulin deficiency, an excess of glucose in the blood and the return of diabetes.

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