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Health and Medicine Week

Susan Hasty, Publisher

Table of Contents . . . March 8th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Health and Medicine Week | Other Publications

Myocardial Infarction - Growth factor boosts heart cell production in damaged hearts

Complementary and Alternative Medicine - Ginkgo biloba extracts could be an alternative to hormone replacement therapy

Hypoxia - Project demonstrates inherited ability to adapt to life at high altitudes

Pediatric Obesity - National campaign to get kids physically active is working

AIDS Therapy - Data presented on potential new class of antiretroviral therapy

Abortion - Ramosetron prevents nausea and vomiting associated with pregnancy termination

Acne - Laser therapy prevents acne from graduating to scars

Acromegaly - Growth hormone disorder puts patients at risk for CAD, diabetes, hypertension

Acromegaly - Surgery leads to biochemical remission of acromegaly in 55% of patients

Acute Myeloid Leukemia - PCR asay aids Aspergillus endocarditis diagnosis in AML patients

Addiction Medicine - Publication addresses compulsive gambling

Addiction Medicine - Study uncovers how stress and hormones lead to smoking relapse

Adverse Drug Effects - In utero exposure to NSAIDS sometimes leads to neonatal renal failure

Age-Related Macular Degeneration - The macular pigment Raman detector assesses carotenoid status in the retina

Alcohol Abuse - Five million parents have alcohol problems, federal report says

Alcoholism - Better methods needed to treat people with both mental health, alcohol-use problems

Alcoholism - Brief interventions work best for problem drinking among young people

Alcoholism - Genetics may determine response to alcohol, subsequent behavior

Alcoholism - Proteomics may be able to help identify and treat alcohol's effects on the body

Allergy - Children with fever before age 1 less likely to develop allergies

Allergy - Contact dermatitis on face could be caused by variety of allergens

Alzheimer Disease - Broad patent granted for neurologic gene therapy

Alzheimer Disease - Cathepsin B identified as important in mediating nerve cell death

Alzheimer Disease - Cholesterol implicated in the development of Alzheimer disease

Alzheimer Disease - New study may explain how fats damage neurons

Alzheimer Disease - Possible mechanism for link between diabetes and AD discovered

Alzheimer Disease - Researchers describe how AD meds may reduce interference with learning, memory

Alzheimer Disease - Survey finds gaps in public's knowledge of treatments for AD

Amyloidosis - FDA grants fast track approval for Fibrillex

Amyotrophic Lateral Sclerosis - Metabolomics company awarded biomarker study collaboration

Amyotrophic Lateral Sclerosis - RNA interference represses mutated SOD1 genes in mammalian cells

Anastamosis - Multiple anastomoses may reduce risk of thrombosis in free-flap transfer

Anesthesia - FDA issues clearance of next generation anesthesia monitor

Anesthesia - Skin permeation device facilitates rapid skin anesthesia within 5 minutes

Ankle Fractures - Less-invasive surgery shows promise for foot and ankle fractures

Anthrax -  B. anthracis spores can germinate, grow and reproduce in soil

Anthrax - Surface layer protein EA1 is not component of Bacillus anthracis spores

Anti-Infectives - Artemisinin alkylates human hemoglobin A0

Antiangiogenesis - THAM-derived cotelomers bearing thalidomide units stop new vessel growth

Antibiotics - Solid-phase synthesis of cyclic decapeptide antibiotic streptocidins reported

Antisense Technology - New lipophilic cation conjugates direct antisense agents to the inner cell

Anxiety - In-silico anxiety drug to undergo phase I clinical trials

Anxiety - Many Americans still upset, fearful after 9-11 attacks

Apoptosis - Sepsis drug also protects brain cells

Assisted Reproduction - Genetic screening counseling should be offered to infertility patients

Assisted Reproduction - Religion guides views of fertility treatment in Middle East

Assisted Reproduction - Surrogate mother legislation passes Oklahoma House committee

Asthma - Children's flu vaccination does not relieve exacerbations

Asthma - New diagnostic test developed

Asthma - One in five asthmatics highly sensitive to aspirin

Asthma - Survey finds many women stop or reduce asthma drugs during pregnancy

Atopic Dermatitis - Antisense molecules delivered by iontophoresis improves skin lesions in mice

Atopic Dermatitis - Infants exposed to dogs have reduced risk of developing atopic dermatitis

Atrial Fibrillation - U.K. facing costly "epidemic" of heart pump disturbance

Automated External Defibrillators - External defibrillators move into retailing via Walgreens online

Avian Influenza - Bird flu not going away soon, WHO says

Avian Influenza - Expert warns bird flu outbreak could evolve into SARS-like epidemic

Avian Influenza - Infection-control company launches fight against avian flu

Avian Influenza - Leopard reportedly dies of bird flu; study of patients shows short incubation period

Avian Influenza - New approach may provide prompt recovery from bird flu

Avian Influenza - New research could lead to potential treatment for avian flu

Avian Influenza - South Asia health officials hold emergency meeting on avian influenza

Avian Influenza - U.S. senators want task force to deal with avian flu

Avian Influenza - Vaccine could be made quickly if Asian bird flu goes global, U.S. officials say

Bacillus - BH1999 protein of Bacillus halodurans C-125 is a thioesterase

Bacillus Calmette-Guerin Vaccine - Intranasal BCG vaccine better than subcutaneous vaccine against pulmonary TB

Bacteriology - Community-acquired pyelonephritis is linked to drug-resistant E. coli

Bioinformatics - Ingenuity's products licensed for drug discovery

Biotechnology - Autologous fibrin glue useful for maxillofacial surgery

Blood Banking - Therapeutic company files five patent infringement lawsuits

Botulinum Toxin - Mouse bioassay and ELISA compared for detecting botulinum toxin in food

Bovine Spongiform Encephalopathy - New form of mad cow disease is discovered

Bovine Spongiform Encephalopathy - Researchers search for new mad cow test

Bovine Spongiform Encephalopathy - Slaughterhouse owners dispute USDA "downer" claims of its mad cow

Brain Cancer - Mouse brain cancer is monitored longitudinally with MRI

Brain Cancer - New scan could predict response to brain cancer treatment

Brain Research - Hong Kong, mainland scientists to set up Chinese brain bank

Brain Tumors - Higher spatial resolution of fMRI is needed for neurosurgical planning

Breast Cancer - Breast cancer risk significantly reduced in association with soy intake

Breast Cancer - Breast surgeons' group to lead MammoSite RTS patient registry

Breast Cancer - Community screening trials provide new answers about early detection

Breast Cancer - Deregulated EZH2 gene may be related to poorly differentiated breast carcinoma

Breast Cancer - Folate-targeted lipid-based gene vectors reduce breast adenocarcinoma volume

Breast Cancer - Gamma-tocotrienol can induce apoptosis in human breast cancer cells

Breast Cancer - Having an outlet for stress may lower patients' mortality risk

Breast Cancer - Imaging equipment provider broadens mammography product line

Breast Cancer - Invasive micropapillary breast carcinoma demonstrates high vessel density

Breast Cancer - Long-term use of antibiotics possibly linked with increased disease risk

Breast Cancer - Most general surgeons in Canada treat breast disease

Breast Cancer - New breast cancer test introduced

Breast Cancer - Nonattendance at breast cancer screenings may be due to socioeconomic factors

Breast Cancer - Phase III study of RSR13 initiated in women with brain metastases

Breast Cancer - Reproductive history is unrelated to progression to invasive breast cancer

Breast Cancer - Significant disparities still exist in screening mammography rates

Breast Cancer - Study finds nipple-sparing mastectomy is a reasonable option for certain patients

Breast Cancer - Women at high risk of breast cancer pleased with preventive mastectomy decision

Breast Cancer Risk Factor - Adipose PCB increases risk of breast cancer recurrence in women

Business & Finance - Connecticut hospitals still going through financial crunch

Business & Finance - Developing countries seek international system for biodiversity sharing

Business & Finance - Hospital essential to city's health has powerful help in dispute

Business & Finance - Hospital funding debated in Wyoming

Business & Finance - House committee narrowly passes cigarette tax increase

Business & Finance - Medical services tax dropped from bill approved by New Mexico house

Business & Finance - PatientKeeper mobile computing closes 2003 with record fourth quarter

Business & Finance - Pennsylvania hospitals show mixed results on finances

Business & Finance - Pennsylvania state police in favor of proposed law restricting medicine sales

Business & Finance - Pharmaceutical alliances result in greater profits, reports analyst

Business & Finance - Pharmaceutical company signs agreement to promote Riomet

Business & Finance - Private pharmacy companies complain about unfair competition

Business & Finance - Trospium maker reports net loss for first quarter 2004

Business Update - Agreement reached for workers at one of the nation's largest nursing home chains

Business Update - Biotech business donated to Pittsburgh medical center by Rohm and Haas Co.

Business Update - Collaboration provides financial services for consumer-driven healthcare

Business Update - European sales for expanded for oncology sales

Business Update - Hospital's appeal claims plan to build competing facility is illegal

Business Update - Las Vegas selects consumer-driven healthcare program

Business Update - Levulan PDT generates excitement at AAD meeting

Business Update - Mail-order contract from Medco Health taken over

Business Update - Nurse overtime bill passed by West Virginia house

Business Update - Strategic alliance formed to deliver new generation of healthcare

Cancer Diagnosis - Aging hepatitis C virus carriers should undergo screenings for liver cancer

Cancer Metastases - Tumor blood vessels forecast the risk of breast cancer travel to lymph nodes

Cancer Research Award - Pan-Mass Genomic Services grant awarded to help fund cancer research

Cancer Risk - Harvard study says aspirin may lower risk of Hodgkin disease

Cancer Risk - Large study to assess vitamin use and cancer risk

Cancer Suppression - Forced expression of connexin 26 arrests the growth of prostate cancer cells

Cancer Therapy - Amidox inhibits ribonucleotide reductase in human leukemia cells

Cancer Therapy - Clinical study to investigate the combination of GTI-2040 and gemcitabine

Cancer Therapy - Company announces publication of gambogic acid research

Cancer Therapy - Docetaxel may be an effective alternative to taxane in ovarian cancer

Cancer Therapy - Gutless vectors encoding transgenes enhance the effect of oncolytic viruses

Cancer Therapy - Norwegian Radium Hospital receive FUGE grant to develop new anticancer agents

Cancer Therapy - Novel triaryl methane derivatives fight cancer without injuring the liver

Cancer Therapy - Salvinal has antimitotic activity in drug-resistant human tumor cells

Cancer Therapy - Scientists overpower cancer's drug defenses

Cancer Therapy - Three Thai medicinal plants show toxicity to certain tumors in vitro

Cancer Therapy - Vascular targeting agent technology reviewed in medical journal

Cancer Therapy - p53 Gene transfer won't harm normal cells

Cancer Vaccine - Electrofusion of dendritic cells and tumor generates therapeutic vaccine

Cardiac Ischemia - New marker linked with heart disease in women

Cardiology - High heart rate reduces arterial distensibility

Cardiology - Modulation of potassium channels is dependent on protein tyrosine kinase

Cardiovascular Disease -  APOA5 locus strongly influences plasma triglyceride levels in ethnic groups

Cardiovascular Disease -  MTHFR mutation raises pediatric hyperhomocysteinemia risk

Cardiovascular Disease - Angiotensin II causes oxidative stress in hypertension patients

Cardiovascular Disease - Cardiac troponin I mutation linked to idiopathic dilated cardiomyopathy

Cardiovascular Disease - Effect of APOE gene variants on European life expectancy clarified

Cardiovascular Disease - Heart resynchronization can resolve pacemaker-induced mitral regurgitation

Cardiovascular Disease - Hypertension-induced cardiac remodeling reviewed

Cardiovascular Disease - Lower blood pressure credited for reduced CVD mortality in Israel

Cardiovascular Disease - Paraoxonase pharmacogenetics reviewed

Cardiovascular Disease - Post-revascularization contractile recovery in LV dysfunction patients evaluated

Cardiovascular Disease - Stem-cell transplantation can prevent lysosomal storage disease-induced CVD

Cardiovascular Disease Diagnostics - Biomarkers of acute coronary artery disease reviewed

Cardiovascular Disease Diagnostics - Hand-held ultrasound valuable for field CVD diagnosis

Cataract Surgery - A new technique for cataract surgery does not use preoperative eye drops

Cataracts - CollAm intraocular lens can be implanted during active uveitis

Catheter-Related Infections - U.S. Food and Drug Administration approves clinical trial for MethLock

Cell Biology - Chemical that turns mouse stem cells into heart muscles discovered

Cell Biology - DHEA boosts growth rate of human neural stem cells

Cell Biology - Equine cloning's triple play sheds light on calcium, cell signaling

Cell Biology - Hepatitis C virus relies on cellular proliferation for genomic replication

Cell Biology - Stem cell "ribbon" found in adult human brain

Cervical Cancer - Atypical glandular cells in HPV+ patients may indicate serious disease

Cervical Cancer - Cervical cancer prevention should include human papillomavirus testing

Cervical Cancer - Hycamtin-cisplatin regimen shows cervical cancer survival advantage

Cervical Cancer - Meta-analysis suggests HPV testing helps identify potential cases

Cervical Cancer - Optical detection system with colposcopy improves cervical cancer detection

Cervical Cancer - Overexpression of HER-2/neu uncommon in invasive carcinoma of uterine cervix

Cervical Cancer - Study characterizes gene silencing in precursor to disease

Chagas Disease - Role of chemokine receptors in chagasic cardiomyopathy evaluated

Chemoprevention - Lycopene and carotenoids may slightly reduce the risk of rectal cancer in women

Chickenpox - Effectiveness of vaccine decreases after 1 year

Childhood Cancer - Male fertility must be considered when evaluting treatment for childhood cancer

Childhood Immunization - Parents must get more information to counter immunization fears

Childhood Obesity - Pilot program aimed at preventing obesity in children did not reduce obesity

Childhood Obesity Risk Factor - British children become sedentary at young age

Children's Health Insurance - SCHIP provided health coverage to 5.8 million U.S. children in 2003

Chlamydia - Disease incidence set North Dakota record in 2003

Chocolate - Symposium yields good news for chocolate lovers

Chronic Beryllium Disease - Electrostatics affect antigen recognition in chronic beryllium disease

Chronic Liver Disease - Genome-wide scans could identify genes that present a risk for liver fibrosis

Chronic Myelogenous Leukemia - Lack of cytogenetic response after imatinib treatment predicts relapse

Chronic Obstructive Pulmonary Disease - Daxas submitted for European approval

Chronic Renal Failure - Effects of homocysteine on left ventricular hypertrophy in pediatric CRF clarified

Cloning - Cloned stem cells regenerate heart muscle following a heart attack

Cognitive Function - Fitness can improve thinking among aging

Collaborations - Development, sales, support agreement signed with Applied Biosystems

Collaborations - Emory, partner, identify topical microbicides for drug development

Collaborations - GPC Biotech achieves milestone in osteoarthritis alliance

Collaborations - High-throughput medicinal chemistry deployed in alliance

Collaborations - MDS Pharma Services announces strategic alliance

Collaborations - Manufacturing, business development partner named for m-doc technology

Collaborations - Merck enters alliance to develop and commercialize gaboxadol for sleep disorders

Collaborations - Milestone payment received from licensing agreement with Pfizer

Collaborations - Mouse genetics deal signed to generate mice for gene function analysis studies

Collaborations - Negotiations proceed on deal to formulate new type of aspirin

Collaborations - PET supplier reports renewal of supply, license agreements with Merck

Collaborations - Premier enters contract for supply of medical gases

Collaborations - Research milestone reached in deal with Amgen

Colon Cancer - Gender and location may be related to the pathogenesis of colon cancer

Colon Cancer - Osteopontin correlates with colon cancer tumor progression

Colorectal Cancer - Study shows RAY1/ST7 is not a colorectal cancer tumor suppressor gene

Complementary and Alternative Medicine - FDA approves acupressure wristband for nausea

Complementary and Alternative Medicine - Regulatory issues on safety and efficacy of herbal remedies discussed

Congestive Heart Failure - Nearly half of Americans experience delay in heart failure diagnosis

Congestive Heart Failure - Peptide may help predict heart disease

Congestive Heart Failure - Statin medications may markedly improve survival of heart failure patients

Consumer Information - Kiosk Information Systems and Healthnotes launch consumer health kiosks

Consumer-Driven Health Insurance - Survey: Programs encourage behavior changes that lead to healthier outcomes

Contraception - Bush advocates abstinence-only education

Contraception - Court says company's health benefits must cover prescription birth control

Contraception - FDA postpones morning-after pill decision

Contraception - Survey shows slow start for California's new "pharmacy access" program

Coronary Artery Bypass - Ischemic preconditioning cuts rhythm disturbances after coronary artery bypass

Coronary Artery Bypass - Pulsatile pump preserves platelets better

Coronary Artery Bypass - Simultaneous OPCAB and esophagectomy feasible for esophageal cancer patients

Coronary Atherectomy - A new plaque excision system for complex coronary lesions shows early success

Coronary Heart Disease - Apolipoprotein A phenotypes mark CHD familial aggregation

Cosmetic Surgery - Working party reports on feasibility of facial transplantation

Coughing - Chronic cough significantly impacts life quality in women

Critical Care - Study compares clinical diagnoses and autopsy diagnoses in ICU deaths

Cysticercosis -  Taenia solium antigen diagnostic for cysticercosis characterized

Cytomegalovirus Vaccine - Glycoprotein B DNA vaccine prevents congenital cytomegalovirus transmission

DNA Variants - System introduced for DNA sequence variation studies

Dengue Fever - Dengue virus strains show promise for candidate vaccines

Dengue Fever - Factors affecting vector competence of dengue virus mosquitoes studied

Dengue Fever - Live-attenuated dengue virus vaccine stimulates TH1 immune responses

Dengue Fever - Safe and immunogenic monovalent attenuated dengue vaccines developed

Dengue Virus - Dengue virus envelope protein changes structure after membrane fusion

Depression - Can drugs prevent recurrence of depression? The news is depressing

Dermatology - Hair disorders: Dermatologists identify the top causes of tress distress

Developmental Biology - Fat and smart - the perfect combination?

Developmental Biology - Jefferson researchers uncover biochemical clues to how cells migrate in embryos

Diabetes - Limb-saving procedures reduce diabetic foot amputations

Diabetes - People with diabetes warned of increased risk of heart disease, stroke

Diabetes - Young people prone to type 2 diabetes exhibit alterations in mitochondrial activity

Diabetes Genomics and Genetics - Rat Iddm4 mapped to segments on HSA7 and MMU6

Diabetes Management - FDA approves new Guardian Continuous Glucose Monitoring System

Diabetes Pathogenesis - Cross-priming of diabetogenic T cells dissociated from autoantigen shedding

Diabetes Pathogenesis - Leptin, TNF-alpha, and NO affect insulin resistance via different mechanisms

Diabetes Pathogenesis - Troglitazone prevents increased activity of 11-beta-HSD-1 in diabetic islets

Diabetes Risk Factor - Children with history of diabetes have reduced beta-cell function

Diabetes Therapy -  Rehmannia glutinosa oligosaccharide is hypoglycemic in diabetic rats

Diabetes Therapy - Beta-carbolines potentiates insulin secretion from islets of Langerhans

Diabetes Therapy - Electronic monitoring can improve diabetes care

Diabetic Nephropathy - Cytomegalovirus ischemic colitis develops in renal transplant recipient

Diabetic Neuropathy - Cases of diabetic cervical radiculopathy with capsulitis of shoulder reported

Diabetic Neuropathy - Glycation end products accumulate in kidney, retina, and peripheral nerve

Diagnostics - A fully automated chemiluminescent microparticle immunoassay counts HBV antigen

Diagnostics - Bile carcinoembryonic antigen can be helpful in diagnosing bile duct cancer

Diagnostics - Blood test could avoid inappropriate use of antibiotics for respiratory infections

Diagnostics - Circulating markers are important in diagnosing neuroendocrine tumors

Diagnostics - FDG PET imaging is optimal for assessing head and neck carcinoma

Diagnostics - Frozen sections cancer diagnosis is quick and reliable for most tumors

Diagnostics - Orofacial pain syndromes can be evaluated by laser stimuli

Diagnostics - Rapid diarrhea test saves lives

Diagnostics - The LCx HCV RNA quantitative assay possesses several key attributes

Diagnostics - The in vivo chamber angiogenesis assay measures angiogenic activity in mice

Diagnostics - [18F]FDG-PET identifies patients ready for reconstructive surgery

Dialysis - FDA clears SpeedLyser infusion catheter

Diet and Nutrition - Amino acid composition of soybean protein affects carbohydrate oxidation

Diet and Nutrition - Breastfeeding longer is beneficial

Diet and Nutrition - Cysteine-containing garlic derivatives have antioxidative activity in mice

Diet and Nutrition - Dietary lignins are precursors of murine lignans

Diet and Nutrition - Fighting hunger today could help prevent obesity tomorrow

Diet and Nutrition - Lifestyle strongly influences immune function during hypercholesterolemia

Diet and Nutrition - Postpartum weight-loss classes work

Disease - Hospital confirms one Norwalk virus case, second hospital suspected

Disease Management - Computerized disease registries offer key to improving chronic disease care

Disease Prevention - Aging CDC labs will be improved with appropriation of $250 million

Disease Prevention - Federal panel recommends increased mad cow testing

Disease Prevention - Medicine may be handled by post office in national emergency

Drug Delivery - ANDA filed for Toprol-XL; generic version of Lotensin launched

Drug Delivery - Aeroneb Go Nebulizer introduced in U.S.

Drug Delivery - Anticompression therapies could open up tumors to anticancer drugs

Drug Delivery - Cell fusion could repair organs, deliver cancer vaccines

Drug Delivery - Company enters R&D agreement to develop a topical gel for treating pain

Drug Delivery - Intracoronary abciximab in coronary stenting may be better than i.v method

Drug Delivery - Study shows effective transdermal delivery of testosterone

Drug Design - Studies offer new insight into HIV vaccine development

Drug Development -  Bacillus thuringiensis crystal proteins protect against malaria in mice

Drug Development - Amino acid-conjugated quinolinamines are potent antimalarials

Drug Development - Bicyclam-GalCer agents have disappointing antiretroviral activity

Drug Development - Cyclohexane derivatives strongly inhibit HIV integrase activity

Drug Development - Galactopyranosyl amino alcohols show promise as antimicrobial agents

Drug Development - Novel compounds reveal an ability to stem hepatitis C virus replication

Drug Development - Novel method improves bremazocine enantiomer synthesis

Drug Development - Novel trioxane derivatives have improved antimalarial activity

Drug Development - Water-soluble dipeptide HIV PI prodrugs synthesized

Drug Discovery - Drug discovery and pharmaceutical companies sign research agreement

Drug Discovery - Lab filters earn Zymark/Caliper exclusive certification

Drug Discovery - New, nonradioactive screen for antimalarial compounds developed

Drug Guidelines - Investigation focuses on payments to state agency, officials

Drug Safety - Group joins FDA effort to ensure integrity of drug supply

Drug Settlement - Banner Health Systems settlement money being distributed

Drug Use - New test could help reduce unnecessary antibiotic use

Ebola Virus - Ebola virus-like particles protect from lethal Ebola virus infection

Ebola Virus - Infection with Ebola virus persists under conditions of partial immunity

Ebola Virus - Novel Ebola virus-like particles produced from cDNAs

Encephalitis Vaccine - Nipah virus vaccine provides protection in hamster model

Endocrinology - ACE inhibitors ameliorate connective tissue growth factor-induced retinopathy

Endocrinology - Can early experiences predispose to hormonal disorders later in life?

Endocrinology - Female apolipoprotein E-knockout mice experience early cognitive decline

Endocrinology - Ghrelin promotes adipogenesis directly in vivo

Endocrinology - High neonatal 5HT levels antagonize the masculinizing effects of testosterone

Endocrinology - Phenotypic array of hypothalamic neuronal cell models generated

Endocrinology - Progestins have little impact on how estrogens influence bone health

Endocrinology - Treatment for endocrine disease: Is something missing?

Endometrial Cancer - Estrogen replacement therapy associated with low endometrial cancer recurrence

Endometriosis - Aromatase inhibitor shows therapeutic promise for endometriosis

Endoscopic Ultrasonography - Endoscopic ultrasonography is advancing to guide tissue sampling

Environmental Health - Environmentalists say President Bush, Florida governor are harming water quality

Environmental Toxins - Exposure to low-level magnetic fields causes DNA damage in rat brain cells

Environmental Toxins - High rate of respiratory symptoms seen in police at World Trade Center site

Enzymology - Matrix enzyme polices cellular proliferation by controlling IGF bioavailability

Enzymology - Peptidyl-alpha-ketoamide inhibitors take unusual steps to block HCV protease

Enzymology - Protease inhibitors detected by reverse zymography method

Epicardial Echocardiography - Intraoperative epicardial echocardiography can assess valve function

Epidemiology - Leukemia panel will meet once more in northern Nevada town

Escherichia Coli - GenProtEC provides improved analysis of E. coli K-12 protein functions

Ethics - Bioethicists take differing views on cloning breakthrough

Evolutionary Biology - Researcher offers a new perspective on human evolution

Exercise & Health - Retired gymnasts retain high levels of bone mass during early adulthood

Expansion - MedCath announces opening of 12th hospital

Fabry Disease - Replagal receives Canadian approval to treat Fabry disease

Facial Implants - Zygomatic implants restore function in patients with resorbed maxillae

Fetal Medicine - Fetal mouse brain cells self-destruct when maternal folate levels are deficient

Finance - Albuferon maker reports increased net loss in 2003

Finance - Band-Aid maker reports 40% increase in revenues

Finance - Biomaterials company reports 49% increase in product sales

Finance - Biopharma company to issue $150M of convertible notes in private offering

Finance - Biopharmaceutical company announces initial public offering

Finance - Biopharmaceutical company reports earnings of $1.44 per share

Finance - Bioscience company reports 2003 financial results

Finance - Biotech company reports 19% revenue growth for 2003

Finance - Biotech company reports 2003 and fourth quarter financial results

Finance - Biotech firm completes $2.5M revolving credit, security agreement

Finance - Blood products firm reports repayment of debentures

Finance - CVProfilor maker completes $2.75M equity financing announced in August 2003

Finance - Cancer drug maker reports loss of $0.18 per share

Finance - Cancer-focused biopharma reports second quarter net losses

Finance - Capsule endoscopy company announces record sales, positive cash flow in fourth quarter

Finance - Cardiovascular disease drug maker reports loss of $1.21 per share

Finance - Catalytic antioxidants maker reports net loss in first quarter

Finance - Consumer products company increased gross revenues in first quarter

Finance - Contract research services company reports 26% revenue increase

Finance - Defibrillator maker secures line of credit

Finance - Dental lab company reports increased sales for fourth quarter and full year 2003

Finance - Device company secures new financing, announces expansion

Finance - Device firm reports revenue growth, quarterly earnings

Finance - Device maker reports sales of $2.3M in fourth

Finance - Diagnostic products manufacturer announces positive 2003 financials

Finance - Diagnostics company reports first quarter net losses

Finance - Diagnostics company reports increased revenue in fourth quarter, full year 2003

Finance - Diagnostics company reports strong financial results for Q4 and full year 2003

Finance - Diagnostics maker reports 10.3% decrease in sales

Finance - Diagnostics maker reports 9.5% increase in revenue

Finance - Drug delivery company reports 8.6% decrease in contract revenue

Finance - Drug delivery company's debt upgraded by Moody's

Finance - Federal grant supports advances in infant heart disease

Finance - Gene-variation company reports fourth quarter and year end results for 2003

Finance - Genesis HealthCare Corp. reports first quarter fiscal 2004 results

Finance - Genomics company prices private placement of $100M notes

Finance - Gentiva reports fourth quarter and full year 2003 growth

Finance - Healthcare product supplier to China reports loss of $0.10 per share

Finance - Heath-products company reports positive third quarter earnings

Finance - Hemophilia treatment developer reports yearly loss of $1.28 per share

Finance - Higher revenue, earnings reported by medical device firm

Finance - Immunotherapeutics firm announces $25M in equity financing

Finance - Implant company's 2003 revenues increase by 20% over 2002

Finance - Inflammatory diseases drug maker reports quarterly loss of $0.43 per share

Finance - Laser maker reports 41% increase in fourth quarter 2003 revenues

Finance - Life sciences company raises an additional $1.15 million

Finance - LymphoCide maker reports net loss in second quarter

Finance - Medical device manufacturer announces 2003 financial results

Finance - Medical products manufacturer announces 2003 financial results

Finance - Metabolic/endocrine-focused company reports improved financial results

Finance - Mitsui makes equity investment in proteomics company

Finance - Molina Healthcare reports fourth quarter and year end results

Finance - Neurobiological Technologies receives $2.25M related to Memantine

Finance - Neuroscience company reports net loss of $0.02 per share

Finance - Nutritional supplements developer reports fiscal second quarter results

Finance - Ophthalmic pharmaceutical company announces completion of financing round

Finance - Ophthalmology company receives first round financing

Finance - Oscilloscope maker files registration statement for follow-on public offering

Finance - Pennsylvania biotech greenhouse invests $3M in regional enterprises

Finance - Pharmaceutical company announces 2003 financial results

Finance - Pharmaceutical company board announces stock split

Finance - Pharmaceutical company reports "challenging yet successful" year

Finance - Pharmaceutical company reports 2003 financial results

Finance - Pharmaceutical company reports increased losses, reduced revenues

Finance - Pharmaceutical company reports loss of $0.09 per share

Finance - Pharmaceutical company reports loss of $0.29 per share

Finance - Pharmaceutical firm moves to NASDAQ market under new symbol

Finance - Pregnancy-test maker completes private placement

Finance - Private equity financing to help fund development of KRX-101 and KRX-0401

Finance - Private pharmaceutical company receives $15.3 million in series A financing round

Finance - Product revenues increase 17% for cardiovascular device maker

Finance - Research company reports increased fourth quarter revenues

Finance - Respiratory care products company reports profitable 2Q

Finance - Respiratory-therapy company reports 19% increase in revenues

Finance - Robotics company reports record $27.6 million fourth quarter sales, up 30%

Finance - Sales grow 13.7% for pharmaceutical company

Finance - Senior care firm announces call of $4.5M of its 10% notes

Finance - Ultrasound technology company reports positive financial results for 2003

Fitness - Indoor school activity areas often closed to public

Fitness - Super Bowl ends many gym-goers' drive

Follicular Thyroid Carcinoma - A cell-mediated approach to sFlt-1 gene therapy targets thyroid cancer

Food Safety - Kansas panel endorses bill moving food safety duties to agricultural agency

Food-borne Illness -  Yersinia pseudotuberculosis traced to fresh produce for the first time

Food-borne Illness - Effects of handling on biogenic amine formation in fish reported

Food-borne Illness - Putrescine indicates decomposition in penaeid shrimp

Food-borne Illness - World food safety experts offer new methods to assess risk

Gastric Cancer - Computer program helps with planning gastric cancer surgery

Gastroenterology -  Helicobacter pylori has been implicated in the formation of liver cancer

Gastroenterology - VEGF might be a predictor of gastric cancer transformation

Gastrointestinal Tumors - Targeted molecular autofluoresence can detect murine intestinal adenomas

Gene Expression - Genetic diseases often caused by mutations in highly expressed genes

Gene Therapy - Scientist warns gene therapy could build superathletes

Gene Transfer - A new gene carrier steers interleukin-12 to solid tumors

Gene Transfer - An autogene-based cytoplasmic expression system improves gene expression

Gene Transfer - Insulin gene nasal inoculations improve diabetes in insulin-dependent models

Generic Drugs - Company announces approval and launch of benazepril hydrochloride tablets

Generic Drugs - FDA approves Benazepril Hydrochloride ANDA

Genetic Disorder - Contraception choices for woman with factor V Leiden outlined

Genital Cancer - Estrogen affects ultrastructure of testis germinal epithelium in Wistar rats

Genomics - A new cis-acting replication element will provide insight into HCV RNA action

Genomics and Genetics - Relation of Msx homeobox gene family and craniofacial development reviewed

Geriatrics - Elderly patients in Taiwan have quality of life changes after hip fracture

Geriatrics - What are your odds of surviving into your hundreds?

Germ Cell Tumors - Temozolomide proves ineffective in cisplatin-refractory germ cell tumors

Gluten Intolerance - Celiac disease may predict schizophrenia

Gynecological Cancer - Image fusion helps resolve discrepant findings between FDG-PET and MRI/CT

HIV Diagnosis - FDA clearances granted for ViroSeq HIV-1 genotyping system

HIV/AIDS - Billions budgeted in South Africa for fight against AIDS

HIV/AIDS - Controversial Nebraska bills would create new HIV-related crimes

HIV/AIDS - Iowa Hospice worker helps African hospice cope with AIDS

HIV/AIDS - Japanese doctor accused in HIV scandal unfit to stand trial

HIV/AIDS - Officials to experience life in Chinese AIDS villages

HIV/AIDS Diagnostics - Real-time SYBR green PCR useful for HIV viremia measurement

HIV/AIDS Drug Resistance - Genotypic resistance after abacavir, efavirenz salvage treatment characterized

HIV/AIDS Education - Grant to support HIV/AIDS education among religious cults in Brazil

HIV/AIDS Epidemiology - For first time since 1992, AIDS cases rise in Los Angeles County

HIV/AIDS Epidemiology - Illinois AIDS cases decline

HIV/AIDS Epidemiology - UN: HIV growth rates in Estonia, Russia and Ukraine among world's fastest

HIV/AIDS Pain - NGX-4010 demonstrates pain reduction in HIV-associated neuropathy study

HIV/AIDS Pathogenesis - Conformation of HIV gp41 during cell entry determined

HIV/AIDS Pathogenesis - HIV-1 trans-activator protein affects pathogenesis of HIV-1 infection

HIV/AIDS Pathogenesis - Immune failure occurs without CD4+ T-cell depletion in SIV-infected macaques

HIV/AIDS Pediatric - Cytotoxic T-cell CD38 expression predicts viral control in HAART-treated children

HIV/AIDS Perinatal Medicine - HIV coreceptor expression determined in exposed but uninfected infants

HIV/AIDS Prevention - Germany launches first HIV/AIDS vaccine trial

HIV/AIDS Proteomics - Effects of P-TEFb on HIV transcription elucidated

HIV/AIDS Proteomics - Entropic switch regulates myristate exposure in HIV matrix protein

HIV/AIDS RNA Research - Perinuclear HIV RNA release mediated by hRIP

HIV/AIDS RNA Research - Retroviral replication system aids HIV TAR study

HIV/AIDS Therapy - Adiponectin attenuates protease inhibitor-induced dyslipidemia

HIV/AIDS Therapy - Adiponectin levels linked to lipodystrophy, stavudine treatment

HIV/AIDS Therapy - CTP biosynthesis inhibitors augment 3TC efficacy

HIV/AIDS Therapy - Drug "cocktail" benefits women with advanced HIV/AIDS

HIV/AIDS Therapy - Efavirenz-induced sleep abnormalities evaluated

HIV/AIDS Therapy - No GPG-NH2 resistance mutations seen in vitro

HIV/AIDS Therapy - Once-daily lopinavir/ritonavir pill evaluated

HIV/AIDS Therapy - Sarcoidosis rate and severity reduced in HAART era

HIV/AIDS Therapy - Significance of residual lymphoid HIV RNA determined

HIV/AIDS Transmission - Heterosexual Hispanics, blacks account for high proportion of cases

HIV/AIDS Treatemnt - Human clinical trials of HIV maturation inhibitor to commence

HIV/AIDS Treatment - New data reported on Serostim treatment in HARS patients

HIV/AIDS Treatment - New data suggest potential for once-daily dosing regimen of Kaletra

HIV/AIDS Treatment - Phase II HIV study results of Reverset announced

HIV/AIDS Tuberculosis - Rifampin strongly reduces indinavir levels

HIV/AIDS Vaccine - Company presents model for a new therapeutic vaccination strategy against HIV

HIV/AIDS Vaccine - Vaginal infection with influenza A elicits immune response to HIV epitope

HIV/AIDS Vertical Transmission - Novel DNA extraction method enables HIV diagnosis via dried blood

HIV/AIDS Woman's Health - GBV-C infection has protective effect in HIV+ mothers

HIV/AIDS Woman's Health - Injected contraceptive use heightens acute HIV viremia

Head and Neck Cancer - Angiogenesis is difficult to quantify in oral cancers

Head and Neck Cancer - The angiogenic switch is an early event in esophageal squamous cell carcinoma

Health Prevention - Defibrillators donated to high schools in South Carolina

Health and Well-Being - New Jersey middle school puts a limit on bathroom breaks

Healthcare Coverage - Almost 1 in 5 South Carolinans have no health coverage

Healthcare Coverage - Catholic hospitals in California adopt policies to protect uninsured patients

Healthcare Coverage - Employee health insurance is looked over by South Dakota lawmakers

Healthcare Coverage - Florida lawmakers shape budget

Healthcare Coverage - Full Medicaid changes put on hold in Vermont

Healthcare Coverage - Health savings accounts: Interest high, knowledge low

Healthcare Coverage - HealthAmerica and HealthAssurance expand hospital network in Pennsylvania

Healthcare Coverage - HealthPartners plans to offer drug discount card for Medicare beneficiaries

Healthcare Coverage - Kentucky governor's health insurance plan draws complaints

Healthcare Coverage - KidCare money among main healthcare issues

Healthcare Coverage - McCoy says Mississippi House budget to fully fund insurance

Healthcare Coverage - Missouri's proposed Medicaid cuts could leave 48,000 without coverage

Healthcare Coverage - Nonprofit housing operator files for bankruptcy

Healthcare Coverage - Shawano County Rural Health Initiative created in Wisconsin

Healthcare Coverage - Ukraine criticizes U.N. decision to suspend funding for HIV/AIDS

Healthcare Economics - Finances, changing needs a challenge for rural hospitals in West Virginia

Healthcare Economics - Poll shows health, retirement costs weigh on Iowans' minds

Healthcare Trends - Report looks at healthcare leaders under pressure

Heart Disease - FDA requests additional information on decellularized heart valves

Heart Disease - Minority women in U.S. unaware of higher risk

Heart Disease Mortality - Cheap, four-drug combo saves heart patients' lives

Heart Disease Risk - For heart disease, efforts that click are better than changes that never stick

Heart Disease Risk - More needs to be done to fight heart disease in young people

Heart Disease Risk - Routine tests, scans not recommended for patients at low risk for heart disease

Heart Disease Therapy - Improved medical treatment of serious heart problems focus of study

Heart Failure - QRS prolongation prevalence in hospitalized HF patients evaluated

Heart Failure - Rate of LV hypertrophy progression to heart failure evaluated

Heart Failure - Rights acquired to a key cardiac marker, NT-proBNP

Heart Failure Therapy - Nesiritide superior to nitroglycerine treatment

Heart Failure Therapy - Superiority of ACE inhibitors remains questionable

Heatstroke - Wearable air-conditioners: Hot, new microtechnology keeps GIs cool

Hematology - Peripheral blood lymphocyte reference for Asian populations developed

Hemodialysis - Dialysate iron therapy for hemodialysis patients receives patent

Hemodialysis Catheter - A new catheter introducer sheath is an improvement but has some problems

Hemophilia Therapy - FVIII gene-carrying SIV vectors show promise

Hepatitis - VIR201 data presented at conference

Hepatitis B Virus - Nabi signs international distribution agreement for Nabi-HB

Hepatitis C Virus - Results reported in landmark study evaluating Ribavirin in HIV/HCV patients

Hepatitis C Virus - Vaccine possible for multiple strains of hepatitis C, evidence shows

Hepatitis E Vaccine - Hepatitis E virus DNA vaccine protected cynomolgus macaques against infection

Hepatocellular Carcinoma - Splenectomy in patients with HCC and secondary hypersplenism can improve staging

Hepatocellular Carcinoma - Surgery for biliary tumor thrombus prolongs survival in hepatocellular cancer

Hepatology - Viral DNA remains in the chronically infected liver despite viral clearance

Herpesvirus - Glycoprotein M need in herpes morphogenesis varies among virus family members

Hodgkin Disease - Modified cytotoxic T cells ferry interleukin-12 to local tumor sites

Hodgkin Lymphoma - Hodgkin lymphoma treatment should focus on improving late morbidity, mortality

Hormone Replacement Therapy - HRT pros, cons should be considered for women with severe menopausal symptoms

Hyperglycemia - Insulin-producing cells found in a variety of tissues in diabetes

Hyperparathyroidism - Some types of familial isolated hyperparathyroidism have unknown cause

Hypertension - Benazepril Hydrochloride Tablets approved for marketing

Hypertension - Black and green tea polyphenols lower blood pressure in rats

Hypertension - Causes of fibrosis in hypertensive heart disease patients reviewed

Hypertension - Company receives final approval on benazepril HCl/HCTZ tablets

Hypertension - FDA plans expedited evaluation of AmVaz NDA

Hypertension - Phase II trial of ALT-711 initiated in endothelial function

Hypertension - Superior blood pressure control reported with use of treatment algorithm

Hypertension - Vasodilation, improved endothelial function underlie effects of quercetin

Idiopathic Dilated Cardiomyopathy - Myocardial perfusion not linked to peripheral endothelial function

Imaging - Medical Media Systems buys tumor-imaging technology

Immunizations - A-Fujian strain tentatively added to influenza vaccine for next year

Immunizations - Committee approves mandatory hepatitis vaccines for Indiana high schools

Immunizations - Short supply of booster shots forcing delay in baby vaccinations

Immunoassays - Eleven diagnostic assays approved for hepatitis, PSA, alpha-fetoprotein

Immunology - Autoimmune tendencies spark inflated immune response to adeno-associated virus

Immunology - Bucillamine uses dual pathways to regulate VEGF in systemic fibrosis patients

Immunology - FDA grants orphan drug designation for Altastaph

Immunology - Immunogene therapy prevents angiogenesis in study animals

Immunology - Swift production of neutralizing antibody halts hepadnavirus infection

Infant Care - Contact lenses could help some infants

Infectious Disease - Epidemiology of human M. bovis infection in the U.K. characterized

Infectious Disease - Medical examiner database useful for fatal infectious disease surveillance

Influenza - Flu vaccine's results leave experts uncertain of next season preparations

Influenza - Report finds inactivated influenza virus vaccines effective in children

Influenza - Vaccine development against H5N1 virus "should be made a priority"

Influenza - WHO adds Fujian flu to vaccine list for next winter

Influenza Vaccine - Benefit of new influenza vaccine in healthy children investigated

Influenza Vaccine - Signed consent requirement for influenza vaccination should be eliminated

Information Technology - Antibacterials developer selects software for chemical reaction planning

Information Technology - CIBEX contains experimental data on gene expression research

Information Technology - Cottage Health Care System selects ibex PulseCheck

Information Technology - Hershey Medical Center selects MedAssets-OSI Systems

Information Technology - Lawson signs contract with Palmetto Health

Information Technology - New patient-monitoring system helps improve patient care

Information Technology - Researchers develop a retroviral tagged cancer gene database

Information Technology - SNP500Cancer database helps researchers map diseases

Information Technology - Use of IT in hospitals bodes well for future, report says

Insomnia - FDA allows IND for extended-release formulation of Sonata

Irritable Bowel Syndrome - Awareness, understanding of IBS key to promoting new drugs

Kaposi Sarcoma - Mechanisms of HHV-8 IL-6 mimicry determined

Kidney Cancer - Tumor-based vaccine shows promise

Kidney Disease - Cardiovascular disease risk factors may also predict development of kidney disease

Kidney Disease - Leptin, ghrelin, and cytokines have nutritional impact in kidney disease

Kidney Disease - Many vaccines are safe and effective in patients with chronic kidney disease

Kidney Failure - BMP-7 prevents bone disease in a model of chronic kidney failure

Klippel-Trenaunay Syndrome - Gene for rare vascular disorder identified

Laboratory Systems - Johns Hopkins installs six BenchMark XT systems

Laryngoscopy - The merits of suspension laryngoscopy should be reexamined

Legal Decisions - Florida legislature still unclear on end-of-life laws

Legal Issues - Arkansas insurer files notice of appeal in 'any-willing-provider' case

Legal Issues - Attorney given prison sentence for City of Hope theft case

Legal Issues - Federal appeals court upholds dismissal of Zoloft lawsuit

Legal Issues - German doctor arrested in connection with eight cases of "mercy killing"

Legal Issues - Hospital in Pennsylvania settles suit against Independence Blue Cross

Legal Issues - Kindred Healthcare announces settlement with Kentucky Attorney General

Legal Issues - Methadone clinics tackled by West Virginia house

Legal Issues - Restrictions pursued for OTC cold medications containing meth ingredient

Legal Issues - U.S. Justice Department demands abortion records

Legal Issues - Washington state lawmakers push 'three strikes and you're out' for doctors

Legal Issues - Women accuse chiropractor of rape

Leishmaniasis - New antibiotic improves treatment of parasitic infection

Leishmaniasis - RAPD method allows Leishmania species differentiation

Leptin Studies - Local, systemic angiotensin II regulate adipocyte leptin release differently

Leptin Studies - Melanocortin receptors mediate leptin effects on hypothalamic neurons

Letter to the Editor - Domestic violence, guns among topics of women's health conference

Leukemia - GATA1 mutations are common children with Down syndrome

Leukemia - Generic Purinethol tablets receive marketing clearance

Leukemia - Immature B cell cancers generate proangiogenic growth factor

Leukemia Pathogenesis - E2a/Pbx1 triggers proliferation of SCF-dependent pro-T cells

Leukemia Therapy - BAVC SCT conditioning comparable to BuCy regimen

Leukemia Therapy - Novel regimen effective for JMML patients without stem-cell donors

Leukemia Therapy - SCT with voriconazole treatment feasible for AML with pulmonary aspergillosis

Leukemia Therapy - Utility of STR markers for post-SCT chimerism evaluated

Limb Ischemia - Cutting balloon angioplasty is feasible for symptomatic limb ischemia

Liposuction - Liposuction improves cholesterol, glucose, and insulin metabolism

Liver Cancer - Management of inferior vena cava injury during hepatectomy is discussed

Lung Biopsy - Contrast-enhanced sonography guides transthoracic biopsy of lung lesions

Lung Cancer - Lung cancer compound phase II trial commences

Lung Cancer - Peroxisome proliferator-activated receptor-gamma activation inhibits NSCLC

Lymphoma Therapy - Mantle cell lymphoma treatment reviewed

Macromolecular Modeling - Insight II and Catalyst now available on Linux

Malaria -  P. vivax heightens erythrocyte deformability

Malaria - In African highlands, climate extremes are critical factor in malaria epidemics

Malaria Drug Resistance - Molecular basis of P. jirovecii atovaquone resistance clarified

Malaria Genomics & Genetics - Fc gamma receptor IIa polymorphism linked to severe malaria in West Africa

Malaria Genomics & Genetics - Murine plasmodial ABC genes identified

Malaria Pathogenesis - Platelets reorient endothelial adhesion of infected RBC

Malaria Pathogenesis - Some malaria parasites are capable of HA and CSA adhesion

Malaria Vaccine - Polymorphism reducing P. falciparum rosetting protects against malaria

Market Analysis - Advanced wound care dressings to be growth engine of European market

Market Analysis - Healthcare costs tops list of Americans' concerns

Market Analysis - Healthcare spending growth projected to nearly double in next decade

Maternal Mortality - WHO: More effort needed to cut the half-million annual deaths in childbirth

Medicaid - Auditors say Houston school district should repay federal funds

Medical Malpractice - Doctors leaving nursing-home patient care because insurers won't cover them

Medical Malpractice - Gynecologist sentenced to 45 years for sexually abusing patients

Medical Malpractice - Kentucky House panel approves proposal for medical malpractice insurance

Medical Malpractice - U.S. Treasury secretary calls for lawsuit damage cap

Medicare - Analysis explains why advantage rate increases for 2004 will vary across U.S.

Medicare - Canadian analysts say new U.S. law hurts seniors, helps drug firms, insurers

Medicare - Cancer experts ask Congress to hold chemo reimbursement rates at 2004 level

Medicare - Choosing hospice care raises federal program costs for last year of life

Medicare - State pharmacy assistance programs help reduce costs, improve patient safety

Melanoma - Data on autologous cell vaccine published

Melanoma - Nodal nevi are more frequent in patients with melanoma-associated cutaneous nevi

Melanoma - The Libechov minipig model is suitable for studying human melanoma

Meningitis - Health groups recommend temporary suspension of pediatric vaccine dose

Menopause - FDA approves EstroGel transdermal gel for estrogen therapy

Menopause - Hot flashes, night sweats treatment now available in U.S. pharmacies

Menopause - Progestins can be a hindrance or a help to women with certain disorders

Mental Health - Amnesia blamed on nightmare, though skeptics remain

Mental Health - Depression and anxiety relate to alexithymia in women with eating disorders

Mental Health - Hundreds of coins found in patient's belly

Mental Health - Late-night mental health niche filled in Maryland

Mental Health - Law to force treatment for mentally ill upheld by New York high court

Mental Health - Mental health reform plan nothing new

Mergers and Acquisitions - Acquisition gives Nanogen foothold in point-of-care diagnostics market

Mergers and Acquisitions - Acquisition of Applied Molecular Evolution complete

Mergers and Acquisitions - Agreement signed to be acquired by Fisher Scientific

Mergers and Acquisitions - Amedisys provides update on purchase of home care agencies

Mergers and Acquisitions - Attentus Healthcare to negotiate acquisition of SunLink Health Systems

Mergers and Acquisitions - China-based pharmaceutical company acquired

Mergers and Acquisitions - FTC clears way for merger of drug benefits companies

Mergers and Acquisitions - GTCR Golder Rauner announces acquisition

Mergers and Acquisitions - Genome Therapeutics merger complete; merged company focused on anti-infectives

Mergers and Acquisitions - Harvard inks letter of intent to acquire assets of antibody development company

Mergers and Acquisitions - HepatoTech's cell culture business acquired

Mergers and Acquisitions - Invitrogen completes acquisition

Mergers and Acquisitions - Microwave surgical cardiac ablation developer acquired by Guidant

Mergers and Acquisitions - Neurologix completes merger

Mergers and Acquisitions - SJ Strategic Investments will not pursue acquisition proposal

Mergers and Acquisitions - University of Pittsburgh Medical Center acquires biotechnology firm

Mesothelioma - CT, MR, and PET imaging should be used to assess malignant pleural mesothelioma

Metastatic Cancer - CT and MRI can identify inferior vena caval thrombus in metastasis to the kidney

Methadone - Nebraska aims to protect children from methadone laboratories

Molecular Biology - Computer scientists develop tool for mining genomic data

Morbid Obesity - Kidney transplants can be successfully performed in morbidly obese patients

Mowat-Wilson Syndrome - Frameshift mutation involved in syndromic corpus callosum agenesis

Multiple Sclerosis - Neutralizing antibodies negatively impact MS therapy's effectiveness

Multiple Sclerosis - Widespread nerve fiber damage associated with fatigue

Muscle Injury - Quadriceps femoris function is restored with a latissimus dorsi muscle transfer

Mutagenesis - Altered iron associates with mutations in those with chronic hepatitis C

Mycobacterium - Luminex profiling system applied to M. tuberculosis genotyping

Myelodysplastic Syndromes - Low-dose topotecan in myelodysplastic syndromes has no effect

Myelodysplastic Syndromes - Treatment monitoring in MDS patients reviewed

Myocardial Infarction - Insulin decreases inflammation, aids clot-busting drugs in heart attack patients

Nanomedicine Trends - Nanobiotech pioneers predict nanomedicine impact within 5 years

Nanotechnology - Synthetic DNA strand could be copied easily

Nerve Damage - Key advance reported in regenerating nerve fibers

Nerve Damage - Stem cells found in adults may repair nerves

Neuroendocrine Tumors - Genetic abnormalities are related to neuroendocrine tumor progression

Neuroendocrine Tumors - Specialty nurses benefit patients with neuroendocrine tumors

Neurology - In utero exposure to alcohol appears to boost risk of psychiatric disorders

Neurology - Mother's exposure to lead linked to schizophrenia in children

Neurology - Small amounts of alcohol or anesthetics may damage the developing brain

Neuroscience - 5HT3 receptors quantified in brain of serotonin-transporter-deficient mice

Neuroscience - Gender should be noted when emotions are mapped on functional brain images

Neuroscience - Mast cells localize near blood vessels in the human area postrema

Neuroscience - Protein synthesis necessary for dendritic spine proliferation in adult brain

Neuroscience - Small interfering RNA's curtail the Huntington disease gene in cell cultures

Neurotoxins - Method to measure toxicity of polypeptides on neuroblastoma cells developed

Nicotine Addiction - Maternal smoking compromises lung function of offspring in several ways

Nicotine Addiction - Tests suggest some predisposed to smoke

Non-Hodgkin Lymphoma - Hair dye use increases blood-cancer risk in women

Nursing Care - Violations found at nursing home where nurse charged after patient death

Nursing Shortage - Plan announced to aid nursing students in Iowa

Nutrition - Food pyramid recommendations made to U.S. Congress

Nutrition - Government computerizes calorie plan

Nutrition - Group suggests dietary intake levels must be realistic for consumers

Nutrition - Wild Oats Markets removes all products containing hydrogenated oils

Obesity - Grant aims to battle obesity in Honolulu

Obesity Genomics and Genetics - Dissection of multigenic obesity traits in congenic mouse strains reported

Obesity Risk Factor - Hypothalamic genes implicated in Psammomys obesus obesity identified

Obesity Survival and Mortality - Mild obesity increases risk of anastomotic leakage after organs transplant

Obesity Therapy -  Salix matsudana leaves exhibit antiobesity action

Obesity Therapy - Anorexigenic fatty acid synthase inhibitor is nonspecific neuronal activator

Obstetrics - Continuous spinal anesthesia feasible for C-section in CHF patients

Obstetrics - Epidural analgesia relieves pain caused by acute symphysis pubis dysfunction

Obstetrics - Factors identified that may contribute to higher stillbirth risk on weekends

Obstetrics - Infants of women who used SSRIs while pregnant show variety of neurobehaviors

Obstetrics - Maternal selenium deficiency increases oxidative stress in fetuses

Obstetrics - Number of cesarean deliveries in Pennsylvania continue to rise

Obstetrics - Prophylactic ondansetron won't alleviate fentanyl-induced itching during labor

Occupational Therapy - Virtual play boosts disabled children's self-image

Oncogenesis - The proto-oncogene hSecurin is highly expressed in some myeloid leukemias

Oncology - COX-2-derived prostaglandin E-2 is a potent breast cancer stimulant

Oncology - Effusions from patients with cancer harbor high levels of angiostatin

Ophthalmic Antibiotic - FDA approves Neomycin, Polymyxin B Sulfates, Bacitracin Zinc ophthalmic ointment

Ophthalmology - Agents aimed at wound healing elements could treat choroidal neovascularization

Oral Cancer - Decades of surgical, therapeutic advances have improved oral cancer survival

Oral Cancer - Smoking black tobacco and drinking alcohol increases risk of oral cancer

Orthopedics - Rapid bone loss is a transient and unfixed phenomenon

Orthopedics - Soluble VEGF isoforms are essential for epiphyseal vascularization

Osteoarthritis - Seniors with best drug coverage more likely to use prescription pain medication

Osteoporosis - Bias clouds attempts to assess quality of life in women with hip fractures

Osteoporosis - Education is key to preventing vertebral compression fractures in the elderly

Osteoporosis - Few women regard spinal fractures as a sign of bone thinning

Osteoporosis - Growth hormone appears to limit fracture risk in people with acromegaly

Osteoporosis - Hormone found to protect bones

Osteoporosis - Patients hospitalized for fracture are being under-treated for osteoporosis

Osteoporosis - Specific bone loss interventions help patients after hip fracture

Osteosarcoma - Noninvasive approach to salvaging limbs helps young bone cancer patients

Ovarian Cancer - Anticancer drug Phenoxodiol produces promising results

Ovarian Cancer - COX-2 and angiogenic status yield ovarian carcinoma prognosis

Ovarian Cancer - Experimental drug used to treat recurrent disease shows promising results

Ovarian Cancer - Guidelines help ovarian cancer patients receive proper treatment referrals

Ovarian Cancer - Raf is necessary for Ras transformation of ovarian epithelial cells

Packaging - Agreement inked for prefilled dual chamber pharmaceutical mixing device

Pain Medicine - Accidental dural puncture during epidural anesthesia causes subdural hematoma

Pain Medicine - Empathy, placebo's power studied

Pain Medicine - Epidural analgesia for labor may be linked to breast-feeding problems

Pain Medicine - Quinolizidine template for opioid receptor ligands synthesized

Pain Medicine - Some patients want to know more than typically offered about labor analgesia

Pain Medicine - Synacthen Depot offers no advantages for treating postdural puncture headache

Pain Medicine - Women with temporomandibular disorder show a cervical lordorsis angle link

Pancreatic Cancer - Multidetector CT may improve imaging of pancreatic adenocarcinoma

Parasitology - Discovery could lead to better treatment for cryptosporidum infections

Parkinson Disease - Link found between parkinsonism and dementia

Patents - Company announces notice of allowance on key AOD9604 obesity patent

Patents - Company granted United States patent for cyclosporine antibodies

Patents - Company receives patent for its adenoviral formulation technology

Patents - Key nanotechnology patent issued

Patents - Locus Pharmaceuticals wins drug-design patents

Patents - New patent on gene targeting broadens genetics company's portfolio

Patents - Patent issued for exosome technology - a new approach to immunology

Patents - Ruling invalidating University of Rochester pain-drug is upheld

Patient Privacy - Judge orders patients names to be turned over by agency

Patient Safety - Minneapolis-St. Paul Children's Hospitals convert to Masimo SET Oximetry

Pediatric Cancer - Computer program aids chemotherapy regimen planning

Pediatric Cancer - MYCN oncogene mediates multidrug resistance-associated protein in neuroblastoma

Pediatric Urology - Croatian and American children bear similar-appearing kidney stones

Pediatrics - Centrality indices characterize fat deposition in youngsters

Pediatrics - Dental and minor physical anomalies reveal youth with developmental disorders

Pediatrics - Premature babies of anxious moms more likely to have worse development outcomes

Pelvic Reconstruction - Transpelvic vertical rectus flaps can cover complex perineal wounds

Perception - Food tastes stronger when you're hungry

Peripheral Artery Disease - IND Application filed for peripheral artery disease therapy

Personnel - Ahmed named senior VP of global productivity at drug discovery firm

Personnel - Ashleigh Palmer named new chief business officer at biotech company

Personnel - Biomaterials company announces sales and marketing organization changes

Personnel - Biopharmaceutical company names Shirley Liu Clayton chief executive officer

Personnel - Biotechnology company announces appointment of new independent director

Personnel - Boess named VP, chief financial officer at pharmaceutical firm

Personnel - Brewer named to biotech company's board of directors

Personnel - Company names new chief technology officer and VP, development

Personnel - Daniel S. Lynch named CEO and director of Erbitux maker

Personnel - David B. Karpf, MD, named chief medical officer

Personnel - Dennis J. Allingham named president and CEO of biomaterials company

Personnel - Device company names Vartan Ghazarossian president and CEO

Personnel - Device firm announces management team changes

Personnel - Device firm names John Grotting chairman, CEO

Personnel - Diabetes company names Michael Mawby as chief government affairs officer

Personnel - Dr. Pradeep Sanghvi to join drug-delivery company

Personnel - Former McKesson executive joins Opus Healthcare Solutions

Personnel - Gary Beil named interim CFO of DaVita

Personnel - Hawkins named new CEO at biotech firm

Personnel - Hythiam names David Smith, MD, as senior vice president of medical affairs

Personnel - Integrated Healthcare Systems appoints Jay C. Grant as vice president, sales

Personnel - James Pennington, MD, joins biopharmaceutical company as chief medical officer

Personnel - John H. Jungbauer joins cardiothoracic-device maker as CFO

Personnel - Kuo, Sedlack named to board of directors at vaccine development company

Personnel - Life sciences company announces new director of business development

Personnel - Manny Villafana to step down as chairman of board of directors

Personnel - Medical device manufacturer announces product advisory board

Personnel - Medical products company names new senior vice president

Personnel - Men's health company taps Greg Deener to head marketing and sales team

Personnel - Mississippi Health Department names new state epidemiologist

Personnel - Mozambique premier to take up research post at U.N. health agency

Personnel - New member appointed to U.S. Health & Human Services advisory committee

Personnel - Pharmaceutical company announces new chief financial officer

Personnel - Pharmaceutical firm announces promotions, management changes

Personnel - Protein therapeutics company announces additions to management team

Personnel - Regence names new executive vice president, health care services

Personnel - Systems regulatory compliance company names new VP, quality assurance

Personnel - Venter to chair scientific advisory board at genomics firm

Personnel - Vice chairman at company resigns at clinical lab firm

Phacoemulsification - Iris hooks can stabilize the capsular bag during phacoemulsification

Pharmaceutical & Drug Development - Novel class of non-covalent cathepsin K inhibitors reported

Physical Activity - Massachusetts girls lag behind boys in sports participation

Physical Fitness - Health plan introduces wellness program in Arizona

Plasma - Scientists tackle human blood plasma proteome

Poliomyelitis Vaccine - Vaccine-derived polioviruses decline in patients with poliomyelitis

Post-thrombotic Syndrome - Post-thrombotic syndrome often complicates deep venous thrombosis

Postoperative Pain - LogPad electronic patient diary to be used in postop pain clinical trial

Postpartum Depression - Magellan identifies barriers to diagnosis, treatment of postpartum depression

Premenstrual Syndrome - New premenstrual syndrome supplement pack launched

Presbyopia - FDA panel recommends approval of CK System for near vision improvement

Prescription Drug Costs - New Hampshire leader suggests state buy drugs in bulk and pass on savings

Prescription Drug Importation - House votes to let Washington state buy drugs from Canada

Preventive Medicine - Practice-based education for doctors improves delivery of preventive childcare

Product Licensing - Nuvelo licenses rNAPc2, an anticoagulant

Prophylactic Antibiotics - Antibiotic prophylaxis in aseptic orthopedic surgery is evaluated

Prostate Cancer - Beta-catenin nuclear signaling molecule may be an oncogene in prostate cancer

Prostate Cancer - New view of recurrent prostate cancer proposed

Prostate Cancer - Sulforaphane reduces PC-3 xenografts in vivo in a murine model

Prostate Cancer - Vibroacoustography holds promise for brachytherapy metal seed imaging

Prosthetics - Cadence HP prosthetic foot now rated up to 350 pounds

Protease Inhibitors - Boosted saquinavir demonstrates superior lipid safety profile vs. Kaletra

Proteomics - Divalent cations augment endostatin after heparin and heparan sulfate binding

Proteomics - Lilly makes $3.2 million commitment to new research center

Proteomics - Phe*-Ala-based pentapeptide mimetics are BACE inhibitors

Proteomics - ProTherm, version 4.0, is thermodynamic database for proteins and mutants

Proteomics - Prostaglandin-J2 has oxygen-dependent effects on VEGF expression

Proteomics - Recombinant human erythropoietin fuels intussusceptive microvascular growth

Proteomics - TrSDB is a proteome database of transcription factors

Proteomics - Update on the 2004 Database of Interacting Proteins reported

Psoriasis - Amevive with common treatments improves chronic plaque psoriasis outcome

Psoriasis - Studies: Tazarotene is well tolerated

Psoriasis - U.S. Soriatane (acitretin) product rights acquired from Roche

Psoriatic Arthritis - Remicade shows promising results in psoriatic arthritis study

Psychology - The coping and defense styles of women with postnatal depression diverge

Psychology - The gravity of one's pregnancy is reflected by certain temperamental traits

Public Health - Infant deaths up in U.S. for first time since 1958

Pulmonary Medicine - Rapid preoxygenation is more effective for women with acute obstetric emergency

Quality Assurance - Respiratory products manufacturer receives FDA warning letter

Quality Assurance - Senate committee OKs medical translator bill

Quality Assurance - Study finds problems with access to credible health information online

Quality Assurance - Sweep of Texas nursing home results in seven arrests

RNA Research - Poly(A) binding protein binds AU-rich RNA via RNA-binding domains 3 and 4

Radiation Oncology - New technology may help doctors more accurately target tumors

Receptor Studies - Cytoskeletal protein 4.1G binds to loop of A1 adenosine receptor

Receptor Studies - RNA editing of serotonin receptor disrupts transactivation of G-protein RhoA

Reproduction - Study: Small newborns indicate higher risk of later stillbirths

Reproductive Medicine - Study finds vasectomy reversal highly effective, even after 15 years

Research Ethics - The link between funding and the disclosure of clinical trial results

Respiratory Medicine - Two formulations of ambroxol hydrochloride tablets are bioequivalent

Respiratory Syncytial Virus - IL-2 expression during RSV infection improves memory CD8 T cell development

Retinopathy - Intravitreal triamcinolone has no impact on VEGF mRNA expression

Salmonella - Assay for detecting salmonella in water used for sprout seeds developed

Schizophrenia - Risperdal Consta significantly reduces need for institutional psychiatric care

Schizophrenia - Ziprasidone improves cognitive function in schizophrenic patients

Scleroderma - Preliminary results reported from phase I/II trial of Cat-192

Sepsis - Docs aim to reduce blood infection deaths

Sepsis - Nitric oxide blockade's role in treating septic shock unclear

Sexual Dysfunction - Future pill for premature ejaculation under study

Sexual and Reproductive Health - Kentucky Senate passes fetal homicide bill

Signaling Networks - Use of its BioMAP technology demonstrated to determine functions of genes

Skin Cancer - Link between tanning devices and skin cancer still unproven but worrisome

Skin Cancer - More patients protect themselves from the sun after skin cancer surgery

Skin Cancer - Sun exposure behaviors correlated with dose of ultraviolet radiation received

Sleep Apnea - Modified surgical procedure appears effective for treating sleep disorder

Smallpox - Few cases of vaccinia transfer reported

Smallpox - Surveillance and containment would be effective against deliberate attack

Smoking Ban - Ireland will outlaw smoking in pubs and other workplaces

Spectroscopy - Laser method identifies, counts toxic molecules

Spinal Cord Injury - Neurologists create a font of human nerve cells

Spinal Cord Injury - Single neurons found to control whisker movement in rats

Spinal Surgery - The risk of acute pancreatitis is increased in children after spinal fusion

Sports Medicine - Gene therapy could lead to super athletes

State Medicaid - Financing measures sent to New Mexico's governor

State Medicaid - Massachusetts governor to propose new way to care for elderly

State Medicaid - Tennessee governor hits the road to promote plan

Stem-Cell Research - Four-color immunofluorescence enables mesenchymal stem cell identification

Stem-Cell Research - Hedgehog-independent pathway identified for oligodendrocyte development

Stem-Cell Research - OLIG2 inhibits astrocyte differentiation

Stem-Cell Transplantation - Minisequencing useful for SNP analysis

Stem-Cell Transplantation - Post-SCT immunological recovery similar in CLL, NHL patients

Stem-Cell Transplantation - Proteasomal cleavage analysis useful for mHps prediction

Stem-Cell Transplantation - Rituximab effective against post-SCT autoimmune hemolytic anemia

Stensen Duct Repair - A vein graft is used as a conduit for Stensen duct defect reconstruction

Stress Urinary Incontinence - Study: More than one out of three women with urinary incontinence have SUI

Stroke - Brain cooling technology may reduce stroke damage

Study Ethics - Unusual study tests artificial blood without patients' consent

Survival & Mortality - Most deaths after hospitalization for vertebral fracture are due to comorbidity

Systemic Lupus Erythematosus - Enrollment complete in confirmatory phase III clinical trial of Prestara

Teratomas - Gonadal teratoma behavior depends upon tumor site and patient age

Thrombocytopenia - Thrombotic thrombocytopenic purpura linked to mutation in ADAMTS13

Thrombopoietin - TPO and anti-FLAG antibodies differentially affect receptor signaling

Thyroid Cancer - Ultrasonography can help guide fine needle aspiration biopsy of thyroid nodules

Thyroid Carcinoma - Quality of life lower during periods of hypothyroidism in thyroid carcinoma

Tick-borne Encephalitis - Widespread immunization reduces incidence of tick-borne encephalitis

Tissue Engineering - Cultured alumina ceramics could prevent aseptic loosening of joint implants

Tissue Engineering - Pioneering techniques may overcome some current challenges

Tobacco Proposal - Congress urged to link buy out of farmers with health regulations

Tobacco Use - Smoking ban proposed at Kentucky capitol

Total Hip Arthroplasty - BiCONTACT revision stems with distal interlocking screws prove satisfactory

Total Hip Arthroplasty - COX inhibitors compared for heterotopic ossification following arthroplasty

Total Hip Arthroplasty - Cementless femoral stems are improved by a high-offset design

Total Hip Arthroplasty - Hydroxyapatite-coated stems may be better than porous-coated stems

Total Knee Arthroplasty - 10-Year survival of PCL-substituting TKA in young rheumatoid patients nears 100%

Total Knee Arthroplasty - Osteolysis in posterior stabilized TKA is best detected with oblique films

Toxicogenomics - FDA supporting toxicogenomic research through ArrayTrack

Toxicology - More women are using atypical antipsychotics during pregnancy

Toxoplasmosis - SAG2 internal image of anti-idiotype antibody protects against toxoplasmosis

Transplant Medicine - Database on blood and marrow stem cell transplants now available online

Transplant Medicine - Hepatocyte growth factor gene therapy improves islet transplantation outcomes

Transplant Medicine - Physicians predict risks of deadly infections after cord blood transplants

Trends - Market growing for energy-based therapeutic technologies

Tuberculosis - Gates Foundation commits $82.9 million to develop new tuberculosis vaccines

Tuberculosis - Nitric oxide mediates anti-TB effects of vitamin D

Tuberculosis Diagnostics - Antibody response to mycobacterial ESAT-6 characterized

Tuberculosis Diagnostics - Glycolipidic antigens can improve TB serodiagnosis

Tuberculosis Diagnostics - Novel mass spectrometry assay aids genotype identification

Tuberculosis Diagnostics - Serum ferritin levels marking iron deficiency in TB patients determined

Tuberculosis Drug Resistance - IS6110 augments phoP transcription in MDR TB

Tuberculosis Epidemiology - TB genotypes in Casablanca characterized

Tuberculosis Pathogenesis - Cholesterol-specific receptor enables mycobacterial cell entry

Tuberculosis Prevention - Clinical trial of new TB vaccine begins

Tuberculosis Proteomics - Structure of M. tuberculosis MPT51 protein characterized

Tuberculosis Therapy - Celiac disease can impair TB therapy

Tuberculosis Therapy - Isoniazid more cost-effective than rifampin-pyrazinamide for latent TB treatment

Tumor Growth - Amine oxidases and tumors are correlated

Type 1 Diabetes Pathogenesis - Expression of MHC molecule leads to thymic deletion of diabetogenic T cells

Type 1 Diabetes Pathogenesis - Self-peptide with superagonist activity blocks type 1 diabetes

Universal Healthcare - Group applauds Massachusetts doctors for supporting single-payer system

Vaccine Development - Tumor-pulsed dendritic cells activate antitumor protection

Vaccinia Virus - Protein kinase has essential catalytic role in vaccinia virus morphogenesis

Varicella-Zoster Virus - Pathogenetic tropism of varicella-zoster virus to human hepatocytes reported

Vascular Dilatation - Vascular dilatation in the pelvis can be due to obstruction or tumor

Vector Delivery - Single photon emission computed tomography tracks genes in minute lung tumors

Vector Development - Coupled carriers may offer a better way to transfer genes to tumor cells

Vector Development - Hybrid vectors generate cells that sustain long-term transgene expression

Vector-borne Disease - E.U. research aims for prevention, control of highly transmissible animal diseases

Vectors and Zoonoses - Multiple anopheline digestive trypsins identified

Venous Leg Ulcers - Frozen OrCel promotes superior healing in venous leg ulcers, study shows

Venous Thromboembolism - Sodium fondaparinux, heparin compared for preventing VTE

Veteran Care - Staffing at Mississippi veterans' homes questioned

Viral Genomics - Denaturing high-performance liquid chromatography can do HCV genotyping

Viral, Bacterial Detection - SMD technology plus lab card device to provide diagnosis of organisms

Virology - A new expression vector augments the cloning of full-length HBV genomes

Virology - Multiply modified retroviral vectors carry high titers in lab evaluations

Virology - gp64-Pseudotyped vectors are appealing because of narrower cell attraction

Vitreoretinal Disease - Horizontal suture fixation of an intralocular lens should be avoided

Wasting Syndrome - Ghrelin upregulated in cachectic nude mice bearing human melanoma cells

Wiskott-Aldrich Syndrome - Wiskott-Aldrich syndrome protein provides little selective benefit to B cells

Women's Health - Clip markers can migrate after imaging-guided directional vacuum-assisted biopsy

Women's Health - Digital mammography has not yet improved cancer detection rates

Wound Care - Angiogenic growth factor is required for wound healing but not wound closing

Wound Care - Ascorbic acid modulates the effects of radiation-delayed wound healing

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