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Adverse Drug Effects
Tumor necrosis factor signals mediate acetaminophen-induced liver injury
March 22nd, 2004
Tumor necrosis factor signals mediate acetaminophen-induced liver injury. According to recent research published in the Journal of Leukocyte Biology, "acetaminophen (APAP) causes a massive production of intrahepatic tumor necrosis factor alpha (TNF-alpha). However, it still remains elusive regarding the roles of TNF-alpha in APAP-induced liver injury. Hence, we examined pathogenic roles of the TNF-alpha-TNF receptor with a molecular weight of 55 kDa (TNF-Rp55) axis in APAP-induced hepatotoxicity using TNF-Rp55-deficient [TNF-Rp55-knockout (KO)] mice." "When wild-type (WT) BALB/c and TNF-Rp55-KO mice were intraperitoneally injected with a...
Source: Health & Medicine Week (2004-03-22)
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