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Antimicrobials
Dose adjustments are not required for elderly patients on ertapenem
March 22nd, 2004
Dose adjustments are not required for elderly patients on ertapenem. "Ertapenem is a new once-a-day parenteral carbapenem antimicrobial agent. The pharmacokinetics of unbound and total concentrations of ertapenem in plasma were investigated in elderly subjects and compared with historical data from young adults. In a single- and multiple-dose study, healthy elderly males and females (n = 14) 65 years old or older were given a 1-g intravenous (i.v.) dose once daily for 7 days," scientists writing in the journal Antimicrobial Agents and Chemotherapy report. "Plasma and urine samples collected for 24 hours on days 1 and 7 following administration...
Source: Health & Medicine Week (2004-03-22)
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