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Antisense Technology
Schizophyllan shows promise for transporting antisense oligonucleotides
March 22nd, 2004
Schizophyllan shows promise for transporting antisense oligonucleotides. "Schizophyllan is a natural beta-(1 --> 3)-D-glucan existing as a triple helix in water and as a single chain in dimethylsulfoxide (DMSO), respectively. As we already reported, when some homo-phosphodiester polynucleotide (for example, poly(dA) or poly(C)) is added to the schizophyllan/DMSO solution and subsequently DMSO is exchanged for water, the single chain of schizophyllan forms a complex with the polynucleotide. Furthermore, we have already demonstrated that one of the potential applications of this novel complex is an antisense-oligonucleotide (AS ODN) carrier," researchers in Japan...
Source: Health & Medicine Week (2004-03-22)
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