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Bacteriology
RickA protein of Rickettsia conorii activates Arp2/3 complex
March 22nd, 2004
The RickA protein of Rickettsia conorii activates the Arp2/3 complex. "Actin polymerization, the main driving force for cell locomotion, is also used by the bacteria Listeria and Shigella and vaccinia virus for intracellular and intercellular movements. Seminal studies have shown the key function of the Arp2/3 complex in nucleating actin and generating a branched array of actin filaments during membrane extension and pathogen movement. Arp2/3 requires activation by proteins such as the WASP-family proteins or ActA of Listeria," scientists in France and the United States report. "We previously reported that actin tails of...
Source: Health & Medicine Week (2004-03-22)
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