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Bioengineering
The angiogenesis inhibitor borrelidin is synthesized within microbes
March 22nd, 2004
The angiogenesis inhibitor borrelidin is synthesized within microbes. According to recent research published in the journal Chemistry & Biology, "the biosynthetic gene cluster for the angiogenesis inhibitor borrelidin has been cloned from Streptomyces parvulus Tu4055." "Sequence analysis indicates that the macrolide ring of borrelidin is formed by a modular polyketide synthase (PKS) (borA1-A6), a result that was confirmed by disruption of borA3. The borrelidin PKS is striking because only seven rather than the nine modules expected for a nonaketide product are encoded by borA1-A6," explained C. Olano and colleagues, University of...
Source: Health & Medicine Week (2004-03-22)
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