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Acute Drug Effects
Arthritis patients with rare polymorphisms risk acute hepatitis with leflunomide
March 22nd, 2004
Arthritis patients with rare polymorphisms risk acute hepatitis with leflunomide. "Leflunomide, a new immunomodulatory agent, was prescribed to a 67-year-old female patient with rheumatoid arthritis. Fifteen days later she developed diarrhea and elevated liver enzymes. A liver biopsy showed a pattern of acute hepatitis," scientists in Spain report. "The patient was homozygous for the rare CYP2C9*3 allele, which determines the slowest metabolic rate for CYP2C9 enzymatic activity that is probably involved in the metabolism of leflunomide," explained C. Sevilla-Mantilla and colleagues, Complutense University, Madrid, Gastroenterology Service. ...
Source: Health & Medicine Week (2004-03-22)
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