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Immunology

Immature myeloid DCs predominant in umbilical cord blood

Published in Health and Medicine Week, March 29th, 2004

Immature myeloid DCs are predominant in umbilical cord blood from healthy newborns.

"It has been suggested lately that some types of antigen presenting cells-myeloid dendritic (DC-1) cells can differentiate the immune response towards Th1 type immunity, whereas lymphoid cells (DC-2) can stimulate Th2 type immunity," immunologists in Poland explained. "It has been observed that neonates are deficient in Th1 response."

D. Darmochwal-Kolarz and colleagues at the University of Lublin conducted a study "to estimate the proportions of immature myeloid (CD1c) and lymphoid (BDCA-2+, BDCA-4) dendritic cells and the CD1c+:BDCA-2+ cell ratio in cord blood of...

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