Meningococcal Vaccine
Integrity assay for meningococcal type B conjugate vaccine developed
Published in Health and Medicine Week, June 21st, 2004
"The development of an analytical procedure for the evaluation of a conjugate vaccine's structural wholeness or integrity is described. The principle component of the vaccine was the N-propionylated group B meningococcal polysaccharide (NPr-GBMP) covalently attached to a carrier protein. The goal of the procedure was to determine whether any whole polysaccharide, oligosaccharide, or monosaccharide, from minute to moderate levels, became detached off the conjugate," scientists in the United States report.
"Free saccharide was isolated from the formulation,...
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