Oncogenesis
Cyclin-dependent kinase 4 may foster liver cancer formation
Published in Health and Medicine Week, June 21st, 2004
"It has been shown that a variety of cell cycle-related proteins play important roles in the process of carcinogenesis including hepatocarcinogenesis. In the present study, we evaluated mRNA and protein expression of G1 phase-related cell cycle molecules in the process of hepatocarcinogenesis, using Long-Evans Cinnamon (LEC) rats, an animal model of hepatocellular carcinoma (HCC). The expression of cyclin D1, cyclin-dependent kinase 4 (Cdk4) and Cdk6 was measured quantitatively by real-time polymerase chain reaction," scientists in Japan report.
"Cyclin D1 mRNA expression was increased...
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