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Wound Healing

Chronic wounds: Hypothesis on their pathogenesis and implications for therapy

Published in Health and Medicine Week, July 26th, 2004

A hypothesis on the pathogenesis of chronic wounds is presented with implications for therapy.

"The development of new therapies for treatment of chronic wounds has not matched the availability of treatment modalities forecast by the pharmaceutical industry," investigators in the United States report. "This is attributable in large part to difficulties encountered in clinical trials as well as in isolating study design variables. Our hypothesis attempts to address this shortcoming."

T. Mustoe and colleagues, Northwestern University, explained "We are proposing that chronic wound pathogenesis is based on three fundamental factors: the cellular and...

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