Leukemia

Complex chromosomes not always associated with rapid disease evolution in MDS

Published in Health and Medicine Week, July 26th, 2004

According to a study from Austria, Myelodysplasia associated with a complex karyotype is usually associated with advanced stage myelodysplastic syndrome (MDS) and an enhanced risk to develop secondary leukemia.

The investigators reported on a 36-year-old female patient who was first presented in 1997 because of 'Pseudo Pelger-Huet' neutrophils. The remaining blood and differential Counts were normal.

"Bone marrow examination revealed dysplasia in the erythroid and granulocytic series, no increase in blasts, and a karyotype with complex aberrations involving chromosomes 7, 13, 20 and 22," according to the report.

"Almost all...

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Source: Health and Medicine Week (2004-07-26)

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