Drug Delivery
Microparticles prolong the effect of glycyrrhetic acid in the liver
Published in Health and Medicine Week, August 2nd, 2004
"The microparticles (MPs) of an anti-hepatotoxic drug, glycyrrhetic acid (GLA), were prepared using poly(DL-lactic acid-co-glycolic acid) as a drug carrier, and their in-vitro properties, biodistribution and therapeutic effects were investigated," investigators in Japan report.
"The MPs showed a particle diameter distribution of 1.0-1.4 mcm and a drug content of approximately 10% (w/w). In the in-vitro release in a mixture of methanol and phosphate-buffered saline pH 7.4 (3:7, v/v), slow release was observed after an initial burst release of approximately 30% (w/w). After i.v....
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