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Syntaxin 1A and RACK1 interact with hDAT N-terminal region

Published in Health and Medicine Week, August 2nd, 2004

The proteins RACK1 and syntaxin 1A interact with the N-terminal region of the dopamine transporter (DAT) in humans.

According to recent research from South Korea, the DAT "regulates the extent and duration of dopamine receptor activation through sodium-dependant reuptake of dopamine into presynaptic neurons, resulting in termination of dopaminergic neurotransmission."

"Using the yeast two-hybrid system," K.H. Lee and coauthors at Hanyang University "identified novel interactions between DAT, the SNARE protein syntaxin 1A, and the receptor for activated C kinases (RACK1)."

"This association involves the intracellular N-terminal...

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