Obesity Pathogenesis
Role of arachidonate cascade during changes in adipocyte life cycle described
Published in Health and Medicine Week, October 18th, 2004
According to a study from Japan, "Although some eicosanoids serve as potent natural ligands to activate peroxisome proliferator-activated receptor (PPAR-gamma), the ability of adipocytes to produce eicosanoids and regulate PPAR-gamma remains unclear. Here, adipogenic 3T3-L1 cells were employed to determine the gene expression of isoforms of biosynthetic enzymes in the arachidonate cyclooxygenase (COX) pathway and the synthesis of prostaglandins (PGs). The expression of COX-2 was induced transiently...
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