Proteomics
Function of Rit42 protein elucidated
Published in Health and Medicine Week, November 1st, 2004
"Mutations in the Drg1/RTP/Rit42 gene are commonly identified in hereditary neuropathies of the motor and sensory systems," scientists in the United States explained. "This gene was also identified as a p53 target gene and a differentiation-related, putative metastatic suppressor gene in human colon and prostate cancer."
In a recent study, K.T. Kim and colleagues at Massachusetts General Hospital found that "the Rit42 protein is a microtubule-associated protein that localizes to the centrosomes and participates in the spindle checkpoint in a p53-dependent manner."
"When...
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